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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 15, 2012 - Issue 5
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Research articles

Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death

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Pages 34-41 | Published online: 19 Jul 2013

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Dillip K. Senapati, D. Jagadeesh Kumar, Priya Narayan, Nagendra H. G.Venkatesha M. A.Govindaraju M.K. R. K. Easwaran, K. V. Ramanathan & S. Raghothama. (2023) Structural analysis of the AICD central 12 residue peptide stretch and its interactions with metals and polyphenols, as a potential drug target for AD. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-9.
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Elif Nur Yilmaz, Sadik Bay, Gurkan Ozturk & Mehmet Hikmet Ucisik. (2020) Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model. International Journal of Nanomedicine 15, pages 9211-9229.
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Xin-Mei Hao, Lian-Da Li, Chang-Ling Duan & Yu-Juan Li. (2017) Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson’s disease in differentiated SH-SY5Y cells. Journal of Asian Natural Products Research 19:8, pages 833-845.
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E. Tapia, L. G. Sánchez-Lozada, W. R. García-Niño, E. García, A. Cerecedo, F. E. García-Arroyo, H. Osorio, A. Arellano, M. Cristóbal-García, M. L. Loredo, E. Molina-Jijón, J. Hernández-Damián, M. Negrette-Guzmán, C. Zazueta, S. Huerta-Yepez, J. L. Reyes, M. Madero & J. Pedraza-Chaverrí. (2014) Curcumin prevents maleate-induced nephrotoxicity: Relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Free Radical Research 48:11, pages 1342-1354.
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Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A.H. Ganie, Sayed M. Eldin, Asimul Islam, Ilyas Khan & Md. Imtaiyaz Hassan. (2023) Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits. Biomedicine & Pharmacotherapy 163, pages 114710.
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Emeka J. Iweala, Miracle E. Uche, Emmanuel Dike Dike, Lotanna Richard Etumnu, Titilope M. Dokunmu, Adurosakin E. Oluwapelumi, Benedict Chukwuebuka Okoro, Omoremime E. Dania, Abiodun H. Adebayo & Eziuche Amadike Ugbogu. (2023) Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles—A review. Pharmacological Research - Modern Chinese Medicine 6, pages 100222.
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Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng & Zhijian Wei. (2023) Multiple mechanisms of curcumin targeting spinal cord injury. Biomedicine & Pharmacotherapy 159, pages 114224.
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Yuan-Yen Chang, Meilin Wang, Jui-Hsuan Yeh, Shang-Chun Tsou, Tzu-Chun Chen, Min-Yen Hsu, Yi-Ju Lee, Inga Wang & Hui-Wen Lin. (2023) The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways. Food & Function.
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Vasin Yuvanatemiya, Pao Srean, Wiyada Kwanhian Klangbud, Karthikeyan Venkatachalam, Jittimon Wongsa, Thanya Parametthanuwat & Narin Charoenphun. (2022) A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps. Molecules 27:24, pages 8775.
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Maryam Davoudi, Yasaman Jadidi, Kiana Moayedi, Vida Farrokhi & Reza Afrisham. (2022) Ameliorative impacts of polymeric and metallic nanoparticles on cisplatin-induced nephrotoxicity: a 2011–2022 review. Journal of Nanobiotechnology 20:1.
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Siao-Pei Guo, Hua-Ching Chang, Long-Sheng Lu, Der-Zen Liu & Tsung-Jen Wang. (2021) Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells. Biomedicine & Pharmacotherapy 141, pages 111834.
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Aihong Yang, Chang Liu, Jiarui Wu, Xiaodi Kou & Rui Shen. (2021) A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease. European Journal of Pharmacology 897, pages 173950.
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Iván Zepeda-Quiróz, Helen Sánchez-Barrera, Zaira Colín-Val, Diana Xochiquetzal Robledo-Cadena, Sara Rodríguez-Enríquez & Rebeca López-Marure. (2020) Curcumin promotes oxidative stress, apoptosis and autophagy in H9c2 rat cardiomyoblasts. Molecular & Cellular Toxicology 16:4, pages 441-453.
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Kooi‐Yeong Khaw, Pravin Kumar, Siti Rafidah Yusof, Surash Ramanathan & Vikneswaran Murugaiyah. (2020) Probing simple structural modification of α‐mangostin on its cholinesterase inhibition and cytotoxicity. Archiv der Pharmazie 353:11, pages 2000156.
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Nur Zuliani Ramli, Mohamad Fairuz Yahaya, Ikuo Tooyama & Hanafi Ahmad Damanhuri. (2020) A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases. Antioxidants 9:10, pages 1019.
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Ha Thi Thu Do & Jungsook Cho. (2020) Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles. International Journal of Molecular Sciences 21:17, pages 6211.
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Mariangela Di Giacomo, Vincenzo Zara, Paolo Bergamo & Alessandra Ferramosca. (2019) Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds. Nutrition Research Reviews 33:1, pages 90-101.
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Abhijeet Parkhe, Pathik Parekh, Lakshmi Vineela Nalla, Nishant Sharma, Monika Sharma, Anagha Gadepalli, Abhijeet Kate & Amit Khairnar. (2020) Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson’s disease. Neuroscience Letters 716, pages 134652.
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Abhijit Dey, Banadipa Nanda, Samapika Nandy, Anuradha Mukherjee & Devendra Kumar Pandey. 2020. Bioactive Natural Products. Bioactive Natural Products 27 79 .
Bibi Marjan Razavi & Hossein Hosseinzadeh. 2020. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. Oxidative Stress and Dietary Antioxidants in Neurological Diseases 249 269 .
Alyna Turner, John J. McGrath, Olivia M. Dean, Seetal Dodd, Andrea Baker, Susan M. Cotton, James G. Scott, Bianca E. Kavanagh, Melanie M. Ashton, Adam J. Walker, Ellie Brown & Michael Berk. (2019) Protocol and Rationale: A 24-week Double-blind, Randomized, Placebo Controlled Trial of the Efficacy of Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia . Clinical Psychopharmacology and Neuroscience 17:2, pages 297-307.
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Shameemah Abrahams, William L. Haylett, Glynis Johnson, Jonathan A. Carr & Soraya Bardien. (2019) Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience 406, pages 1-21.
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Youngmun Lee, Sunyoung Kim, Yeonsoo Oh, Young-Mi Kim, Young-Won Chin & Jungsook Cho. (2019) Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ -Mangostin: In Vitro and In Vivo Evidence . Oxidative Medicine and Cellular Longevity 2019, pages 1-14.
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Sabino H. Avila-Rojas, Edilia Tapia, Alfredo Briones-Herrera, Omar E. Aparicio-Trejo, Juan C. León-Contreras, Rogelio Hernández-Pando & José Pedraza-Chaverri. (2018) Curcumin prevents potassium dichromate (K2Cr2O7)-induced renal hypoxia. Food and Chemical Toxicology 121, pages 472-482.
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Angélica Montiel-Dávalos, Guadalupe Jazmin Silva Sánchez, Elizabeth Huerta-García, Cristhiam Rueda-Romero, Giovanny Soca Chafre, Irma B. Mitre-Aguilar, Ernesto Alfaro-Moreno, José Pedraza-Chaverri & Rebeca López-Marure. (2017) Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells. PLOS ONE 12:12, pages e0188169.
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Youling Fan, Hongtao Chen, Huihua Peng, Fang Huang, Jiying Zhong & Jun Zhou. (2017) Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury. Frontiers in Pharmacology 8.
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Mark L. Failla & Fabiola Gutiérrez‐Orozco*. 2017. Fruit and Vegetable Phytochemicals. Fruit and Vegetable Phytochemicals 165 182 .
Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh. V. Ambudkar & Yu-Shan Wu. (2017) Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter. Molecular Pharmaceutics 14:8, pages 2805-2814.
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Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi & Amirhossein Sahebkar. (2017) Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacological Research 117, pages 218-227.
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Ming-Hui WANG, Kuo-Jun ZHANG, Qin-Lan GU, Xiao-Ling BI & Jin-Xin WANG. (2017) Pharmacology of mangostins and their derivatives: A comprehensive review. Chinese Journal of Natural Medicines 15:2, pages 81-93.
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Dinesh Kumar, Pooja Sharma, Harmanpreet Singh, Kunal Nepali, Girish Kumar Gupta, Subheet Kumar Jain & Fidele Ntie-Kang. (2017) The value of pyrans as anticancer scaffolds in medicinal chemistry. RSC Advances 7:59, pages 36977-36999.
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Yuan Fang, Tu Su, Xiaorong Qiu, Pingan Mao, Yidan Xu, Zizhong Hu, Yi Zhang, Xinhua Zheng, Ping Xie & Qinghuai Liu. (2016) Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Scientific Reports 6:1.
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Joyce Trujillo, Eduardo Molina-Jijón, Omar Noel Medina-Campos, Rafael Rodríguez-Muñoz, José Luis Reyes, María L. Loredo, Diana Barrera-Oviedo, Enrique Pinzón, Daniela Saraí Rodríguez-Rangel & José Pedraza-Chaverri. (2016) Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress. Food & Function 7:1, pages 279-293.
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Akhlaq A. FarooquiAkhlaq A. Farooqui. 2016. Therapeutic Potentials of Curcumin for Alzheimer Disease. Therapeutic Potentials of Curcumin for Alzheimer Disease 151 181 .
Krassimira Yoncheva, Magdalena Kondeva-Burdina, Virginia Tzankova, Petar Petrov, Mohamed Laouani & Silvia S. Halacheva. (2015) Curcumin delivery from poly(acrylic acid-co-methyl methacrylate) hollow microparticles prevents dopamine-induced toxicity in rat brain synaptosomes. International Journal of Pharmaceutics 486:1-2, pages 259-267.
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Prachya Janhom & Permphan Dharmasaroja. (2015) Neuroprotective Effects of Alpha-Mangostin on MPP + -Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells . Journal of Toxicology 2015, pages 1-11.
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Amporn Jariyapongskul, Chonticha Areebambud, Sunit Suksamrarn & Chantana Mekseepralard. (2015) Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats. BioMed Research International 2015, pages 1-10.
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Xinhua Zhou, Longjun Zhu, Liang Wang, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Simon Ming-Yuen Lee, Pei Yu & Yuqiang Wang. (2015) Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxidative Medicine and Cellular Longevity 2015, pages 1-8.
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Lara Gibellini, Elena Bianchini, Sara De Biasi, Milena Nasi, Andrea Cossarizza & Marcello Pinti. (2015) Natural Compounds Modulating Mitochondrial Functions. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-13.
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Joyce Trujillo, Luis Fernando Granados-Castro, Cecilia Zazueta, Ana Cristina Andérica-Romero, Yolanda Irasema Chirino & José Pedraza-Chaverrí. (2014) Mitochondria as a Target in the Therapeutic Properties of Curcumin. Archiv der Pharmazie 347:12, pages 873-884.
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Bo-hyun Choi, Kyung-Shin Kang & Mi-Kyoung Kwak. (2014) Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease. Molecules 19:8, pages 12727-12759.
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Moe Pwint Phyu & Jitbanjong Tangpong. (2014) Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment. Food and Chemical Toxicology 70, pages 151-156.
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Primchanien Moongkarndi, Nattapon Jaisupa, Jutima Samer, Nuttavut Kosem, Julaporn Konlata, Ekkarat Rodpai & Narongchai Pongpan. (2014) Comparison of the biological activity of two different isolates from mangosteen. Journal of Pharmacy and Pharmacology 66:8, pages 1171-1179.
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Jaewon Lee, Dong-Gyu Jo, Daeui Park, Hae Young Chung & Mark P. Mattson. (2014) Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System. Pharmacological Reviews 66:3, pages 815-868.
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Jianjun Lei, Xiongwei Huo, Wanxing Duan, Qinhong Xu, Rong Li, Jiguang Ma, Xuqi Li, Liang Han, Wei Li, Hao Sun, Erxi Wu & Qingyong Ma. (2014) α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. Cancer Letters 347:1, pages 129-138.
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Yuanlin Qi, Mingfang Zhang, Hui Li, Jacqueline A. Frank, Lu Dai, Huijuan Liu & Gang Chen. (2014) MicroRNA-29b Regulates Ethanol-induced Neuronal Apoptosis in the Developing Cerebellum through SP1/RAX/PKR Cascade. Journal of Biological Chemistry 289:14, pages 10201-10210.
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Tonali Blanco-Ayala, Rafael Lugo-Huitrón, Elizabeth M Serrano-López, Ricardo Reyes-Chilpa, Edgar Rangel-López, Benjamín Pineda, Omar Noel Medina-Campos, Laura Sánchez-Chapul, Enrique Pinzón, Trejo-Solis Cristina, Daniela Silva-Adaya, José Pedraza-Chaverrí, Camilo Ríos, Verónica Pérez de la Cruz & Mónica Torres-Ramos. (2013) Antioxidant properties of xanthones from Calophyllum brasiliense: prevention of oxidative damage induced by FeSO4. BMC Complementary and Alternative Medicine 13:1.
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Tian-Tian Zhang & Jian-Guo Jiang. (2013) α-mangostin: One of the best dietary supplements. Molecular Nutrition & Food Research 57:7, pages 1121-1122.
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Susana González-Reyes, Silvia Guzmán-Beltrán, Omar Noel Medina-Campos & José Pedraza-Chaverri. (2013) Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats. Oxidative Medicine and Cellular Longevity 2013, pages 1-14.
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Joyce Trujillo, Yolanda Irasema Chirino, Eduardo Molina-Jijón, Ana Cristina Andérica-Romero, Edilia Tapia & José Pedraza-Chaverrí. (2013) Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biology 1:1, pages 448-456.
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