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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 15, 2012 - Issue 6
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Original research papers

Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress

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Pages 257-263 | Published online: 19 Jul 2013

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Mahboobeh Ghasemzadeh Rahbardar, Batool Hemadeh, Bibi Marjan Razavi, Farhad Eisvand & Hossein Hosseinzadeh. (2022) Effect of carnosic acid on acrylamide induced neurotoxicity: in vivo and in vitro experiments. Drug and Chemical Toxicology 45:4, pages 1528-1535.
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Articles from other publishers (36)

Kaviyarasi Renu, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Uddesh Ramesh Wanjari, Sandra Kannampuzha, Reshma Murali, Vishnu Priya Veeraraghavan, Sathishkumar Vinayagam, Soraya Paz-Montelongo, Alex George, Balachandar Vellingiri & Harishkumar Madhyastha. (2023) Protective effects of macromolecular polyphenols, metals (zinc, selenium, and copper) - Polyphenol complexes, and different organs with an emphasis on arsenic poisoning: A review. International Journal of Biological Macromolecules 253, pages 126715.
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Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha & Hwan-Suck Chung. (2023) Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases. Frontiers in Pharmacology 14.
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Himanshu Verma, Naveen Shivavedi, Mukesh Kumar & Prasanta Kumar Nayak. 2023. Traditional Medicine for Neuronal Health. Traditional Medicine for Neuronal Health 191 212 .
Fatima Javed Mirza, Saadia Zahid & R. M. Damian Holsinger. (2023) Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action. Molecules 28:5, pages 2306.
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Solomon Habtemariam. (2023) Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol. Biomedicines 11:2, pages 545.
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Nawaf Al-Maharik, Nidal Jaradat, Mohammed Hawash, Saad Al-Lahham, Mohammad Qadi, Izzeddin Shoman, Shatha Jaber, Raghad Abdel Rahem, Fatimah Hussein & Linda Issa. (2022) Chemical Composition, Antioxidant, Antimicrobial and Anti-Proliferative Activities of Essential Oils of Rosmarinus officinalis from five Different Sites in Palestine. Separations 9:11, pages 339.
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Iriny M. Ayoub, Mina Y. George, Esther T. Menze, Maryhan Mahmoud, Mariam Botros, Mariam Essam, Israa Ashmawy, Pussey Shendi, Andrew Hany, Mohammed Galal, Mohamed Ayman & Rola M. Labib. (2022) Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model . Food & Function 13:4, pages 2253-2268.
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Jung-Yeon Kim, Hyo-Lim Hong, Gyun Moo Kim, Jaechan Leem & Hyun Hee Kwon. (2021) Protective Effects of Carnosic Acid on Lipopolysaccharide-Induced Acute Kidney Injury in Mice. Molecules 26:24, pages 7589.
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Tainara Cristina Michelotti, Erminio Trevisi & Johan S. Osorio. (2021) An Exploration of the Effects of an Early Postpartum Intravenous Infusion with Carnosic Acid on Physiological Responses of Transition Dairy Cows. Antioxidants 10:9, pages 1478.
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Na Zhou, Ze-yu Wang, Yong Wu, Xiang-jian Zhong, Xin Wang, Jin-jie Li & Xiao-ya Shang. (2021) Norursane-type triterpenoids from Rosmarinus officinalis and their anti-inflammatory activity evaluation. Fitoterapia 153, pages 104982.
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Radhia Aitfella Lahlou, Mustapha Bounechada, Arezki Mohammedi, Luís R. Silva & Gilberto Alves. (2021) Dietary use of Rosmarinus officinalis and Thymus vulgaris as anticoccidial alternatives in poultry. Animal Feed Science and Technology 273, pages 114826.
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Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri & Hossein Hosseinzadeh. (2020) An updated review of protective effects of rosemary and its active constituents against natural and chemical toxicities. Phytotherapy Research 35:3, pages 1313-1328.
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Jie Cheng, Tao Xu, Chuanhui Xun, Hailong Guo, Rui Cao, Shutao Gao & Weibin Sheng. (2021) Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway. Life Sciences 266, pages 118905.
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Mudassar Azhar, Guirong Zeng, Ayaz Ahmed, Ahsana Dar Farooq, Muhammad I. Choudhary, Jiang De‐Jiang & Xinmin Liu. (2020) Carnosic acid ameliorates depressive‐like symptoms along with the modulation of FGF9 in the hippocampus of middle carotid artery occlusion‐induced Sprague Dawley rats . Phytotherapy Research 35:1, pages 384-391.
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Abdullah A. AlKahtane, Esraa Ghanem, Simona G. Bungau, Saud Alarifi, Daoud Ali, Gadah AlBasher, Saad Alkahtani, Lotfi Aleya & Mohamed M. Abdel-Daim. (2020) Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues. Environmental Science and Pollution Research 27:11, pages 11663-11670.
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Marcos Roberto de Oliveira. 2020. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. Oxidative Stress and Dietary Antioxidants in Neurological Diseases 217 230 .
Asrin Babahajian, Arash Sarveazad, Fereshteh Golab, Gelareh Vahabzadeh, Akram Alizadeh, Homa Rasoolijazi, Naser Amini, Maedeh Entezari, Mansoureh Soleimani, Majid Katebi & Seyed Mohammad Amin Haramshahi. (2019) Neuroprotective Effects of Trolox, Human Chorionic Gonadotropin, and Carnosic Acid on Hippocampal Neurodegeneration After Ischemiareperfusion Injury. Current Stem Cell Research & Therapy 14:2, pages 177-183.
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Sahir Sultan Alvi, Parvej Ahmad, Maleeha Ishrat, Danish Iqbal & M. Salman Khan. 2019. Natural Bio-active Compounds. Natural Bio-active Compounds 1 24 .
Irene Dini. 2018. Food Quality: Balancing Health and Disease. Food Quality: Balancing Health and Disease 433 469 .
Anchalee Prasansuklab, Krai Meemon, Prasert Sobhon & Tewin Tencomnao. (2017) Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. BMC Complementary and Alternative Medicine 17:1.
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Ngoc Uy Nguyen & Brendan David Stamper. (2017) Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes. Chemico-Biological Interactions 277, pages 129-136.
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Yu-Long Ma, Li-xia Zhang, Guang-lin Liu, Yanhong Fan, Ye Peng & Wu-Gang Hou. (2016) N-Myc Downstream-Regulated Gene 2 (Ndrg2) Is Involved in Ischemia–Hypoxia-Induced Astrocyte Apoptosis: a Novel Target for Stroke Therapy. Molecular Neurobiology 54:5, pages 3286-3299.
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Chia-Yuan Lin & Chia-Wen Tsai. (2016) Carnosic Acid Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells by Inducing Autophagy Through an Enhanced Interaction of Parkin and Beclin1. Molecular Neurobiology 54:4, pages 2813-2822.
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Andrea del Pilar Sánchez-Camargo & Miguel Herrero. (2017) Rosemary ( Rosmarinus officinalis ) as a functional ingredient: recent scientific evidence. Current Opinion in Food Science 14, pages 13-19.
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Severina Pacifico, Simona Piccolella, Annamaria Lettieri, Paola Nocera, Flavia Bollino & Michelina Catauro. (2017) A metabolic profiling approach to an Italian sage leaf extract (SoA541) defines its antioxidant and anti-acetylcholinesterase properties. Journal of Functional Foods 29, pages 1-9.
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Taiwo Olayemi Elufioye, Tomayo Ireti Berida & Solomon Habtemariam. (2017) Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-27.
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Chia-Yuan Lin, Chia-Wen Tsai & Chia-Wen Tsai. (2016) Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway. Neuropharmacology 110, pages 109-117.
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Marcos Roberto de Oliveira. (2015) The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View. Molecular Neurobiology 53:9, pages 6155-6168.
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Qi GuoZhiyang ShenHongxia YuGaofeng LuYong YuXia LiuPengyuan Zheng. (2016) Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice. The Korean Journal of Physiology & Pharmacology 20:1, pages 15.
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Solomon Habtemariam. (2016) The Therapeutic Potential of Rosemary ( Rosmarinus officinalis ) Diterpenes for Alzheimer’s Disease . Evidence-Based Complementary and Alternative Medicine 2016, pages 1-14.
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Yan HuNing ZhangQing FanMusen LinCe ZhangGuangjun FanXiaohan ZhaiFeng ZhangZhao ChenJihong Yao. (2015) Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway. Canadian Journal of Physiology and Pharmacology 93:8, pages 625-631.
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Qilong Gao, Huaimin Liu, Yamin Yao, Liang Geng, Xinfeng Zhang, Lifeng Jiang, Bian Shi & Feng Yang. (2015) Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. Journal of Applied Toxicology 35:5, pages 485-492.
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Chi-Rei Wu, Chia-Wen Tsai, Shu-Wei Chang, Chia-Yuan Lin, Li-Chun Huang & Chia-Wen Tsai. (2015) Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction. Chemico-Biological Interactions 225, pages 40-46.
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Hu Yan, Yao Jihong, Zhang Feng, Xu Xiaomei, Zhai Xiaohan, Wang Guangzhi, Ma Zhenhai, Gao Dongyan, Ma Xiaochi, Fan Qing, Liu Kexin & Tian Xiaofeng. (2014) Sirtuin 1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury. Critical Care Medicine 42:5, pages e373-e381.
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María Romo Vaquero, Rocío García Villalba, Mar Larrosa, María J. Yáñez-Gascón, Emilie Fromentin, John Flanagan, Marc Roller, Francisco A. Tomás-Barberán, Juan C. Espín & María-Teresa García-Conesa. (2013) Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. Molecular Nutrition & Food Research 57:10, pages 1834-1846.
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Khushwant S. Bhullar & H. P. Vasantha Rupasinghe. (2013) Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2013, pages 1-18.
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