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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 18, 2015 - Issue 8
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Original research paper

Novel relationships between B12, folate and markers of inflammation, oxidative stress and NAD(H) levels, systemically and in the CNS of a healthy human cohort

Jade GuestAustralasian Research Institute, Sydney Adventist Hospital, NSW, Australia;Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
,
Ayse BilginDepartment of Statistics, Macquarie University, Sydney, NSW, Australia
,
Bevan HokinDepartment of Pathology, Sydney Adventist Hospital, NSW, Australia
,
Trevor A. MoriSchool of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia
,
Kevin D. CroftSchool of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia
&
Ross GrantAustralasian Research Institute, Sydney Adventist Hospital, NSW, Australia;Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia;Sydney Adventist Hospital Clinical School, University of Sydney, NSW, AustraliaCorrespondence[email protected]
Pages 355-364 | Published online: 11 Aug 2015

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Smitha Padmanabhan, Mostafa I. Waly, Varna Taranikanti, Nejib Guizani, Amanat Ali, Mohammad S. Rahman, Zaher Al-Attabi, Raya N. Al-Malky, Sultan N. M. Al-Maskari, Bader R. S. Al-Ruqaishi, Jianan Dong & Richard C. Deth. (2019) Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer. Nutrition and Cancer 71:1, pages 100-110.
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Manjeswori Ulak, Ingrid Kvestad, Ram K Chandyo, Catherine Schwinger, Sudha Basnet, Merina Shrestha, Suman Ranjitkar, Linda Vy Nguyen, Diana Corona-Pérez, Immaculata De Vivo, Per M Ueland, Adrian McCann & Tor A Strand. (2023) The Effect of Vitamin B12 Supplementation on Leukocyte Telomere Length in Mildly Stunted Nepalese Children: A Secondary Outcome of a Randomized Controlled Trial. The Journal of Nutrition.
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Inés Domínguez‐López, Marta Kovatcheva, Rosa Casas, Estefanía Toledo, Montserrat Fitó, Emilio Ros, Ramon Estruch, Manuel Serrano & Rosa M. Lamuela‐Raventós. (2023) Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice . Journal of the Science of Food and Agriculture.
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Man Cheng, Xiaoshan Liang, Linran Shi, Qiang Zhang, Liwen Zhang, Zhongying Gong, Suhui Luo, Xuan Wang & Xumei Zhang. (2023) Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia‐reperfusion by enhancing the interaction between IL ‐6 and JAK ‐1/ pSTAT3 . CNS Neuroscience & Therapeutics 29:6, pages 1537-1546.
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Ioannis Liampas, Vasileios Siokas, Christos Bakirtzis & Efthimios Dardiotis. 2023. Vitamins and Minerals in Neurological Disorders. Vitamins and Minerals in Neurological Disorders 309 322 .
Larissa Marcely Gomes Cassiano, Marina da Silva Oliveira & Roney Santos Coimbra. 2023. Vitamins and Minerals in Neurological Disorders. Vitamins and Minerals in Neurological Disorders 399 416 .
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Ye-Seul Koo, Yong-Jae Lee & Jae-Min Park. (2022) Inverse Association of Serum Folate Level with Metabolic Syndrome and Its Components in Korean Premenopausal Women: Findings of the 2016–2018 Korean National Health Nutrition Examination Survey. Nutrients 14:4, pages 880.
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Kamila S Batista, Vanessa M Cintra, Paulo A F Lucena, Raul Manhães-de-Castro, Ana E Toscano, Larissa P Costa, Maria E B S Queiroz, Suellen M de Andrade, Omar Guzman-Quevedo & Jailane de S Aquino. (2022) The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle–gut–brain axis and implications for SARS-CoV-2 infection. Nutrition Reviews 80:3, pages 561-578.
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Bahareh Nikooyeh & Tirang R. Neyestani. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 1007 1041 .
Bahareh Nikooyeh & Tirang R. Neyestani. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 1 36 .
Sung Yong Park, Gina Faraci, Sayan Nanda, Sonia Ter-Saakyan, Tanzy M.T. Love, Wendy J. Mack, Michael P. Dubé & Ha Youn Lee. (2021) Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses. Microbial Pathogenesis 160, pages 105209.
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Anne CC Lee, Sara Cherkerzian, Ingrid E Olson, Salahuddin Ahmed, Nabidul Haque Chowdhury, Rasheda Khanam, Sayedur Rahman, Chloe Andrews, Abdullah H Baqui, Wafaie Fawzi, Terrie E Inder, Stephanie Nartey, Charles A Nelson, Emily Oken, Sarbattama Sen & Raina Fichorova. (2021) Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort. Nutrients 13:11, pages 3792.
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Ana M. Puga, Mar Ruperto, Mª de Lourdes Samaniego-Vaesken, Ana Montero-Bravo, Teresa Partearroyo & Gregorio Varela-Moreiras. (2021) Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer’s Disease: A Narrative Review. Nutrients 13:9, pages 2966.
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Lihua Zhang, Zhongliang Li, Changcheng Xing, Xiaoshan Ma & Rui Xu. (2021) The protective mechanism of folic acid on hyperhomocysteinemia-related arterial injury in spontaneously hypertensive rats: Folic acid against arterial inflammation. Vascular, pages 170853812110365.
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Rakesh Jain, Sloan Manning & Andrew J. Cutler. (2019) Good, better, best: clinical scenarios for the use of L-methylfolate in patients with MDD. CNS Spectrums 25:6, pages 750-764.
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Jiaqi Tong, Senthil Kumaran Satyanarayanan & Huanxing Su. (2020) Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis. Brain, Behavior, and Immunity 90, pages 403-419.
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Sigrun Hope, Terje Nærland, Anne Lise Høiland, Tonje Torske, Eva Malt, Tore Abrahamsen, Mari Nerhus, Kirsten Wedervang–Resell, Vera Lonning, Jarle Johannessen, Nils Eiel Steen, Ingrid Agartz, Nina Stenberg, Thomas Hundhausen, Lars Mørkrid & Ole A. Andreassen. (2020) Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia. The FASEB Journal 34:6, pages 8114-8124.
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Fei Ma, Xuan Zhou, Qing Li, Jiangang Zhao, Aili Song, Peilin An, Yue Du, Weili Xu & Guowei Huang. (2019) Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design. Current Alzheimer Research 16:7, pages 622-632.
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Man Cheng, Liu Yang, Zhiping Dong, Mengying Wang, Yan Sun, Huan Liu, Xuan Wang, Na Sai, Guowei Huang & Xumei Zhang. (2019) Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. Journal of Cellular and Molecular Medicine 23:7, pages 4795-4807.
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Emine M. Onal, Baris Afsar, Adrian Covic, Nosratola D. Vaziri & Mehmet Kanbay. (2018) Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease. Hypertension Research 42:2, pages 123-140.
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E.A. Ostrakhovitch & S. Tabibzadeh. (2019) Homocysteine and age-associated disorders. Ageing Research Reviews 49, pages 144-164.
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Avisek Majumder, Mahavir Singh, Akash K. George, Rubens Petit Homme, Anwesha Laha & Suresh C. Tyagi. (2018) Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective. Journal of Cellular Biochemistry 120:1, pages 77-92.
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Alexander J Layden, Kristos Täse & Julia L Finkelstein. (2018) Neglected tropical diseases and vitamin B12: a review of the current evidence. Transactions of The Royal Society of Tropical Medicine and Hygiene 112:10, pages 423-435.
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Yuzhen Qiang, Qianwen Li, Yongjuan Xin, Xuexian Fang, Yongmei Tian, Jifei Ma, Jianyao Wang, Qingqing Wang, Ruochen Zhang, Junhao Wang & Fudi Wang. (2018) Intake of Dietary One-Carbon Metabolism-Related B Vitamins and the Risk of Esophageal Cancer: A Dose-Response Meta-Analysis. Nutrients 10:7, pages 835.
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Nicholas E. Buglak, Elena V. Batrakova, Roberto Mota & Edward S. M. Bahnson. (2018) Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxidative Medicine and Cellular Longevity 2018, pages 1-23.
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Marina Manhães, Marcelo Cesar, Rayssa Justo, Mauro Geller, Mendel Suchmacher & Rafael Cisne. 2017. Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development. Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development.
Kaveri Arora, Jeffrey M. Sequeira, Alejandro I. Hernández, Juan M. Alarcon & Edward V. Quadros. (2017) Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse. PLOS ONE 12:5, pages e0177156.
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Fernanda Viana Paulin, Alessandro Moura Zagatto, Gaspar R. Chiappa & Paulo de Tarso Müller. (2017) Addition of vitamin B12 to exercise training improves cycle ergometer endurance in advanced COPD patients: A randomized and controlled study. Respiratory Medicine 122, pages 23-29.
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Francesco Bonetti, Gloria Brombo & Giovanni Zuliani. (2016) The relationship between hyperhomocysteinemia and neurodegeneration. Neurodegenerative Disease Management 6:2, pages 133-145.
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