Advanced search
Publication Cover
Hematology Volume 17, 2012 - Issue 4
Submit an article Journal homepage
729
Views
35
CrossRef citations to date
0
Altmetric
HEMATOLOGICAL MALIGNANCY

Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription

Seyed H. GhaffariDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
,
Majid MomenyDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Davood BashashDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; and Department of Hematology, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Roohollah MirzaeiDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Ardeshir GhavamzadehDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
&
Kamran AlimoghaddamDepartment of HematologyOncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Pages 198-206 | Published online: 18 Jul 2013

Citations (35)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Meihua Guo, Jin Zhou, Shengjin Fan, Limin Li, Hongzhu Chen, Liwang Lin, Qilei Zhao, Xinyu Wang, Wensheng Liu, Zhiqiang Wu & Xin Hai. (2021) Characteristics and clinical influence factors of arsenic species in plasma and their role of arsenic species as predictors for clinical efficacy in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide. Expert Review of Clinical Pharmacology 14:4, pages 503-512.
Read now
Peter Møller, Regitze Sølling Wils, Ditte Marie Jensen, Maria Helena Guerra Andersen & Martin Roursgaard. (2018) Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology. Critical Reviews in Toxicology 48:9, pages 761-788.
Read now

Articles from other publishers (33)

Archana Chaudhary, Sadhan Kumar Bhardwaj, Azmi Khan, Amrita Srivastava, Kislay Kumar Sinha, Mehboob Ali & Rizwanul Haque. (2022) Combinatorial Effect of Arsenic and Herbal Compounds in Telomerase-Mediated Apoptosis Induction in Liver Cancer. Biological Trace Element Research 201:7, pages 3300-3310.
Crossref
Kyi Mar Wai, Thinzar Swe, Maw Thoe Myar, Cindy Rahman Aisyah & Thae Su Su Hninn. (2023) Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?. Frontiers in Public Health 10.
Crossref
Ananta, Swati Banerjee, Paul B. Tchounwou & Sanjay Kumar. (2023) Mechanistic update of Trisenox in blood cancer. Current Research in Pharmacology and Drug Discovery 5, pages 100166.
Crossref
Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár & Dos D. Sarbassov. (2022) Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside. Cells 11:21, pages 3454.
Crossref
Sedigheh Baakhlagh, Bahareh Kashani, Zahra Zandi, Davood Bashash, Malihe Moradkhani, Ali Nasrollahzadeh, Marjan Yaghmaei, Seyed A. Mousavi & Seyed H. Ghaffari. (2021) Toll-like receptor 4 signaling pathway is correlated with pathophysiological characteristics of AML patients and its inhibition using TAK-242 suppresses AML cell proliferation. International Immunopharmacology 90, pages 107202.
Crossref
Ali Nasrollahzadeh, Davood Bashash, Majid Kabuli, Zahra Zandi, Bahareh Kashani, Azam Zaghal, Seyed A. Mousavi & Seyed H. Ghaffari. (2020) Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway. Life Sciences 257, pages 118060.
Crossref
Negar Sheikh‐Zeineddini, Ava Safaroghli-azar, Sina Salari & Davood Bashash. (2020) C-Myc inhibition sensitizes pre-B ALL cells to the anti-tumor effect of vincristine by altering apoptosis and autophagy: Proposing a probable mechanism of action for 10058-F4. European Journal of Pharmacology 870, pages 172821.
Crossref
Faranak Alipour, Niknam Riyahi, Ava Safaroghli-Azar, Soyar Sari, Zahra Zandi & Davood Bashash. (2019) Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). The International Journal of Biochemistry & Cell Biology 116, pages 105615.
Crossref
Negar Sheikh‐Zeineddini, Davood Bashash, Ava Safaroghli‐Azar, Niknam Riyahi, Rima Manafi Shabestari, Ehsan Janzamin & Majid Safa. (2019) Suppression of c‐Myc using 10058‐F4 exerts caspase‐3‐dependent apoptosis and intensifies the antileukemic effect of vincristine in pre‐B acute lymphoblastic leukemia cells. Journal of Cellular Biochemistry 120:8, pages 14004-14016.
Crossref
Vera Mugoni, Riccardo Panella, Giulia Cheloni, Ming Chen, Olga Pozdnyakova, Dina Stroopinsky, Jlenia Guarnerio, Emanuele Monteleone, Jonathan David Lee, Lourdes Mendez, Archita Venugopal Menon, Jon Christopher Aster, Andrew A. Lane, Richard Maury Stone, Ilene Galinsky, José Cervera Zamora, Francesco Lo-Coco, Manoj Kumar Bhasin, David Avigan, Letizia Longo, John Gerard Clohessy & Pier Paolo Pandolfi. (2019) Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy. Cell Research 29:6, pages 446-459.
Crossref
Atieh Pourbagheri-Sigaroodi, Davood Bashash, Ava Safaroghli-Azar, Masoumeh Farshi-Paraasghari, Majid Momeny, Fahimeh Nemati Mansoor & Seyed H. Ghaffari. (2019) Contributory role of microRNAs in anti-cancer effects of small molecule inhibitor of telomerase (BIBR1532) on acute promyelocytic leukemia cell line. European Journal of Pharmacology 846, pages 49-62.
Crossref
Yan-Lai Tang, Xi Sun, Li-Bin Huang, Xiao-Jian Liu, Ge Qin, Li-Na Wang, Xiao-Li Zhang, Zhi-Yong Ke, Jie-Si Luo, Cong Liang, Chun-Jin Peng, Wen-Yan Tang, Yu Li, Wenlin Huang, Xue-Qun Luo & Wuguo Deng. (2019) Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. Cancer Letters 443, pages 167-178.
Crossref
Davood Bashash, Mahda Delshad, Niknam Riyahi, Ava Safaroghli-Azar, Atieh Pourbagheri-Sigaroodi & Majid Momeny. (2018) Inhibition of PI3K signaling pathway enhances the chemosensitivity of APL cells to ATO: Proposing novel therapeutic potential for BKM120. European Journal of Pharmacology 841, pages 10-18.
Crossref
Lu Zhong, Fei Xu & Fangyuan Chen. (2018) Arsenic trioxide induces the apoptosis and decreases NF‑κB expression in lymphoma cell lines. Oncology Letters.
Crossref
Magali Humbert, Elena A Federzoni & Mario P Tschan. (2017) Distinct TP73–DAPK2–ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. Journal of Leukocyte Biology 102:6, pages 1357-1370.
Crossref
Leila Asghari-Kia, Davood Bashash, Ava Safaroghli-Azar, Majid Momeny, Mohsen Hamidpour & Seyed H. Ghaffari. (2017) Targeting human telomerase RNA component using antisense oligonucleotide induces rapid cell death and increases ATO-induced apoptosis in APL cells. European Journal of Pharmacology 809, pages 215-223.
Crossref
Majid Zaki Dizaji, Seyed H Ghaffari, Elham Hosseini, Nasrin Alizadeh, Shahrbano Rostami, Majid Momeny, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2017) Survivin isoform expression in arsenic trioxide-treated acute promyelocytic leukemia cell line and patients: The odd expression pattern of survivin-2α. Asia-Pacific Journal of Clinical Oncology 13:2, pages e21-e30.
Crossref
Farima Moghaddaskho, Haniyeh Eyvani, Mohsen Ghadami, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh & Seyed H Ghaffari. (2017) Demethylation and alterations in the expression level of the cell cycle–related genes as possible mechanisms in arsenic trioxide–induced cell cycle arrest in human breast cancer cells. Tumor Biology 39:2, pages 101042831769225.
Crossref
Elaheh Nooshinfar, Davood Bashash, Mahnaz Abbasalizadeh, Ava Safaroghli-Azar, Parisa Sadreazami & Mohammad Esmaeil Akbari. (2017) The Molecular Mechanisms of Tobacco in Cancer Pathogenesis. Iranian Journal of Cancer Prevention In Press:In Press.
Crossref
Haniyeh Eyvani, Farima Moghaddaskho, Majid Kabuli, Ali Zekri, Majid Momeny, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh & Seyed H. Ghaffari. (2016) Arsenic trioxide induces cell cycle arrest and alters DNA methylation patterns of cell cycle regulatory genes in colorectal cancer cells. Life Sciences 167, pages 67-77.
Crossref
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin & Xi Mo. (2016) Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia. Oncology Letters 12:5, pages 3755-3762.
Crossref
Claudia Bruedigam & Steven W. Lane. (2016) Telomerase in hematologic malignancies. Current Opinion in Hematology 23:4, pages 346-353.
Crossref
SZE-KWAN LAM, YUAN-YUAN LI, CHUN-YAN ZHENG & JAMES CHUNG-MAN HO. (2015) Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. International Journal of Oncology 46:1, pages 113-122.
Crossref
Yao Zhang, Miao Sun, Weiwei Shi, Qingling Yang, Changjie Chen, Zhiwei Wang & Xin Zhou. (2015) Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells. Toxicology Letters 232:2, pages 481-489.
Crossref
Limengmeng Wang, Haowen Xiao, Xing Zhang, Chong Wang & He Huang. (2014) The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation. Journal of Hematology & Oncology 7:1.
Crossref
SZE-KWAN LAM, YUAN-YUAN LI, CHUN-YAN ZHENG, LEANNE LEE LEUNG & JAMES CHUNG-MAN HO. (2014) E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. International Journal of Oncology 45:5, pages 2033-2043.
Crossref
Ali Khaleghian, Seyed H. Ghaffari, Shahin Ahmadian, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2014) Metabolism of Arsenic Trioxide in Acute Promyelocytic Leukemia Cells. Journal of Cellular Biochemistry 115:10, pages 1729-1739.
Crossref
Meysam Yousefi, Seyed H. Ghaffari, Ali Zekri, Samad Ghanizadeh-Vesali, Elham Hosseini, Masoumeh Rostami, Saeed Hassani, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide. Neurochemistry International 63:8, pages 809-817.
Crossref
Xiao-Hui Zhang, Ru Feng, Meng Lv, Qian Jiang, Hong-Hu Zhu, Ya-Zhen Qing, Jia-Ling Bao, Xiao-Jun Huang & X. Long Zheng. (2013) Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway. Leukemia Research 37:12, pages 1719-1725.
Crossref
Alois Gratwohl, Helen Baldomero & Jakob Passweg. (2013) Hematopoietic stem cell transplantation activity in Europe. Current Opinion in Hematology 20:6, pages 485-493.
Crossref
Beatriz Soldevilla, Coral San Millán, Félix Bonilla & Gemma Domínguez. (2013) The TP73 complex network: Ready for clinical translation in cancer? . Genes, Chromosomes and Cancer 52:11, pages 989-1006.
Crossref
Ali Zekri, Seyed H. Ghaffari, Meysam Yousefi, Samad Ghanizadeh-Vesali, Majid Mojarrad, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis. Molecular and Cellular Endocrinology 377:1-2, pages 84-92.
Crossref
Saeed Hassani, Seyed H. Ghaffari, Farhad Zaker, Rohellah Mirzaee, Hajar Mardani, Davood Bashash, Ali Zekri, Meysam Yousefi, Azam Zaghal, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest. Annals of Hematology 92:9, pages 1207-1220.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.