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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 30, 2008 - Issue 10: Nerve Regeneration and Nerve Repair
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Articles

Neuronal death after peripheral nerve injury and experimental strategies for neuroprotection

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Pages 999-1011 | Published online: 19 Jul 2013

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Mikel Sánchez, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive & Sabino Padilla. (2017) Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration. Expert Opinion on Biological Therapy 17:2, pages 197-212.
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Jin-Hee Han, Dong-Ok Kim, Jae-Woo Yi, Sung-Wook Park, Wha-Ja Kang, Young-Kyoo Choi, Sang-Hoon Kim, Il-Gyu Ko, Jun-Jang Jin, Sung-Eun Kim & Chang-Ju Kim. (2014) Dexmedetomidine, α2-adrenoceptor agonist, does not induce apoptosis in the brachial plexus of rats. Animal Cells and Systems 18:6, pages 407-415.
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Articles from other publishers (75)

Juqing Song, Baiheng Lv, Wencong Chen, Peng Ding & Yong He. (2023) Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair. International Journal of Extreme Manufacturing 5:3, pages 032008.
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Sara Pourshahidi, Ahmad Reza Shamshiri, Samira Derakhshan, Saba Mohammadi & Mahdi Ghorbani. (2023) The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review. Neurochemical Research 48:8, pages 2335-2344.
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T. Kretschmer. (2023) Rekonstruktive Neurochirurgie: nicht nur bei NervenverletzungenReconstructive neurosurgery: not just for nerve injury. DGNeurologie 6:4, pages 287-296.
Crossref
Stanislav Rodkin, Chizaram Nwosu, Alexander Sannikov, Margarita Raevskaya, Alexander Tushev, Inna Vasilieva & Mitkhat Gasanov. (2023) The Role of Hydrogen Sulfide in Regulation of Cell Death following Neurotrauma and Related Neurodegenerative and Psychiatric Diseases. International Journal of Molecular Sciences 24:13, pages 10742.
Crossref
Wesley S. Warner, Christopher Stubben, Stewart Yeoh, Alan R. Light & Mark A. Mahan. (2023) Next-generation RNA sequencing elucidates transcriptomic signatures of pathophysiologic nerve regeneration. Scientific Reports 13:1.
Crossref
Valdas Macionis. (2023) Chronic pain and local pain in usually painless conditions including neuroma may be due to compressive proximal neural lesion. Frontiers in Pain Research 4.
Crossref
Ariadna Arbat-Plana, Sara Bolívar, Xavier Navarro, Esther Udina & Francisco J. Alvarez. (2023) Massive Loss of Proprioceptive Ia Synapses in Rat Spinal Motoneurons after Nerve Crush Injuries in the Postnatal Period. eneuro 10:2, pages ENEURO.0436-22.2023.
Crossref
Jörg BahmJörg Bahm. 2023. Surgical Rationales in Functional Reconstructive Surgery of the Upper Extremity. Surgical Rationales in Functional Reconstructive Surgery of the Upper Extremity 1 20 .
Suzanne E Thomson, Nigel YB Ng, Mathis O Riehle, Paul J Kingham, Lars B Dahlin, Mikael Wiberg & Andrew M Hart. (2022) Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb. Cochrane Database of Systematic Reviews 2022:12.
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Zheng Wang, Dong Zhang, Xin Zeyu Yi, Yong Zhao & Aixi Yu. (2022) Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy. Frontiers in Neuroscience 16.
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Tana S. Pottorf, Travis M. Rotterman, William M. McCallum, Zoë A. Haley-Johnson & Francisco J. Alvarez. (2022) The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury. Cells 11:13, pages 2083.
Crossref
Napatr Sriraksa, Ratchaniporn Kongsui & Sitthisak Thongrong. (2022) Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury. Biomedical Reports 16:4.
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Xiao-Lei Chu, Xi-Zi Song, Qi Li, Yu-Ru Li, Feng He, Xiao-Song Gu & Dong Ming. (2022) Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation. Neural Regeneration Research 17:10, pages 2185.
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Luke C.E. Allen & Grainne Bourke. (2022) Microsurgical Reconstruction for Reanimation of Foot Dorsiflexion in Children. Plastic and Reconstructive Surgery - Global Open 10:3, pages e4041.
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Gustav Andersson & Paul J. Kingham. 2022. Peripheral Nerve Tissue Engineering and Regeneration. Peripheral Nerve Tissue Engineering and Regeneration 415 435 .
Melissa L. D. Rayner, Jess Healy & James B. Phillips. 2022. Peripheral Nerve Tissue Engineering and Regeneration. Peripheral Nerve Tissue Engineering and Regeneration 437 463 .
Liheng Chen, Emmanuel Ogalo, Chloe Haldane, Sean G. Bristol & Michael J. Berger. (2021) Relationship Between Sensibility Tests and Functional Outcomes in Patients With Traumatic Upper Limb Nerve Injuries: A Systematic Review. Archives of Rehabilitation Research and Clinical Translation 3:4, pages 100159.
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Poornima Ramburrun, Pradeep Kumar, Elias Ndobe & Yahya E. Choonara. (2021) Gellan-Xanthan Hydrogel Conduits with Intraluminal Electrospun Nanofibers as Physical, Chemical and Therapeutic Cues for Peripheral Nerve Repair. International Journal of Molecular Sciences 22:21, pages 11555.
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Lena Stenberg, Derya Burcu Hazer Rosberg, Sho Kohyama, Seigo Suganuma & Lars B. Dahlin. (2021) Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair. International Journal of Molecular Sciences 22:16, pages 8624.
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Gustav Andersson & Paul J. Kingham. 2020. Peripheral Nerve Tissue Engineering and Regeneration. Peripheral Nerve Tissue Engineering and Regeneration 1 22 .
Arash Abdolmaleki, Saber Zahri & Abolfazl Bayrami. (2020) Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat. European Journal of Pharmacology 882, pages 173260.
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T. Neubauer, J. Brand & A. Hartmann. (2020) Neurovaskuläre Komplikationen bei Frakturen der Extremitäten, Teil 2Neuromuscular complications of fractures of the extremities, part 2. Der Unfallchirurg 123:3, pages 225-237.
Crossref
Nahide Ekici-Günay. 2020. Pathology. Pathology 235 245 .
M. L. D. Rayner, J. Healy & J. B. Phillips. 2020. Peripheral Nerve Tissue Engineering and Regeneration. Peripheral Nerve Tissue Engineering and Regeneration 1 27 .
Sizheng Zhou, Min Wu, Gang Chen, Mathias Tremp, Daniel Kalbermatten, Wei Wang & Wenjin Wang. (2019) Effects of repeated transection and coaptation of peripheral nerves on axonal regeneration and motoneuron survival. Journal of Plastic, Reconstructive & Aesthetic Surgery 72:8, pages 1326-1333.
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SarahL Martin, AdamJ Reid, Alexei Verkhratsky, Valerio Magnaghi & Alessandro Faroni. (2019) Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation, cell death and nociception. Neural Regeneration Research 14:6, pages 939.
Crossref
Oliver Bogen, Olaf Bender, Pedro Alvarez, Marie Kern, Stefan Tomiuk, Ferdinand Hucho & Jon D Levine. (2019) Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats. Molecular Pain 15, pages 174480691987455.
Crossref
M.D. Sarker, Saman Naghieh, Adam D. McInnes, David J. Schreyer & Xiongbiao Chen. (2018) Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli. Progress in Neurobiology 171, pages 125-150.
Crossref
Ye Peng, Kai-Yuan Li, Yu-Fei Chen, Xiao-Jie Li, Shu Zhu, Zheng-Yu Zhang, Xiao Wang, Li-Na Duan, Zhuo-Jing Luo, Jun-Jie Du & Jian-Chang Wang. (2018) Beagle sciatic nerve regeneration across a 30 mm defect bridged by chitosan/PGA artificial nerve grafts. Injury 49:8, pages 1477-1484.
Crossref
Deborah O. Setter, Melissa M. Haulcomb, Taylor Beahrs, Rena M. Meadows, Nicole D. Schartz, Sara K. Custer, Virginia M. Sanders & Kathryn J. Jones. (2018) Identification of a resilient mouse facial motoneuron population following target disconnection by injury or disease. Restorative Neurology and Neuroscience 36:3, pages 417-422.
Crossref
Mohammad Ali Hosseinian, Sadegh Shirian, Ali Gharibi Loron, Abdul Ali Ebrahimy & Gholam Hossein Hayatolah. (2017) Distal sensory to distal motor nerve anastomosis can protect lower extremity muscle atrophy in a murine model. European Journal of Plastic Surgery 41:1, pages 9-14.
Crossref
Vijayamma K.N, Ushavathy P & Margret William. (2018) SPINAL CORD- A CADAVERIC STUDY. Journal of Evidence Based Medicine and Healthcare 5:3, pages 265-270.
Crossref
Valentina Cirillo, Jared Bushman, Vincenzo Guarino, Joachim Kohn & Luigi Ambrosio. 2018. Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices. Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices 329 349 .
Jelena M. Janjic & Vijay S. Gorantla. (2017) Peripheral Nerve Nanoimaging: Monitoring Treatment and Regeneration. The AAPS Journal 19:5, pages 1304-1316.
Crossref
Siamak Afshin-Majd, Keyhan Bashiri, Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Reza Sedaghat & Mehrdad Roghani. (2017) Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson’s disease in the rat. Biomedicine & Pharmacotherapy 89, pages 1-9.
Crossref
Suzanne E Thomson, Nigel YB Ng, Mathis O Riehle, Paul J Kingham, Lars B Dahlin, Mikael Wiberg & Andrew M Hart. (2017) Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb. Cochrane Database of Systematic Reviews.
Crossref
N. Mokarram, A. Jain, K. Dymanus, C.M. Valmikinathan & R.V. Bellamkonda. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 288 307 .
Ganlu Hu, Kevin Huang, Youjin Hu, Guizhen Du, Zhigang Xue, Xianmin Zhu & Guoping Fan. (2016) Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Scientific Reports 6:1.
Crossref
Silvan M. Klein, Jody Vykoukal, De-Pei Li, Hui-Lin Pan, Katharina Zeitler, Eckhard Alt, Sebastian Geis, Oliver Felthaus & Lukas Prantl. (2016) Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue–Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration–Approved Nerve Conduit. Plastic & Reconstructive Surgery 138:1, pages 132-139.
Crossref
GERBURG KEILHOFF, BENJAMIN LUCAS, KATJA UHDE & HISHAM FANSA. (2016) Selected gene profiles of stressed NSC-34 cells and rat spinal cord following peripheral nerve reconstruction and minocycline treatment. Experimental and Therapeutic Medicine 11:5, pages 1685-1699.
Crossref
Bo XiaoRami R. ZanounGeorge E. Carvell, Daniel J. Simons & Kia M. Washington. (2016) Response properties of whisker-associated primary afferent neurons following infraorbital nerve transection with microsurgical repair in adult rats. Journal of Neurophysiology 115:3, pages 1458-1467.
Crossref
C. Radtke & P. M. Vogt. 2016. Grundkurs Mikrochirurgie. Grundkurs Mikrochirurgie 125 137 .
YONG-GUANG ZHANG, QING-SONG SHENG, ZHI-JUN WANG, LI LV, WEI ZHAO, JIAN-MEI CHEN & HAO XU. (2015) Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats. Experimental and Therapeutic Medicine 10:2, pages 727-732.
Crossref
Sophie C. Payne, Philip J. Belleville & Janet R. Keast. (2015) Regeneration of sensory but not motor axons following visceral nerve injury. Experimental Neurology 266, pages 127-142.
Crossref
Alessandro Faroni, S. Atefeh Mobasseri, Paul J. Kingham & Adam J. Reid. (2015) Peripheral nerve regeneration: Experimental strategies and future perspectives. Advanced Drug Delivery Reviews 82-83, pages 160-167.
Crossref
Mario Giraldo-Prieto. (2015) Axonal, bladder and bowel impairment: evidence based clinical review of gaps in guidelines for spinal stenosis. Revista Colombiana de Médicina Física y Rehabilitación 25:1, pages 53-62.
Crossref
C. Radtke & P.M. Vogt. (2014) Nervenverletzungen und posttraumatische VersorgungNerve injuries and posttraumatic therapy. Humanmedizin kompakt.
Crossref
Hajime Matsumine, Yuichi Takeuchi, Ryo Sasaki, Tomohiko Kazama, Koichiro Kano, Taro Matsumoto, Hiroyuki Sakurai, Mariko Miyata & Masayuki Yamato. (2014) Adipocyte-Derived and Dedifferentiated Fat Cells Promoting Facial Nerve Regeneration in a Rat Model. Plastic and Reconstructive Surgery 134:4, pages 686-697.
Crossref
C. Radtke & P.M. Vogt. (2014) Nervenverletzungen und posttraumatische VersorgungNerve injuries and posttraumatic therapy. Der Unfallchirurg 117:6, pages 539-556.
Crossref
Paul J. KinghamMallappa K. KolarLiudmila N. NovikovaLev N. NovikovMikael Wiberg. (2014) Stimulating the Neurotrophic and Angiogenic Properties of Human Adipose-Derived Stem Cells Enhances Nerve Repair. Stem Cells and Development 23:7, pages 741-754.
Crossref
Thomas Kretschmer & Gregor Antoniadis. 2014. Nervenchirurgie. Nervenchirurgie 95 182 .
Thomas Kretschmer & Gregor Antoniadis. 2014. Nervenchirurgie. Nervenchirurgie 95 182 .
Juanita J. Anders, Helina Moges, Xingjia Wu, Isaac D. Erbele, Stephanie L. Alberico, Edward K. Saidu, Jason T. Smith & Brian A. Pryor. (2014) In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves. Lasers in Surgery and Medicine 46:1, pages 34-45.
Crossref
Christian Alexander West, Christina Ljungberg, Mikael Wiberg & Andrew Hart. (2013) Sensory Neuron Death After Upper Limb Nerve Injury and Protective Effect of Repair. Neurosurgery 73:4, pages 632-640.
Crossref
Martina Lichtenfels, Lucas Colomé, Alessandra Deise Sebben & Jefferson Braga-Silva. (2013) Effect of platelet rich plasma and platelet rich fibrin on sciatic nerve regeneration in a rat model. Microsurgery 33:5, pages 383-390.
Crossref
Qing-Song Sheng, Zhi-Jun Wang, Jun Zhang & Yong-Guang Zhang. (2013) Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. NeuroReport 24:5, pages 217-223.
Crossref
Peng Wu, Robert J. Spinner, Yudong Gu, Michael J. Yaszemski, Anthony J. Windebank & Huan Wang. (2013) Delayed repair of the peripheral nerve: A novel model in the rat sciatic nerve. Journal of Neuroscience Methods 214:1, pages 37-44.
Crossref
Vasanthy Vigneswara, Martin Berry, Ann Logan & Zubair Ahmed. (2013) Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal. PLoS ONE 8:2, pages e57861.
Crossref
Christian Alexander West, Andrew McKay Hart, Giorgio Terenghi & Mikael Wiberg. (2012) Sensory Neurons of the Human Brachial Plexus. Neurosurgery 70:5, pages 1183-1194.
Crossref
Keren Ben-Yaakov, Shachar Y Dagan, Yael Segal-Ruder, Ophir Shalem, Deepika Vuppalanchi, Dianna E Willis, Dmitry Yudin, Ida Rishal, Franziska Rother, Michael Bader, Armin Blesch, Yitzhak Pilpel, Jeffery L Twiss & Mike Fainzilber. (2012) Axonal transcription factors signal retrogradely in lesioned peripheral nerve. The EMBO Journal 31:6, pages 1350-1363.
Crossref
Ivica Ducic, Rose Fu & Matthew L. Iorio. (2012) Innovative Treatment of Peripheral Nerve Injuries. Annals of Plastic Surgery 68:2, pages 180-187.
Crossref
A.J. Reid, M. Sun, M. Wiberg, S. Downes, G. Terenghi & P.J. Kingham. (2011) Nerve repair with adipose-derived stem cells protects dorsal root ganglia neurons from apoptosis. Neuroscience 199, pages 515-522.
Crossref
K. O'Shea, J. H. Feinberg & S. W. Wolfe. (2011) Imaging and electrodiagnostic work-up of acute adult brachial plexus injuries. Journal of Hand Surgery (European Volume) 36:9, pages 747-759.
Crossref
Helina Moges, Xingjia Wu, Jennifer McCoy, Olavo M. Vasconcelos, Howard Bryant, Neil E. Grunberg & Juanita J. Anders. (2011) Effect of 810 nm light on nerve regeneration after autograft repair of severely injured rat median nerve. Lasers in Surgery and Medicine 43:9, pages 901-906.
Crossref
A. Jain, C.M. Valmikinathan & R.V. Bellamkonda. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 421 434 .
Andrew Hart, Giorgio Terenghi & Mikael Wiberg. 2011. Tissue Engineering. Tissue Engineering 245 262 .
Simon P.J. Kay, Mikael Wiberg & Daniel J.A. Thornton. (2010) Nerves are living structures whose injury requires urgent repair. Journal of Plastic, Reconstructive & Aesthetic Surgery 63:12, pages 1939-1940.
Crossref
Amit Pabari, Shi Yu Yang, Alexander M. Seifalian & Ash Mosahebi. (2010) Modern surgical management of peripheral nerve gap. Journal of Plastic, Reconstructive & Aesthetic Surgery 63:12, pages 1941-1948.
Crossref
T Sun, Z Liu, S Liu & S Xu. (2010) The clinical study of repairing cauda equina fibres with fibrin glue after lumbar fracture and dislocation. Spinal Cord 48:8, pages 633-637.
Crossref
Qing-Gui Xu, Joanne Forden, Sarah K. Walsh, Tessa Gordon & Rajiv Midha. (2010) Motoneuron survival after chronic and sequential peripheral nerve injuries in the rat. Journal of Neurosurgery 112:4, pages 890-899.
Crossref
Fernando M MarFilipa FranquinhoCarolina E FlemingMónica M Sousa. (2009) Transthyretin in peripheral nerve regeneration. Future Neurology 4:6, pages 723-730.
Crossref
Kristian Sorensen & Keith Allison. (2009) An overview of limb replantation. Trauma 11:4, pages 209-220.
Crossref
Adam J. Reid, Susan G. Shawcross, Alex E. Hamilton, Mikael Wiberg & Giorgio Terenghi. (2009) N-Acetylcysteine alters apoptotic gene expression in axotomised primary sensory afferent subpopulations. Neuroscience Research 65:2, pages 148-155.
Crossref
Harukazu Saito, Martin Kanje & Lars B. Dahlin. (2009) Delayed nerve repair increases number of caspase 3 stained Schwann cells. Neuroscience Letters 456:1, pages 30-33.
Crossref
Giorgio Terenghi, Mikael Wiberg & Paul J. Kingham. 2009. 393 403 .

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