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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 31, 2009 - Issue 8: Stroke
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Articles

5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9

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Pages 848-852 | Published online: 19 Jul 2013

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Jerry J Flores, Yang Zhang, Damon W Klebe, Tim Lekic, Weiling Fu & John H Zhang. (2014) Small molecule inhibitors in the treatment of cerebral ischemia. Expert Opinion on Pharmacotherapy 15:5, pages 659-680.
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Dong Kug Choi, Sushruta Koppula, Mijung Choi & Kyoungho Suk. (2010) Recent developments in the inhibitors of neuroinflammation and neurodegeneration: inflammatory oxidative enzymes as a drug target. Expert Opinion on Therapeutic Patents 20:11, pages 1531-1546.
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Jiheng Hao, Yao Feng, Xin Xu, Long Li, Kun Yang, Gaolei Dai, Weiwei Gao, Meng Zhang, Yaming Fan, Tengkun Yin, Jiyue Wang, Bin Yang, Liqun Jiao & Liyong Zhang. (2022) Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke. Frontiers in Immunology 13.
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Hui-Yuan Su, Yi-Cheng Tsai, Hung-Pei Tsai & Chih-Lung Lin. (2022) Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway. International Journal of Molecular Sciences 23:9, pages 4910.
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Te-Yu Hung, Chin-Wei Huang & Sheng-Nan Wu. (2020) High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate IK(Ca) but suppress IK(DR) and IK(M) independently of 5-lipoxygenase inhibition. European Journal of Pharmacology 887, pages 173482.
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Akari Nakamura, Kento Otani & Takashi Shichita. (2020) Lipid mediators and sterile inflammation in ischemic stroke. International Immunology 32:11, pages 719-725.
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Hua-bin Zhang, Xian-kun Tu, Shi-wei Song, Ri-sheng Liang & Song-sheng Shi. (2020) Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats. Chinese Journal of Integrative Medicine 26:7, pages 510-518.
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Cai-Hong Liu, Yuan-Zhi Tan, Dan-Dan Li, Su-Su Tang, Xiao-An Wen, Yan Long, Hong-Bin Sun, Hao Hong & Mei Hu. (2020) Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. International Immunopharmacology 78, pages 105947.
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Su Jing Chan, Mary P. E. Ng, Hui Zhao, Geelyn J. L. Ng, Chuan De Foo, Peter T.-H. Wong & Raymond C. S. Seet. (2019) Early and Sustained Increases in Leukotriene B4 Levels Are Associated with Poor Clinical Outcome in Ischemic Stroke Patients. Neurotherapeutics 17:1, pages 282-293.
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Syed Obaidur Rahman, Rakesh Kumar Singh, Salman Hussain, Mohd. Akhtar & Abul Kalam Najmi. (2019) A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease. European Journal of Pharmacology 842, pages 208-220.
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Dan-Dan Li, Hang Xie, Yi-Feng Du, Yan Long, Miranda N. Reed, Mei Hu, Vishnu Suppiramaniam, Hao Hong & Su-Su Tang. (2018) Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice. Journal of Affective Disorders 227, pages 672-680.
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Zhang Tao, Hua Yue, Luo Hao, Chen Hongmei, Shao Meng, Fu Xiuqiong, John Man-Tak Chu, Huang Guiqiong, Liu Bin & Zhou Yingchun. (2017) Differential gene expression profile of Buyanghuanwu decoction in rats with ventricular remodeling post-myocardial infarction. Journal of Traditional Chinese Medicine 37:3, pages 341-354.
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Paolo Gelosa, Francesca Colazzo, Elena Tremoli, Luigi Sironi & Laura Castiglioni. (2017) Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases. Mediators of Inflammation 2017, pages 1-15.
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Arijit Ghosh, Fang Chen, Abhimanyu Thakur & Hao Hong. (2016) Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders. CNS Neuroscience & Therapeutics 22:12, pages 943-951.
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Xian-kun Tu, Hua-bin Zhang, Song-sheng Shi, Ri-sheng Liang, Chun-hua Wang, Chun-mei Chen & Wei-zhong Yang. (2016) 5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway. Neurochemical Research 41:10, pages 2779-2787.
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FENG-TAO JI, JIAN-JUN LIANG, LI-PING MIAO, QIANG WU & MING-HUI CAO. (2015) Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. Molecular Medicine Reports 12:2, pages 2049-2055.
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Juan Gaztanaga, Michael Farkouh, James H.F. Rudd, Tilmann M. Brotz, David Rosenbaum, Venkatesh Mani, Todd C. Kerwin, Rebecca Taub, Jean-Claude Tardif, Ahmed Tawakol & Zahi A. Fayad. (2015) A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome. Atherosclerosis 240:1, pages 53-60.
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Xiao-Yan Zhang, Lu Chen, Yi Yang, Dong-Min Xu, Si-Ran Zhang, Chen-Tan Li, Wei Zheng, Shu-Ying Yu, Er-Qing Wei & Li-Hui Zhang. (2014) Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1. Brain Research 1572, pages 59-71.
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Song-sheng Shi, Wei-zhong Yang, Xian-kun Tu, Chun-hua Wang, Chen-mei Chen & Yan Chen. (2013) 5-Lipoxygenase Inhibitor Zileuton Inhibits Neuronal Apoptosis Following Focal Cerebral Ischemia. Inflammation 36:6, pages 1209-1217.
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Phillip Pian, Edward Labovitz, Keith Hoffman, Claudia F. Clavijo, Rachael Rzasa Lynn, Jeffrey L. Galinkin, Alexander A. Vinks, Punam Malik & Uwe Christians. (2013) Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 937, pages 79-83.
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Mary Chatterjee, Subhadeep Das, Kaushik Roy & Malay Chatterjee. (2011) Overexpression of 5‐lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12‐dimethylbenz(α)anthracene‐induced rat mammary carcinogenesis. Molecular Carcinogenesis 52:5, pages 359-369.
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Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda & Debra Yourick. (2012) Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. NeuroToxicology 33:6, pages 1476-1490.
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J. Marc Simard, Zhihua Geng, Frank L. Silver, Kevin N. Sheth, W. Taylor Kimberly, Barney J. Stern, Mario Colucci & Volodymyr Gerzanich. (2012) Does inhibiting Sur1 complement rt-PA in cerebral ischemia?. Annals of the New York Academy of Sciences 1268:1, pages 95-107.
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Anna Morancho, Anna Rosell, Lidia García-Bonilla & Joan Montaner. (2010) Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?. Annals of the New York Academy of Sciences 1207:1, pages 123-133.
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Xian-kun Tu, Wei-zhong Yang, Chun-hua Wang, Song-sheng Shi, Yong-liang Zhang, Chun-mei Chen, Yi-kun Yang, Chang-dan Jin & Shuai Wen. (2010) Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats. Inflammation 33:5, pages 344-352.
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Xian-kun Tu, Wei-zhong Yang, Song-sheng Shi, Chun-hua Wang, Guo-liang Zhang, Tian-rui Ni, Chun-mei Chen, Rui Wang, Jian-wen Jia & Qi-min Song. (2010) Spatio-Temporal Distribution of Inflammatory Reaction and Expression of TLR2/4 Signaling Pathway in Rat Brain Following Permanent Focal Cerebral Ischemia. Neurochemical Research 35:8, pages 1147-1155.
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