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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 33, 2011 - Issue 4
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Original Article

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

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Pages 396-404 | Published online: 19 Jul 2013

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Read on this site (4)

Xiaoni Zhang, Yi Li, Xiangpen Li, Xiaoming Rong, Yamei Tang & Ying Peng. (2017) Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study. International Journal of Neuroscience 127:12, pages 1059-1064.
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Sherifa A. Hamed. (2017) Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications. Expert Review of Clinical Pharmacology 10:4, pages 409-428.
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Haiqing Yan, Zhixin Yan, Xiaolu Niu, Jianling Wang, Yongkun Gui & Ping Zhang. (2017) Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study. Neurological Research 39:4, pages 337-343.
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Articles from other publishers (29)

A-ling Tang, Xiao-yu Liu, Nan Gao, Tian-peng Hu, Sheng-tao Yan & Guo-qiang Zhang. (2023) Dl-3-n-butylphthalide improves intestinal microcirculation disorders in septic rats by regulating the PI3K/AKT signaling pathway and autophagy. International Immunopharmacology 118, pages 110049.
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Shu-wen Tan, Tian Xie, Tayyab Hamid Malik & Ying Gao. (2022) Advances of neurovascular protective potential of 3-N-butylphthalide and its derivatives in diabetic related diseases. Journal of Diabetes and its Complications 36:11, pages 108335.
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Wenwen Cui, Yuanyuan Hao, Mingye Wang, Qiuyan Zhang, Junmei Wang, Gang Wei & Yunlong Hou. (2022) Inhibition of Autophagy Facilitates XY03-EA-Mediated Neuroprotection against the Cerebral Ischemia/Reperfusion Injury in Rats. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
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Shu-Chen Liao, Shih-Chieh Shao, Kun-Ju Yang & Chen-Chang Yang. (2021) Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning. Scientific Reports 11:1.
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Yan Han, Ying Chen, Qian Zhang, Bo-Wen Liu, Li Yang, You-Hua Xu & Yong-Hua Zhao. (2021) Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke. Phytomedicine 90, pages 153652.
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José Marco-Contelles & Yihua Zhang. (2020) From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3- n -Butylphthalide . Journal of Medicinal Chemistry 63:21, pages 12485-12510.
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Ayong Tian, Wan Li, Qing Zai, Hui Li & Rong‑Wei Zhang. (2020) 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway. Molecular Medicine Reports 22:1, pages 525-533.
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Hui-xia Ma, Fan Hou, Ai-ling Chen, Ting-ting Li, Ya-fei Zhu & Qi-peng Zhao. (2020) Mu-Xiang-You-Fang protects PC12 cells against OGD/R-induced autophagy via the AMPK/mTOR signaling pathway. Journal of Ethnopharmacology 252, pages 112583.
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Yao Chen, ChunFang Song, Zhenfeng Li, Haiying Chen & Guangyuan Jin. (2019) Effects of hot air and combined microwave and hot air drying on the quality attributes of celery stalk slices. Journal of Food Processing and Preservation 44:1.
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Feng Niu, Aruna Sharma, Zhenguo Wang, Lianyuan Feng, Dafin F. Muresanu, Seaab Sahib, Z. Ryan Tian, José Vicente Lafuente, Anca D. Buzoianu, Ala Nozari, Ranjana Patnaik, Lars Wiklund & Hari Shanker Sharma. 2020. Neuropharmacology of Neuroprotection. Neuropharmacology of Neuroprotection 101 155 .
Fangyu Du, Qifan Zhou, Xiaoxiao Fu, Yajie Shi, Yuanguang Chen, Wuhong Fang, Jingyu Yang & Guoliang Chen. (2019) Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents. RSC Advances 9:5, pages 2498-2508.
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Longjian Huang, Shan Wang, Fei Ma, Yong Zhang, Yuchen Peng, Changhong Xing, Yipu Feng, Xiaoliang Wang & Ying Peng. (2018) From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacological Research 135, pages 201-211.
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Pei Wang, Bo-Zong Shao, Zhiqiang Deng, Shi Chen, Zhenyu Yue & Chao-Yu Miao. (2018) Autophagy in ischemic stroke. Progress in Neurobiology 163-164, pages 98-117.
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Pei Wang & Chao-Yu Miao. 2018. Autophagy and Cardiometabolic Diseases. Autophagy and Cardiometabolic Diseases 137 148 .
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie & Xiao-Ping Pu. (2017) Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging. International Journal of Molecular Sciences 18:11, pages 2451.
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Juan Chen, Jingyang Wang, Jiyan Zhang & Chuanqiang Pu. (2017) Effect of butylphthalide intervention on experimental autoimmune myositis in guinea pigs. Experimental and Therapeutic Medicine.
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Zhilin Xiong, Weibiao Lu, Lihui Zhu, Ling Zeng, Changzheng Shi, Zhen Jing, Yonghui Xiang, Wenxian Li, Chi Kwan Tsang, Yiwen Ruan & Li’an Huang. (2017) Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion. Frontiers in Aging Neuroscience 9.
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Daniela Kasprowska, Grzegorz Machnik, Alicja Kost & Bożena Gabryel. (2016) Time-Dependent Changes in Apoptosis Upon Autophagy Inhibition in Astrocytes Exposed to Oxygen and Glucose Deprivation. Cellular and Molecular Neurobiology 37:2, pages 223-234.
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Xiaoling Chen & Kewei Wang. (2016) The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995–2015. Acta Pharmaceutica Sinica B 6:6, pages 522-530.
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Li‑Xia Xue, Ting Zhang, Yu‑Wu Zhao, Zhi Geng, Jing‑Jiong Chen & Hao Chen. (2016) Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: Effects on neurological and behavioral outcomes in acute ischemic stroke. Experimental and Therapeutic Medicine.
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Yanlin Jian, Jing Ji, Zhangjian Huang, Yang Gao, Xiao Sheng, Wei Yin, Dayong Zhang, Hui Ji & Yihua Zhang. (2016) Enantiomers of 3-pentylbenzo[c]thiophen-1(3H)-one: preparation and evaluation of anti-ischemic stroke activities. RSC Adv. 6:43, pages 36888-36897.
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Cristina Carvalho, Maria S. Santos, Catarina R. Oliveira & Paula I. Moreira. (2015) Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:8, pages 1665-1675.
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Rong-fu Chen, Ting Zhang, Yin-yi Sun, Ya-meng Sun, Wen-qi Chen, Nan Shi, Fang Shen, Yan Zhang, Kang-yong Liu & Xiao-jiang Sun. (2015) Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells. Neural Regeneration Research 10:9, pages 1433.
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Jie Li, Songyun Zhang, Lihui Zhang, Ruiying Wang & Mian Wang. (2014) Effects of l-3-n-Butylphthalide on Cognitive Dysfunction and NR2B Expression in Hippocampus of Streptozotocin (STZ)-Induced Diabetic Rats. Cell Biochemistry and Biophysics 71:1, pages 315-322.
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T. Zhang, H. Wang, Q. Li, J. Huang & X. Sun. (2014) Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model. Neuroscience 263, pages 130-137.
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Ning Wei, Shan-Ping Yu, Xiao-Huan Gu, Dong-Dong Chen, Matthew K. Whalin, Ge-Lin Xu, Xin-Feng Liu & Ling Wei. (2013) The Involvement of Autophagy Pathway in Exaggerated Ischemic Brain Damage in Diabetic Mice. CNS Neuroscience & Therapeutics, pages n/a-n/a.
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Sung Min Son, Hyundong Song, Jayoung Byun, Kyong Soo Park, Hak Chul JangYoung Joo Park & Inhee Mook-Jung. (2012) Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway. Diabetes 61:12, pages 3126-3138.
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Kai Wei, Pei Wang & Chao‐Yu Miao. (2012) A Double‐Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury. CNS Neuroscience & Therapeutics 18:11, pages 879-886.
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Lihong Zhang, Lanhai Lü, W. M. Chan, Yin Huang, Maria S. M. Wai & David T. Yew. (2012) Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis. Neurochemical Research 37:5, pages 911-919.
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