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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 35, 2013 - Issue 9
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Original Article

Combination of high-sensitivity C-reactive protein and homocysteine predicts the short-term outcomes of Chinese patients with acute ischemic stroke

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Pages 912-921 | Received 28 Feb 2013, Accepted 28 Apr 2013, Published online: 18 Nov 2013

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Read on this site (3)

Lingyun Cui, Ping Lu, Shiyu Li, YueSong Pan, Mengxing Wang, Zixiao Li, Xiaoling Liao & Yongjun Wang. (2021) Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack. Neuropsychiatric Disease and Treatment 17, pages 3607-3616.
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Marina Yurievna Maksimova, Alexander Vladimirovich Ivanov, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Fatima Ramazanovna Ochtova, Ekaterina Taymurazovna Suanova, Maria Petrovna Kruglova, Mikhail Aleksanrovich Piradov & Aslan Amirkhanovich Kubatiev. (2021) Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status. Redox Report 26:1, pages 117-123.
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Ziyi Hu, Junyu Lai, Lisha Chen, Ying Yi, Renliang Li & Weimin Liao. (2020) Can baseline C-reactive protein level predict functional outcome in acute ischaemic stroke? A meta-analysis. Biomarkers 25:7, pages 525-532.
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Articles from other publishers (42)

Liuting Chen, Min Wang, Chanrui Yang, Yefei Wang & Bonan Hou. (2023) The role of high-sensitivity C-reactive protein serum levels in the prognosis for patients with stroke: a meta-analysis. Frontiers in Neurology 14.
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Lingling Huang, Rong Zhang, Jiahui Ji, Fengdan Long, Yadong Wang, Juan Lu, Ge Xu & Yaming Sun. (2022) Hypersensitive C‐reactive protein‐albumin ratio is associated with stroke‐associated pneumonia and early clinical outcomes in patients with acute ischemic stroke. Brain and Behavior 12:7.
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Qiong Chen, Wen-Tong Ling & Deng-Ke Han. (2022) Study on the Association of Homocysteine and C-Reactive Protein with Neurofunctional Changes in Patients with Acute Ischemic Stroke After Endovascular Stent Treatment. Neuropsychiatric Disease and Treatment Volume 18, pages 881-889.
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会娟 孟. (2022) Study on Risk Factors of Fatigue after Stroke. Advances in Clinical Medicine 12:05, pages 4496-4502.
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Juan Marta-Enguita, Manuel Navarro-Oviedo, Idoia Rubio-Baines, Nuria Aymerich, Maria Herrera, Beatriz Zandio, Sergio Mayor, Jose-Antonio Rodriguez, Jose-Antonio Páramo, Estefania Toledo, Maite Mendioroz, Roberto Muñoz & Josune Orbe. (2021) Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke. Journal of Neuroinflammation 18:1.
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Oh Joo Kweon, Yong Kwan Lim, Mi-Kyung Lee & Hye Ryoun Kim. (2021) Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke. Disease Markers 2021, pages 1-10.
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Qingjia Zeng, Yaying Zeng, Mark Slevin, Baoqiang Guo, Zhipeng Shen, Binbin Deng & Wenbo Zhang. (2021) C-Reactive Protein Levels and Clinical Prognosis in LAA-Type Stroke Patients: A Prospective Cohort Study. BioMed Research International 2021, pages 1-8.
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Shengming Huang, Jirui Cai & Yuejun Tian. (2021) The Prognostic Value of Homocysteine in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis. Frontiers in Systems Neuroscience 14.
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Po-Ju Chen, Yueh-Chien Lu, Pei-Ming Wang, Chih-Fang Huang & Song-Seng Loke. (2021) Factors associated with hyperhomocysteinemia in relatively healthy Taiwanese adults. Medicine 100:3, pages e23829.
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X. Liu, B. Wang, X. Wang, M. Tian, X. Wang & Y. Zhang. (2020) Elevated plasma high‐sensitivity C‐reactive protein at admission predicts the occurrence of post‐stroke fatigue at 6 months after ischaemic stroke. European Journal of Neurology 27:10, pages 2022-2030.
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Lu Wang, Yuxiao Li, Changyi Wang, Wen Guo & Ming Liu. (2020) C-reactive Protein, Infection, and Outcome After Acute Ischemic Stroke: A Registry and Systematic Review. Current Neurovascular Research 16:5, pages 405-415.
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Yun Luo, Hang Jin, Zhen-Ni Guo, Peng Zhang, Li-Yue Zhang, Jie Chen, Yao Yu, Yan Wang, Jie Liu, Qian-Yan He, Xin Sun & Yi Yang. (2019) Effect of Hyperhomocysteinemia on Clinical Outcome and Hemorrhagic Transformation After Thrombolysis in Ischemic Stroke Patients. Frontiers in Neurology 10.
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Jun-Chao Xie, Ying-Ying Lin, Xiao-Hui Liu, Yi-Chen Zhao, Xiao-Ye Ma, Jia Yu, Xue-Yuan Liu & Yan-Xin Zhao. (2018) Homocysteine is Associated with Exaggerated Morning Blood Pressure Surge in Patients with Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases 27:10, pages 2650-2656.
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Jieyun Yin, Chongke Zhong, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Libing Guo, Xuemei Wang, Jintao Zhang, Yong Cui, Dong Li, Jianhui Zhang, Zhong Ju, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang & Jiang He. (2018) Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke. Clinica Chimica Acta 479, pages 132-137.
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Li-Shan Cheng, Wen-Jun Tu, Yuan Shen, Li-Jun Zhang & Kangxiang Ji. (2017) Combination of High-Sensitivity C-Reactive Protein and Homocysteine Predicts the Post-Stroke Depression in Patients with Ischemic Stroke. Molecular Neurobiology 55:4, pages 2952-2958.
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Huimin Fan, Shuna Yang, Yue Li, Jiangmei Yin, Wei Qin, Lei Yang, Junliang Yuan & Wenli Hu. (2018) Assessment of Homocysteine as a Diagnostic and Early Prognostic Biomarker for Patients with Acute Lacunar Infarction. European Neurology 79:1-2, pages 54-62.
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Feng Zhou, Lv Zhou, Tie Guo, Nianzhen Wang, Haizhen Hao, Yanhui Zhou & Dan Yu. (2017) Plasma proteomics reveals coagulation, inflammation, and metabolic shifts in H-type hypertension patients with and without acute ischemic stroke. Oncotarget 8:59, pages 100384-100395.
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Yong-Bo Zhang, Zhiming Yin, Xinwen Han, Quanliang Wang, Zhen Zhang & Jia Geng. (2017) Association of circulating high-sensitivity C-reactive protein with late recurrence after ischemic stroke. NeuroReport 28:10, pages 598-603.
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Zusen Ye, Zhizhong Zhang, Hao Zhang, Yonggang Hao, Jun Zhang, Wenhua Liu, Gelin Xu & Xinfeng Liu. (2017) Prognostic Value of C-Reactive Protein and Homocysteine in Large-Artery Atherosclerotic Stroke: a Prospective Observational Study. Journal of Stroke and Cerebrovascular Diseases 26:3, pages 618-626.
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Hong Yu, Yue Huang, XinYu Chen, WenBao Nie, YongJun Wang, Yan Jiao, Guy L. Reed, Weikuan Gu & Hong Chen. (2017) High-sensitivity C-reactive protein in stroke patients – The importance in consideration of influence of multiple factors in the predictability for disease severity and death. Journal of Clinical Neuroscience 36, pages 12-19.
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Smitha Kalarikkal Satheesan, Shibu Thadathil Sreedharan & Parvathi Krishna Warrier. (2017) SERUM HOMOCYSTEINE AS A RISK FACTOR IN ISCHAEMIC STROKE- A CROSS-SECTIONAL OBSERVATIONAL STUDY IN A TERTIARY CARE TEACHING HOSPITAL IN NORTHERN KERALA. Journal of Evidence Based Medicine and Healthcare 4:4, pages 163-167.
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Merdin Markišić, Aleksandra M. Pavlović & Dragan M. Pavlović. (2017) The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. BioMed Research International 2017, pages 1-6.
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Jiaokun Jia, Anxin Wang, Jing Wang, Jianwei Wu, Xiujuan Yan, Yong Zhou, Shengyun Chen & Xingquan Zhao. (2016) Homocysteine and Its Relationship to Asymptomatic Carotid Stenosis in a Chinese Community Population. Scientific Reports 6:1.
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Alejandro Bustamante, Alba Simats, Andrea Vilar-Bergua, Teresa García-Berrocoso & Joan Montaner. (2016) Blood/Brain Biomarkers of Inflammation After Stroke and Their Association With Outcome: From C-Reactive Protein to Damage-Associated Molecular Patterns. Neurotherapeutics 13:4, pages 671-684.
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Emre Kumral, Gülsüm Saruhan, Dilara Aktert & Mehmet Orman. (2016) Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke. Journal of Stroke and Cerebrovascular Diseases 25:8, pages 2047-2054.
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Xianwei Zeng, Guoqing Zhang, Bin Yang, Bo Zhang, Linpeng Zhang, Ying Ni, Chen Liu & Yumeng Luo. (2015) Neopterin as a Predictor of Functional Outcome and Mortality in Chinese Patients with Acute Ischemic Stroke. Molecular Neurobiology 53:6, pages 3939-3947.
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He-Hong Geng, Xin-Wang Wang, Rong-Li Fu, Meng-Juan Jing, Ling-Ling Huang, Qing Zhang, Xiao-Xiao Wang & Pei-Xi Wang. (2016) The Relationship between C-Reactive Protein Level and Discharge Outcome in Patients with Acute Ischemic Stroke. International Journal of Environmental Research and Public Health 13:7, pages 636.
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Yan Han, Shuai Wu, Qiang Hu, Jian-Qi Xiao, Dong-Mei Wei, Li-Li Liu & Ze-Zhi Li. (2015) Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians. Molecular Neurobiology 53:4, pages 2659-2667.
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Chao-Zhi Tang, Yu-Ling Zhang, Wen-Sheng Wang, Wei-Guo Li & Ji-Peng Shi. (2015) Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels. Molecular Neurobiology 53:4, pages 2152-2160.
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Paola Forti, Fabiola Maioli, Giorgia Arnone, Maura Coveri, Gian Luca Pirazzoli, Marco Zoli & Gaetano Procaccianti. (2016) Homocysteinemia and early outcome of acute ischemic stroke in elderly patients. Brain and Behavior 6:5.
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Chao Wang, Li Gao, Zhi-Guo Zhang, Yu-Qian Li, Yan-Long Yang, Tao Chang, Long-Long Zheng, Xing-Ye Zhang, Ming-Hao Man & Li-Hong Li. (2015) Procalcitonin Is a Stronger Predictor of Long-Term Functional Outcome and Mortality than High-Sensitivity C-Reactive Protein in Patients with Ischemic Stroke. Molecular Neurobiology 53:3, pages 1509-1517.
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Rui-rui Yang, Bo-cheng Lu, Tao Li, Yi-feng Du, Xiang Wang & Yan-xia Jia. (2016) The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study. International Journal of Geriatric Psychiatry 31:3, pages 231-239.
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En-Sheng YaoYan TangMin-Jie XieMing-Huan WangHong WangXiang Luo. (2016) Elevated Homocysteine Level Related to Poor Outcome After Thrombolysis in Acute Ischemic Stroke. Medical Science Monitor 22, pages 3268-3273.
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Mustafa Ceylan, Ahmet Yalcin, O. Faruk Bayraktutan, Omer Atis & Ethem Acar. (2015) Serum pentraxin-3 levels in acute stroke: No association with stroke prognosis. Atherosclerosis 243:2, pages 616-620.
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Dan Xie, Li Deng, Xiao-dong Liu, Ji-mei Li & Yong-bo Zhang. (2015) Role of high sensitivity C-reactive protein and other risk factors in intracranial and extracranial artery occlusion in patients with ischaemic stroke. Journal of International Medical Research 43:5, pages 711-717.
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Hong-Juan Fu, Li-Bo Zhao, Ju-Jun Xue, Zhi-Xuan Wu, Yue-Ping Huang, Wei Liu & Zhan Gao. (2015) Elevated Serum Homocysteine (Hcy) Levels May Contribute to the Pathogenesis of Cerebral Infarction. Journal of Molecular Neuroscience 56:3, pages 553-561.
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Lihua Jia, Fang Hao, Weihua Wang & Yang Qu. (2015) Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients. Cell Biochemistry and Function 33:5, pages 314-319.
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You-Mei Li & Xue-Yuan Liu. (2015) Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke. Journal of the Neurological Sciences 352:1-2, pages 68-73.
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Chongke Zhong, Liying Lv, Changjiang Liu, Liang Zhao, Mo Zhou, Wenjie Sun, Tan Xu & Weijun Tong. (2014) High Homocysteine and Blood Pressure Related to Poor Outcome of Acute Ischemia Stroke in Chinese Population. PLoS ONE 9:9, pages e107498.
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Chang-yi Wang, Zhong-wei Chen, Tao Zhang, Jun Liu, Si-han Chen, Sheng-yuan Liu, Li-yuan Han, Zhao-hui Hui & Yu-ming Chen. (2014) Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients. European Journal of Internal Medicine 25:6, pages 538-544.
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Shao-yi Li, Yun Gao, Wei-ning Ma, Hua-chao Wang, Gang Zhou, Wen-chang Guo & Yun-hui Liu. (2013) The Relationship Between Serum Lipoprotein (a) Levels and Ischemic Stroke Risk: A Cohort Study in the Chinese Population. Inflammation 37:3, pages 686-693.
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