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Redox Report
Communications in Free Radical Research
Volume 15, 2010 - Issue 3
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Research article

Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide

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Pages 115-122 | Published online: 19 Jul 2013

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Sarika Singh, Supriya Swarnkar, Poonam Goswami & Chandishwar Nath. (2011) Astrocytes and Microglia: Responses to Neuropathological Conditions. International Journal of Neuroscience 121:11, pages 589-597.
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Shubhangini Tiwari, Abhishek Singh, Parul Gupta, Amrutha K & Sarika Singh. (2023) UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death. ACS Chemical Neuroscience 14:5, pages 839-850.
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Ivanka Kostadinova, Magdalena Kondeva-Burdina, Lyubomir Marinov, Lubomir L. Vezenkov & Rumyana Simeonova. (2023) Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease. Life 13:1, pages 139.
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Jiahui Shao, Xuan Liu, Mengjia Lian & Youbing Mao. (2022) Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotoxicity Research 40:6, pages 2221-2237.
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David Mallet, Raphael Goutaudier, Emmanuel L. Barbier, Sebastien Carnicella, Jerry R. Colca, Florence Fauvelle & Sabrina Boulet. (2022) Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson’s Disease. Molecular Neurobiology 59:10, pages 6170-6182.
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Amrutha K, Amit Mishra & Sarika Singh. (2022) Implications of intracellular protein degradation pathways in Parkinson's disease and therapeutics. Journal of Neuroscience Research 100:10, pages 1834-1844.
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Shubhangini Tiwari, Parul Gupta, Abhishek Singh, Swati Chaturvedi, M. Wahajuddin, Amit Mishra & Sarika Singh. (2022) 4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson’s Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation. Neurochemical Research.
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Xian‐Guo Zou, Meng‐Ting Xu, Xiao‐Li Dong, You‐Min Ying, Rong‐Fa Guan, Wei‐Cheng Wu, Kai Yang & Pei‐Long Sun. (2022) Solid‐state‐cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6‐hydroxydopamine‐induced toxicity in PC12 cells . Journal of Food Biochemistry 46:8.
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Suchita Ganesan & Venkatachalam Deepa Parvathi. (2021) Deconstructing the molecular genetics behind the PINK1/Parkin axis in Parkinson’s disease using Drosophila melanogaster as a model organism. Egyptian Journal of Medical Human Genetics 22:1.
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Ashish Singh, Arun Kumar Yadawa, Swati Chaturvedi, M. Wahajuddin, Amit Mishra & Sarika Singh. (2021) Mechanism for antiParkinsonian effect of resveratrol: Involvement of transporters, synaptic proteins, dendrite arborization, biochemical alterations, ER stress and apoptosis. Food and Chemical Toxicology 155, pages 112433.
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Shubhangini Tiwari & Sarika Singh. (2020) Reciprocal Upshot of Nitric Oxide, Endoplasmic Reticulum Stress, and Ubiquitin Proteasome System in Parkinson’s Disease Pathology. The Neuroscientist 27:4, pages 340-354.
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Sonam Gupta, Amit Mishra & Sarika Singh. (2021) Cardinal role of eukaryotic initiation factor 2 (eIF2α) in progressive dopaminergic neuronal death & DNA fragmentation: Implication of PERK:IRE1α:ATF6 axis in Parkinson's pathology. Cellular Signalling 81, pages 109922.
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Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra & Sarika Singh. (2021) Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. Biochemical Journal 478:7, pages 1435-1451.
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Swathi Kesh, Rajaretinam Rajesh Kannan, Kalaiarasi Sivaji & Anandan Balakrishnan. (2021) Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson’s disease model. Neuroscience Letters 740, pages 135426.
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Nathalie Satta, Rémy Weppe, Sabrina Pagano, Miguel Frias, Catherine Juillard & Nicolas Vuilleumier. (2020) Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis. Oncotarget 11:46, pages 4266-4280.
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Claudia Luna-Herrera, Irma A. Martínez-Dávila, Luis O. Soto-Rojas, Yazmin M. Flores-Martinez, Manuel A. Fernandez-Parrilla, Jose Ayala-Davila, Bertha A. León-Chavez, Guadalupe Soto-Rodriguez, Victor M. Blanco-Alvarez, Francisco E. Lopez-Salas, Maria E. Gutierrez-Castillo, Bismark Gatica-Garcia, America Padilla-Viveros, Cecilia Bañuelos, David Reyes-Corona, Armando J. Espadas-Alvarez, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-lópez & Daniel Martinez-Fong. (2020) Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra. Journal of Immunology Research 2020, pages 1-19.
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Ashish Singh, Pratibha Tripathi, Arun Kumar Yadawa & Sarika Singh. (2020) Promising Polyphenols in Parkinson’s Disease Therapeutics. Neurochemical Research 45:8, pages 1731-1745.
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Manish Kumar Tripathi, Maryam Kartawy & Haitham Amal. (2020) The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders. Redox Biology 34, pages 101567.
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Monika Pichla, Łukasz Pulaski, Katarzyna Dominika Kania, Ireneusz Stefaniuk, Bogumił Cieniek, Natalia Pieńkowska, Grzegorz Bartosz & Izabela Sadowska-Bartosz. (2020) Nitroxide Radical-Containing Redox Nanoparticles Protect Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine Toxicity. Oxidative Medicine and Cellular Longevity 2020, pages 1-19.
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Sonam Gupta, Joyshree Biswas, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Amit Mishra & Sarika Singh. (2019) Salubrinal attenuates nitric oxide mediated PERK:IRE1α: ATF-6 signaling and DNA damage in neuronal cells. Neurochemistry International 131, pages 104581.
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Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Amit Mishra, Rakesh Maurya & Sarika Singh. (2019) Ulmosides A: Flavonoid 6-C-glycosides from Ulmus wallichiana attenuates lipopolysacchride induced oxidative stress, apoptosis and neuronal death. NeuroToxicology 73, pages 100-111.
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Nour S. Erekat. 2018. Parkinson’s Disease: Pathogenesis and Clinical Aspects. Parkinson’s Disease: Pathogenesis and Clinical Aspects 65 82 .
Dinesh Kumar Verma, Sonam Gupta, Joyshree Biswas, Neeraj Joshi, K. Sivarama Raju, Mu. Wahajuddin & Sarika Singh. (2018) Metabolic Enhancer Piracetam Attenuates the Translocation of Mitochondrion-Specific Proteins of Caspase-Independent Pathway, Poly [ADP-Ribose] Polymerase 1 Up-regulation and Oxidative DNA Fragmentation. Neurotoxicity Research 34:2, pages 198-219.
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Dinesh Kumar Verma, Sonam Gupta, Joyshree Biswas, Neeraj Joshi, Abhishek Singh, Parul Gupta, Shubhangini Tiwari, K. Sivarama Raju, Swati Chaturvedi, M. Wahajuddin & Sarika Singh. (2018) New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:6, pages 2078-2096.
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Daniel Hernandez-Baltazar, Rasajna Nadella, Maria de Jesus Rovirosa-Hernandez, Laura Mireya Zavala-Flores & Christian de Jesus Rosas Jarquin. 2018. Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy. Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy.
Dinesh Kumar Verma, Dhirendra Kumar Singh, Sonam Gupta, Parul Gupta, Abhishek Singh, Joyshree Biswas & Sarika Singh. (2018) Minocycline diminishes the rotenone induced neurotoxicity and glial activation via suppression of apoptosis, nitrite levels and oxidative stress. NeuroToxicology 65, pages 9-21.
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Neeraj Joshi & Sarika Singh. (2018) Updates on immunity and inflammation in Parkinson disease pathology. Journal of Neuroscience Research 96:3, pages 379-390.
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D. Hernandez-Baltazar, L.M. Zavala-Flores & A. Villanueva-Olivo. (2017) The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model. Neurología (English Edition) 32:8, pages 533-539.
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D. Hernandez-Baltazar, L.M. Zavala-Flores & A. Villanueva-Olivo. (2017) El modelo de 6-hidroxidopamina y la fisiopatología parkinsoniana: nuevos hallazgos en un viejo modelo. Neurología 32:8, pages 533-539.
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Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma & Sarika Singh. (2017) Streptozotocin alters glucose transport, connexin expression and endoplasmic reticulum functions in neurons and astrocytes. Neuroscience 356, pages 151-166.
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Russell Dahl. (2017) A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorganic & Medicinal Chemistry 25:1, pages 53-57.
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Elaine Del-Bel, Mariza Bortolanza, Maurício Dos-Santos-Pereira, Keila Bariotto & Rita Raisman-Vozari. (2016) l -DOPA-induced dyskinesia in Parkinson's disease: Are neuroinflammation and astrocytes key elements? . Synapse 70:12, pages 479-500.
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Poonam Goswami, Sonam Gupta, Joyshree Biswas, Sharad Sharma & Sarika Singh. (2015) Endoplasmic Reticulum Stress Instigates the Rotenone Induced Oxidative Apoptotic Neuronal Death: a Study in Rat Brain. Molecular Neurobiology 53:8, pages 5384-5400.
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B. Pramila, P. Kalaivani, A. Anita & C. Saravana Babu. (2015) l-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats. Pharmacology Biochemistry and Behavior 135, pages 246-253.
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Neeraj Joshi, Joyshree Biswas, C. Nath & Sarika Singh. (2014) Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology. Molecular Neurobiology 52:1, pages 330-340.
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Poonam Goswami, Sonam Gupta, Neeraj Joshi, Sharad Sharma & Sarika Singh. (2015) Astrocyte activation and neurotoxicity: A study in different rat brain regions and in rat C6 astroglial cells. Environmental Toxicology and Pharmacology 40:1, pages 122-139.
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Sonam Gupta, Poonam Goswami, Joyshree Biswas, Neeraj Joshi, Sharad Sharma, C. Nath & Sarika Singh. (2015) 6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 778, pages 22-36.
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Carlos J. Baier, María Eugenia Pallarés, Ezequiela Adrover, María R. Katunar, Rita Raisman-Vozari & Marta C. Antonelli. (2014) Intrastriatal 6-OHDA Lesion Differentially Affects Dopaminergic Neurons in the Ventral Tegmental Area of Prenatally Stressed Rats. Neurotoxicity Research 26:3, pages 274-284.
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Sonam Gupta, Dinesh Kumar Verma, Joyshree Biswas, K. Siva Rama Raju, Neeraj Joshi, Wahajuddin & Sarika Singh. (2014) The metabolic enhancer piracetam attenuates mitochondrion-specific endonuclease G translocation and oxidative DNA fragmentation. Free Radical Biology and Medicine 73, pages 278-290.
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Wei-Guo Liu, Jun-Yi Zhao, Hao Zhang, Xin-Yong Liu & Xiu-Li Guo. (2014) MSTMP, a Stilbene Derivative, Protects SH-SY5Y Cells Against Oxidative Stress. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 41:3, pages 382-388.
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Satya Prakash Gupta, Sharawan Yadav, Naveen Kumar Singhal, Manindra Nath Tiwari, Sarad Kumar Mishra & Mahendra Pratap Singh. (2013) Does Restraining Nitric Oxide Biosynthesis Rescue from Toxins-Induced Parkinsonism and Sporadic Parkinson's Disease?. Molecular Neurobiology 49:1, pages 262-275.
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Vietla S. Rao, Ana C. Carvalho, Maria Teresa S. Trevisan, Geanne M. Andrade, Helio V. NobreJúniorJúnior, Manoel O. Moraes, Hemerson I. Magalhães H. Iury, Talita C. Morais & Flavia A. Santos. (2012) Mangiferin ameliorates 6-hydroxydopamineinduced cytotoxicity and oxidative stress in ketamine model of schizophrenia. Pharmacological Reports 64:4, pages 848-856.
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Terina N. MartinezJ. Timothy Greenamyre. (2012) Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease. Antioxidants & Redox Signaling 16:9, pages 920-934.
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Erin K. Butler, Aaron Voigt, A. Kathrin Lutz, Jane P. Toegel, Ellen Gerhardt, Peter Karsten, Björn Falkenburger, Andrea Reinartz, Konstanze F. Winklhofer & Jörg B. Schulz. (2012) The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity. PLoS Genetics 8:2, pages e1002488.
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Galina Vavilova, Tatyana Shimanskaya, Nataliya Strutynska, Sergey Talanov & Vadim Sagach. 2012. Intermittent Hypoxia and Human Diseases. Intermittent Hypoxia and Human Diseases 59 69 .
Min-Kyoung Kim, Sang-Cheol Kim, Jung-Il Kang, Jae-Hee Hyun, Hye-Jin Boo, Su-Yong Eun, Deok-Bae Park, Eun-Sook Yoo, Hee-Kyoung Kang & Ji-Hoon Kang. (2010) 6-Hydroxydopamine-Induced PC12 Cell Death is Mediated by MEF2D Down-regulation. Neurochemical Research 36:2, pages 223-231.
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Kemal Ugur Tufekci, Sermin Genc & Kursad Genc. (2011) The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease. Parkinson's Disease 2011, pages 1-25.
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