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Cochlear Implants International
An Interdisciplinary Journal for Implantable Hearing Devices
Volume 15, 2014 - Issue 5
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Original research papers

Development of a safe dexamethasone-eluting electrode array for cochlear implantation

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Read on this site (5)

Elise Ajay, Niliksha Gunewardene & Rachael Richardson. (2022) Emerging therapies for human hearing loss. Expert Opinion on Biological Therapy 22:6, pages 689-705.
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Yanjing Luo, Anning Chen, Muqing Xu, Dongxiu Chen, Jie Tang, Dong Ma & Hongzheng Zhang. (2021) Preparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants. Drug Delivery 28:1, pages 1673-1684.
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Karina Needham, Dimitra Stathopoulos, Carrie Newbold, Jason Leavens, Frank Risi, Shahram Manouchehri, Irfan Durmo & Robert Cowan. (2020) Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear array. Cochlear Implants International 21:2, pages 98-109.
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Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol & Robert Cowan. (2019) Protecting against electrode insertion trauma using dexamethasone. Cochlear Implants International 20:1, pages 1-11.
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Dimitra Stathopoulos, Scott Chambers, Louise Adams, Roy Robins-Browne, Christopher Miller, Ya Lang Enke, Benjamin P C Wei, Stephen O'Leary, Robert Cowan & Carrie Newbold. (2015) Meningitis and a safe dexamethasone-eluting intracochlear electrode array. Cochlear Implants International 16:4, pages 201-207.
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Articles from other publishers (32)

Wiebke Behrends, Daniel Ahrens, Jens P. Bankstahl, Karl-Heinz Esser, Gerrit Paasche, Thomas Lenarz & Verena Scheper. (2023) Refinement of systemic guinea pig deafening in hearing research: Sensorineural hearing loss induced by co-administration of kanamycin and furosemide via the leg veins. Laboratory Animals 57:6, pages 631-641.
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Jolan Wellens, Olivier Deschaume, Tristan Putzeys, Samuel Eyley, Wim Thielemans, Nicolas Verhaert & Carmen Bartic. (2023) Sulfobetaine-based ultrathin coatings as effective antifouling layers for implantable neuroprosthetic devices. Biosensors and Bioelectronics 226, pages 115121.
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Robert D. Gay, Ya Lang Enke, Jonathon R. Kirk & Denise R. Goldman. (2022) Therapeutics for hearing preservation and improvement of patient outcomes in cochlear implantation—Progress and possibilities. Hearing Research 426, pages 108637.
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Sebastian A. Ausili, Matias Parreño, Florencia Fernandez, Carlos M. Boccio & Federico A. Di Lella. (2022) Biological Response Dynamics to Cochlear Implantation: Modeling and Modulating the Electrode–Tissue Interface. Ear & Hearing 43:6, pages 1687-1697.
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Sabrina L. Macias & Benjamin G. Keselowsky. (2022) Perspectives on immunometabolism at the biomaterials interface. Molecular Aspects of Medicine 83, pages 100992.
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Dongxiu Chen, Yanjing Luo, Jing Pan, Anning Chen, Dong Ma, Muqing Xu, Jie Tang & Hongzheng Zhang. (2021) Long-Term Release of Dexamethasone With a Polycaprolactone-Coated Electrode Alleviates Fibrosis in Cochlear Implantation. Frontiers in Cell and Developmental Biology 9.
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Jinsong Hao & S. Kevin Li. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 377 392 .
Seong-Hun Jeong, Yoonjoong Kim, Ah-Ra Lyu, Sun-Ae Shin, Tae Hwan Kim, Yang Hoon Huh, A Reum Je, Akanksha Gajibhiye, Yang Yu, Yongde Jin, Min Jung Park & Yong-Ho Park. (2021) Junctional Modulation of Round Window Membrane Enhances Dexamethasone Uptake into the Inner Ear and Recovery after NIHL. International Journal of Molecular Sciences 22:18, pages 10061.
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Philippine Toulemonde, Michaël Risoud, Pierre Emmanuel Lemesre, Cyril Beck, Jean Wattelet, Meryem Tardivel, Juergen Siepmann & Christophe Vincent. (2021) Evaluation of the Efficacy of Dexamethasone-Eluting Electrode Array on the Post-Implant Cochlear Fibrotic Reaction by Three-Dimensional Immunofluorescence Analysis in Mongolian Gerbil Cochlea. Journal of Clinical Medicine 10:15, pages 3315.
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Kate M. Brody, Amy J. Hampson, Hyun-jung Cho, Prudence Johnson & Stephen J. O’Leary. (2020) A new method for three-dimensional immunofluorescence study of the cochlea. Hearing Research 392, pages 107956.
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Robert Briggs, Stephen O ’Leary, Catherine Birman, Kerrie Plant, Ruth English, Pamela Dawson, Frank Risi, Jason Gavrilis, Karina Needham & Robert Cowan. (2020) Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear™ Contour Advance® electrode in adult cochlear implant recipients. Hearing Research 390, pages 107924.
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Arne Liebau, Sören Schilp, Kenneth Mugridge, Ilona Schön, Michel Kather, Bernd Kammerer, Jochen Tillein, Susanne Braun & Stefan K. Plontke. (2020) Long-Term in vivo Release Profile of Dexamethasone-Loaded Silicone Rods Implanted Into the Cochlea of Guinea Pigs. Frontiers in Neurology 10.
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Jessica K. Choong, Amy J. Hampson, Kate M. Brody, Jonathon Lo, Christofer W. Bester, Anthony W. Gummer, Nicholas P. Reynolds & Stephen J. O’Leary. (2020) Nanomechanical mapping reveals localized stiffening of the basilar membrane after cochlear implantation. Hearing Research 385, pages 107846.
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Chanan Shaul, Padmavathi K. Venkatagiri, Jonathon Lo, Hayden T. Eastwood, Christofer W. Bester, Robert J. S. Briggs & Stephen J. O’Leary. (2019) Glucocorticoid for Hearing Preservation After Cochlear Implantation: A Systemic Review and Meta-analysis of Animal Studies. Otology & Neurotology 40:9, pages 1178-1185.
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Enrique Perez, Andrea Viziano, Zaid Al-Zaghal, Fred F. Telischi, Rachele Sangaletti, Weitao Jiang, William Dalton Dietrich, Curtis King, Michael E. Hoffer & Suhrud M. Rajguru. (2019) Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery. Otology & Neurotology 40:9, pages 1167-1177.
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Yutian Ma, Andrew K. Wise, Robert K. Shepherd & Rachael T. Richardson. (2019) New molecular therapies for the treatment of hearing loss. Pharmacology & Therapeutics 200, pages 190-209.
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R.D. Frisina, M. Budzevich, X. Zhu, G.V. Martinez, J.P. Walton & D.A. Borkholder. (2018) Animal model studies yield translational solutions for cochlear drug delivery. Hearing Research 368, pages 67-74.
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Muqing Xu, Dong Ma, Dongxiu Chen, Jieqing Cai, Qiaofang He, Fan Shu, Jie Tang & Hongzheng Zhang. (2018) Preparation, characterization and application research of a sustained dexamethasone releasing electrode coating for cochlear implantation. Materials Science and Engineering: C 90, pages 16-26.
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Ah-Ra Lyu, Dong Hyun Kim, Seung Hun Lee, Dong-Sik Shin, Sun-Ae Shin & Yong-Ho Park. (2018) Effects of dexamethasone on intracochlear inflammation and residual hearing after cochleostomy: A comparison of administration routes. PLOS ONE 13:3, pages e0195230.
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Jonathon Lo, Luke Campbell, Phillip Sale, Scott Chambers, Amy Hampson, Hayden Eastwood & Stephen O’Leary. (2017) The Role of Preoperative Steroids in Atraumatic Cochlear Implantation Surgery. Otology & Neurotology 38:8, pages 1118-1124.
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Verena Scheper, Roland Hessler, Mareike Hütten, Maciej Wilk, Claude Jolly, Thomas Lenarz & Gerrit Paasche. (2017) Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation. PLOS ONE 12:8, pages e0183820.
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Jonathon Lo, Phillip Sale, Sudanthi Wijewickrema, Luke Campbell, Hayden Eastwood & Stephen John O’leary. (2017) Defining the Hook Region Anatomy of the Guinea Pig Cochlea for Modeling of Inner Ear Surgery. Otology & Neurotology 38:6, pages e179-e187.
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Herbert Mauch & Paul Boyd. (2016) TRADUCCIÓN ESTIMULACIÓN ELECTRO-ACÚSTICA UNA OPCIÓN CUANDO LOS AUDÍFONOS NO SON SUFICIENTE. Revista Médica Clínica Las Condes 27:6, pages 787-797.
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Herbert Mauch Biomed & Paul Boyd. (2016) ELECTRO-ACOUSTIC STIMULATION - AN OPTION WHEN HEARING AIDS ARE NOT ENOUGH. Revista Médica Clínica Las Condes 27:6, pages 776-786.
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Esperanza Bas, Jorge Bohorquez, Stefania Goncalves, Enrique Perez, Christine T. Dinh, Carolyn Garnham, Roland Hessler, Adrien A. Eshraghi & Thomas R. Van De Water. (2016) Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study. Hearing Research 337, pages 12-24.
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Ya Liu, Claude Jolly, Susanne Braun, Thomas Stark, Elias Scherer, Stefan K. Plontke & Jan Kiefer. (2015) In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants. European Archives of Oto-Rhino-Laryngology 273:7, pages 1745-1753.
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H. Jia, F. François, J. Bourien, M. Eybalin, R.V. Lloyd, T.R. Van De Water, J.-L. Puel & F. Venail. (2016) Prevention of trauma-induced cochlear fibrosis using intracochlear application of anti-inflammatory and antiproliferative drugs. Neuroscience 316, pages 261-278.
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Ingo Todt, Arneborg Ernst & Philipp Mittmann. (2016) Effects of Round Window Opening Size and Moisturized Electrodes on Intracochlear Pressure Related to the Insertion of a Cochlear Implant Electrode. Audiology and Neurotology Extra 6:1, pages 1-8.
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Maciej Wilk, Roland Hessler, Kenneth Mugridge, Claude Jolly, Michael Fehr, Thomas Lenarz & Verena Scheper. (2016) Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode. PLOS ONE 11:2, pages e0147552.
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Ya Liu, Claude Jolly, Susanne Braun, Thomas Janssen, Elias Scherer, Jochen Steinhoff, Harald Ebenhoch, Andrea Lohner, Thomas Stark & Jan Kiefer. (2015) Effects of a dexamethasone-releasing implant on cochleae: A functional, morphological and pharmacokinetic study. Hearing Research 327, pages 89-101.
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H. Smeds, H.T. Eastwood, A.J. Hampson, P. Sale, L.J. Campbell, B.D. Arhatari, S. Mansour & S.J. O'Leary. (2015) Endolymphatic hydrops is prevalent in the first weeks following cochlear implantation. Hearing Research 327, pages 48-57.
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Kyeung A. Ryu, Ah-Ra Lyu, Heesung Park, Jin Woong Choi, Gang Min Hur & Yong-Ho Park. (2015) Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study. PLOS ONE 10:8, pages e0136617.
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