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Research articles

Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent association in men with chronic spinal cord injury

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Ahmad Al-Qudimat, Raed M. Al-Zoubi, Aksam A. Yassin, Mustafa Alwani, Omar M. Aboumarzouk, Khaled AlRumaihi, Raidh Talib & Abdulla Al Ansari. (2021) Testosterone treatment improves liver function and reduces cardiovascular risk: A long-term prospective study. Arab Journal of Urology 19:3, pages 376-386.
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Aksam A. Yassin, Mustafa Alwani, Riadh Talib, Yousef Almehmadi, Joanne E. Nettleship, Khalid Alrumaihi, Bassam Albaba, Daniel M. Kelly & Farid Saad. (2020) Long-term testosterone therapy improves liver parameters and steatosis in hypogonadal men: a prospective controlled registry study. The Aging Male 23:5, pages 1553-1563.
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David R. Gater$suffix/text()$suffix/text(), Gary J. Farkas, Arthur S. Berg & Camilo Castillo. (2019) Prevalence of metabolic syndrome in veterans with spinal cord injury. The Journal of Spinal Cord Medicine 42:1, pages 86-93.
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Tom E. Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S. Gill, Teodoro Castillo, Robert A. Adler & Ashraf S. Gorgey. (2018) Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review. The Journal of Spinal Cord Medicine 41:6, pages 624-636.
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Arcangelo Barbonetti, Maria Rosaria C. Vassallo, Giorgio Felzani, Sandro Francavilla & Felice Francavilla. (2016) Association between 25(OH)-vitamin D and testosterone levels: Evidence from men with chronic spinal cord injury. The Journal of Spinal Cord Medicine 39:3, pages 246-252.
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Articles from other publishers (45)

Alan L. Hutchison, Federica Tavaglione, Stefano Romeo & Michael Charlton. (2023) Endocrine aspects of metabolic dysfunction-associated steatotic liver disease (MASLD): Beyond insulin resistance. Journal of Hepatology 79:6, pages 1524-1541.
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Jinlin Xu, Yuehui Jin, Chengwu Song, Guangya Chen, Qiaoyu Li, Hao Yuan, Sha Wei, Min Yang, Sen Li & Shuna Jin. (2023) Comparative analysis of the synergetic effects of Diwuyanggan prescription on high fat diet-induced non-alcoholic fatty liver disease using untargeted metabolomics. Heliyon 9:11, pages e22151.
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Nicola Caretta, Raffaele Scafa, Andrea Graziani, Maria Cristina Crepaldi, Monica Vedovato, Angelo Avogaro & Alberto Ferlin. (2023) Noninvasive Indices of MASLD Are Associated With Hypogonadism in Male Patients With Type 2 Diabetes Mellitus. The Journal of Clinical Endocrinology & Metabolism.
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F. Di Giulio, C. Castellini, D. Tienforti, G. Felzani, M. G. Baroni & A. Barbonetti. (2023) Independent association of hypovitaminosis d with non-alcoholic fatty liver disease in people with chronic spinal cord injury: a cross-sectional study. Journal of Endocrinological Investigation.
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Dan Eisenberg, Katherine D. Arnow, Nicolas B. Barreto, Kristen Davis, Sherri L. LaVela, Susan M. Frayne, Andrea L. Nevedal, Justina Wu & Alex H. S. Harris. (2022) Interaction between increasing body mass index and spinal cord injury to the probability of developing a diagnosis of nonalcoholic fatty liver disease. Obesity Science & Practice 9:3, pages 253-260.
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L. J. Yang, J. Z. Zhou, Y. F. Zheng, X. Hu, Z. Y. He, L. J. Du, X. Gu, X. Y. Huang, J. Li, Y. Q. Li, L. Y. Pan, X. X. Zhang & X. J. Gu. (2023) Association of non-alcoholic fatty liver disease with total testosterone in non-overweight/obese men with type 2 diabetes mellitus. Journal of Endocrinological Investigation 46:8, pages 1565-1572.
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K. F. Reid, T. W. Storer, K. M. Pencina, R. Valderrabano, N. K. Latham, L. Wilson, C. Ghattas, R. Dixon, A. Nunes, N. Bajdek, G. Huang, S. E. Skeels, A. P. Lin, S. M. Merugumala, H. J. Liao, M. L. Bouxsein, R. D. Zafonte & S. Bhasin. (2022) A multimodality intervention to improve musculoskeletal health, function, metabolism, and well-being in spinal cord injury: study protocol for the FIT-SCI randomized controlled trial. BMC Musculoskeletal Disorders 23:1.
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Sara Arefhosseini, Mehrangiz Ebrahimi-Mameghani, Farzad Najafipour & Helda Tutunchi. (2022) Non-alcoholic fatty liver disease across endocrinopathies: Interaction with sex hormones. Frontiers in Endocrinology 13.
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N. Narinx, K. David, J. Walravens, P. Vermeersch, F. Claessens, T. Fiers, B. Lapauw, L. Antonio & D. Vanderschueren. (2022) Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology. Cellular and Molecular Life Sciences 79:11.
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Hykoush A. Asaturyan, Nicolas Basty, Marjola Thanaj, Brandon Whitcher, E. Louise Thomas & Jimmy D. Bell. (2022) Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling. PLOS ONE 17:9, pages e0273171.
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Madalena Von-Hafe, Marta Borges-Canha, Catarina Vale, Ana Rita Leite, João Sérgio Neves, Davide Carvalho & Adelino Leite-Moreira. (2022) Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review. Metabolites 12:4, pages 298.
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Murat İSPİROĞLU. (2022) Testosteron Tedavisinin Hipogonad Hastalardaki Non-Alkolik Yağlı Karaciğer Hastalığı Üzerine Etkisinin Fibroscan ile DeğerlendirilmesiEvaluation of the Effect of Testosterone Treatment on Non-Alcoholic Fatty Liver Disease in Hypogonad Patients with Fibroscan. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 17:1, pages 186-192.
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Man-Qiu Mo, Zi-Chun Huang, Zhen-Hua Yang, Yun-Hua Liao, Ning Xia & Ling Pan. (2022) Relationship between total testosterone, sex hormone–binding globulin levels and the severity of non-alcoholic fatty liver disease in males: a meta-analysis. Therapeutic Advances in Endocrinology and Metabolism 13, pages 204201882211068.
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Arcangelo Barbonetti, Chiara Castellini, Sandro Francavilla, Felice Francavilla & Settimio D’Andrea. 2022. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury 377 388 .
Bess M. Miller, Isaac M. Oderberg & Wolfram Goessling. (2021) Hepatic Nervous System in Development, Regeneration, and Disease. Hepatology 74:6, pages 3513-3522.
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Antonio Parisi, Maria Totaro, Chiara Castellini, Settimio D’ Andrea, Daniele Tienforti, Sara Palazzi, Federica D’ Amato, Mario Muselli, Sandro Francavilla & Arcangelo Barbonetti. (2021) Men with spinal cord injury have a smaller prostate volume than age-matched able-bodied men: a meta-analysis of case-control studies. Spinal Cord 59:11, pages 1210-1215.
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Matthew T. Goodus, Kaitlin E. Carson, Andrew D. Sauerbeck, Priyankar Dey, Anthony N. Alfredo, Phillip G. Popovich, Richard S. Bruno & Dana M. McTigue. (2021) Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits. Experimental Neurology 342, pages 113725.
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Arthur Sefiani & Cédric G. Geoffroy. (2021) The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury. Frontiers in Neuroscience 15.
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Kristin Alexandra Dayton, Fernando Bril, Diana Barb, Jinping Lai, Srilaxmi Kalavalapalli & Kenneth Cusi. (2021) Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes. PLOS ONE 16:6, pages e0251449.
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Marc-Olivier Deguise, Lucia Chehade & Rashmi Kothary. (2021) Metabolic Dysfunction in Spinal Muscular Atrophy. International Journal of Molecular Sciences 22:11, pages 5913.
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S. D’Andrea, A. Martorella, F. Coccia, C. Castellini, E. Minaldi, M. Totaro, A. Parisi, F. Francavilla, S. Francavilla & A. Barbonetti. (2020) Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis. Endocrine 72:1, pages 49-61.
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L.K. Parkhomenko, L.A. Strashok, S.I. Turchyna, Z.V. Yeloyeva, T.M. Klymenko, H.V. Kosovtsova, D.A. Kashkalda, E.M. Zavelya, M.Y. Isakova, A.V. Yeshchenko & T.P. Kostenko. (2021) Mechanisms of hepatic steatosis formation in adolescent boys with hypoandrogenism. REPRODUCTIVE ENDOCRINOLOGY:57, pages 79-83.
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Kylie J. Nabata, Emmanuel K. Tse, Tom E. Nightingale, Amanda H.X. Lee, Janice J. Eng, Matthew Querée, Matthias Walter & Andrei V. Krassioukov. (2021) The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review. Current Neuropharmacology 19:3, pages 402-432.
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Hong Phan, Aline Richard, Mariana Lazo, William G. Nelson, Samuel R. Denmeade, John Groopman, Norma Kanarek, Elizabeth A. Platz & Sabine Rohrmann. (2021) The association of sex steroid hormone concentrations with non‐alcoholic fatty liver disease and liver enzymes in US men. Liver International 41:2, pages 300-310.
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Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti, Camelia Cojocariu & Anca Trifan. (2021) Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications. Canadian Journal of Gastroenterology and Hepatology 2021, pages 1-8.
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S. D’Andrea, C. Castellini, E. Minaldi, M. Totaro, G. Felzani, S. Francavilla, F. Francavilla & A. Barbonetti. (2020) Testosterone, level of the lesion and age are independently associated with prostate volume in men with chronic spinal cord injury. Journal of Endocrinological Investigation 43:11, pages 1599-1606.
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Yuying Wang, Xiaojing Guo, Wendi Xu, Jie Cai, Yi Zhang, Chunhua Wu, Shengxian Li, Yun Sun, Wei Liu & Tao Tao. (2020) Role of Androgen in Liver Fat Content in Women: Metabolically Advantageous or Disadvantageous?. Endocrine Practice 26:9, pages 1003-1016.
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Stergios A. Polyzos, Athanasios Mousiolis, Gesthimani Mintziori & Dimitrios G. Goulis. (2020) Nonalcoholic fatty liver disease in males with low testosterone concentrations. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14:5, pages 1571-1577.
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S. D’Andrea, O. Berardicurti, A. Berardicurti, G. Felzani, F. Francavilla, S. Francavilla, R. Giacomelli & A. Barbonetti. (2020) Clinical features and prognosis of COVID-19 in people with spinal cord injury: a case–control study. Spinal Cord Series and Cases 6:1.
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Settimio D'Andrea, Elisa Minaldi, Chiara Castellini, Francesca Cavallo, Giorgio Felzani, Sandro Francavilla, Felice Francavilla & Arcangelo Barbonetti. (2020) Independent Association of Erectile Dysfunction and Low Testosterone Levels with Life Dissatisfaction in Men with Chronic Spinal Cord Injury. The Journal of Sexual Medicine 17:5, pages 911-918.
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Matthew T. Goodus & Dana M. McTigue. (2020) Hepatic dysfunction after spinal cord injury: A vicious cycle of central and peripheral pathology?. Experimental Neurology 325, pages 113160.
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Ricardo A. BattaglinoNguyen NguyenMegan SummersLeslie R. Morse. (2019) B Cell–Activating Factor Is Associated with Testosterone and Smoking Status in Non-Ambulatory Men with Chronic Spinal Cord Injury. Journal of Neurotrauma 36:24, pages 3332-3337.
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Stefano Ballestri, Alessandro Mantovani, Fabio Nascimbeni, Simonetta Lugari & Amedeo Lonardo. (2019) Extra-hepatic manifestations and complications of nonalcoholic fatty liver disease. Future Medicinal Chemistry 11:16, pages 2171-2192.
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Jae-Min ParkHye Sun LeeJoowon OhYong-Jae Lee. (2019) Serum Testosterone Level Within Normal Range Is Positively Associated with Nonalcoholic Fatty Liver Disease in Premenopausal but Not Postmenopausal Women. Journal of Women's Health 28:8, pages 1077-1082.
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Julia H. Chariker, Sujata Saraswat Ohri, Cynthia Gomes, Fiona Brabazon, Kathryn A. Harman, Kathryn M. DeVeau, David S. K. Magnuson, Michal Hetman, Jeffrey C. Petruska, Scott R. Whittemore & Eric C. Rouchka. (2019) Activity/exercise-induced changes in the liver transcriptome after chronic spinal cord injury. Scientific Data 6:1.
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Amedeo Lonardo, Alessandro Mantovani, Simonetta Lugari & Giovanni Targher. (2019) NAFLD in Some Common Endocrine Diseases: Prevalence, Pathophysiology, and Principles of Diagnosis and Management. International Journal of Molecular Sciences 20:11, pages 2841.
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A. Barbonetti, S. D’Andrea, J. Samavat, A. Martorella, G. Felzani, S. Francavilla, M. Luconi & F. Francavilla. (2018) Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic–pituitary regulation of testosterone production is impaired? The model of spinal cord injury. Journal of Endocrinological Investigation 42:2, pages 167-173.
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Marianna Rita Stancampiano, Angela K. Lucas-Herald, Gianni Russo, Alan D. Rogol & S. Faisal Ahmed. (2019) Testosterone Therapy in Adolescent Boys: The Need for a Structured Approach. Hormone Research in Paediatrics 92:4, pages 215-228.
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Jeong Yoon Yim, Jinju Kim, Donghee Kim & Aijaz Ahmed. (2018) Serum testosterone and non-alcoholic fatty liver disease in men and women in the US. Liver International 38:11, pages 2051-2059.
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Paula Iruzubieta, Marta González, Joaquín Cabezas, María Teresa Arias-Loste & Javier Crespo. 2018. Liver Research and Clinical Management. Liver Research and Clinical Management.
Takashi Himoto, Koji Fujita, Teppei Sakamoto, Takako Nomura, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba & Tsutomu Masaki. (2018) Clinical efficacy of free androgen index, a surrogate hallmark of circulating free testosterone level, in male patients with HCV-related chronic liver disease. Journal of Clinical Biochemistry and Nutrition 63:3, pages 238-245.
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Robert D. GuberVarun TakyarAngela KokkinisDerrick A. FoxHawwa AlaoIlona KatsDara BakarAlan T. RemaleyStephen M. HewittDavid E. KleinerChia-Ying LiuColleen HadiganKenneth H. FischbeckYaron RotmanChristopher Grunseich. (2017) Nonalcoholic fatty liver disease in spinal and bulbar muscular atrophy. Neurology 89:24, pages 2481-2490.
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Lina Schiffer, Punith Kempegowda, Wiebke Arlt & Michael W O’Reilly. (2017) MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease. European Journal of Endocrinology 177:3, pages R125-R143.
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Arcangelo Barbonetti, Francesca Cavallo, Settimio D'Andrea, Mario Muselli, Giorgio Felzani, Sandro Francavilla & Felice Francavilla. (2017) Lower Vitamin D Levels Are Associated With Depression in People With Chronic Spinal Cord Injury. Archives of Physical Medicine and Rehabilitation 98:5, pages 940-946.
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Kathleen C. Rankin, Laura C. O’Brien, Liron Segal, M. Rehan Khan & Ashraf S. Gorgey. (2017) Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. BioMed Research International 2017, pages 1-11.
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