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Invited Article

Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries

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Pages 200-216 | Received 18 Sep 2012, Accepted 24 Sep 2012, Published online: 12 Nov 2013

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Michał Sienkiewicz, Andrzej Jaśkiewicz, Aleksandra Tarasiuk & Jakub Fichna. (2022) Lactoferrin: an overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance. Critical Reviews in Food Science and Nutrition 62:22, pages 6016-6033.
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Shilong Pang, Yuexin Shao, Yan Yu, Kela Sha, Yanting Jiang, Xian Zhang, Yuling Zhong, Huaiping Shi & Weijuan Li. (2023) The miR-214-5p/Lactoferrin/miR-224-5p/ADAM17 Axis Is Involved in Goat Mammary Epithelial Cells’ Immune Regulation. Animals 13:18, pages 2835.
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Michele Basilicata, Massimo Pieri, Giulia Marrone, Eleonora Nicolai, Manuela Di Lauro, Vincenza Paolino, Flaminia Tomassetti, Ilaria Vivarini, Patrizio Bollero, Sergio Bernardini & Annalisa Noce. (2023) Saliva as Biomarker for Oral and Chronic Degenerative Non-Communicable Diseases. Metabolites 13:8, pages 889.
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Giusi Ianiro, Luigi Rosa, Maria Carmela Bonaccorsi di Patti, Piera Valenti, Giovanni Musci & Antimo Cutone. (2022) Lactoferrin: from the structure to the functional orchestration of iron homeostasis. BioMetals 36:3, pages 391-416.
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Luigi Rosa, Antimo Cutone, Maria Pia Conte, Elena Campione, Luca Bianchi & Piera Valenti. (2022) An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection. BioMetals 36:3, pages 417-436.
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Antonietta Lucia Conte, Catia Longhi, Maria Pia Conte, Anna Maria Costanzo, Rosalba Paesano, Stefano Santangeli, Francesco Venditto, Giovanni Tripepi, Enrico Naldi, Giuditta Pollio, Valeria Cavallini, Marco Marrani, Patrizia Faltoni, Piera Valenti & Luigi Rosa. (2022) Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences. BioMetals 36:3, pages 491-507.
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Peter A. M. Ntenda, Angeziwa C. Chirambo, Owen Nkoka, Walaa M. El-Meidany & Jessy Goupeyou-Youmsi. (2022) Implication of asymptomatic and clinical Plasmodium falciparum infections on biomarkers of iron status among school-aged children in Malawi. Malaria Journal 21:1.
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Jeffrey L. Ward, Moises Torres-Gonzalez & Mary Cloud B. Ammons. (2022) The Influence of Viral Infections on Iron Homeostasis and the Potential for Lactoferrin as a Therapeutic in the Age of the SARS-CoV-2 Pandemic. Nutrients 14:15, pages 3090.
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Melasinee Laosuwan, Netsirin Gissawong, Nuttaya Butwong, Supalax Srijaranai & Siriboon Mukdasai. (2022) Facile liquid colorimetric sensor using high-density deep eutectic solvent for trace detection and speciation of iron in milk. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 272, pages 121020.
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Fernando Bartolomé, Luigi Rosa, Piera Valenti, Francisco Lopera, Jesús Hernández-Gallego, José Luis Cantero, Gorka Orive & Eva Carro. (2022) Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease Patients. Frontiers in Immunology 13.
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Lindsey H. Burton, Maryam F. Afzali, Lauren B. Radakovich, Margaret A. Campbell, Lauren A. Culver, Christine S. Olver & Kelly S. Santangelo. (2022) Systemic administration of a pharmacologic iron chelator reduces cartilage lesion development in the Dunkin-Hartley model of primary osteoarthritis. Free Radical Biology and Medicine 179, pages 47-58.
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Helena Tiekou Lorinczova, Owen Fitzsimons, Leah Mursaleen, Derek Renshaw, Gulshanara Begum & Mohammed Gulrez Zariwala. (2020) Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants 9:8, pages 645.
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Luigi Rosa, Maria Stefania Lepanto, Antimo Cutone, Rosa Anna Siciliano, Rosalba Paesano, Roberta Costi, Giovanni Musci & Piera Valenti. (2020) Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders. BioMetals 33:2-3, pages 159-168.
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Romina Mancinelli, Luigi Rosa, Antimo Cutone, Maria Stefania Lepanto, Antonio Franchitto, Paolo Onori, Eugenio Gaudio & Piera Valenti. (2020) Viral Hepatitis and Iron Dysregulation: Molecular Pathways and the Role of Lactoferrin. Molecules 25:8, pages 1997.
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Antimo Cutone, Luigi Rosa, Giusi Ianiro, Maria Stefania Lepanto, Maria Carmela Bonaccorsi di Patti, Piera Valenti & Giovanni Musci. (2020) Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action. Biomolecules 10:3, pages 456.
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Peter Austin Morton Ntenda, Sosten Chilumpha, Edward Tisungane Mwenyenkulu, Jane Flora Kazambwe & Walaa El-Meidany. (2019) Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015–2016 Malawi micronutrient survey. Infectious Diseases of Poverty 8:1.
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Maria Stefania Lepanto, Luigi Rosa, Antimo Cutone, Mellani Jinnett Scotti, Antonietta Lucia Conte, Massimiliano Marazzato, Carlo Zagaglia, Catia Longhi, Francesca Berlutti, Giovanni Musci, Piera Valenti & Maria Pia Conte. (2019) Bovine Lactoferrin Pre-Treatment Induces Intracellular Killing of AIEC LF82 and Reduces Bacteria-Induced DNA Damage in Differentiated Human Enterocytes. International Journal of Molecular Sciences 20:22, pages 5666.
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Afsal Kolloli, Pooja Singh, G. Marcela Rodriguez & Selvakumar Subbian. (2019) Effect of Iron Supplementation on the Outcome of Non-Progressive Pulmonary Mycobacterium tuberculosis Infection. Journal of Clinical Medicine 8:8, pages 1155.
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Chen Cheng, De-chun Huang, Li-yan Zhao, Chong-jiang Cao & Gui-tang Chen. (2019) Preparation and in vitro absorption studies of a novel polysaccharide‑iron (III) complex from Flammulina velutipes. International Journal of Biological Macromolecules 132, pages 801-810.
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Maria Stefania Lepanto, Luigi Rosa, Rosalba Paesano, Piera Valenti & Antimo Cutone. (2019) Lactoferrin in Aseptic and Septic Inflammation. Molecules 24:7, pages 1323.
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Maria Stefania Lepanto, Luigi Rosa, Antimo Cutone, Maria Pia Conte, Rosalba Paesano & Piera Valenti. (2018) Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study. Frontiers in Immunology 9.
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Luigi Rosa, Antimo Cutone, Maria Stefania Lepanto, Mellani Jinnett Scotti, Maria Pia Conte, Rosalba Paesano & Piera Valenti. (2018) Physico-chemical properties influence the functions and efficacy of commercial bovine lactoferrins. BioMetals 31:3, pages 301-312.
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Maria Carmela Bonaccorsi di Patti, Antimo Cutone, Fabio Polticelli, Luigi Rosa, Maria Stefania Lepanto, Piera Valenti & Giovanni Musci. (2018) The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin. BioMetals 31:3, pages 399-414.
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Francesco Calvani, Antimo Cutone, Maria Stefania Lepanto, Luigi Rosa, Valentino Valentini & Piera Valenti. (2018) Efficacy of bovine lactoferrin in the post-surgical treatment of patients suffering from bisphosphonate-related osteonecrosis of the jaws: an open-label study. BioMetals 31:3, pages 445-455.
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Piera Valenti, Luigi Rosa, Daniela Capobianco, Maria Stefania Lepanto, Elisa Schiavi, Antimo Cutone, Rosalba Paesano & Paola Mastromarino. (2018) Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense. Frontiers in Immunology 9.
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Chiara Gramaccioni, Yang Yang, Alessandra Procopio, Alexandra Pacureanu, Sylvain Bohic, Emil Malucelli, Stefano Iotti, Giovanna Farruggia, Inna Bukreeva, Andrea Notargiacomo, Michela Fratini, Piera Valenti, Luigi Rosa, Francesca Berlutti, Peter Cloetens & Stefano Lagomarsino. (2018) Nanoscale quantification of intracellular element concentration by X-ray fluorescence microscopy combined with X-ray phase contrast nanotomography. Applied Physics Letters 112:5.
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Hatem Abu Hashim, Osama Foda & Essam Ghayaty. (2017) Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. European Journal of Obstetrics & Gynecology and Reproductive Biology 219, pages 45-52.
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Luigi Rosa, Antimo Cutone, Maria Lepanto, Rosalba Paesano & Piera Valenti. (2017) Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis. International Journal of Molecular Sciences 18:9, pages 1985.
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Antimo Cutone, Luigi Rosa, Maria Stefania Lepanto, Mellani Jinnett Scotti, Francesca Berlutti, Maria Carmela Bonaccorsi di Patti, Giovanni Musci & Piera Valenti. (2017) Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages. Frontiers in Immunology 8.
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C Gramaccioni, A Procopio, G Farruggia, E Malucelli, S Iotti, A Notargiacomo, M Fratini, Y Yang, A Pacureanu, P Cloetens, S Bohic, L Massimi, A Cutone, P Valenti, L Rosa, F Berlutti & S Lagomarsino. (2017) Combined use of X-ray fluorescence microscopy, phase contrast imaging for high resolution quantitative iron mapping in inflamed cells. Journal of Physics: Conference Series 849, pages 012008.
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Anamika Pandey, Mohd Kamran Khan, Erdogan E. Hakki, George Thomas, Mehmet Hamurcu, Sait Gezgin, Ozge Gizlenci & Mahinur S. Akkaya. (2016) Assessment of genetic variability for grain nutrients from diverse regions: potential for wheat improvement. SpringerPlus 5:1.
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Ronit Herzog & Susanna Cunningham-Rundles. 2015. Mucosal Immunology. Mucosal Immunology 1461 1479 .
Rosalba Paesano, Enrica Pacifici, Samanta Benedetti, Francesca Berlutti, Alessandra Frioni, Antonella Polimeni & Piera Valenti. (2014) Safety and efficacy of lactoferrin versus ferrous sulphate in curing iron deficiency and iron deficiency anaemia in hereditary thrombophilia pregnant women: an interventional study. BioMetals 27:5, pages 999-1006.
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