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Leading Articles

Immunomodulation by Macrolide Antibiotics

Pages 3-8 | Published online: 18 Jul 2013

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Yasuo Katayama, Toshiki Inaba, Chikako Nito & Masayuki Ueda. (2016) Neuroprotective effects of erythromycin on ischemic injury following permanent focal cerebral ischemia in rats. Neurological Research 38:3, pages 275-284.
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Toshiki Inaba, Yasuo Katayama, Masayuki Ueda & Chikako Nito. (2015) Neuroprotective effects of pretreatment with macrolide antibiotics on cerebral ischemia reperfusion injury. Neurological Research 37:6, pages 514-524.
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Hakan Emmez, Alp Özgün Börcek, Emre Durdağ, Pınar Göçün Uyar, Memduh Kaymaz & Şükrü Aykol. (2011) Immunomodulatory effectiveness of azithromycin in prevention of postlaminectomy epidural fibrosis. Neurological Research 33:4, pages 344-348.
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Igor Oliynyk, Georgia Varelogianni, Martin Schalling, Monika Stenkvist Asplund, Godfried M. Roomans & Marie Johannesson. (2009) AZITHROMYCIN INCREASES CHLORIDE EFFLUX FROM CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS. Experimental Lung Research 35:3, pages 210-221.
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Hakan Aytan, Ahmet C. Caliskan, Tamer Yener, Fazli Demirturk, Pelin Aytan & Aydan Yenisehirli. (2009) A novel antibiotic, linezolid, reduces intraperitoneal adhesion formation in the rat uterine horn model. Acta Obstetricia et Gynecologica Scandinavica 88:7, pages 781-786.
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Lorraine Johnson & Raphael B Stricker. (2004) Treatment of Lyme disease: a medicolegal assessment. Expert Review of Anti-infective Therapy 2:4, pages 533-557.
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H.M. Ziglam, I. Daniels & R.G. Finch. (2004) Immunomodulating Activity of Rifampicin. Journal of Chemotherapy 16:4, pages 357-361.
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G. Demartini, D. Esposti, P. Marthyn, A. Lapidari, F. Fraschini & F. Scaglione. (2004) Effect of Multiple Doses of Clarithromycin and Amoxicillin on IL-6, IFNγ and IL-10 Plasma Levels in Patients with Community Acquired Pneumonia. Journal of Chemotherapy 16:1, pages 82-85.
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Riana Cockeran, Ronald Anderson & Charles Feldman. (2003) Pneumolysin in the immunopathogenesis and treatment of pneumococcal disease. Expert Review of Anti-infective Therapy 1:2, pages 231-239.
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H. Abdelghaffar, H. Kirst, A. Soukri, C. Babin-Chevaye & M.-T. Labro. (2002) Structure-Activity Relationships Among 9-N-Alkyl Derivatives of Erythromycylamine and Their Effect on the Oxidative Burst of Human Neutrophils In Vitro . Journal of Chemotherapy 14:2, pages 132-139.
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Articles from other publishers (54)

Faezeh Javanbakht, Mohammad Reza Afshar Mogaddam, Mahboob Nemati & Mir Ali Farajzadeh. (2023) Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β‐cyclodextrin grafted polyethylene polymer composite. Journal of Separation Science 46:8.
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Yashdeep Singh Pathania. (2022) Current treatment modalities in granulomatous cheilitis. International Journal of Dermatology 61:6, pages 755-759.
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Giorgio Tulli & Zuanetti Gabriele Maria. 2022. Practical Trends in Anesthesia and Intensive Care 2020-2021. Practical Trends in Anesthesia and Intensive Care 2020-2021 103 140 .
Jennifer A. Kricker, Clive P. Page, Fridrik Runar Gardarsson, Olafur Baldursson, Thorarinn Gudjonsson & Michael J. Parnham. (2022) Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development. Pharmacological Reviews 73:4, pages 1404-1433.
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Axel Dalhoff. (2020) Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?. Infection 49:1, pages 29-56.
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Ju Mi Lee, Jiyun Park, Sangwon Choi, Byung Woo Jhun, Su-Young Kim, Kyung-Wook Jo, Jung Joo Hong, Lee-Han Kim & Sung Jae Shin. (2021) A Clofazimine-Containing Regimen Confers Improved Treatment Outcomes in Macrophages and in a Murine Model of Chronic Progressive Pulmonary Infection Caused by the Mycobacterium avium Complex. Frontiers in Microbiology 11.
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Graham Devereux, Danielle Wrolstad, Stephen J. Bourke, Cori L. Daines, Simon Doe, Ryan Dougherty, Rose Franco, Alastair Innes, Benjamin T. Kopp, Jorge Lascano, Daniel Layish, Gordon MacGregor, Lorna Murray, Daniel Peckham, Vincenzina Lucidi, Emma Lovie, Jennifer Robertson, Douglas J. Fraser-Pitt & Deborah A. O'Neil. (2020) Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial. PLOS ONE 15:12, pages e0242945.
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Alexander J. Adami, Sonali J. Bracken, Linda A. Guernsey, Ektor Rafti, Kendra R. Maas, Joerg Graf, Adam P. Matson, Roger S. Thrall & Craig M. Schramm. (2018) Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma. Pediatric Research 84:3, pages 426-434.
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Yasuo Katayama, Toshiki Inaba, Chikako Nito, Satoshi Suda & Masayuki Ueda. (2017) Neuroprotective effects of clarithromycin against neuronal damage in cerebral ischemia and in cultured neuronal cells after oxygen-glucose deprivation. Life Sciences 168, pages 7-15.
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Robert P Dickson. (2016) The microbiome and critical illness. The Lancet Respiratory Medicine 4:1, pages 59-72.
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F. William Danby. 2014. Acne. Acne 109 170 .
Arnab Majhi, Kiran Kundu, Rana Adhikary, Madhubanti Banerjee, Sayantika Mahanti, Anirban Basu & Biswadev Bishayi. (2014) Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice. Journal of Inflammation 11:1.
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Yasuo Katayama, Toshiki Inaba, Chikako Nito, Masayuki Ueda & Kenichiro Katsura. (2014) Neuroprotective effects of erythromycin on cerebral ischemia reperfusion-injury and cell viability after oxygen-glucose deprivation in cultured neuronal cells. Brain Research 1588, pages 159-167.
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Prakash S. Bisen & Ruchika Raghuvanshi. 2013. Emerging Epidemics. Emerging Epidemics 455 461 .
Ayako Furuya, Kazuhito Asano, Naruo Shoji, Kojiro Hirano, Taisuke Hamasaki & Harumi Suzaki. (2010) Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro. Journal of Inflammation 7:1.
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Daniel Sevilla-Sánchez, Dolors Soy-Muner & Néstor Soler-Porcar. (2010) Utilidad de los macrólidos como antiinflamatorios en las enfermedades respiratorias. Archivos de Bronconeumología 46:5, pages 244-254.
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Daniel Sevilla-Sánchez, Dolors Soy-Muner & Néstor Soler-Porcar. (2010) Usefulness of Macrolides as Anti-inflammatories in Respiratory Diseases. Archivos de Bronconeumología ((English Edition)) 46:5, pages 244-254.
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Lynn Guptill. (2010) Bartonellosis. Veterinary Microbiology 140:3-4, pages 347-359.
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Donald R. Rollins, David A. Beuther & Richard J. Martin. (2010) Update on Infection and Antibiotics in Asthma. Current Allergy and Asthma Reports 10:1, pages 67-73.
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Gregor S Zimmermann, Claus Neurohr, Heidrun Villena-Hermoza, Rudolf Hatz & Juergen Behr. (2009) Anti-inflammatory effects of antibacterials on human bronchial epithelial cells. Respiratory Research 10:1.
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Shahram SADREDDINI, Hamid NOSHAD, Mahshid MOLAEEFARD, Ramona MOLOUDI, Mohamad-Reza ARDALAN & Morteza GHOJAZADEH. (2009) A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis. International Journal of Rheumatic Diseases 12:1, pages 44-51.
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Joseph P. LynchIIIIII, Rajeev Saggar, Robert D. Suh & Michael C. Fishbein. 2009. Pulmonary Arterial Hypertension and Interstitial Lung Diseases. Pulmonary Arterial Hypertension and Interstitial Lung Diseases 111 138 .
Terence A. R. Seemungal, Tom M. A. Wilkinson, John R. Hurst, Wayomi R. Perera, Ray J. Sapsford & Jadwiga A. Wedzicha. (2008) Long-term Erythromycin Therapy Is Associated with Decreased Chronic Obstructive Pulmonary Disease Exacerbations. American Journal of Respiratory and Critical Care Medicine 178:11, pages 1139-1147.
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Annamari Kilkkinen, Harri Rissanen, Timo Klaukka, Eero Pukkala, Markku Heliövaara, Pentti Huovinen, Satu Männistö, Arpo Aromaa & Paul Knekt. (2008) Antibiotic use predicts an increased risk of cancer. International Journal of Cancer 123:9, pages 2152-2155.
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Magdalena Leiva, Alfonso Ruiz-Bravo, Encarnación Moreno & Maria Jiménez-Valera. (2008) Telithromycin inhibits the production of proinflammatory mediators and the activation of NF-κB in in vitro -stimulated murine cells . FEMS Immunology & Medical Microbiology 53:3, pages 343-350.
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Masaharu Shinkai, Markus O. Henke & Bruce K. Rubin. (2008) Macrolide antibiotics as immunomodulatory medications: Proposed mechanisms of action. Pharmacology & Therapeutics 117:3, pages 393-405.
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Mohammad Fararjeh, Mohammad K. Mohammad, Yasser Bustanji, Hatim AlKhatib & Shtaywy Abdalla. (2008) Evaluation of immunosuppression induced by metronidazole in Balb/c mice and human peripheral blood lymphocytes. International Immunopharmacology 8:2, pages 341-350.
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Daniel P. Healy. (2007) Macrolide immunomodulation of chronic respiratory diseases. Current Infectious Disease Reports 9:1, pages 7-13.
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Robert A. Stockley, Stephen I. Rennard, Klaus Rabe & Bartolome CelliRobert Wilson. 2007. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 139 147 .
Masataka Kuwana & Yasuo Ikeda. (2006) Helicobacter pylori and Immune Thrombocytopenic Purpura: Unsolved Questions and Controversies. International Journal of Hematology 84:4, pages 309-315.
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Mario Cazzola, Francesco Blasi, Paolo Tarsia, Maddalena Zanardelli & Luigi Allegra. (2006) Role of Macrolides as Immunomodular Agents. Clinical Pulmonary Medicine 13:5, pages 274-281.
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F BlasiM CazzolaP TarsiaS AlibertiC BaldessariV Valenti. (2006) Telithromycin in lower respiratory tract infections. Future Microbiology 1:1, pages 7-16.
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Richard J. Martin. (2006) Infections and Asthma. Clinics in Chest Medicine 27:1, pages 87-98.
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Jeffrey C. Hoyt, Janelle Ballering, Hiroki Numanami, John M. Hayden & Richard A. Robbins. (2006) Doxycycline Modulates Nitric Oxide Production in Murine Lung Epithelial Cells. The Journal of Immunology 176:1, pages 567-572.
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Pilar Garcia-Roca, Javier Mancilla-Ramirez, Araceli Santos-Segura, Marisol Fernández-Avilés & Ernesto Calderon-Jaimes. (2006) Linezolid Diminishes Inflammatory Cytokine Production from Human Peripheral Blood Mononuclear Cells. Archives of Medical Research 37:1, pages 31-35.
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Diane E. Stover & Debra Mangino. (2005) Macrolides. Chest 128:5, pages 3611-3617.
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Sonoko Nagai, Takateru Izumi & Masanori Kitaichi. 2005. Tropical Lung Disease, Second Edition. Tropical Lung Disease, Second Edition 455 473 .
Masaharu Shinkai, Chang Sik Park & Bruce K. Rubin. (2005) Immunomodulatory Effects of Macrolide Antibiotics. Clinical Pulmonary Medicine 12:6, pages 341-348.
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Michael J. Parnham, Ognjen Čulić, Vesna Eraković, Vesna Munić, Sanja Popović-Grle, Karmela Barišić, Martina Bosnar, Karmen Brajša, Ivana Čepelak, Snježana Čužić, Ines Glojnarić, Zoran Manojlović, Renata Novak-Mirčetić, Katarina Oresković, Verica Pavičić-Beljak, Senka Radošević & Mirna Sučić. (2005) Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment. European Journal of Pharmacology 517:1-2, pages 132-143.
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I.R. Grant. (2005) Zoonotic potential of Mycobacterium avium ssp. paratuberculosis : the current position . Journal of Applied Microbiology 98:6, pages 1282-1293.
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Bruce K. Rubin, Markus O. Henke & Axel Dalhoff. 2005. Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Antibiotics as Anti-Inflammatory and Immunomodulatory Agents 247 267 .
Hans F. Berg, Jeroen H. T. Tjhie, Gert-Jan Scheffer, Marcel F. Peeters, Peter H. J. van Keulen, Jan A. J. W. Kluytmans & Ellen E. Stobberingh. (2004) Emergence and Persistence of Macrolide Resistance in Oropharyngeal Flora and Elimination of Nasal Carriage of Staphylococcus aureus after Therapy with Slow-Release Clarithromycin: a Randomized, Double-Blind, Placebo-Controlled Study . Antimicrobial Agents and Chemotherapy 48:11, pages 4183-4188.
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F. Araujo, T. Slifer, S. Li, A. Kuver, L. Fong & J. Remington. (2004) Gemifloxacin inhibits cytokine secretion by lipopolysaccharide stimulated human monocytes at the post-transcriptional level. Clinical Microbiology and Infection 10:3, pages 213-219.
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David A. Beuther & Richard J. Martin. (2004) Antibiotics in asthma. Current Allergy and Asthma Reports 4:2, pages 132-138.
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Mario Cazzola, Maria Gabriella Matera & Francesco Blasi. (2004) Macrolide and occult infection in asthma. Current Opinion in Pulmonary Medicine 10:1, pages 7-14.
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Monica M Lahra & Heather E Jeffery. (2004) A fetal response to chorioamnionitis is associated with early survival after preterm birth. American Journal of Obstetrics and Gynecology 190:1, pages 147-151.
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Takeshi Fujii, Aikichi Iwamoto, Tetsuya Nakamura & Aikichi Iwamoto. (2004) Current concepts in SARS treatment. Journal of Infection and Chemotherapy 10:1, pages 1-7.
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Axel Dalhoff & Itamar Shalit. (2003) Immunomodulatory effects of quinolones. The Lancet Infectious Diseases 3:6, pages 359-371.
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Allan S. Wagman & Mary Lee. 2003. 183 192 .
Fausto G. Araujo, Teri L. Slifer & Jack S. Remington. (2002) Inhibition of Secretion of Interleukin-1α and Tumor Necrosis Factor Alpha by the Ketolide Antibiotic Telithromycin. Antimicrobial Agents and Chemotherapy 46:10, pages 3327-3330.
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Joanne M. Wolter, Sharon L. Seeney & Joseph G. McCormack. (2012) Macrolides in Cystic Fibrosis. American Journal of Respiratory Medicine 1:4, pages 235-241.
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Alexis Denis & Christelle Renou. (2002) Novel N-demethylation of ketolide: application to the solution phase parallel synthesis of N-desosaminyl-substituted ketolides using ion exchange resins. Tetrahedron Letters 43:23, pages 4171-4174.
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Jeffrey C Hoyt & Richard A Robbins. (2001) Macrolide antibiotics and pulmonary inflammation. FEMS Microbiology Letters 205:1, pages 1-7.
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Ognjen Čulić, Vesna Eraković & Michael J. Parnham. (2001) Anti-inflammatory effects of macrolide antibiotics. European Journal of Pharmacology 429:1-3, pages 209-229.
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