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Case Reports

Adverse Interaction Between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters and Bleeding: Case Report and Review of the Literature

Pages 339-342 | Published online: 18 Jul 2013

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Rachel P. Riechelmann & Everardo D. Saad. (2006) A Systematic Review on Drug Interactions in Oncology. Cancer Investigation 24:7, pages 704-712.
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Khalefa Althiab, Manal Aljohani, Sultan Alraddadi & Mohammed Algarni. (2022) Capecitabine and Warfarin Interaction: A Case Report With Review of Literature and Management Options. Frontiers in Cardiovascular Medicine 8.
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Hideo SHIOHIRA, Koya FUKUNAGA, Jose Carlos S. TAYAG, Yurika TAMASHIRO, Taisei MUSHIRODA & Katsunori NAKAMURA. (2021) Effect of 5-fluorouracil on mRNA expression of drug metabolizing enzyme and transporter genes in human hepatoma cell lines. Biomedical Research 42:4, pages 121-127.
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Muge Akbulut & Yuksel Urun. (2020) Onco-cardiology: Drug-drug interactions of antineoplastic and cardiovascular drugs. Critical Reviews in Oncology/Hematology 145, pages 102822.
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Manvi Sharma, Aisha Vadhariya, Soumya Chikermane, Suma Gopinathan, Mariana Chavez-MacGregor, Sharon H. Giordano, Michael L. Johnson & Holly M. Holmes. (2019) Clinical Outcomes Associated with Drug–Drug Interactions of Oral Chemotherapeutic Agents: A Comprehensive Evidence-Based Literature Review. Drugs & Aging 36:4, pages 341-354.
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Tsuyoshi Hata, Toshihiro Kudo, Daisuke Sakai, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori & Taroh Satoh. (2016) Impact of capecitabine and S-1 on anticoagulant activity of warfarin in patients with gastrointestinal cancer. Cancer Chemotherapy and Pharmacology 78:2, pages 389-396.
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Sachin R Shah, Randall Martin, Jonathan E Dowell & Sarah M Gressett Ussery. (2010) Comparison of the 5-Fluorouracil–Warfarin and Capecitabine-Warfarin Drug Interactions. Pharmacotherapy 30:12, pages 1259-1265.
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Masaru Nakajima, Tomoo Genda, Mayu Suehira, Hiroki Satoh, Akiko Miki, Satoko Hori & Yasufumi Sawada. (2010) Increased anticoagulant activity of warfarin used in combination with doxifluridine. Cancer Chemotherapy and Pharmacology 66:5, pages 969-972.
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Giovanni Giunta. (2010) Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report. Case Reports in Medicine 2010, pages 1-4.
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Shivaani Kummar, Martin Gutierrez, James H Doroshow & Anthony J. Murgo. (2006) Drug development in oncology: classical cytotoxics and molecularly targeted agents. British Journal of Clinical Pharmacology 62:1, pages 15-26.
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Heather R. Shah, Leslie Ledbetter, Robert Diasio & M. Wasif Saif. (2006) A Retrospective Study of Coagulation Abnormalities in Patients Receiving Concomitant Capecitabine and Warfarin. Clinical Colorectal Cancer 5:5, pages 354-358.
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. (2006) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 15:1, pages i-xii.
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