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Anticancer Chemotherapy

Preclinical Pharmacology of the Pyrrolobenzodiazepine (PBD) Monomer DRH-417 (NSC 709119)

Pages 66-78 | Published online: 20 Nov 2013

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Sanjay D. Hadiyal, Jaydeep N. Lalpara, Nilesh D. Parmar & Hitendra S. Joshi. (2022) Microwave Irradiated Targeted Synthesis of Pyrrolobenzodiazepine Embrace 1,2,3-Triazole by Click Chemistry Synthetic Aspect and Evaluation of Anticancer and Antimicrobial Activity. Polycyclic Aromatic Compounds 42:7, pages 4752-4768.
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John A Hartley. (2011) The development of pyrrolobenzodiazepines as antitumour agents. Expert Opinion on Investigational Drugs 20:6, pages 733-744.
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Ronald A. Glabonjat, Maksym Kitsera, Katrin Unterhauser, Christian Lembacher-Fadum, Christoph Högenauer, Georg Raber, Rolf Breinbauer & Ellen L. Zechner. (2021) Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labeled internal standards. Talanta 222, pages 121677.
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Arnaud C. Tiberghien & Jeremy S. Parker. 2020. Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3. Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 3 215 252 .
Hans R Hendriks, Anne-Sophie Govaerts, Iduna Fichtner, Sally Burtles, Andrew D Westwell & Godefridus J Peters. (2017) Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative. British Journal of Cancer 117:2, pages 195-202.
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Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi & Changshou Gao. 2017. Platform Technologies in Drug Discovery and Validation. Platform Technologies in Drug Discovery and Validation 441 480 .
Robert V. Kolakowski, Thomas D. Young, Philip W. Howard, Scott C. Jeffrey & Peter D. Senter. (2015) Synthesis of a C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine monomer enabling the convergent construction of symmetrical and non-symmetrical dimeric analogs. Tetrahedron Letters 56:30, pages 4512-4515.
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Barbara Gerratana. (2010) Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Medicinal Research Reviews 32:2, pages 254-293.
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Dyeison AntonowDavid E. Thurston. (2010) Synthesis of DNA-Interactive Pyrrolo[2,1- c ][1,4]benzodiazepines (PBDs) . Chemical Reviews 111:4, pages 2815-2864.
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Heinz-Herbert Fiebig & Angelika M. Burger. 2011. Tumor Models in Cancer Research. Tumor Models in Cancer Research 167 193 .
Maciej Kaliszczak, Dyeison Antonow, Katan I. Patel, Philip Howard, Duncan I. Jodrell, David E. Thurston & Sylvie M. Guichard. (2010) Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters. The AAPS Journal 12:4, pages 617-627.
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Philip W. Howard, Zhizhi Chen, Stephen J. Gregson, Luke A. Masterson, Arnaud C. Tiberghien, Nectaroula Cooper, Min Fang, Marissa J. Coffils, Sarah Klee, John A. Hartley & David E. Thurston. (2009) Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate. Bioorganic & Medicinal Chemistry Letters 19:22, pages 6463-6466.
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Dyeison AntonowTeresa BarataTerence C. JenkinsGary N. ParkinsonPhilip W. HowardDavid E. ThurstonMire Zloh. (2008) Solution Structure of a 2:1 C2-(2-Naphthyl) Pyrrolo[2,1- c ][1,4]benzodiazepine DNA Adduct: Molecular Basis for Unexpectedly High DNA Helix Stabilization . Biochemistry 47:45, pages 11818-11829.
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A. V. Vargiu, P. Ruggerone, A. Magistrato & P. Carloni. (2008) Dissociation of minor groove binders from DNA: insights from metadynamics simulations. Nucleic Acids Research 36:18, pages 5910-5921.
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