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Research Article

Cardioprotective effects of trimetazidine: a review

Pages 661-672 | Accepted 10 Sep 2003, Published online: 22 Sep 2008

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Guy L Weinberg & Malek G Massad. (2007) Metabolic modulation for cardiac protection. Expert Review of Cardiovascular Therapy 5:2, pages 135-138.
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Articles from other publishers (45)

Martin Baroch, Hana Dejmková & Frank-Michael Matysik. (2023) Determination of trimetazidine in urine by capillary electrophoresis with amperometric detection. Monatshefte für Chemie - Chemical Monthly 154:9, pages 1013-1018.
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Mohammad Hosein Farzaei, Fatemeh Ramezani-Aliakbari, Maryam Ramezani-Aliakbari, Mohammad Zarei, Alireza Komaki, Siamak Shahidi, Abdolrahman Sarihi & Iraj Salehi. (2023) Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury. Naunyn-Schmiedeberg's Archives of Pharmacology 396:8, pages 1633-1646.
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Kamila Chomaničová, Élida Alechaga Silva & Rosa Ventura Alemany. (2023) Metabolic study of trimetazidine using ultra-high performance liquid chromatography-tandem mass spectrometry. Brazilian Journal of Pharmaceutical Sciences 59.
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Susmita Patra, Pratibha Gupta, Reshma Kumari, Sandipan Jana, Pallab Kanti Haldar, Rudranil Bhowmik, Avishek Mandal, Md. Adil Shaharyar, Hindol Mazumdar, Kumar Anand & Sanmoy Karmakar. 2023. How Synthetic Drugs Work. How Synthetic Drugs Work 329 348 .
Houyong Zhu, Hanxin Wang, Xinyu Zhu, Qilan Chen, Xiaojiang Fang, Xiaoqun Xu, Yan Ping, Beibei Gao, Guoxin Tong, Yu Ding, Tielong Chen & Jinyu Huang. (2022) The Importance of Integrated Regulation Mechanism of Coronary Microvascular Function for Maintaining the Stability of Coronary Microcirculation: An Easily Overlooked Perspective. Advances in Therapy 40:1, pages 76-101.
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Liana Kuprash, Olena Kuprash & Svetlana Gudarenko. (2022) Metabolic cardiocytoprotectors (trimetazidine and trimethylhydrazine) in geriatrics. Short review. Ageing & Longevity:2 2022, pages 63-70.
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Juan P. Ortiz Fragola, Gabriel Cao, Mariano Tumarkin, Marisa Moriondo, Angélica Muller, Martin Sangiorgio, Francisco Azzato, Giuseppe Ambrosio & José Milei. (2022) Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock. Journal of Cardiovascular Pharmacology 79:6, pages 896-903.
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Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra & Gaaminepreet Singh. (2021) Trimetazidine an emerging paradigm in renal therapeutics: Preclinical and clinical insights. European Journal of Pharmacology 913, pages 174624.
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Elena Bobescu, Luigi Geo Marceanu, Lorena Dima, Andreea Balan, Christian Gabriel Strempel & Alexandru Covaciu. (2021) Trimetazidine Therapy in Coronary Artery Disease: The Impact on Oxidative Stress, Inflammation, Endothelial Dysfunction, and Long-Term Prognosis. American Journal of Therapeutics 28:5, pages e540-e547.
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Kamila Raziyeva, Aiganym Smagulova, Yevgeniy Kim, Saltanat Smagul, Ayan Nurkesh & Arman Saparov. (2020) Preconditioned and Genetically Modified Stem Cells for Myocardial Infarction Treatment. International Journal of Molecular Sciences 21:19, pages 7301.
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Manolis S. Kallistratos, Leonidas E. Poulimenos, Sofia Giannitsi, Pavlos Tsinivizov & Athanasios J. Manolis. (2018) Trimetazidine in the Prevention of Tissue Ischemic Conditions. Angiology 70:4, pages 291-298.
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B. O. van Driel, A. C. van Rossum, M. Michels, R. Huurman & J. van der Velden. (2019) Extra energy for hearts with a genetic defect: ENERGY trial. Netherlands Heart Journal 27:4, pages 200-205.
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Pravin G. Vanol, Manish Yadav, Mallika Sanyal, Priyanka A. Shah & Pranav S. Shrivastav. (2018) Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLC-MS/MS. Biomedical Chromatography 32:2, pages e4095.
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Giacinta Guarini, Alda Huqi, Doralisa Morrone, Paola Francesca Giuseppina Capozza & Mario Marzilli. (2018) Trimetazidine and Other Metabolic Modifiers. European Cardiology Review 13:2, pages 1.
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D. I. Trukhan, A. L. Mazurov & E. L. Davydov. (2017) MYOCARDIAL CYTOPROTECTOR TRIMETAZIDINE MB-PREPARAT, INCREASES THE EFFECTIVENESS OF TREATMENT OF CHRONIC HEART FAILURE AND CORONARY HEART DISEASE. Medical Council:7, pages 75-83.
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Arif Suner & Mustafa Cetin. (2016) The effect of trimetazidine on ventricular repolarization indexes and left ventricular diastolic function in patients with coronary slow flow. Coronary Artery Disease 27:5, pages 398-404.
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Giacinta Guarini, Alda Huqi, Doralisa Morrone & Mario Marzilli. (2016) Pharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update. Cardiovascular Drugs and Therapy 30:4, pages 379-391.
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Csaba A. Dézsi. (2016) Trimetazidine in Practice. American Journal of Therapeutics 23:3, pages e871-e879.
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Hayam AteyyaHala YosefManar A. Nader. (2016) Ameliorative effect of trimetazidine on cisplatin-induced hepatotoxicity in rats. Canadian Journal of Physiology and Pharmacology 94:2, pages 225-230.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 279 284 .
Jinhong Wei, Hao Xu, Liang Shi, Jie Tong & Jianbao Zhang. (2015) Trimetazidine protects cardiomyocytes against hypoxia-induced injury through ameliorates calcium homeostasis. Chemico-Biological Interactions 236, pages 47-56.
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D. I Trukhan. (2014) Therapeutic possibilities of myocardial cytoprotector trimetazidine MR incoronary heart disease. CardioSomatics 5:3-4, pages 41-47.
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Anna Jarek, Marzena W?jtowicz, Dorota Kwiatkowska, Monika Kita, Ewa Turek-Lepa, Katarzyna Chajewska, Sylwia Lewandowska-Pachecka & Andrzej Pokrywka. (2014) The prevalence of trimetazidine use in athletes in Poland: excretion study after oral drug administration. Drug Testing and Analysis 6:11-12, pages 1191-1196.
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Jianjun Zhang, Meng Fu, Minyan Zhang, Liang Xu & Yuan Gao. (2014) Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride. International Journal of Pharmaceutics 465:1-2, pages 32-41.
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Giacinta Guarini, Alda Huqi & Mario Marzilli. 2014. Cardiac Energy Metabolism in Health and Disease. Cardiac Energy Metabolism in Health and Disease 237 248 .
Gulistan Beshimovna Dorofeeva, Ivan Vasil'evich Dorofeev, Yuliya Viktorovna Trofimova & Ol'ga Vladimirovna Manerova. (2013) Rol' trimetazidina v regulyatsii energeticheskogo metabolizma miokarda pri serdechno-sosudistykh zabolevaniyakh. Systemic Hypertension 10:3, pages 92-97.
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De la Cruz Rodríguez Lilia Cristina, Rey María del Rosario, Araujo Carmen Rosa & Oldano Ana Veronica. (2013) On the Performance of Trimetazidine and Vitamin E as Pharmacoprotection Agents in Cyclosporin A-Induced Toxicity. ISRN Pharmacology 2013, pages 1-9.
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H P Rang, M M Dale, J M Ritter, R J Flower & G Henderson. 2012. Rang & Dale's Pharmacology. Rang & Dale's Pharmacology 246 264 .
Vladimír Teplan. (2011) Use of trimetazidine in preventing contrast-induced nephropathy: a nephrologist's perspective. Cor et Vasa 53:4-5, pages 264-266.
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Lilia Cristina De la Cruz Rodríguez, Carmen Rosa Araujo, Sara Emilia Posleman & María Rosario Rey. (2010) Attenuation of gentamicin‐induced nephrotoxicity: trimetazidine versus N ‐acetyl cysteine . Journal of Applied Toxicology 30:4, pages 343-353.
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Yilmaz Gunes, Unal Guntekin, Mustafa Tuncer & Musa Sahin. (2009) Improved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study. Heart and Vessels 24:4, pages 277-282.
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Gitte Meriläinen, Werner Schmitz, Rik K. Wierenga & Petri Kursula. (2008) The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester‐dependent enzyme. The FEBS Journal 275:24, pages 6136-6148.
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Christophe Jayle, Frederic Favreau, Kequiang Zhang, Carole Doucet, Jean Michel Goujon, William Hebrard, Michel Carretier, Michel Eugene, Gerard Mauco, Jean Paul Tillement & Thierry Hauet. (2007) Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model. American Journal of Physiology-Renal Physiology 292:3, pages F1082-F1093.
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Alexandra Labrou, George Giannoglou, Dimitrios Zioutas, Nikolaos Fragakis, George Katsaris & George Louridas. (2007) Trimetazidine Administration Minimizes Myocardial Damage and Improves Left Ventricular Function after Percutaneous Coronary Intervention. American Journal of Cardiovascular Drugs 7:2, pages 143-150.
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HP Rang, MM Dale, JM Ritter & RJ Flower. 2007. Rang & Dale's Pharmacology. Rang & Dale's Pharmacology 277 297 .
Ger J. van der Vusse & Marc van Bilsen. (2016) Free Fatty Acids and Postischemic Myocardial Function. Seminars in Cardiothoracic and Vascular Anesthesia 10:3, pages 231-235.
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Dan Meng, Lin Feng, Xiang-Jian Chen, Di Yang & Ji-Nan Zhang. (2006) Trimetazidine improved Ca 2+ handling in isoprenalinemediated myocardial injury of rats . Experimental Physiology 91:3, pages 591-601.
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Ergun Topal, Ramazan Ozdemir, Irfan Barutcu, Yüksel Aksoy, Isa Sincer, Erdal Akturk & Sengül Çehreli. (2006) The effects of trimetazidine on heart rate variability in patients with slow coronary artery flow. Journal of Electrocardiology 39:2, pages 211-218.
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Evaristo Castedo, Javier Segovia, Cristina Escudero, Begoña Olmedilla, Fernando Granado, Carmen Blas, José M. Guardiola, Isabel Millán, Luis A. Pulpón & Juan Ugarte. (2005) Daño por isquemia-reperfusión durante el trasplante cardíaco experimental. Evaluación del papel citoprotector de la trimetazidina. Revista Española de Cardiología 58:8, pages 941-950.
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Marisol Ruiz-Meana. (2005) Trimetazidina, estr?s oxidativo y da?o celular durante la reperfusi?n mioc?rdica. Revista Espa?ola de Cardiolog?a 58:8, pages 895-897.
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Evaristo Castedo, Javier Segovia, Cristina Escudero, Begoña Olmedilla, Fernando Granado, Carmen Blas, José M. Guardiola, Isabel Millán, Luis A. Pulpón & Juan Ugarte. (2005) Ischemia-Reperfusion Injury During Experimental Heart Transplantation. Evaluation of Trimetazidine's Cytoprotective Effect. Revista Española de Cardiología (English Edition) 58:8, pages 941-950.
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Marisol Ruiz-Meana. (2005) Trimetazidine, Oxidative Stress, and Cell Injury During Myocardial Reperfusion. Revista Espa?ola de Cardiolog?a (English Edition) 58:8, pages 895-897.
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Isabella Tritto, Penghai Wang, Periannan Kuppusamy, Roberto Giraldez, Jay L Zweier & Giuseppe Ambrosio. (2005) The Anti-Anginal Drug Trimetazidine Reduces Neutrophil-Mediated Cardiac Reperfusion Injury. Journal of Cardiovascular Pharmacology 46:1, pages 89-98.
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C. Pantos, A. Bescond-Jacquet, S. Tzeis, I. Paizis, I. Mourouzis, P. Moraitis, V. Malliopoulou, E. D. Politi, H. Karageorgiou, D. Varonos & D. V. Cokkinos. (2004) Trimetazidine protects isolated rat hearts against ischemia?reperfusion injury in an experimental timing ? dependent manner. Basic Research in Cardiology 100:2, pages 154-160.
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Taher El-Kady, Khaled El-Sabban, Mohamed Gabaly, Ahmed Sabry & Sherif Abdel-Hady. (2005) Effects of Trimetazidine on Myocardial Perfusion and the Contractile Response of Chronically Dysfunctional Myocardium in Ischemic Cardiomyopathy. American Journal of Cardiovascular Drugs 5:4, pages 271-278.
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