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Research Article

Sildenafil citrate does not affect cardiac contractility in human or dog heart

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Pages 747-752 | Accepted 26 Sep 2003, Published online: 22 Sep 2008

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Si Chen & Chen Yan. (2021) An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases. Expert Opinion on Drug Discovery 16:2, pages 183-196.
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Josef Stehlik & Matthew A Movsesian. (2006) Inhibitors of cyclic nucleotide phosphodiesterase 3 and 5 as therapeutic agents in heart failure. Expert Opinion on Investigational Drugs 15:7, pages 733-742.
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Articles from other publishers (56)

Sumon Roy, Robert A. Kloner, Fadi N. Salloum & Ion S. Jovin. (2021) Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety. Cardiovascular Drugs and Therapy 37:4, pages 793-806.
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Rima Kamel, Jérôme Leroy, Grégoire Vandecasteele & Rodolphe Fischmeister. (2022) Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure. Nature Reviews Cardiology 20:2, pages 90-108.
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Nada Banjac, Velibor Vasović, Nebojša Stilinović, Ana Tomas, Lucija Vasović, Nikola Martić, Dušan Prodanović & Vladimir Jakovljević. (2023) The Effects of Different Doses of Sildenafil on Coronary Blood Flow and Oxidative Stress in Isolated Rat Hearts. Pharmaceuticals 16:1, pages 118.
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M. Goweder Fawzia, T. M. Abu El-Nasr & A. A. El-Sayed. (2021) The effect of sesame intake on adult albino rat testis during sildenafil long-term administration. The Journal of Basic and Applied Zoology 82:1.
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Adinoyi Seriki Samuel. (2021) Sildenafil citrate in healthy and diseased hearts. Journal of Cardiology and Cardiovascular Medicine 6:1, pages 033-039.
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Yoshiko Okai, Keiko Matsune, Kazunori Yamanaka, Toshikatsu Matsui, Emily Pfeiffer Kaushik, Kosuke Harada, Hiroshi Kohara, Akimitsu Miyawaki, Harushige Ozaki, Matthew Wagoner & Tadahiro Shinozawa. (2020) Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes. Journal of Pharmacological and Toxicological Methods 105, pages 106893.
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Michael E. J. Preedy. (2020) Cardiac Cyclic Nucleotide Phosphodiesterases: Roles and Therapeutic Potential in Heart Failure. Cardiovascular Drugs and Therapy 34:3, pages 401-417.
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Edwin A. Li, Wang Xi, Young Soo Han & Frank V. Brozovich. (2019) Phosphodiesterase expression in the normal and failing heart. Archives of Biochemistry and Biophysics 662, pages 160-168.
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Anastacia M. GarciaStephanie J. NakanoAnis Karimpour-FardKarin NunleyPenny Blain-NelsonNatalie M. StaffordBrian L. StaufferCarmen C. SucharovShelley D. Miyamoto. (2018) Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circulation: Heart Failure 11:9.
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Kun Liu, Qiongyu Hao, Jie Wei, Gong-Hao Li, Yong Wu & Yun-Feng Zhao. (2018) MicroRNA-19a/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A. Journal of Hypertension 36:9, pages 1847-1857.
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Chantal V. Degen, Kalkidan Bishu, Rosita Zakeri, Ozgur Ogut, Margaret M. Redfield & Frank V. Brozovich. (2015) The Emperor's New Clothes: PDE5 and the Heart. PLOS ONE 10:3, pages e0118664.
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V.O. Oka, A.L. Udefa, V.U. Nna & D.U. Owu. (2015) Sildenafil Citrate and Tramadol Administered Separately and in Combination Affects Basal Metabolic Rate, Triiodothyronine (T3) and Cortisol Levels in Albino Wistar Rats. Trends in Medical Research 10:3, pages 51-62.
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Walter Knight & Chen Yan. (2013) Therapeutic potential of PDE modulation in treating heart disease. Future Medicinal Chemistry 5:14, pages 1607-1620.
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Nilanjana Ph. D.Mahesh Thirunavukkarasu & Murugavel Ponnusamy. 2013. Cardiovascular Diseases. Cardiovascular Diseases 439 458 .
David A. Kass. (2012) Cardiac Role of Cyclic-GMP Hydrolyzing Phosphodiesterase Type 5: From Experimental Models to Clinical Trials. Current Heart Failure Reports 9:3, pages 192-199.
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Dong I. Lee & David A. Kass. (2012) Phosphodiesterases and Cyclic GMP Regulation in Heart Muscle. Physiology 27:4, pages 248-258.
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A.R. Harmer, N. Abi-Gerges, M.J. Morton, G.F. Pullen, J.P. Valentin & C.E. Pollard. (2012) Validation of an in vitro contractility assay using canine ventricular myocytes. Toxicology and Applied Pharmacology 260:2, pages 162-172.
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Clarke E. Atkins & Jens Häggström. (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14:1, pages 165-184.
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B. R. Lindman & M. M. Chakinala. (2010) Modulating the nitric oxide - cyclic GMP pathway in the pressure-overloaded left ventricle and group II pulmonary hypertension. International Journal of Clinical Practice 64, pages 15-22.
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Clint L. Miller & Chen Yan. (2010) Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications. Journal of Cardiovascular Translational Research 3:5, pages 507-515.
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Sharron H. Francis, Jennifer L. Busch & Jackie D. Corbin. (2010) cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action. Pharmacological Reviews 62:3, pages 525-563.
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Bo Jin, Xin-Ping Luo, Huan-Chun Ni & Hai-Ming Shi. (2010) Phosphodiesterase Type 5 Inhibitors for High-Altitude Pulmonary Hypertension. Clinical Drug Investigation 30:4, pages 259-265.
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Tilman Humpl & Ingram Schulze-Neick. 2010. Paediatric Cardiology. Paediatric Cardiology 1147 1161 .
Judy W. M. Cheng & Selamawit R. Berhane. (2009) Managing Erectile Dysfunction in Patients With Cardiovascular Diseases: The Efficacy and Safety of Phosphodiesterase-5 Inhibitors. American Journal of Lifestyle Medicine 3:3, pages 201-211.
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Praneet Kumar, Gary S. Francis & W. H. Wilson Tang. (2009) Phosphodiesterase 5 inhibition in heart failure: mechanisms and clinical implications. Nature Reviews Cardiology 6:5, pages 349-355.
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Yuan James Rao & Lei Xi. (2008) Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts. Acta Pharmacologica Sinica 30:1, pages 1-24.
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S. Hsu, T. Nagayama, N. Koitabashi, M. Zhang, L. Zhou, D. Bedja, K. L. Gabrielson, J. D. Molkentin, D. A. Kass & E. Takimoto. (2008) Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Cardiovascular Research 81:2, pages 301-309.
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Manling Zhang, Norimichi Koitabashi, Takahiro Nagayama, Ryan Rambaran, Ning Feng, Eiki Takimoto, Trisha Koenke, Brian O'Rourke, Hunter C. Champion, Michael T. Crow & David A. Kass. (2008) Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes. Cellular Signalling 20:12, pages 2231-2236.
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Marco Guazzi. (2008) Clinical Use of Phosphodiesterase-5 Inhibitors in Chronic Heart Failure. Circulation: Heart Failure 1:4, pages 272-280.
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David A. KassHunter C. ChampionJoseph A. Beavo. (2007) Phosphodiesterase Type 5. Circulation Research 101:11, pages 1084-1095.
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D. A. Kass. (2007) Hypertrophied Right Hearts Get Two for the Price of One: Can Inhibiting Phosphodiesterase Type 5 Also Inhibit Phosphodiesterase Type 3?. Circulation 116:3, pages 233-235.
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J. Nagendran, S. L. Archer, D. Soliman, V. Gurtu, R. Moudgil, A. Haromy, C. St. Aubin, L. Webster, I. M. Rebeyka, D. B. Ross, P. E. Light, J. R.B. Dyck & E. D. Michelakis. (2007) Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility. Circulation 116:3, pages 238-248.
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J Y Jeremy, R A Jones, A J Koupparis, M Hotston, R Persad, G D Angelini & N Shukla. (2006) Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase. International Journal of Impotence Research 19:3, pages 265-280.
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Oleg E. Osadchii. (2007) Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease. Cardiovascular Drugs and Therapy 21:3, pages 171-194.
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E R Schwarz, V Kapur, J Rodriguez, S Rastogi & S Rosanio. (2006) The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems. International Journal of Impotence Research 19:2, pages 139-148.
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Pierre Fesler, Alberto Pagnamenta, Benoit Rondelet, François Kerbaul & Robert Naeije. (2006) Effects of sildenafil on hypoxic pulmonary vascular function in dogs. Journal of Applied Physiology 101:4, pages 1085-1090.
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Shahzad G. Raja, Mark D. Danton, Kenneth J. MacArthur & James C. Pollock. (2006) Treatment of Pulmonary Arterial Hypertension With Sildenafil: From Pathophysiology to Clinical Evidence. Journal of Cardiothoracic and Vascular Anesthesia 20:5, pages 722-735.
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Graham Jackson, Piero Montorsi & Melvin D. Cheitlin. (2006) Cardiovascular safety of sildenafil citrate (Viagra?): An updated perspective. Urology 68:3, pages 47-60.
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Milan D. Patel & Stuart D. Katz. (2005) Phosphodiesterase 5 Inhibition in Chronic Heart Failure and Pulmonary Hypertension. The American Journal of Cardiology 96:12, pages 47-51.
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Jackie D. Corbin, Alfreda Beasley, Mitsi A. Blount & Sharron H. Francis. (2005) High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors. Biochemical and Biophysical Research Communications 334:3, pages 930-938.
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Nilima Shukla, Robert Jones, Raj Persad, Gianni D. Angelini & Jamie Y. Jeremy. (2005) Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. European Journal of Pharmacology 517:3, pages 224-231.
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Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang & David A Kass. (2005) Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nature Medicine 11:2, pages 214-222.
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Gregory D. Lewis & Marc J. Semigran. (2004) Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertension. Current Heart Failure Reports 1:4, pages 183-189.
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Shahzad G. Raja & Suneela H. Nayak. (2004) Sildenafil: Emerging Cardiovascular Indications. The Annals of Thoracic Surgery 78:4, pages 1496-1506.
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