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Research Article

Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study

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Pages 565-572 | Accepted 23 Jan 2004, Published online: 05 Mar 2004

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In Sun Goak, Jin A Lee, Min Ho Jeong, Seol Ju Moon & Min Gul Kim. (2022) Pharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects. Drug Design, Development and Therapy 16, pages 4439-4448.
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Serge Jabbour & Barry Ziring. (2011) Advantages of Extended-Release Metformin in Patients with Type 2 Diabetes Mellitus. Postgraduate Medicine 123:1, pages 15-23.
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Hermes Florez, Jiacong Luo, Sumaya Castillo-Florez, Georgia Mitsi, John Hanna, Leonardo Tamariz, Ana Palacio, Sukumar Nagendran & Michael Hagan. (2010) Impact of Metformin-Induced Gastrointestinal Symptoms on Quality of Life and Adherence in Patients with Type 2 Diabetes. Postgraduate Medicine 122:2, pages 112-120.
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N Papanas, E Maltezos & DP Mikhailidis. (2009) Metformin: diamonds are forever. Expert Opinion on Pharmacotherapy 10:15, pages 2395-2397.
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Crossref
Clifford J. Bailey. (2017) Metformin: historical overview. Diabetologia 60:9, pages 1566-1576.
Crossref
Fabrice Bonnet & André Scheen. (2017) Understanding and overcoming metformin gastrointestinal intolerance. Diabetes, Obesity and Metabolism 19:4, pages 473-481.
Crossref
George Grunberger. (2017) Should Side Effects Influence the Selection of Antidiabetic Therapies in Type 2 Diabetes?. Current Diabetes Reports 17:4.
Crossref
Andrew J. Krentz & Alan J. Sinclair. 2017. Diabetes in Old Age. Diabetes in Old Age 298 322 .
Huang-tz Ou, Pei-Chi Chen & Meng-Hsing Wu. (2017) Effect of metformin by employing 2-hour postload insulin for measuring insulin resistance in Taiwanese women with polycystic ovary syndrome. Journal of the Formosan Medical Association 116:2, pages 80-89.
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Rhona Johnston, Olalekan Uthman, Ewen Cummins, Christine Clar, Pamela Royle, Jill Colquitt, Bee Kang Tan, Andrew Clegg, Saran Shantikumar, Rachel Court, J Paul O’Hare, David McGrane, Tim Holt & Norman Waugh. (2017) Canagliflozin, dapagliflozin and empagliflozin monotherapy for treating type 2 diabetes: systematic review and economic evaluation. Health Technology Assessment 21:2, pages 1-218.
Crossref
Yoshihito Fujita & Nobuya Inagaki. (2017) Metformin: New Preparations and Nonglycemic Benefits. Current Diabetes Reports 17:1.
Crossref
G. Verstraete, P. Mertens, W. Grymonpré, P.J. Van Bockstal, T. De Beer, M.N. Boone, L. Van Hoorebeke, J.P. Remon & C. Vervaet. (2016) A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices. International Journal of Pharmaceutics 513:1-2, pages 602-611.
Crossref
M P van der Aa, M A J Elst, E M W van de Garde, E G A H van Mil, C A J Knibbe & M M J van der Vorst. (2016) Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial. Nutrition & Diabetes 6:8, pages e228-e228.
Crossref
An-Katrien Vynckier, Jody Voorspoels, Jean Paul Remon & Chris Vervaet. (2016) Co-extrusion as a processing technique to manufacture a dual sustained release fixed-dose combination product. Journal of Pharmacy and Pharmacology 68:5, pages 721-727.
Crossref
Timothy J. Church & Stuart T. Haines. (2016) Treatment Approach to Patients With Severe Insulin Resistance. Clinical Diabetes 34:2, pages 97-104.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 969 983 .
Michael Mendoza & Colleen Loo-Gross. 2016. Men's Health in Primary Care. Men's Health in Primary Care 125 143 .
Linda Tran, Angela Zielinski, Arpi H. Roach, Jennifer A. Jende, Ann Marie Householder, Emily E. Cole, Shuruq A. Atway, Melinda Amornyard, Mallory L. Accursi, Suzanna W. Shieh & Erin E. Thompson. (2015) Pharmacologic Treatment of Type 2 Diabetes. Annals of Pharmacotherapy 49:5, pages 540-556.
Crossref
Linong Ji, Bernard Zinman, Sanjay Patel, Jinfeng Ji, Zelie Bailes, Sandra Thiemann & Thomas Seck. (2015) Efficacy and Safety of Linagliptin Co-Administered with Low-Dose Metformin Once Daily Versus High-Dose Metformin Twice Daily in Treatment-Naïve Patients with Type 2 Diabetes: a Double-Blind Randomized Trial. Advances in Therapy 32:3, pages 201-215.
Crossref
Lawrence Blonde, Zinnia T. San Juan & Peggy Bolton. (2014) Fixed-Dose Combination Therapy in Type 2 Diabetes Mellitus. Endocrine Practice 20:12, pages 1322-1332.
Crossref
Antonio R. Chacra. (2014) Evolving Metformin Treatment Strategies in Type-2 Diabetes. American Journal of Therapeutics 21:3, pages 198-210.
Crossref
Avinash G. Thombre, Alfred Berchielli & Janyce F. Rogers. (2014) Extemporaneously prepared controlled release formulations for accelerating the early phase development of drug candidates. Drug Discovery Today 19:5, pages 694-700.
Crossref
S. V Kakorin, I. A Averkova & A. M Mkrtumyan. (2014) Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure. CardioSomatics 5:1, pages 33-40.
Crossref
Brian J. Gates & Kevin M. Walker. (2014) Physiological Changes in Older Adults and Their Effect on Diabetes Treatment. Diabetes Spectrum 27:1, pages 20-29.
Crossref
Peter Timmins, Samuel R. Pygall & Colin D. Melia. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 1 15 .
Y.-C. Hwang, M. Kang, C. W. Ahn, J. S. Park, S. H. Baik, D. J. Chung, H. C. Jang, K.-A. Kim, I.-K. Lee, K. W. Min, M. Nam, T. S. Park, S. M. Son, Y.-A. Sung, J.-T. Woo, K. S. Park & M.-K. Lee. (2013) Efficacy and safety of glimepiride/metformin sustained release once daily vs. glimepiride/metformin twice daily in patients with type 2 diabetes. International Journal of Clinical Practice 67:3, pages 236-243.
Crossref
Linong Ji, Hongmei Li, Xiaohui Guo, Yan Li, Renming Hu & Zhengying Zhu. (2013) Impact of Baseline BMI on Glycemic Control and Weight Change with Metformin Monotherapy in Chinese Type 2 Diabetes Patients: Phase IV Open-Label Trial. PLoS ONE 8:2, pages e57222.
Crossref
Chul‐Hee Kim, Kyung‐Ah Han, Han‐Jin Oh, Kevin Eng‐Kiat Tan, Radhakrishna Sothiratnam, Askandar Tjokroprawiro & Marcus Klein. (2012) Safety, tolerability, and efficacy of metformin extended‐release oral antidiabetic therapy in patients with type 2 diabetes: An observational trial in Asia. Journal of Diabetes 4:4, pages 395-406.
Crossref
G. Wright BatesJr.Jr. & Anthony M. Propst. (2012) Polycystic Ovarian Syndrome Management Options. Obstetrics and Gynecology Clinics of North America 39:4, pages 495-506.
Crossref
. (2011) Russian Association of Endocrinologists reports commencement of Glucophage XR clinical use. Diabetes mellitus 14:4, pages 124-124.
Crossref
Liana Hakobyan, Flora M. Haaijer-Ruskamp, Dick de Zeeuw, Daniela Dobre & Petra Denig. (2011) Comparing Adverse Event Rates of Oral Blood Glucose-Lowering Drugs Reported by Patients and Healthcare Providers. Drug Safety 34:12, pages 1191-1202.
Crossref
Liana Hakobyan, Flora M Haaijer-Ruskamp, Dick de Zeeuw, Daniela Dobre & Petra Denig. (2011) A review of methods used in assessing non-serious adverse drug events in observational studies among type 2 diabetes mellitus patients. Health and Quality of Life Outcomes 9:1.
Crossref
Mahasen A Radwan, Esraa S Al Taweel, Abdulrahman M Al-Moghairi, Nouf M Aloudah, Muneera A Al Babtain & Hussein S Al-Amri. (2011) Monitoring Metformin in Cardiac Patients Exposed to Contrast Media Using Ultra–High-Performance Liquid Chromatography Tandem Mass-Spectrometry. Therapeutic Drug Monitoring 33:6, pages 742-749.
Crossref
Juliana Levy, Roberta A Cobas & Marília B Gomes. (2010) Assessment of efficacy and tolerability of once-daily extended release metformin in patients with type 2 diabetes mellitus. Diabetology & Metabolic Syndrome 2:1.
Crossref
Rajeev Jain & Dwain L. Thiele. 2010. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. Sleisenger and Fordtran's Gastrointestinal and Liver Disease 557 592.e11 .
Kristiina M. Huttunen, Anne Mannila, Krista Laine, Eeva Kemppainen, Jukka Leppänen, Jouko Vepsäläinen, Tomi Järvinen & Jarkko Rautio. (2009) The First Bioreversible Prodrug of Metformin with Improved Lipophilicity and Enhanced Intestinal Absorption. Journal of Medicinal Chemistry 52:14, pages 4142-4148.
Crossref
Alex J KentBethan Graf, Priyajit Prasad, Matthew R Banks & Michael D Feher. (2009) Diabetes treatments, gastrointestinal symptoms and lower gastrointestinal endoscopy. The British Journal of Diabetes & Vascular Disease 9:3, pages 129-130.
Crossref
L. A. Donnelly, A. D. Morris & E. R. Pearson. (2009) Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study. Diabetes, Obesity and Metabolism 11:4, pages 338-342.
Crossref
N. PapanasE. Maltezos. (2009) Metformin: A Review of Its Use in the Treatment of Type 2 Diabetes. Clinical Medicine. Therapeutics 1, pages CMT.S1085.
Crossref
. 2009. Meyler's Side Effects of Endocrine and Metabolic Drugs. Meyler's Side Effects of Endocrine and Metabolic Drugs 357 473 .
John HB Scarpello & Harry CS Howlett. (2008) Metformin therapy and clinical uses. Diabetes and Vascular Disease Research 5:3, pages 157-167.
Crossref
H. Gao, W. Xiao, C. Wang, J. Zhang, Y. Yang, J. Yang, W. Yang & T. Hong. (2008) The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study. International Journal of Clinical Practice 62:5, pages 695-700.
Crossref
Michael D FeherMa'en Al-Mrayat, Julie Brake & King Sun Leong. (2016) Tolerability of prolonged-release metformin (Glucophage® SR) in individuals intolerant to standard metformin — results from four UK centres. The British Journal of Diabetes & Vascular Disease 7:5, pages 225-228.
Crossref
Louis S. Matza, Kristina S. Boye, Nicole Yurgin, Jessica Brewster-Jordan, Sally Mannix, Jodi M. Shorr & Beth L. Barber. (2007) Utilities and disutilities for type 2 diabetes treatment-related attributes. Quality of Life Research 16:7, pages 1251-1265.
Crossref
R.C.L. Page. 2007. 523 538 .
Thomas W. Donner. (2006) Tight control of hyperglycemia in type 2 diabetes mellitus. Insulin 1:4, pages 166-172.
Crossref
Mike Kirby. (2005) Diabetes in the new General Medical Services contract: targets and adherence to metformin therapy. International Journal of Clinical Practice 59:3, pages 263-266.
Crossref
A Consoli, R Gomis, S Halimi, PD Home, H Mehnert, K Strojek & LF Van Gaal. (2004) Initiating oral glucose-lowering therapy with metformin in tyape 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications. Diabetes & Metabolism 30:6, pages 509-516.
Crossref
Jaime Davidson & Harry Howlett. (2016) New prolonged-release metformin improves gastrointestinal tolerability. The British Journal of Diabetes & Vascular Disease 4:4, pages 273-277.
Crossref

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