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Original Article

Safety, effectiveness, and duration of effect of BOTOX after switching from Dysport for blepharospasm, cervical dystonia, and hemifacial spasm

Pages 433-438 | Accepted 04 Feb 2005, Published online: 04 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Avram Fraint, Padmaja Vittal & Cynthia Comella. (2016) Considerations on patient-related outcomes with the use of botulinum toxins: is switching products safe?. Therapeutics and Clinical Risk Management 12, pages 147-154.
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Aaron Jamison, Maribel Favor & Raman Malhotra. (2022) Patient-reported outcomes following a break in ophthalmic botulinum toxin therapy during the COVID-19 pandemic. Canadian Journal of Ophthalmology.
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Claudia Ledda, Carlo Alberto Artusi, Antonella Tribolo, Domiziana Rinaldi, Gabriele Imbalzano, Leonardo Lopiano & Maurizio Zibetti. (2022) Time to onset and duration of botulinum toxin efficacy in movement disorders. Journal of Neurology 269:7, pages 3706-3712.
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Raja Mehanna & Joseph Jankovic. 2022. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1095 1143 .
Nicola Tambasco, Marta Filidei, Pasquale Nigro, Lucilla Parnetti & Simone Simoni. (2021) Botulinum Toxin for the Treatment of Hemifacial Spasm: An Update on Clinical Studies. Toxins 13:12, pages 881.
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Incı Sule Ozer, Muge Kuzu Kumcu, Sabiha Tezcan Aydemir & Muhittin Cenk Akbostanci. (2021) Dose conversion ratio, comparative efficacy, and adverse events after switching from onabotulinum toxin A to abobotulinum toxin A for neurological conditions. Clinical Neurology and Neurosurgery 209, pages 106889.
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Yolanda Herrero-Infante, Ana Rodríguez-Sanz, Jorge Máñez-Miró & Francisco Vivancos-Matellano. (2021) Hemifacial spasm through the last three decades: From etiology to efficacy and safety of long-term botulinum toxin treatment. Clinical Neurology and Neurosurgery 203, pages 106555.
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Samih Badarny, Raphiq Ibrahim, Zvi Susel, Adnan Zaina, Rema Nasar & Yazid Badarny. (2021) Long-term stable efficacy of botulinum toxin A in facial movement disorders with no need for increasing dose. Medicine 100:25, pages e26481.
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Raja Mehanna & Joseph Jankovic. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 48 .
John C. Bladen, Maribel Favor, Andre Litwin & Raman Malhotra. (2020) Switchover study of onabotulinumtoxinA to incobotulinumtoxinA for facial dystonia . Clinical & Experimental Ophthalmology 48:9, pages 1146-1151.
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Z.A. Zalyalova. (2020) Hemifacial spasm. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 120:8, pages 140.
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Alina Masters‐Israilov & Matthew S. Robbins. (2019) OnabotulinumtoxinA Wear‐off Phenomenon in the Treatment of Chronic Migraine. Headache: The Journal of Head and Face Pain 59:10, pages 1753-1761.
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Shymaa A. Hablas, Doaa W. Nada, Doaa S. Alashkar & Ahmed A. Elsharkawy. (2019) The effect of botulinum toxin type A injection in decreasing intratunnel tendon tension in carpal tunnel syndrome: a randomized controlled trial for efficacy and safety. Egyptian Rheumatology and Rehabilitation 46:4, pages 299-303.
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Babak Azizzadeh, Leslie E. Irvine, Jaqueline Diels, William H. Slattery, Guy G. Massry, Babak Larian, Kiersten L. Riedler & Grace Lee Peng. (2019) Modified Selective Neurectomy for the Treatment of Post–Facial Paralysis Synkinesis. Plastic & Reconstructive Surgery 143:5, pages 1483-1496.
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John C Bladen, Ilan Feldman, Maribel Favor, Marizol Dizon, Andre Litwin & Raman Malhotra. (2018) Long-term outcome of flexible onabotulinum toxin A treatment in facial dystonia. Eye 33:3, pages 349-352.
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Kristina Tedroff, Gustaf Befrits, Carl Johan Tedroff & Stefan Gantelius. (2018) To switch from Botox to Dysport in children with CP, a real world, dose conversion, cost-effectiveness study. European Journal of Paediatric Neurology 22:3, pages 412-418.
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Christopher J. Hwang & Kian Eftekhari. (2018) Benign Essential Blepharospasm: What We Know and What We Don’t. International Ophthalmology Clinics 58:1, pages 11-24.
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Kemar E. Green, David Rastall & Eric Eggenberger. (2017) Treatment of Blepharospasm/Hemifacial Spasm. Current Treatment Options in Neurology 19:11.
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Atsushi Mizuma, Eiichiro Nagata, Takashi Yasuda, Maiko Kouchi, Taira Nakayama, Kazunari Honma, Kentaro Tokuoka, Yasuhisa Kitagawa, Shigeru Nogawa & Shunya Takizawa. (2017) Botulinum toxin A is effective to treat tension-type headache caused by hemifacial spasm. Journal of Clinical Neuroscience 44, pages 284-288.
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Pamela Latino, Letizia Castelli, Luca Prosperini, Maria Rita Marchetti, Carlo Pozzilli & Morena Giovannelli. (2017) Determinants of botulinum toxin discontinuation in multiple sclerosis: a retrospective study. Neurological Sciences 38:10, pages 1841-1848.
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Ryan M. Greene, John P. Arkins & Steven H. Dayan. 2017. Botulinum Toxins. Botulinum Toxins 121 131 .
Paul T. Bremer, Sabine Pellett, James P. Carolan, William H. Tepp, Lisa M. Eubanks, Karen N. Allen, Eric A. Johnson & Kim D. Janda. (2017) Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A. Journal of the American Chemical Society 139:21, pages 7264-7272.
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Asmahan Alshubaili, Hussam Abou-Al-Shaar, Ponnusamy Santhamoorthy, Hosam Attia & Saeed Bohlega. (2016) Ultrasound-guided botulinum toxin A injection in the treatment of belly dancer’s dyskinesia. BMC Neurology 16:1.
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Alma Rystedt, Lena Zetterberg, Joachim Burman, Dag Nyholm & Anders Johansson. (2015) A Comparison of Botox 100 U/mL and Dysport 100 U/mL Using Dose Conversion Ratio 1. Clinical Neuropharmacology 38:5, pages 170-176.
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Mine Hayriye Sorgun, Rezzak Yilmaz, Yusuf Alper Akin, Fatma Nazli Mercan & Muhittin Cenk Akbostanci. (2015) Botulinum toxin injections for the treatment of hemifacial spasm over 16years. Journal of Clinical Neuroscience 22:8, pages 1319-1325.
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Ji Young Yun, Jae Woo Kim, Hee‐Tae Kim, Sun Ju Chung, Jong‐Min Kim, Jin Whan Cho, Jee‐Young Lee, Ha Neul Lee, Sooyeoun You, Eungseok Oh, Heejeong Jeong, Young Eun Kim, Han‐Joon Kim, Won Yong Lee & Beom S. Jeon. (2014) Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: A double‐blind, randomized study. Movement Disorders 30:2, pages 206-213.
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Wallace A Marsh, Deirdre M Monroe, Mitchell F Brin & Conor J Gallagher. (2014) Systematic review and meta-analysis of the duration of clinical effect of onabotulinumtoxinA in cervical dystonia. BMC Neurology 14:1.
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Arianna Guidubaldi, Anna Rita Bentivoglio & Alberto Albanese. 2014. Clinical Applications of Botulinum Neurotoxin. Clinical Applications of Botulinum Neurotoxin 51 93 .
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Hanan Mohamed El Kahky, Heba Mahmoud Diab, Dalia Gamal Aly & Nehal Magdi Farag. (2013) Efficacy of Onabotulinum Toxin A (Botox) versus Abobotulinum Toxin A (Dysport) Using a Conversion Factor (1 : 2.5) in Treatment of Primary Palmar Hyperhidrosis. Dermatology Research and Practice 2013, pages 1-6.
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Daniel Truong. (2012) Botulinum toxins in the treatment of primary focal dystonias. Journal of the Neurological Sciences 316:1-2, pages 9-14.
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Anna Rita Bentivoglio, Tàmara Ialongo, Francesco Bove, Francesca De Nigris & Alfonso Fasano. (2011) Retrospective evaluation of the dose equivalence of Botox® and Dysport® in the management of blepharospasm and hemifacial spasm: a novel paradigm for a never ending story. Neurological Sciences 33:2, pages 261-267.
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Mattias LindeKnut HagenØyvind SalvesenGøril Bruvik GravdahlGrethe HeldeLars Jacob Stovner. (2011) Onabotulinum toxin A treatment of cervicogenic headache: A randomised, double-blind, placebo-controlled crossover study. Cephalalgia 31:7, pages 797-807.
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K. Roger Aoki. 2011. Botulinum Toxins in Clinical Aesthetic Practice. Botulinum Toxins in Clinical Aesthetic Practice 1 14 .
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Nils Erik Gilhus, Michael P. Barnes & Michael BraininA. Albanese, F. Asmus, A. Berardelli, K. Bhatia, A. E. Elia, B. Elibol, G. Filippini, T. Gasser, J. K. Krauss, N. Nardocci, A. Newton, J. Valls‐Solé & M. Vidailhet. 2010. European Handbook of Neurological Management. European Handbook of Neurological Management 191 206 .
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A. R. Bentivoglio, A. Fasano, T. Ialongo, F. Soleti, S. Lo Fermo & A. Albanese. (2009) Fifteen-Year Experience in Treating Blepharospasm with Botox or Dysport: Same Toxin, Two Drugs. Neurotoxicity Research 15:3, pages 224-231.
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Gottfried Kranz, Dietrich Haubenberger, Bernhard Voller, Martin Posch, Peter Schnider, Eduard Auff & Thomas Sycha. (2008) Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study. Movement Disorders 24:2, pages 231-236.
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SYRUS KARSAI & CHRISTIAN RAULIN. (2009) Current Evidence on the Unit Equivalence of Different Botulinum Neurotoxin A Formulations and Recommendations for Clinical Practice in Dermatology. Dermatologic Surgery 35:1, pages 1-8.
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