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Brief Review

Cardiac pacemaker /f current and its inhibition by heart rate-reducing agents

Pages 1115-1122 | Accepted 15 Jun 2005, Published online: 15 Jun 2005

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Sheryl L Chow, Robert L. Page$suffix/text()$suffix/text() & Christophe Depre. (2018) Role of ivabradine and heart rate lowering in chronic heart failure: guideline update. Expert Review of Cardiovascular Therapy 16:7, pages 515-526.
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Ashish K Gupta, David Winchester & Carl J Pepine. (2013) Antagonist molecules in the treatment of angina. Expert Opinion on Pharmacotherapy 14:17, pages 2323-2342.
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Waqas Khan & Jeffrey S Borer. (2011) Critical evaluation of ivabradine for the management of chronic stable angina. Research Reports in Clinical Cardiology 2, pages 87-98.
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Kim Fox. (2006) Selective and specific If inhibition: new perspectives for the treatment of stable angina. Expert Opinion on Pharmacotherapy 7:9, pages 1211-1220.
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Articles from other publishers (52)

Alexander Nedoshivin, Parvoleta T. S. Petrova & Yuri Karpov. (2022) Efficacy and Safety of Ivabradine in Combination with Beta-Blockers in Patients with Stable Angina Pectoris: A Systematic Review and Meta-analysis. Advances in Therapy 39:9, pages 4189-4204.
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Anne-Sophie Depuydt, Steve Peigneur & Jan Tytgat. (2022) Review: HCN Channels in the Heart. Current Cardiology Reviews 18:4.
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M. Mukkanti Eswarudu, A. Lakshmana Rao & K. Vijay. (2022) Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma. Journal of Pharmacological and Toxicological Methods 116, pages 107186.
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Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 133 198 .
Peter Stanko, Tomas Baka, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Andrej Barta, Pavol Janega, Michaela Adamcova, Ludovit Paulis & Fedor Simko. (2020) Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension. Frontiers in Medicine 7.
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Ilaria Rivolta, Anna Binda, Alessio Masi & Jacopo C. DiFrancesco. (2020) Cardiac and neuronal HCN channelopathies. Pflügers Archiv - European Journal of Physiology 472:7, pages 931-951.
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Indranee N. Rajapreyar, Andrew J. Lenneman & Sumanth D. Prabhu. 2020. Emerging Technologies for Heart Diseases. Emerging Technologies for Heart Diseases 359 380 .
Dimitar Divchev & Georg Stöckl. (2019) Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice. Cardiology and Therapy 8:2, pages 317-328.
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Kristine Chobanyan-Jürgens, Karsten Heusser, David Duncker, Christian Veltmann, Marcus May, Heidrun Mehling, Friedrich C. Luft, Christoph Schröder, Jens Jordan & Jens Tank. (2018) Cardiac pacemaker channel (HCN4) inhibition and atrial arrhythmogenesis after releasing cardiac sympathetic activation. Scientific Reports 8:1.
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Dimitar Divchev & Georg Stöckl. (2017) Treatment of Stable Angina with a New Fixed-Dose Combination of Ivabradine and Metoprolol: Effectiveness and Tolerability in Routine Clinical Practice. Cardiology and Therapy 6:2, pages 239-249.
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Vikas Agrawal, Niraj Kumar, Balalji Lohiya, Bhupendra K. Sihag, Rajpal Prajapati, T.B. Singh & Geetha Subramanian. (2016) Metoprolol vs ivabradine in patients with mitral stenosis in sinus rhythm. International Journal of Cardiology 221, pages 562-566.
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Joachim Behar, Ambhighainath Ganesan, Jin Zhang & Yael Yaniv. (2016) The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell Mechanisms. Frontiers in Physiology 7.
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Jonathan S. Gordin & Gregg C. Fonarow. (2016) New medications for heart failure. Trends in Cardiovascular Medicine 26:6, pages 485-492.
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Fernanda C. Silva, Franciny A. Paiva, Flávia C. Müller-Ribeiro, Henrique M. A. Caldeira, Marco A. P. Fontes, Rodrigo C. A. de Menezes, Karina R. Casali, Gláucia H. Fortes, Eleonora Tobaldini, Monica Solbiati, Nicola Montano, Valdo J. Dias Da Silva & Deoclécio A. Chianca. (2016) Chronic Treatment with Ivabradine Does Not Affect Cardiovascular Autonomic Control in Rats. Frontiers in Physiology 7.
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A I Ponomareva, O G Kompaniets, R M Linchak & G S Ivanchura. (2016) Pharmacological therapy, slows the heart rate, in patientswith hypertension and chronic heart failure: theory and application in clinical practice. Systemic Hypertension 13:1, pages 52-57.
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Karsten Heusser, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft & Jens Jordan. (2016) Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High‐Fidelity Cardiovascular Phenotyping. Journal of the American Heart Association 5:1.
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Xingwei Yang, Yanjun Qin, Suxia Shao, Yueqing Yu, Chongyang Zhang, Hua Dong, Guangwei Lv & Shimin Dong. (2016) MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). International Heart Journal 57:2, pages 247-250.
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Karl Werdan, Henning Ebelt, Sebastian Nuding, Florian Höpfner, Georg Stöckl & Ursula Müller-Werdan. (2016) Ivabradine in Combination with Metoprolol Improves Symptoms and Quality of Life in Patients with Stable Angina Pectoris: A post hoc Analysis from the ADDITIONS Trial. Cardiology 133:2, pages 83-90.
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Fausto J. Pinto. (2015) Ivabradine in practice. European Heart Journal Supplements 17:suppl G, pages G37-G40.
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Su Young Han & Chris P. Bolter. (2015) Effects of tertiapin-Q and ZD7288 on changes in sinoatrial pacemaker rhythm during vagal stimulation. Autonomic Neuroscience 193, pages 117-126.
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Pawan Bista, Manuela Cerina, Petra Ehling, Michael Leist, Hans-Christian Pape, Sven G. Meuth & Thomas Budde. (2014) The role of two-pore-domain background K+ (K2P) channels in the thalamus. Pflügers Archiv - European Journal of Physiology 467:5, pages 895-905.
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Ursula Müller-Werdan, Georg Stöckl, Henning Ebelt, Sebastian Nuding, Florian Höpfner & Karl Werdan. (2014) Ivabradine in combination with beta-blocker reduces symptoms and improves quality of life in elderly patients with stable angina pectoris: Age-related results from the ADDITIONS study. Experimental Gerontology 59, pages 34-41.
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Amitabha Bose, Jorge Golowasch, Yinzheng Guan & Farzan Nadim. (2014) The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations. Journal of Computational Neuroscience 37:2, pages 229-242.
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Priyanthi Dias, Thomas Desplantez, Majd A. El-Harasis, Rasheda A. Chowdhury, Nina D. Ullrich, Alberto Cabestrero de Diego, Nicholas S. Peters, Nicholas J. Severs, Kenneth T. MacLeod & Emmanuel Dupont. (2014) Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line. PLoS ONE 9:2, pages e90266.
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Hee Youn Choi, Yook-Hwan Noh, Sang-Heon Cho, Jong-Lyul Ghim, Sangmin Choe, Un-Jib Kim, Jin Ah Jung, Kyun-Seop Bae & Hyeong-Seok Lim. (2013) Evaluation of Pharmacokinetic and Pharmacodynamic Profiles and Tolerability After Single (2.5, 5, or 10 mg) and Repeated (2.5, 5, or 10 mg BID for 4.5 days) Oral Administration of Ivabradine in Healthy Male Korean Volunteers. Clinical Therapeutics 35:6, pages 819-835.
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Carlos Henrique Xavier, Mirza Irfan Beig, Danielle Ianzer, Marco Antônio Peliky FontesEugene Nalivaiko. (2013) Asymmetry in the control of cardiac performance by dorsomedial hypothalamus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304:8, pages R664-R674.
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MC Colak, H Parlakpinar, S Tasdemir, E Samdanci, E Kose, A Polat, E Sarihan & A Acet. (2012) Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Human & Experimental Toxicology 31:9, pages 945-954.
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K. G. Adamyan, L. R. Tumasyan & A. L. Chilingaryan. (2012) EFFICACY OF IVABRADINE THERAPY ON RIGHT HEART PARAMETERS AND PROGNOSIS IN PATIENTS WITH SEVERE SYSTOLIC CHRONIC HEART FAILURE. Eurasian heart journal:2, pages 65-72.
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Karl Werdan, Henning Ebelt, Sebastian Nuding, Florian Höpfner, Guido Hack & Ursula Müller-Werdan. (2012) Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study. Clinical Research in Cardiology 101:5, pages 365-373.
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Abdulhalim J. Kinsara, Hani K. Najm, Menwar Al Anazi & Hani Tamim. (2011) Resting heart rate in patients with ischemic heart disease in Saudi Arabia and Egypt. Journal of the Saudi Heart Association 23:4, pages 225-232.
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Xinping Xu, Zhanna V. Vysotskaya, Qinglian Liu & Lei Zhou. (2010) Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel. Journal of Biological Chemistry 285:47, pages 37082-37091.
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Atul Pathak, Alain Berdeaux, Paul Mulder & Christian Thuillez. (2010) Ivabradine dans la maladie coronaire : pharmacologie expérimentale et clinique. Therapies 65:5, pages 483-489.
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Magnus Baumhäkel, Florian Custodis, Nils Schlimmer, Ulrich Laufs & Michael Böhm. (2010) Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice. Atherosclerosis 212:1, pages 55-62.
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Tatiana M. Vinogradova & Edward G. Lakatta. (2009) Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels. Journal of Molecular and Cellular Cardiology 47:4, pages 456-474.
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