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Original Article

Lipid altering-efficacy of ezetimibe co-administered with simvastatin compared with rosuvastatin: a meta-analysis of pooled data from 14 clinical trials

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Pages 1123-1130 | Accepted 23 May 2005, Published online: 17 Jun 2005

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Read on this site (9)

Dimitri P. Mikhailidis, Richard W. Lawson, Anna-Louise McCormick, Gillian C. Sibbring, Andrew M. Tershakovec, Glenn M. Davies & Kaan Tunceli. (2011) Comparative efficacy of the addition of ezetimibe to statin vs statin titration in patients with hypercholesterolaemia: systematic review and meta-analysis. Current Medical Research and Opinion 27:6, pages 1191-1210.
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Nkechinyere Ijioma & Jennifer G Robinson. (2011) Lipid-lowering effects of ezetimibe and simvastatin in combination. Expert Review of Cardiovascular Therapy 9:2, pages 131-145.
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L. Nherera, N.W. Calvert, K. DeMott, S.E. Humphries, H.A.W. Neil, R. Minhas & M. Thorogood. (2010) Cost-effectiveness analysis of the use of a high-intensity statin compared to a low-intensity statin in the management of patients with familial hypercholesterolaemia. Current Medical Research and Opinion 26:3, pages 529-536.
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Scott L. Charland & Daniel C. Malone. (2010) Prediction of cardiovascular event risk reduction from lipid changes associated with high potency dyslipidemia therapy. Current Medical Research and Opinion 26:2, pages 365-375.
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I. Migdalis, A. Efthimiadis, St. Pappas, D. Alexopoulos, F. Vlasserou & D. P. Mikhailidis. (2009) Clinical experience with ezetimibe/simvastatin in a Mediterranean population. Current Medical Research and Opinion 25:10, pages 2571-2576.
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D. P. Mikhailidis, G. C. Sibbring, C. M. Ballantyne, G. M. Davies & A. L. Catapano. (2007) Meta-analysis of the cholesterol-lowering effect of ezetimibe added to ongoing statin therapy. Current Medical Research and Opinion 23:8, pages 2009-2026.
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Irene F Gazi & Dimitri P Mikhailidis. (2006) Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: an overview. Expert Opinion on Therapeutic Targets 10:6, pages 851-866.
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Alberico L. Catapano, Michael H. Davidson, Christie M. Ballantyne, William E. Brady, Russell A. Gazzara, Joanne E. Tomassini & Andrew M. Tershakovec. (2006) Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients. Current Medical Research and Opinion 22:10, pages 2041-2053.
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Christie M. Ballantyne & Alberico L. Catapano. (2022) The pharmacology of cholesterol-lowering drugs: The pharmacology of cholesterol-lowering drugs. European Atherosclerosis Journal 1:1, pages 2-13.
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Angela Pirillo, Giuseppe D. Norata & Alberico L. Catapano. 2020.
J. D. Kobalava, V. S. Gurevich, A. M. Galyavich, A. I. Kaminnyi, V. V. Kashtalap, V. Yu. Mareev, A. V. Susekov & I. I. Shaposhnik. (2019) Possibilities of clinical use of ezetimibe Otrio (JSC “AKRIKHIN”, Russia) in patients with high and very high cardiovascular risk who have not reached the target values of lipid metabolism. Conclusion of the Board of experts. Kardiologiia 59:5S, pages 47-57.
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David Karásek. (2019) Ezetimibe in the treatment of hypercholesterolaemia. Interní medicína pro praxi 21:2, pages 112-116.
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Yongming Liu, Nan Xia, Wanying Hu & Wei Zhao. (2019) Lipid-altering Efficacy of Ezetimibe/Simvastatin Compared with Rosuvastatin in Hypercholesterolaemic Patients: A Meta-Analysis. International Journal of Pharmacology 15:2, pages 200-208.
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David Karásek. (2018) Combined lipid-lowering therapy. Vnitřní lékařství 64:12, pages 1177-1184.
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Woohyeun Kim, Yeonyee E. Yoon, Sung-Hee Shin, Jang-Whan Bae, Bum-Kee Hong, Soon Jun Hong, Ki Chul Sung, Seung Hwan Han, Weon Kim, Moo-Yong Rhee, Sang-Hyun Kim, Sang Eun Lee, Min Su Hyon, Gyo-Seung Hwang, Jang Won Son, Jang-Young Kim, Min Kyu Kim, Sang Wook Kim, Jae-Hyeong Park, Jin Ho Shin & Chang Gyu Park. (2018) Efficacy and Safety of Ezetimibe and Rosuvastatin Combination Therapy Versus Those of Rosuvastatin Monotherapy in Patients With Primary Hypercholesterolemia. Clinical Therapeutics 40:6, pages 993-1013.
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Michele Massimo Gulizia, Furio Colivicchi, Gualtiero Ricciardi, Simona Giampaoli, Aldo Pietro Maggioni, Maurizio Averna, Maria Stella Graziani, Ferruccio Ceriotti, Alessandro Mugelli, Francesco Rossi, Gerardo Medea, Damiano Parretti, Maurizio Giuseppe Abrignani, Marcello Arca, Pasquale Perrone Filardi, Francesco Perticone, Alberico Catapano, Raffaele Griffo, Federico Nardi, Carmine Riccio, Andrea Di Lenarda, Marino Scherillo, Nicoletta Musacchio, Antonio Vittorio Panno, Giovanni Battista Zito, Mauro Campanini, Leonardo Bolognese, Pompilio Massimo Faggiano, Giuseppe Musumeci, Enrico Pusineri, Marcello Ciaccio, Enzo Bonora, Giorgio Cantelli Forti, Maria Pia Ruggieri, Claudio Cricelli, Francesco Romeo, Roberto Ferrari & Attilio Maseri. (2017) ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on cholesterol and cardiovascular risk: diagnostic–therapeutic pathway in Italy. European Heart Journal Supplements 19:suppl_D, pages D3-D54.
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A. Pirillo, G.D. Norata & A.L. Catapano. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 663 693 .
Lisandro Damián Colantonio, Emilio Carlos Cermignani, Agustín Ciapponi & Juan I Calcagno. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
A. B. Sumarokov & V. V. Kukharchuk. (2014) Hypolipidemic and pleiotropic effects of a combination of simvastatin and ezetimibe in patients with different types of hyperlipidemia. Terapevticheskii arkhiv 86:12, pages 107.
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Yue Qi, Jing Liu, Changsheng Ma, Wei Wang, Xiaohui Liu, Miao Wang, Qiang Lv, Jiayi Sun, Jun Liu, Yan Li & Dong Zhao. (2013) Association between cholesterol synthesis/absorption markers and effects of cholesterol lowering by atorvastatin among patients with high risk of coronary heart disease. Journal of Lipid Research 54:11, pages 3189-3197.
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Ming-Hui ChenJoseph G. IbrahimArvind K. ShahJianxin LinHui Yao. (2012) Meta-analysis methods and models with applications in evaluation of cholesterol-lowering drugs. Statistics in Medicine 31:28, pages 3597-3616.
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Michael S. Kostapanos, Moses S. Elisaf & Dimitri P. Mikhailidis. (2012) Ezetimibe – a new approach in hypercholesterolemia management. Pharmacological Reports 64:4, pages 997-998.
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E. Moutzouri, E. Liberopoulos, D. P. Mikhailidis, M. S. Kostapanos, A. A. Kei, H. Milionis & M. Elisaf. (2011) Comparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistance. International Journal of Clinical Practice 65:11, pages 1141-1148.
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E. Bruckert, M. Farnier & J. Ferrières. (2010) HDL-cholestérol et risque cardiovasculaire : au-delà du LDL !. Médecine des Maladies Métaboliques 4:4, pages 379-388.
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Michalis Kalogirou, Vasilis Tsimihodimos & Moses Elisaf. (2010) Pleiotropic effects of ezetimibe: Do they really exist?. European Journal of Pharmacology 633:1-3, pages 62-70.
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C. Lucioni, S. Mazzi, M. Fagotti, P. Fondi & M. B. Goretti. (2013) Valutazione di un risultato del trattamento con statine: il caso dell’ASL di Foligno (PG)An evaluation of statin treatment results. PharmacoEconomics Italian Research Articles 10:3, pages 123-136.
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Mathias H Konstandin, Erwin Blessing, Andreas Doesch, Kerstin Ammon, Achim Koch, Guido H Wabnitz, Christian A Gleissner, Andrew Remppis, Hugo A Katus & Thomas J Dengler. (2008) Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy. Clinical Transplantation 22:5, pages 639-644.
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C. Lucioni, S. Mazzi, B. Pari, M. Bonello, B. Mazzanti, G. Fresca, M. Fagotti, M. B. Goretti, G. Rossi, G. E. Giuliani, L. Patregnani, C. Bogino, M. D’Orsi, M. Tinella & G. F. Zuccotti. (2013) L’utilizzo delle DDD reference based per la valutazione della compliance terapeutica nel trattamento con statineTreatment with statins. Compliance evaluation using reference based DDDs. PharmacoEconomics Italian Research Articles 10:2, pages 77-88.
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Michael H. Davidson & Jennifer G. Robinson. (2007) Safety of Aggressive Lipid Management. Journal of the American College of Cardiology 49:17, pages 1753-1762.
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Ronald B. Goldberg, John R. Guyton, Theodore Mazzone, Ruth S. Weinstock, Adam Polis, Patricia Edwards, Joanne E. Tomassini & Andrew M. Tershakovec. (2006) Ezetimibe/Simvastatin vs Atorvastatin in Patients With Type 2 Diabetes Mellitus and Hypercholesterolemia: The VYTAL Study. Mayo Clinic Proceedings 81:12, pages 1579-1588.
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Fides Benfatti, Giuliana Cardillo, Luca Gentilucci, Rossana Perciaccante, Alessandra Tolomelli & Alberico Catapano. (2006) Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-β-lactams through Stereo- and Regioselective Epoxide Ring Opening. The Journal of Organic Chemistry 71:24, pages 9229-9232.
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