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Original Article

A comparative, randomised, double-blind study of trazodone prolonged-release and paroxetine in the treatment of patients with major depressive disorder

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Pages 1139-1146 | Accepted 27 May 2005, Published online: 17 Jun 2005

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Read on this site (5)

Cedo D. Miljevic, Dusica Lečić-Toševski & Trazodone Study Group Serbia. (2016) Efficacy and tolerability of trazodone retard monotherapy: results of the Serbian non-interventional study. International Journal of Psychiatry in Clinical Practice 20:3, pages 133-140.
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Arianna Goracci, Rocco N Forgione, Riccardo De Giorgi, Anna Coluccia, Alessandro Cuomo & Andrea Fagiolini. (2016) Practical guidance for prescribing trazodone extended-release in major depression. Expert Opinion on Pharmacotherapy 17:3, pages 433-441.
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Letizia Bossini, Ilaria Casolaro, Despoina Koukouna, Federica Cecchini & Andrea Fagiolini. (2012) Off-label uses of trazodone: a review. Expert Opinion on Pharmacotherapy 13:12, pages 1707-1717.
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Marian W. Roman. (2011) New Additions to the Psychopharmacopia: Extended Release Formulations. Issues in Mental Health Nursing 32:11, pages 717-719.
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C. Munizza, L. Olivieri, G. Di Loreto & P. Dionisio. (2006) A comparative, randomized, double-blind study of trazodone prolonged-release and sertraline in the treatment of major depressive disorder. Current Medical Research and Opinion 22:9, pages 1703-1713.
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Articles from other publishers (30)

Dominika Dudek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Adrian Gerlich, Andrzej Juryk & Marcin Siwek. (2023) TED—trazodone effectiveness in depression: a naturalistic study of the effeciveness of trazodone in extended release formulation compared to SSRIs in patients with a major depressive disorder. Frontiers in Pharmacology 14.
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Andrea Fagiolini, Ana González-Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H. Young & Eduard Vieta. (2023) Role of trazodone in treatment of major depressive disorder: an update. Annals of General Psychiatry 22:1.
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John J. Maurer, Ashley Choi, Isabella An, Nicholas Sathi & Shinjae Chung. (2023) Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics. Neurobiology of Sleep and Circadian Rhythms 14, pages 100095.
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Marcin Siwek, Aleksandra Gorostowicz, Adrian Andrzej Chrobak, Adrian Gerlich, Anna Julia Krupa, Andrzej Juryk & Dominika Dudek. (2023) TED—Trazodone Efficacy in Depression: A Naturalistic Study on the Efficacy of Trazodone in an Extended-Release Formulation Compared to SSRIs in Patients with a Depressive Episode—Preliminary Report. Brain Sciences 13:1, pages 86.
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D.V. Romanov, M.D. Samsonova & P.G. Iuzbashian. (2023) Treatment of mental disorders caused or triggered by somatic and neurological diseases with the use of the multimodal antidepressant trazodone. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123:4, pages 81.
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Joseph F. Goldberg, Michael Q. Steinman & Stephen M. Stahl. (2023) Trazodone once-a-day: A formula for addressing challenges in antidepressant safety and tolerability. Neuroscience Applied 2, pages 101127.
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Umberto Albert, Pallavi Lamba & Stephen M. Stahl. (2021) Early response to trazodone once-a-day in major depressive disorder: review of the clinical data and putative mechanism for faster onset of action. CNS Spectrums 26:3, pages 232-242.
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Christian P. Cheung, Mathura T. Thiyagarajah, Haben Y. Abraha, Celina S. Liu, Krista L. Lanctôt, Alex J. Kiss, Mahwesh Saleem, Ari Juda, Anthony J. Levitt, Ayal Schaffer, Amy H. Cheung & Mark Sinyor. (2021) The association between placebo arm inclusion and adverse event rates in antidepressant randomized controlled trials: An examination of the Nocebo Effect. Journal of Affective Disorders 280, pages 140-147.
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Valeria Tellone, Maria Teresa Rosignoli, Rossella Picollo, Patrizia Dragone, Alessandra Del Vecchio, Alessandro Comandini, Milko Radicioni, Chiara Leuratti & Fabrizio Calisti. (2020) Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects. The Journal of Clinical Pharmacology 60:11, pages 1483-1495.
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Lorenzo Guizzaro, David Dickinson Vaughan Morgan, Andrea Falco & Ciro Gallo. (2020) Hamilton scale and MADRS are interchangeable in meta-analyses but can disagree at trial level. Journal of Clinical Epidemiology 124, pages 106-117.
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Andrea Fagiolini, Umberto Albert, Laura Ferrando, Erik Herman, Cosmina Muntean, Eva Pálová, Agnese Cattaneo, Alessandro Comandini, Giorgio Di Dato, Giorgio Di Loreto, Luisa Olivieri, Enrica Salvatori, Serena Tongiani & Siegfried Kasper. (2020) A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder. International Clinical Psychopharmacology 35:3, pages 137-146.
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Icro Maremmani, Vincenza Spera, Angelo G.I. Maremmani, Marco Carli & Marco Scarselli. (2019) Is Trazodone Contramid Useful in Inducing Patients to Refrain From Using Cocaine After Detoxification, so Avoiding Early Relapse? A Case Series. Addictive Disorders & Their Treatment 18:2, pages 105-112.
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Ai Leng Khoo, Hui Jun Zhou, Monica Teng, Liang Lin, Ying Jiao Zhao, Lay Beng Soh, Yee Ming Mok, Boon Peng Lim & Kok Peng Gwee. (2015) Network Meta-Analysis and Cost-Effectiveness Analysis of New Generation Antidepressants. CNS Drugs 29:8, pages 695-712.
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Katherine A. Lyseng-Williamson. (2015) Trazodone prolonged release: a guide to its use in depression. Drugs & Therapy Perspectives 31:5, pages 137-142.
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Barbara Nussbaumer, Laura C. Morgan, Ursula Reichenpfader, Amy Greenblatt, Richard A. Hansen, Megan Van Noord, Linda Lux, Bradley N. Gaynes & Gerald Gartlehner. (2014) Comparative Efficacy and Risk of Harms of Immediate- versus Extended-Release Second-Generation Antidepressants: A Systematic Review with Network Meta-Analysis. CNS Drugs 28:8, pages 699-712.
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Marianna Purgato, Davide Papola, Chiara Gastaldon, Carlotta Trespidi, Laura R Magni, Carla Rizzo, Toshi A Furukawa, Norio Watanabe, Andrea Cipriani & Corrado Barbui. (2014) Paroxetine versus other anti-depressive agents for depression. Cochrane Database of Systematic Reviews 2014:4.
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Lin Zhang, Wei-Wei Xie, Le-Hua Li, Hong-Geng Zhang, Gang Wang, Da-Chun Chen, Yi Cao, Li-Jun Cui, Ke-Rang Zhang, Jian-Guo Shi, Qing-Rong Tan, Hong-Bo Zheng, Xiu-Feng Xu, Zao-Huo Cheng & Jing-Ping Zhao. (2014) Efficacy and Safety of Prolonged-Release Trazodone in Major Depressive Disorder: A Multicenter, Randomized, Double-Blind, Flexible-Dose Trial. Pharmacology 94:5-6, pages 199-206.
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Andrea Fagiolini, Alessandro Comandini, Mario Catena Dell’Osso & Siegfried Kasper. (2012) Rediscovering Trazodone for the Treatment of Major Depressive Disorder. CNS Drugs 26:12, pages 1033-1049.
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Bret R. Rutherford, Joel R. Sneed & Steven P. Roose. (2012) Does differential drop-out explain the influence of study design on antidepressant response? A meta-analysis. Journal of Affective Disorders 140:1, pages 57-65.
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Dan J SteinMichael Van AmeringenBeth PattersonElizabeth Lee. 2012. Antidepressants and Major Depressive Disorder. Antidepressants and Major Depressive Disorder 26 47 .
Alessandro Serretti, Sara Gibiino & Antonio Drago. (2011) Specificity profile of paroxetine in major depressive disorder: Meta-regression of double-blind, randomized clinical trials. Journal of Affective Disorders 132:1-2, pages 14-25.
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Benjamin Raatjes & Bezalel Dantz. (2011) Trazodone: The Forgotten Antidepressant. Psychiatric Annals 41:3, pages 148-157.
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S. Kasper & H.-J. Möller. 2011. Psychiatrie, Psychosomatik, Psychotherapie. Psychiatrie, Psychosomatik, Psychotherapie 731 766 .
Margaret E. Gruen & Barbara L. Sherman. (2008) Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995–2007). Journal of the American Veterinary Medical Association 233:12, pages 1902-1907.
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Alessandro Serretti & Antonio Drago. 2008. Sleep Disorders. Sleep Disorders 230 245 .
George I. Papakostas & Maurizio Fava. (2020) Metanálisis de ensayos clínicos que compararon los antagonistas de los receptores de serotonina (5HT)-2 trazodona y nefazodona con inhibidores selectivos de la recaptación de serotonina para el tratamiento del trastorno depresivo mayor. European psychiatry (Ed. Española) 15:1, pages 18-22.
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Gerald Gartlehner, Patricia Thieda, Richard A Hansen, Bradley N Gaynes, Angela DeVeaugh-Geiss, Erin E Krebs & Kathleen N Lohr. (2008) Comparative Risk for Harms of Second-Generation Antidepressants. Drug Safety 31:10, pages 851-865.
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José María Bonete Llàcer, Ricard Gandia i Esplà, José Matarredona Català & Enrique Pérez Martínez. (2007) Trazodona combinada con ISRS e ISRN en pacientes deprimidos que presentan ansiedad e insomnio. Psiquiatría Biológica 14:6, pages 204-210.
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George I. Papakostas & Maurizio Fava. (2007) A meta-analysis of clinical trials comparing the serotonin (5HT)-2 receptor antagonists trazodone and nefazodone with selective serotonin reuptake inhibitors for the treatment of major depressive disorder. European Psychiatry 22:7, pages 444-447.
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D. Winkler, R. Ortner, E. Pjrek, H. Aschauer & S. Kasper. (2006) Trazodone‐induced cardiac arrhythmias: a report of two cases. Human Psychopharmacology: Clinical and Experimental 21:1, pages 61-62.
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