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Original Article

Tolerability and short-term effectiveness of hylan G‐F 20 in 4253 patients with osteoarthritis of the knee in clinical practice

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Pages 1261-1269 | Accepted 15 Jun 2005, Published online: 14 Jul 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Tracy R. Ray. (2013) Using Viscosupplementation to Treat Knee Osteoarthritis. The Physician and Sportsmedicine 41:4, pages 16-24.
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A. J. Cianflocco. (2013) Viscosupplementation in Patients with Osteoarthritis of the Knee. Postgraduate Medicine 125:1, pages 97-105.
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Augustine H Conduah, Champ L Baker$suffix/text()$suffix/text() & Champ L Baker$suffix/text()$suffix/text(). (2009) Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20. Journal of Pain Research 2, pages 87-98.
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Daniel Brzusek & David Petron. (2008) Treating knee osteoarthritis with intra-articular hyaluronans. Current Medical Research and Opinion 24:12, pages 3307-3322.
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Alberto Migliore, Sandro Tormenta, Umberto Massafra, Emanuele Bizzi, Francesca Iannessi, Andrea Alimonti & Mauro Granata. (2008) Intra-articular administration of hylan G-F 20 in patients with symptomatic hip osteoarthritis: tolerability and effectiveness in a large cohort study in clinical practice. Current Medical Research and Opinion 24:5, pages 1309-1316.
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Articles from other publishers (49)

Yan Ke, Wenxue Jiang, Yongsheng Xu, Yajun Chen, Qingsong Zhang, Qingyun Xue, Jianhao Lin, Wilson Ngai, Gaowei Nian, Mir Sohail Fazeli, Yao Xie & Zhenan Zhu. (2021) Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis. BMC Musculoskeletal Disorders 22:1.
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David Webner, Yili Huang & Charles D. HummerIIIIII. (2021) Intraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others?. CARTILAGE 13:1_suppl, pages 1619S-1636S.
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Kevin Ong, Edmund Lau, Maria Runa, William Daley & Roy Altman. (2019) Factors Associated with Knee Arthroplasty in a Knee Osteoarthritis Patient Cohort Treated with Intra-articular Injections of Hylan G-F 20. The Journal of Knee Surgery 34:08, pages 886-897.
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Márcia Uchoa de Rezende. (2021) Resposta para o Editor: Em referência à carta para Viscosuplementação - Rezende MU, Campos GC. Rev Bras Ortop 2012;47(2):160-164. Revista Brasileira de Ortopedia 56:02, pages 272-273.
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Francisco Glerison da Silva Nascimento, Pedro Henrique de Souza Ferreira Bringel, Francisco Wildson Silva Maia, Carlos Pinheiro Chagas Lima, Rômulo Couto Alves, Judith Pessoa Andrade Feitosa, Mário Rogério Lima Mota, Ana Maria Sampaio Assreuy & Rondinelle Ribeiro Castro. (2020) Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate. Naunyn-Schmiedeberg's Archives of Pharmacology 394:3, pages 491-501.
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Felice Galluccio, Daniela D’Angela, Barbara Polistena, Francesco Porta, Tatiana Barskova, Lorenzo Tofani, Federico Spandonaro & Marco Matucci-Cerinic. (2021) Comparison of three treatment protocols with intra-articular low or intermediate molecular weight hyaluronic acid in early symptomatic knee osteoarthritis. Therapeutic Advances in Musculoskeletal Disease 13, pages 1759720X2199402.
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Larry E. MillerMichael FredericsonRoy D. Altman. (2020) Hyaluronic Acid Injections or Oral Nonsteroidal Anti-inflammatory Drugs for Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Trials. Orthopaedic Journal of Sports Medicine 8:1, pages 232596711989790.
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A. E. Karateev, Е. Yu. Pogozheva, V. N. Amirdzhanova & Е. S. Filatova. (2018) Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us?. Modern Rheumatology Journal 12:3, pages 40-52.
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Sang Jin Lee, James J. Yoo & Anthony Atala. 2018. Clinical Regenerative Medicine in Urology. Clinical Regenerative Medicine in Urology 17 51 .
Ferdous Khan & Masaru Tanaka. (2017) Designing Smart Biomaterials for Tissue Engineering. International Journal of Molecular Sciences 19:1, pages 17.
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Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji & Ichiro Sekiya. (2016) Weekly injections of Hylan G-F 20 delay cartilage degeneration in partial meniscectomized rat knees. BMC Musculoskeletal Disorders 17:1.
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Thomas H Trojian, Andrew L Concoff, Susan M Joy, John R Hatzenbuehler, Whitney J Saulsberry & Craig I Coleman. (2016) AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes. British Journal of Sports Medicine 50:2, pages 84-92.
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Thomas H. Trojian, Andrew L. Concoff, Susan M. Joy, John R. Hatzenbuehler, Whitney J. Saulsberry & Craig I. Coleman. (2016) AMSSM Scientific Statement Concerning Viscosupplementation Injections for Knee Osteoarthritis. Clinical Journal of Sport Medicine 26:1, pages 1-11.
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Kenton H Fibel. (2015) State-of-the-Art management of knee osteoarthritis. World Journal of Clinical Cases 3:2, pages 89.
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Sang Jin Lee & Anthony Atala. 2014. Polymers in Regenerative Medicine. Polymers in Regenerative Medicine 367 389 .
Holly J. Silvers. (2014) Viscosupplementation During Rehabilitation. Sports Health: A Multidisciplinary Approach 6:5, pages 422-426.
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Sang Jin Lee, James J. Yoo & Anthony Atala. (2014) Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine. Polymer Korea 38:2, pages 113-128.
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Michael E. Zychowicz. (2014) Viscosupplementation for knee osteoarthritis. Journal of the American Association of Nurse Practitioners 26:3, pages 163-175.
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S.J. Lee & A. Atala. 2014. Tissue Engineering Using Ceramics and Polymers. Tissue Engineering Using Ceramics and Polymers 347 386 .
R. Leighton, C. Åkermark, R. Therrien, J.B. Richardson, M. Andersson, M.G. Todman & N.K. Arden. (2014) NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis and Cartilage 22:1, pages 17-25.
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M. Carrington Reid. (2013) Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians. Advances in Therapy 30:11, pages 967-986.
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Demet Uçar, Demirhan Dıraçoğlu, Türker Süleyman & Nalan Çapan. (2013) Intra-Articular Hyaluronic Acid as Treatment in Elderly and Middle-Aged Patients with Knee Osteoarthritis. The Open Rheumatology Journal 7:1, pages 38-41.
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Gustavo Constantino de Campos, Márcia Uchôa de Rezende, Alexandre Felício Pailo, Renato Frucchi, Thiago Pasqualim & Olavo Pires de Camargo. (2013) Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up. Revista Brasileira de Ortopedia (English Edition) 48:4, pages 322-329.
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Gustavo Constantino de Campos, Márcia Uchôa de Rezende, Alexandre Felício Pailo, Renato Frucchi, Thiago Pasqualim & e Olavo Pires de Camargo. (2013) Estudo prospectivo e randomizado que avalia a adição de corticoide à viscossuplementação: três meses de seguimento. Revista Brasileira de Ortopedia 48:4, pages 322-329.
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Christopher Gross, Aman Dhawan, Daniel Harwood, Eric Gochanour & Anthony Romeo. (2012) Glenohumeral Joint Injections. Sports Health: A Multidisciplinary Approach 5:2, pages 153-159.
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Jillian Eyles, Barbara R. Lucas & David J. Hunter. (2013) Targeting Care. Rheumatic Disease Clinics of North America 39:1, pages 213-233.
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Gustavo Constantino de Campos, Marcia U. Rezende, Alexandre F. Pailo, Renato Frucchi & Olavo Pires Camargo. (2012) Adding Triamcinolone Improves Viscosupplementation: A Randomized Clinical Trial. Clinical Orthopaedics and Related Research® 471:2, pages 613-620.
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Tracy A. Webber, Anthony E. Webber & Elizabeth Matzkin. (2012) Rate of Adverse Reactions to More Than 1 Series of Viscosupplementation. Orthopedics 35:4.
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Márcia Uchôa de Rezende & Gustavo Constantino de Campos. (2012) VISCOSUPPLEMENTATION. Revista Brasileira de Ortopedia (English Edition) 47:2, pages 160-164.
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Michele Abate. 2011. Arthritis. Arthritis 183 198 .
Jack M. Bert & David D. Waddell. (2010) Viscosupplementation with hylan G-F 20 in patients with osteoarthrosis of the knee. Therapeutic Advances in Musculoskeletal Disease 2:3, pages 127-132.
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Mauro Batista Albano, Leandro Vidigal, Marcello Zaia de Oliveira, Mario Massatomo Namba, João Luiz Vieira da Silva, Francisco de Assis Pereira Filho, Marcio Alves Barbosa & Elias Marcelo Batista da Silva. (2010) MACROSCOPIC ANALYSES OF THE EFFECTS OF HYALURONATES AND CORTICOSTEROIDS ON INDUCED OSTEOARTHRITIS IN RABBITS’ KNEES. Revista Brasileira de Ortopedia (English Edition) 45:3, pages 273-278.
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Victoria Anne Brander, Ameer Gomberawalla, Michelle Chambers, Mark Bowen & Gordon Nuber. (2010) Efficacy and Safety of Hylan G-F 20 for Symptomatic Glenohumeral Osteoarthritis: A Prospective, Pilot Study. PM&R 2:4, pages 259-267.
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James E. Frampton. (2010) Hylan G-F 20 Single-Injection Formulation. Drugs & Aging 27:1, pages 77-85.
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David D. Waddell & Jack M. Bert. (2010) The Use of Hyaluronan After Arthroscopic Surgery of the Knee. Arthroscopy: The Journal of Arthroscopic & Related Surgery 26:1, pages 105-111.
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Jeffrey Radecki, Susan S Kim & Vijay B Vad. (2009) Synvisc-One™ for the treatment of knee osteoarthritis. International Journal of Clinical Rheumatology 4:6, pages 631-639.
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E. Noël, P. Hardy, F.-W. Hagena, E. Laprelle, F. Goebel, C. Faure, L. Favard, P. Gaudin, R. Christ, C. Baudot, J. Dietl & P. Goupille. (2009) Efficacité et tolérance de l’Hylan GF 20 au cours de l’omarthrose sans rupture de coiffe. Étude ouverte, prospective, multicentrique. Revue du Rhumatisme 76:12, pages 1327-1330.
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Eric Noël, Philippe Hardy, Frank-Wolfgang Hagena, Erick Laprelle, Felix Goebel, Christine Faure, Luc Favard, Pascal Gaudin, Ralph Christ, Christophe Baudot, Julia Dietl & Philippe Goupille. (2009) Efficacy and safety of Hylan G-F 20 in shoulder osteoarthritis with an intact rotator cuff. Open-label prospective multicenter study. Joint Bone Spine 76:6, pages 670-673.
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Shu-Fen Sun, Yi-Jiun Chou, Chien-Wei Hsu & Wen-Ling Chen. (2009) Hyaluronic acid as a treatment for ankle osteoarthritis. Current Reviews in Musculoskeletal Medicine 2:2, pages 78-82.
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T. Conrozier, J. Jerosch, P. Beks, F. Kemper, L. Euller-Ziegler, F. Bailleul & X. Chevalier. (2008) Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study. Archives of Orthopaedic and Trauma Surgery 129:3, pages 417-423.
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R. Raman, A. Dutta, N. Day, H.K. Sharma, C.J. Shaw & G.V. Johnson. (2008) Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee — A prospective randomized clinical trial. The Knee 15:4, pages 318-324.
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J. P. Huskin, B. Vandekerckhove, P. Delincé, R. Verdonk, J.-E. Dubuc, S. Willems, P. Hardy, F. J. Blanco, O. Charrois & F. Handelberg. (2008) Multicentre, prospective, open study to evaluate the safety and efficacy of hylan G-F 20 in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy. Knee Surgery, Sports Traumatology, Arthroscopy 16:8, pages 747-752.
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Todd P Stitik, Asad Kazi & Jong-Hyun Kim. (2008) Synvisc ® in knee osteoarthritis . Future Rheumatology 3:3, pages 215-222.
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Angelique G.H. Witteveen, Sandro Giannini, Giulio Guido, Joerg Jerosch, Heinz Lohrer, Francesca Vannini, Leonardo Donati, Axel Schulz, Jakob Scholl, Inger N. Sierevelt & C. Niek van Dijk. (2008) A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc®) in patients with symptomatic ankle (talo-crural) osteoarthritis. Foot and Ankle Surgery 14:3, pages 145-152.
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David D Waddell. (2007) Viscosupplementation with Hyaluronans for Osteoarthritis of the Knee. Drugs & Aging 24:8, pages 629-642.
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Jamshid Tehranzadeh, Edward Peter Mossop & Maryam Golshan-Momeni. (2006) Therapeutic Arthrography and Bursography. Orthopedic Clinics of North America 37:3, pages 393-408.
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