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Original Article

A randomized, double-blind, 24‐week study of escitalopram (10 mg/day) versus citalopram (20 mg/day) in primary care patients with major depressive disorder

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Pages 1659-1668 | Accepted 23 Aug 2005, Published online: 20 Sep 2005

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SS Stamouli, A Yfantis, E Lamboussis, A Liakouras, V Lagari, M Tzanakaki, D Giailoglou, M Legault & IA Parashos. (2009) Escitalopram in clinical practice in Greece: treatment response and tolerability in depressed patients. Expert Opinion on Pharmacotherapy 10:6, pages 937-945.
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Sidney H. Kennedy, Henning F. Andersen & Michael E. Thase. (2009) Escitalopram in the treatment of major depressive disorder: A meta-analysis. Current Medical Research and Opinion 25:1, pages 161-175.
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Vasilios G. Masdrakis, Panagiotis Oulis, Anastasios V. Kouzoupis, George V. Masdrakis & Constantin R. Soldatos. (2009) Bilateral ankle oedema in a patient taking escitalopram. The World Journal of Biological Psychiatry 10:4-3, pages 939-941.
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Juntao Yin, Xiaoyong Song, Chaoyang Wang, Xuhong Lin & Mingsan Miao. (2023) Escitalopram versus other antidepressive agents for major depressive disorder: a systematic review and meta-analysis. BMC Psychiatry 23:1.
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Carlos Eduardo Miranda Sousa, Noely Camila Tavares Cavalcanti Bedor, Giovana Damasceno Sousa, Guilherme Henrique Onório Oliveira, Leila Bastos Leal, Danilo Cesar Galindo Bedor, Whocely Victor Castro & Davi Pereira Santana. (2021) Selective LC–MS/MS determination of citalopram enantiomers and application to a pharmacokinetic evaluation of generic and reference formulations. Biomedical Chromatography 36:1.
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Tatiyana Mandal, Laxminarayana Kurady Bairy, Podila Satya Venkata Narasimha Sharma & Vijaya Lakshmi Valaparla. (2021) Impact of gender, depression severity and type of depressive episode on efficacy and safety of escitalopram: an observational study on major depressive disorder patients in southern India. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 57:1.
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Xiaoliang Wang, Yimin Fan, Guanjun Li & Huafang Li. (2021) The efficacy of escitalopram in major depressive disorder: a multicenter randomized, placebo-controlled double-blind study. International Clinical Psychopharmacology 36:3, pages 133-139.
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Isaac Ng, H. Karl Greenblatt & David J. Greenblatt. (2016) Stereo-Psychopharmacology: The Case of Citalopram and Escitalopram. Clinical Pharmacology in Drug Development 5:5, pages 331-335.
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Emmanuelle Corruble, Christian de Bodinat, Carole Belaïdi & Guy M. Goodwin. (2013) Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-wk randomized, controlled, double-blind trial. International Journal of Neuropsychopharmacology 16:10, pages 2219-2234.
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Andrea Cipriani, Marianna Purgato, Toshi A Furukawa, Carlotta Trespidi, Giuseppe Imperadore, Alessandra Signoretti, Rachel Churchill, Norio Watanabe & Corrado Barbui. (2012) Citalopram versus other anti-depressive agents for depression. Cochrane Database of Systematic Reviews.
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Mark J.C. Nuijten, Mélanie Brignone, Florence Marteau, Johan A. den Boer & Erik Hoencamp. (2012) Cost-Effectiveness of Escitalopram in Major Depressive Disorder in the Dutch Health Care Setting. Clinical Therapeutics 34:6, pages 1364-1378.
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Hye Yoon Park, Byoung-Jo Lee, Jong-Hoon Kim, Jae-Nam Bae & Bong-Jin Hahm. (2012) Rapid improvement of depression and quality of life with escitalopram treatment in outpatients with breast cancer: A 12-week, open-label prospective trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry 36:2, pages 318-323.
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Dan J. Stein & Ana Garcia Lopez. (2011) Effects of escitalopram on sleep problems in patients with major depression or generalized anxiety disorder. Advances in Therapy 28:11, pages 1021-1037.
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Stuart Montgomery, Thomas Hansen & Siegfried Kasper. (2010) Efficacy of escitalopram compared to citalopram: a meta-analysis. The International Journal of Neuropsychopharmacology 14:02, pages 261-268.
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Jian-Jun Ou, Guang-Lei Xun, Ren-Rong Wu, Le-Hua Li, Mao-Sheng Fang, Hong-Geng Zhang, Shi-Ping Xie, Jian-Guo Shi, Bo Du, Xue-Qin Yuan & Jing-Ping Zhao. (2010) Efficacy and safety of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, randomized, double-blind, flexible-dose study. Psychopharmacology 213:2-3, pages 639-646.
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Andréa D.E. Zomkowski, Daiane Engel, Nelson H. Gabilan & Ana Lúcia S. Rodrigues. (2010) Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. European Neuropsychopharmacology 20:11, pages 793-801.
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Karly P. Garnock-Jones & Paul L. McCormack. (2010) Escitalopram. CNS Drugs 24:9, pages 769-796.
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Brian Leonard & David Taylor. (2010) Review: Escitalopram—translating molecular properties into clinical benefit: reviewing the evidence in major depression. Journal of Psychopharmacology 24:8, pages 1143-1152.
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C. Garcia-LealCM Del-Ben, FM Leal, FG Graeff & FS Guimarães. (2009) Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation. Journal of Psychopharmacology 24:5, pages 683-694.
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Gerald Gartlehner, Laura Morgan, Patricia Thieda & Anthony Fleg. (2010) The effect of study sponsorship on a systematically evaluated body of evidence of head-to-head trials was modest: secondary analysis of a systematic review. Journal of Clinical Epidemiology 63:2, pages 117-125.
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David S. Baldwin, Dan J. Stein, Ornah T. Dolberg & Borwin Bandelow. (2009) How long should a trial of escitalopram treatment be in patients with major depressive disorder, generalised anxiety disorder or social anxiety disorder? An exploration of the randomised controlled trial database. Human Psychopharmacology: Clinical and Experimental 24:4, pages 269-275.
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Andrea Cipriani, Claudio Santilli, Toshi A Furukawa, Alessandra Signoretti, Atsuo Nakagawa, Hugh McGuire, Rachel Churchill & Corrado Barbui. (2009) Escitalopram versus other antidepressive agents for depression. Cochrane Database of Systematic Reviews 2016:5.
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Siegfried Kasper, David S. Baldwin, Sara Larsson Lönn & Jean-Philippe Boulenger. (2009) Superiority of escitalopram to paroxetine in the treatment of depression. European Neuropsychopharmacology 19:4, pages 229-237.
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Dominick Esposito, Peter Wahl, Gregory Daniel, Michael A. Stoto, M. Haim Erder & Thomas W. Croghan. (2009) Results of a retrospective claims database analysis of differences in antidepressant treatment persistence associated with escitalopram and other selective serotonin reuptake inhibitors in the United States. Clinical Therapeutics 31:3, pages 644-656.
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A.G. Wade, T.E. Schlaepfer, H.F. Andersen & C.D. Kilts. (2009) Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD). Journal of Psychiatric Research 43:5, pages 568-575.
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Andrea Cipriani, Toshiaki A Furukawa, Georgia Salanti, John R Geddes, Julian PT Higgins, Rachel Churchill, Norio Watanabe, Atsuo Nakagawa, Ichiro M Omori, Hugh McGuire, Michele Tansella & Corrado Barbui. (2009) Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. The Lancet 373:9665, pages 746-758.
Crossref
Pratap Chokka & Mark Legault. (2008) Escitalopram in the treatment of major depressive disorder in primary-care settings: an open-label trial. Depression and Anxiety 25:12, pages E173-E181.
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Yves Lecrubier, Ornah T. Dolberg, Henning F. Andersen & Emmanuelle Weiller. (2007) Qualitative changes in symptomatology as an effect of treatment with escitalopram in generalized anxiety disorder and major depressive disorder. European Archives of Psychiatry and Clinical Neuroscience 258:3, pages 171-178.
Crossref
Gerald Gartlehner, Patricia Thieda, Richard A Hansen, Bradley N Gaynes, Angela DeVeaugh-Geiss, Erin E Krebs & Kathleen N Lohr. (2008) Comparative Risk for Harms of Second-Generation Antidepressants. Drug Safety 31:10, pages 851-865.
Crossref
Pei-xian Mao, Yi-lang Tang, Feng Jiang, Liang Shu, Xiuling Gu, Ming Li, Mincai Qian, Cui Ma, Philip B. Mitchell & Zhuo-ji Cai. (2008) Escitalopram in major depressive disorder: a multicenter, randomized, double-blind, fixed-dose, parallel trial in a Chinese population. Depression and Anxiety 25:1, pages 46-54.
Crossref
Johan Lundberg, Jacob Strøyer Christophersen, Kamilla Buchberg Petersen, Henrik Loft, Christer Halldin & Lars Farde. (2007) PET measurement of serotonin transporter occupancy: a comparison of escitalopram and citalopram. The International Journal of Neuropsychopharmacology 10:06.
Crossref
P. Van Dijck. (2007) Escitalopram, un développement clinique complet. L'Encéphale 33, pages 134-139.
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David S Baldwin, Elin Heldbo Reines, Christina Guiton & Emmanuelle Weiller. (2016) Escitalopram Therapy for Major Depression and Anxiety Disorders. Annals of Pharmacotherapy 41:10, pages 1583-1592.
Crossref
Nikolas Klein, Julia Sacher, Thomas Geiss-Granadia, Nilufar Mossaheb, Trawat Attarbaschi, Rupert Lanzenberger, Christoph Spindelegger, Alexander Holik, Susanne Asenbaum, Robert Dudczak, Johannes Tauscher & Siegfried Kasper. (2007) Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study. Psychopharmacology 191:2, pages 333-339.
Crossref
David S. Baldwin, James A. Cooper, Anna K.T. Huusom & Ian Hindmarch. (2006) A double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorder. International Clinical Psychopharmacology 21:3, pages 159-169.
Crossref
María Velasco, Luis Salvador, Carmelo Juárez & Fernando Antoñanzas. (2013) Análisis de coste-efectividad de escitalopram comparado con citalopram en el tratamiento de pacientes con depresión mayor grave. PharmacoEconomics Spanish Research Articles 3:2, pages 63-73.
Crossref
Siegfried Kasper, Christian Spadone, Patrice Verpillat & Jules Angst. (2006) Onset of action of escitalopram compared with other antidepressants: results of a pooled analysis. International Clinical Psychopharmacology 21:2, pages 105-110.
Crossref
David Murdoch & Susan J Keam. (2006) Spotlight on Escitalopram in the Management of Major Depressive Disorder1. CNS Drugs 20:2, pages 167-170.
Crossref
&NA;. (2005) Escitalopram is an effective option for managing major depressive disorder in adults. Drugs & Therapy Perspectives 21:12, pages 1-5.
Crossref

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