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Original Article

The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes

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Pages 1141-1147 | Accepted 06 Apr 2006, Published online: 15 May 2006

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Yuri Shelygin, Zoran Krivokapic, S. A. Frolov, I. V. Kostarev, V. L. Astashov, S. V. Vasiliev, A. V. Lakhin, G. V. Rodoman, A. O. Soloviev, Y. M. Stoyko, A. G. Khitaryan & I. A. Nechay. (2016) Clinical acceptability study of micronized purified flavonoid fraction 1000 mg tablets versus 500 mg tablets in patients suffering acute hemorrhoidal disease. Current Medical Research and Opinion 32:11, pages 1821-1826.
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A. F. Avsar & H. L. Keskin. (2010) Haemorrhoids during pregnancy. Journal of Obstetrics and Gynaecology 30:3, pages 231-237.
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T. N. Garmanova, D. R. Markaryan, E. A. Kazachenko, R. V. Ishchenko, A. M. Lukyanov, D. A. Krivonosova & M. A. Agapov. (2023) Results of preoperative application of micronised purified flavonoid fraction as part of a multimodal analgesic regimen in anorectal surgery: a prospective, randomised, placebo-controlled, double-blind study. Surgical practice:2, pages 19-35.
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D. D. Shlyk, I. A. Tulina & P. V. Tsarkov. (2023) Phlebotonics for conservative treatment of haemorrhoids: when, to whom, how?. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia) 20:1, pages 148-155.
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Hyo Seon Ryu. (2022) Treatment of Hemorrhoid in Unusual Condition-Pregnancy. The Ewha Medical Journal 45:4.
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Haiqi Fu, Wenfang Guo, Baochang Zhou, Yibo Liu, Yuan Gao & Minhui Li. (2022) Efficacy and safety of micronized purified flavonoid fractions for the treatment of postoperative hemorrhoid complications: A systematic review and meta-analysis. Phytomedicine 104, pages 154244.
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Antonietta G. Gravina, Raffaele Pellegrino, Angela Facchiano, Giovanna Palladino, Carmelina Loguercio & Alessandro Federico. (2021) Evaluation of the Efficacy and Safety of a Compound of Micronized Flavonoids in Combination With Vitamin C and Extracts of Centella asiatica, Vaccinium myrtillus, and Vitis vinifera for the Reduction of Hemorrhoidal Symptoms in Patients With Grade II and III Hemorrhoidal Disease: A Retrospective Real-Life Study. Frontiers in Pharmacology 12.
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Yung-Lung Chang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Yi-Ping Wu, Ying Kao & Chia-Kuang Tsai. (2021) Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux. International Journal of Molecular Sciences 22:19, pages 10453.
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Philippe Godeberge, Parvez Sheikh, Varut Lohsiriwat, Abel Jalife & Yury Shelygin. (2021) Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease. Journal of Comparative Effectiveness Research 10:10, pages 801-813.
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Raffaele Orefice, Francesco Litta, Angelo Parello, Veronica De Simone, Paola Campennì, Angelo Alessandro Marra & Carlo Ratto. (2021) A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease. Journal of Clinical Medicine 10:8, pages 1549.
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Parvez Sheikh, Varut Lohsiriwat & Yury Shelygin. (2020) Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis. Advances in Therapy 37:6, pages 2792-2812.
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Tamer M. Attia. (2018) Efficacy and Safety of Daflon® in the Treatment of Idiopathic Epistaxis. American Journal of Rhinology & Allergy 33:1, pages 62-68.
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Italo Corsale, Paolo Carrieri, Jacopo Martellucci, Alessandro Piccolomini, Luigi Verre, Marco Rigutini & Sonia Panicucci. (2018) Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I–III degree hemorroidal disease: a double-blind multicenter prospective comparative study. International Journal of Colorectal Disease 33:11, pages 1595-1600.
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Zoriah Aziz, Weng Kit Huin, Muhammad Danish Badrul Hisham, Wei Ling Tang & Saodah Yaacob.. (2018) Efficacy and tolerability of micronized purified flavonoid fractions (MPFF) for haemorrhoids: A systematic review and meta-analysis. Complementary Therapies in Medicine 39, pages 49-55.
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Ahmed Samy Saad & Khalid Abd Aziz Mohamed. (2017) Diosmin versus cabergoline for prevention of ovarian hyperstimulation syndrome. Middle East Fertility Society Journal 22:3, pages 206-210.
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Tetsuo Yamana. (2017) Japanese Practice Guidelines for Anal Disorders I. Hemorrhoids. Journal of the Anus, Rectum and Colon 1:3, pages 89-99.
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S. V. Vasiliev, D. E. Popov, A. I. Nedozimovany & O. S. Sokolova. (2016) MODERN POSSIBILITIES TO PREVENTION AND TREATMENT OF HEMORRHOIDS IN PRENATAL AND EARLY POSTNATAL PERIOD. Koloproktologia:3, pages 13-17.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 999 1001 .
Abdullah Armagan, Faruk Dogan, Taylan Oksay, Tolga Akman, Hakan Darici, Firdevs Aylak & Osman Ergun. (2012) The Effect of Micronized Purified Flavonoid Fraction on the Prevention of Testicular Pathologies in Adolescent Rats with Experimentally Induced Varicocele. The Journal of Urology 188:5, pages 2007-2013.
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Nirmal Perera, Danae Liolitsa, Satheesh Iype, Anna Croxford, Muhammed Yassin, Peter Lang, Obioha Ukaegbu & Christopher van Issum. (2012) Phlebotonics for haemorrhoids. Cochrane Database of Systematic Reviews.
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Felix Aigner, Friedrich Conrad, Ingrid Haunold, Johann Pfeifer, Andreas Salat, Max Wunderlich, Rene Fortelny, Helga Fritsch, Markus Glöckler, Hubert Hauser, Andreas Heuberger, Judith Karner-Hanusch, Christoph Kopf, Peter Lechner, Stefan Riss, Sebastian Roka & Matthias Scheyer. (2012) Konsensusbericht HämorrhoidalleidenConsensus statement haemorrhoidal disease. Wiener klinische Wochenschrift 124:5-6, pages 207-219.
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A.A. Mangoni. 2012. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 311 316 .
Jean-Claude R. Givel & Yannick Cerantola. 2010. Anorectal and Colonic Diseases. Anorectal and Colonic Diseases 301 324 .
D. Soudan. (2009) Traitement médical de la maladie hémorroïdaire: du nouveau en 2009 ?Medical treatment of hemorrhoidal disease: advances in 2009?. Pelvi-périnéologie 4:2, pages 158-162.
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Guillaume Martel & Robin P. Boushey. (2007) The Treatment of Hemorrhoids in Unusual Situations and Difficult Circumstances. Seminars in Colon and Rectal Surgery 18:3, pages 187-196.
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