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Review

Metformin and pioglitazone: effectively treating insulin resistance

Pages S27-S37 | Accepted 30 Jun 2006, Published online: 14 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Bhavik J. Pandya, Morgan Bron, Therese McCall, Andrew P. Yu, Kristina S. Chen, Miles E. Mattson & Eric Q. Wu. (2011) Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus. Current Medical Research and Opinion 27:1, pages 189-195.
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Ángel Rodríguez, Luis Ciprés, Santiago Tofé, Pepa Polavieja & Jesús Reviriego. (2010) Clinical evaluation of combined therapy for type 2 diabetes. Current Medical Research and Opinion 26:5, pages 1171-1183.
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Anthony H Barnett. (2009) Redefining the role of thiazolidinediones in the management of type 2 diabetes. Vascular Health and Risk Management 5, pages 141-151.
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A. H. Barnett. (2006) Introduction: beyond glycemic control in type 2 diabetes. Current Medical Research and Opinion 22:sup2, pages S1-S4.
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Shahriar Shahrokhi & Marc G. Jeschke. (2023) Metabolic and Nutritional Support. Surgical Clinics of North America.
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Tsvetalina Tankova, Elżbieta Senkus, Maria Beloyartseva, Simona Borštnar, Doina Catrinoiu, Mona Frolova, Alinta Hegmane, Andrej Janež, Mladen Krnić, Zoltan Lengyel, Yiola Marcou, Laura Mazilu, Bela Mrinakova, Ruth Percik, Katarina Petrakova, Gábor Rubovszky, Margarita Tokar & Eduard Vrdoljak. (2022) Management Strategies for Hyperglycemia Associated with the α-Selective PI3K Inhibitor Alpelisib for the Treatment of Breast Cancer. Cancers 14:7, pages 1598.
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Xiangyang Yao, Haoran Liu & Hua Xu. (2021) The Impact of Metformin Use with Survival Outcomes in Urologic Cancers: A Systematic Review and Meta-Analysis. BioMed Research International 2021, pages 1-14.
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Anushna Sen & Sayeepriyadarshini Anakk. (2021) Jekyll and Hyde: nuclear receptors ignite and extinguish hepatic oxidative milieu. Trends in Endocrinology & Metabolism 32:10, pages 790-802.
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Marc G. Jeschke. 2021. Burn Care and Treatment. Burn Care and Treatment 81 96 .
Tanya S. McDonald, Pamela A. McCombe, Trent M. Woodruff & John D. Lee. (2020) The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal 34:6, pages 7225-7233.
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Xun CaoYaopan WuJing WangKuiyuan LiuXin Wang. (2017) The Effect of Metformin on Mortality Among Diabetic Cancer Patients: A Systematic Review and Meta-analysis. JNCI Cancer Spectrum 1:1.
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Elena Filipova, Katya Uzunova, Krassimir Kalinov & Toni Vekov. (2017) Pioglitazone and the Risk of Bladder Cancer: A Meta-Analysis. Diabetes Therapy 8:4, pages 705-726.
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Marc G. Jeschke, Abdikarim Abdullahi, Marjorie Burnett, Sarah Rehou & Mile Stanojcic. (2016) Glucose Control in Severely Burned Patients Using Metformin. Annals of Surgery 264:3, pages 518-527.
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Guoxing Wan, Xiongjie Yu, Ping Chen, Xianhe Wang, Dongfeng Pan, Xuanbin Wang, Linjun Li, Xiaojun Cai & Fengjun Cao. (2016) Metformin therapy associated with survival benefit in lung cancer patients with diabetes. Oncotarget 7:23, pages 35437-35445.
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Marc G. Jeschke. (2016) Postburn Hypermetabolism. Journal of Burn Care & Research 37:2, pages 86-96.
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M. Bajaj, R. Gilman, S. Patel, J. Kempthorne‐Rawson, D. Lewis‐D'Agostino & H.‐J. Woerle. (2014) Linagliptin improved glycaemic control without weight gain or hypoglycaemia in patients with Type 2 diabetes inadequately controlled by a combination of metformin and pioglitazone: a 24‐week randomized, double‐blind study. Diabetic Medicine 31:12, pages 1505-1514.
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Ludger Rensing & Volkhard RippeLudger Rensing & Volkhard Rippe. 2014. Altern. Altern 207 224 .
Ming Yin, Jie Zhou, Edward J. Gorak & Fahd Quddus. (2013) Metformin Is Associated With Survival Benefit in Cancer Patients With Concurrent Type 2 Diabetes: A Systematic Review and Meta-Analysis. The Oncologist 18:12, pages 1248-1255.
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M. Ferwana, B. Firwana, R. Hasan, M. H. Al-Mallah, S. Kim, V. M. Montori & M. H. Murad. (2013) Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies. Diabetic Medicine 30:9, pages 1026-1032.
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Marc G. Jeschke. 2013. Burn Care and Treatment. Burn Care and Treatment 91 110 .
E. Bosi, G. C. Ellis, C. A. Wilson & P. R. Fleck. (2011) Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study. Diabetes, Obesity and Metabolism 13:12, pages 1088-1096.
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Mami Takahashi, Mika Hori, Michihiro Mutoh, Keiji Wakabayashi & Hitoshi Nakagama. (2011) Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease. Cancers 3:1, pages 582-602.
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Sihao Liu, Ben Hatano, Minghui Zhao, Chen-Chung Yen, Kihwa Kang, Shannon M. Reilly, Matthew R. Gangl, Cem Gorgun, James A. Balschi, James M. Ntambi & Chih-Hao Lee. (2011) Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation. Journal of Biological Chemistry 286:2, pages 1237-1247.
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Sarah L. Gray, Christine Donald, Arif Jetha, Scott D. Covey & Timothy J. Kieffer. (2010) Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling. Endocrinology 151:9, pages 4178-4186.
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Jun Song, Pingping Ren, Lin Zhang, Xing Li Wang, Li Chen & Ying H. Shen. (2010) Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. Biochemical and Biophysical Research Communications 393:1, pages 89-94.
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Jin Woo LeeIl Seong Nam-GoongJae Geun KimChang Ho YunSe Jin KimJung Il ChoiYoung IL KimEun Sook Kim. (2010) Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats. Korean Diabetes Journal 34:3, pages 191.
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María L. Villanueva-Peñacarrillo, Pablo G. Prieto, Jésus Cancelas, Verónica Sancho, Paola Moreno, Willy J. Malaisse & Isabel Valverde. 2010. Olives and Olive Oil in Health and Disease Prevention. Olives and Olive Oil in Health and Disease Prevention 1205 1211 .
Chen-Ko Kuo, Lian-Yu Lin, Yau-Hua Yu, Kuan-Han Wu & Hsu-Ko Kuo. (2009) Inverse association between insulin resistance and gait speed in nondiabetic older men: results from the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2002. BMC Geriatrics 9:1.
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Daniel Fischman & Vinod K. Nookala. (2008) Cystic Fibrosis-Related Diabetes Mellitus: Etiology, Evaluation, and Management. Endocrine Practice 14:9, pages 1169-1179.
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Paula Lima Bosi, Gabriel Borges Delfino, João Luiz Quagliotti Durigan, Karina Maria Cancelliero, Maria Luiza Ozores Polacow & Carlos Alberto da Silva. (2008) Metformina minimiza as alterações morfométricas no músculo sóleo de ratos submetidos à imobilização articular. Revista Brasileira de Medicina do Esporte 14:5, pages 436-439.
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Guang-Wei He, Wei-Jing Qu, Bin Fan, Rong Jing & Rong He. (2012) The Protective Effect of Yi-Qi-Yang-Yin-Ye, a Compound of Traditional Chinese Herbal Medicine in Diet-Induced Obese Rats. The American Journal of Chinese Medicine 36:04, pages 705-717.
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F. Moreau, S. Boullu-Sanchis, C. Vigouroux, C. Lucescu, O. Lascols, R. Sapin, D. Ruimy, B. Guerci, M. Pinget & N. Jeandidier. (2007) Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report. Diabetes & Metabolism 33:5, pages 385-389.
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Mario Perello, Daniel Castrogiovanni, Andres Giovambattista, Rolf C. Gaillard & Eduardo Spinedi. (2007) Impairment in insulin sensitivity after early androgenization in the post-pubertal female rat. Life Sciences 80:19, pages 1792-1798.
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