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Current Medical Research and Opinion Volume 22, 2006 - Issue 12
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Original Article

Short-term treatment with topical diclofenac epolamine plaster in patients with symptomatic knee osteoarthritis: pooled analysis of two randomised clinical studies

Pius Brühlmann Clinic of Rheumatology and Physical Medicine, University Hospital, Zürich Switzerland
,
Florent de Vathaire National Institute of Health and Medical Research (INSERM), Unité 605, Institut Gustave Roussy, 94800 Villejuif, France
,
Renée L. Dreiser Department of Rheumatology, Hospital Bichat, 7 rue Pierre Haret 75009 Paris, France
&
Beat A. Michel Clinic of Rheumatology and Physical Medicine, University Hospital, Zürich Switzerland
Pages 2429-2438 | Accepted 11 Oct 2006, Published online: 02 Nov 2006

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K. D. Rainsford, Michael S. Roberts, Alessandro Nencioni & Clarence Jones. (2019) Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster. Current Medical Research and Opinion 35:6, pages 989-1002.
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Chunde Li, Valeria Frangione, Stefano Rovati & Qingshan Zheng. (2013) Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial. Current Medical Research and Opinion 29:9, pages 1137-1146.
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Peter Hoffmann, Pavel Kopačka, Barbara Gugliotta & Stefano Rovati. (2012) Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial. Current Medical Research and Opinion 28:8, pages 1313-1321.
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David R Lionberger, Eric Joussellin, Jillmarie Yanchick, Merrell Magelli & Arturo Lanzarotti. (2011) Pooled analysis of clinical trial data evaluating the safety and effectiveness of diclofenac epolamine topical patch 1.3% for the treatment of acute ankle sprain. Open Access Journal of Sports Medicine 2, pages 75-84.
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Roy D. Altman & Peter J. Fowler. (2011) Pharmacologic Treatment of Knee Osteoarthritis in Athletic Women. The Physician and Sportsmedicine 39:3, pages 39-44.
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H. Richard Barthel & Robert A. Axford-Gatley. (2010) Topical Nonsteroidal Anti-Inflammatory Drugs for Osteoarthritis. Postgraduate Medicine 122:6, pages 98-106.
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A. Klainguti, A. Forgacs, I. Berkes & E. Castellacci. (2010) A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma: a double-blind randomized study. Current Medical Research and Opinion 26:9, pages 2243-2251.
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J.-M. Coudreuse & F. de Vathaire. (2010) Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study. Current Medical Research and Opinion 26:9, pages 2221-2228.
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J. Yanchick, M. Magelli, J. Bodie, J. Sjogren & S. Rovati. (2010) Time to significant pain reduction following DETP application vs placebo for acute soft tissue injuries. Current Medical Research and Opinion 26:8, pages 1993-2002.
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Alan R. Brewer, Bill McCarberg & Charles E. Argoff. (2010) Update on the Use of Topical NSAIDs for the Treatment of Soft Tissue and Musculoskeletal Pain: A Review of Recent Data and Current Treatment Options. The Physician and Sportsmedicine 38:2, pages 62-70.
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Herbert S. B. Baraf, Morris S. Gold, Michael B. Clark & Roy D. Altman. (2010) Safety and Efficacy of Topical Diclofenac Sodium 1% Gel in Knee Osteoarthritis: A Randomized Controlled Trial. The Physician and Sportsmedicine 38:2, pages 19-28.
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Roy Altman & Robert L. Barkin. (2009) Topical Therapy for Osteoarthritis: Clinical and Pharmacologic Perspectives. Postgraduate Medicine 121:2, pages 139-147.
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Maggi Banning. (2008) Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries. Expert Opinion on Pharmacotherapy 9:16, pages 2921-2929.
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K. D. Rainsford, W. F. Kean & G. E. Ehrlich. (2008) Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine. Current Medical Research and Opinion 24:10, pages 2967-2992.
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Sergey Yakushin, Svetlana Polyakova, Yury Shvarts, Alexander Kastanayan, Diana Krechikova, Olga Ershova, Natalia Nikulenkova, Irina Vinogradova, Bok Jin Hyun & Ji Eun Cha. (2021) Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. Clinical Therapeutics 43:10, pages 1720-1734.
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Min-Gyue Park, Jae-Doo Yoo & Kyu-Ho Lee. (2020) Current Guidelines for Non-Steroidal Anti-Inflammatory Drugs. Journal of the Korean Orthopaedic Association 55:1, pages 9.
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Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt & Hans Zischka. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 217 228 .
Zengdong Meng & Rongzhong Huang. (2018) Topical Treatment of Degenerative Knee Osteoarthritis. The American Journal of the Medical Sciences 355:1, pages 6-12.
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Robert L Barkin. (2015) Topical Nonsteroidal Anti-Inflammatory Drugs. American Journal of Therapeutics 22:5, pages 388-407.
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Giannapia Affaitati, Alessandra Fabrizio, Valeria Frangione, Arturo Lanzarotti, Mariangela Lopopolo, Emmanuele Tafuri, Domenico Lapenna, Maria Adele Giamberardino & Raffaele Costantini. (2015) Effects of Topical Diclofenac Plus Heparin (Dhep+H Plaster) on Somatic Pain Sensitivity in Healthy Subjects With a Latent Algogenic Condition of the Lower Limb. Pain Practice 15:1, pages 58-67.
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Asokumar Buvanendran. 2015. Treatment of Chronic Pain by Medical Approaches. Treatment of Chronic Pain by Medical Approaches 33 42 .
Timothy J. Atkinson, Jeffrey Fudin, Abhinetri Pandula & Maira Mirza. (2013) Medication Pain Management in the Elderly: Unique and Underutilized Analgesic Treatment Options. Clinical Therapeutics 35:11, pages 1669-1689.
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Asokumar Buvanendran. 2013. Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches. Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches 35 44 .
Roy D. Altman & H. Richard Barthel. (2011) Topical Therapies for Osteoarthritis. Drugs 71:10, pages 1259-1279.
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Norifumi Tanida, Kotaro Maekawa & Masaru Nakanishi. 2011. Arthritis. Arthritis 165 182 .
Bryan S. Williams & Asokumar Buvanendran. 2011. Essentials of Pain Medicine. Essentials of Pain Medicine 130 139 .
B. H. McCarberg & C. E. Argoff. (2010) Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury. International Journal of Clinical Practice 64:11, pages 1546-1553.
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Bindu Nair & Regina Taylor-Gjevre. (2010) A Review of Topical Diclofenac Use in Musculoskeletal Disease. Pharmaceuticals 3:6, pages 1892-1908.
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Paul L. DeSandre & Tammie E. Quest. (2010) Management of Cancer-Related Pain. Hematology/Oncology Clinics of North America 24:3, pages 643-658.
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Paul L. DeSandre & Tammie E. Quest. (2009) Management of Cancer-Related Pain. Emergency Medicine Clinics of North America 27:2, pages 179-194.
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Birte Petersen & Stefano Rovati. (2009) Diclofenac Epolamine (Flector®) Patch. Clinical Drug Investigation 29:1, pages 1-9.
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Todd M. Listwa & Stephen H. Thomas. 2009. Emergency Department Analgesia. Emergency Department Analgesia 94 110 .
R. Andrew Moore, Sheena Derry & Henry J. McQuay. (2008) Topical Agents in the Treatment of Rheumatic Pain. Rheumatic Disease Clinics of North America 34:2, pages 415-432.
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