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Current Medical Research and Opinion Volume 23, 2007 - Issue 2
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Original Article

Pharmacokinetic model and simulations of dose conversion from immediate- to extended-release tramadol*

Bindu P. Murthy Global Clinical Pharmacokinetics, Johnson & Johnson PRD, Raritan, NJ, USA
,
Donna M. Skee Global Clinical Pharmacokinetics, Johnson & Johnson PRD, Raritan, NJ, USA
,
Alexander P. Danyluk Medical Communications, Ortho-McNeil Janssen Scientific Affairs, LLC, Raritan, NJ, USACorrespondence[email protected]
,
Vincent Brett Medical Communications, Ortho-McNeil Janssen Scientific Affairs, LLC, Raritan, NJ, USA
,
Gary J. Vorsanger Medical Affairs, PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ, USA
&
Bruce L. Moskovitz Medical Affairs, PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ, USA
Pages 275-284 | Accepted 21 Nov 2006, Published online: 02 Jan 2007

Citations (13)

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Joomi Lee, Hee-Doo Yoo, Jung-Woo Bae, Sooyeun Lee & Kwang-Hee Shin. (2019) Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Design, Development and Therapy 13, pages 1751-1761.
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Paul C. Langley, Anuprita D. Patkar, Kimberly A. Boswell, Carmela J. Benson & Jeff R. Schein. (2010) Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain. Current Medical Research and Opinion 26:1, pages 239-251.
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Maria Luz G. Pascual, Rosa Rosanna B. Fleming, Theophilus J. Gana & Gary J. Vorsanger. (2007) Open-label study of the safety and effectiveness of long-term therapy with extended-release tramadol in the management of chronic nonmalignant pain. Current Medical Research and Opinion 23:10, pages 2531-2542.
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Articles from other publishers (10)

Xiurui Zhang, Xiaoxiao Li, Yilin Xiong, Yilun Wang, Jie Wei, Chao Zeng, Tingting Sha & Guanghua Lei. (2022) Efficacy and Safety of Tramadol for Knee or Hip Osteoarthritis: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials . Arthritis Care & Research 75:1, pages 158-165.
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Aymen A. Al-Qurain, Richard N. Upton, Rami Tadros, Michael S. Roberts & Michael D. Wiese. (2022) Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients. European Journal of Drug Metabolism and Pharmacokinetics 47:3, pages 387-402.
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Todd M. Conner, Vahagn C. Nikolian, Patrick E. Georgoff, Manjunath P. Pai, Hasan B. Alam, Duxin Sun, Ronald C. Reed & Tao Zhang. (2018) Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex. European Journal of Pharmaceutical Sciences 111, pages 465-481.
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Sybil Skinner-Robertson, Caroline Fradette, Sylvie Bouchard, Mohamad-Samer Mouksassi & France Varin. (2015) Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects. Drugs & Aging 32:12, pages 1029-1043.
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Nina Brvar, Tatjana Mateović-Rojnik & Iztok Grabnar. (2014) Population pharmacokinetic modelling of tramadol using inverse Gaussian function for the assessment of drug absorption from prolonged and immediate release formulations. International Journal of Pharmaceutics 473:1-2, pages 170-178.
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Chiara Angeletti, Cristiana Guetti, Antonella Paladini & Giustino Varrassi. (2013) Tramadol Extended-Release for the Management of Pain due to Osteoarthritis. ISRN Pain 2013, pages 1-16.
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Byron P DeLemos, Jim Xiang, Carmela Benson, Theophilus J Gana, Maria Luz G Pascual, R Rosanna & B Fleming. (2011) Tramadol Hydrochloride Extended-Release Once-Daily in the Treatment of Osteoarthritis of the Knee and/or Hip: A Double-Blind, Randomized, Dose-Ranging Trial. American Journal of Therapeutics 18:3, pages 216-226.
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Warren A. Katz & Robert L. Barkin. (2010) Dilemmas in Chronic/Persistent Pain Management. Disease-a-Month 56:4, pages 233-250.
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Warren A Katz & Robert L Barkin. (2008) Dilemmas in Chronic/Persistent Pain Management. American Journal of Therapeutics 15:3, pages 256-264.
Crossref
Robert L Barkin. (2008) Extended-Release Tramadol (ULTRAM®ER): A Pharmacotherapeutic, Pharmacokinetic, and Pharmacodynamic Focus on Effectiveness and Safety in Patients with Chronic/Persistent Pain. American Journal of Therapeutics 15:2, pages 157-166.
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