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Current Medical Research and Opinion Volume 24, 2008 - Issue 8
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Original Article

A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects*

Sujata Vaidyanathan Novartis Pharmaceuticals CorporationEast Hanover, NJ, USA
,
Mojdeh Maboudian Novartis Pharmaceuticals CorporationEast Hanover, NJ, USA
,
Vance Warren Novartis Pharmaceuticals CorporationEast Hanover, NJ, USA
,
Ching-Ming Yeh Novartis Pharmaceuticals CorporationEast Hanover, NJ, USA
,
Hans Armin Dieterich Novartis Pharma AG, Basel, Switzerland
,
Dan Howard Novartis Pharmaceuticals CorporationEast Hanover, NJ, USA
&
William P. Dole Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USACorrespondence[email protected]
 show all
Pages 2313-2326 | Accepted 11 Jun 2008, Published online: 30 Jun 2008

Citations (19)

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Abdul Ali Abdellatif. (2012) The role of renin inhibition in treating the hypertensive patient with diabetes: a summary of preclinical and clinical evidence. Expert Review of Cardiovascular Therapy 10:2, pages 251-263.
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Articles from other publishers (18)

Joost Boeckmans, Alessandra Natale, Matthias Rombaut, Karolien Buyl, Brent Cami, Veerle De Boe, Anja Heymans, Vera Rogiers, Joery De Kock, Tamara Vanhaecke & Robim M Rodrigues. (2020) Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. Cell Biology and Toxicology 37:2, pages 293-311.
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Susan A. S. Farhadi & Kawa F. Dizaye. (2019) Aliskiren, Fosinopril, and Their Outcome on Renin-Angiotensin-Aldosterone System (RAAS) in Rats with Thyroid Dysfunction. International Journal of Endocrinology 2019, pages 1-9.
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Nikolaos-Dimitrios Pantzaris, Evangelos Karanikolas, Konstantinos Tsiotsios & Dimitrios Velissaris. (2017) Renin Inhibition with Aliskiren: A Decade of Clinical Experience. Journal of Clinical Medicine 6:6, pages 61.
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Tore Bjerregaard Stage, Moa P. Lee, Jesper Hallas, Mette Marie Hougaard Christensen, Kim Brøsen, Kaare Christensen, Joshua J. Gagne & Anton Pottegård. (2016) Early Discontinuation of Metformin in Individuals Treated with Inhibitors of Transporters of Metformin. Basic & Clinical Pharmacology & Toxicology 118:6, pages 487-495.
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Lori A. Gordon, Christine Y. Malati, Colleen Hadigan, Mary McLaughlin, Raul M. Alfaro, Mónica M. Calderón, Joseph A. Kovacs & Scott R. Penzak. (2016) Lack of an Effect of Ritonavir Alone and Lopinavir-Ritonavir on the Pharmacokinetics of Fenofibric Acid in Healthy Volunteers. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 36:1, pages 49-56.
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Tore Bjerregaard Stage, Kim Brøsen & Mette Marie Hougaard Christensen. (2015) A Comprehensive Review of Drug–Drug Interactions with Metformin. Clinical Pharmacokinetics 54:8, pages 811-824.
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Bjoern B. Burckhardt, Sergej Ramusovic, Jutta Tins & Stephanie Laeer. (2013) Determination of aliskiren in human serum quantities by HPLC-tandem mass spectrometry appropriate for pediatric trials. Biomedical Chromatography 27:4, pages 477-486.
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Zeynep Aydoğmuş. (2012) Spectrofluorimetric determination of aliskiren in dosage forms and urine. Luminescence 27:6, pages 489-494.
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Rania A Elrashidy, Mervat E Asker & Hoda E Mohamed. (2012) Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy. Journal of Pharmacy and Pharmacology 64:6, pages 862-871.
Crossref
M. Azizi, M. Frank, O. Steichen & A. Blanchard. (2011) Intérêts et limites de l’inhibition de la rénine par l’aliskiren. Annales Pharmaceutiques Françaises 69:3, pages 142-150.
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Garry G. Graham, Jeroen Punt, Manit Arora, Richard O. Day, Matthew P. Doogue, Janna K. Duong, Timothy J. Furlong, Jerry R. Greenfield, Louise C. Greenup, Carl M. Kirkpatrick, John E. Ray, Peter Timmins & Kenneth M. Williams. (2011) Clinical Pharmacokinetics of Metformin. Clinical Pharmacokinetics 50:2, pages 81-98.
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Jamie J. Coleman, Anthony R. Cox & Nicholas J. Cowley. 2011. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 413 435 .
Venkateswar Jarugula, Ching‐Ming Yeh, Dan Howard, Christopher Bush, Deborah L. Keefe & William P. Dole. (2013) Influence of Body Weight and Gender on the Pharmacokinetics, Pharmacodynamics, and Antihypertensive Efficacy of Aliskiren. The Journal of Clinical Pharmacology 50:12, pages 1358-1366.
Crossref
Sean T. Duggan, Claudine M. Chwieduk & Monique P. Curran. (2010) Aliskiren. Drugs 70:15, pages 2011-2049.
Crossref
Donald J. AbrahamColin M. Tice, Gerard M. McGeehan & David A. Claremon. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 239 266 .
Zafar H Israili, Manuel Velasco & Valmore Bermúdez. (2010) Direct Renin Inhibitors as Antihypertensive Agents. American Journal of Therapeutics 17:3, pages 237-254.
Crossref
Salvatore Novo, Giovanni Fazio & Elena Raccuglia. (2009) Aliskiren: Just a New Drug for Few Selected Patients or an Innovative Molecule Predestinated to Replace Arbs and Ace-Inhibitors?. Pharmaceuticals 2:3, pages 118-124.
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. (2009) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 16:3, pages 260-277.
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