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Original Article

The efficacy and tolerability of multiple-dose tapentadol immediate release for the relief of acute pain following orthopedic (bunionectomy) surgery

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Pages 3185-3196 | Accepted 03 Sep 2008, Published online: 15 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Estelle Watson, Akash Khandelwal, Jan Freijer, John van den Anker, Claudia Lefeber & Mariëlle Eerdekens. (2019) Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population. Journal of Pain Research 12, pages 2835-2850.
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Joseph V. Pergolizzi$suffix/text()$suffix/text(), Jo Ann LeQuang, Robert Taylor$suffix/text()$suffix/text(), Michael H. Ossipov, Daniel Colucci & Robert B. Raffa. (2018) Designing safer analgesics: a focus on μ-opioid receptor pathways. Expert Opinion on Drug Discovery 13:10, pages 965-972.
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Laura E. Gressler, Drayton A. Hammond & Jacob T. Painter. (2017) Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. Journal of Pain & Palliative Care Pharmacotherapy 31:3-4, pages 228-236.
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M. Förster, S. Helfert, R. Dierschke, M. Großkopf, P. Hüllemann, T. Keller, R. Baron & A. Binder. (2016) Evaluation of the antihyperalgesic effect of tapentadol in two human evoked pain models – the TapCapMentho pilot trial. Expert Opinion on Pharmacotherapy 17:13, pages 1717-1725.
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Yeung-Jen Chen, Chao-Ching Chiang, Peng-Ju Huang, Jason Huang, Keith Karcher & Honglan Li. (2015) Tapentadol immediate-release for acute postbunionectomy pain: a phase 3, randomized, double-blind, placebo-controlled, parallel-group study in Taiwan. Current Medical Research and Opinion 31:11, pages 2001-2009.
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Nebojsa Nick Knezevic, Tatiana Tverdohleb, Ivana Knezevic & Kenneth D Candido. (2015) Unique pharmacology of tapentadol for treating acute and chronic pain. Expert Opinion on Drug Metabolism & Toxicology 11:9, pages 1475-1492.
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Neil Singla, Rachel Margulis, Kenneth Kostenbader, Yanping Zheng, Thomas Barrett, Michael J. Giuliani, Yin Chen & Jim L. Young. (2015) Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. The Physician and Sportsmedicine 43:2, pages 126-137.
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Y. K. Lee, J. S. Ko, H. Y. Rhim, E. J. Lee, K. Karcher, H. Li, D. Shapiro & H. S. Lee. (2014) Acute postoperative pain relief with immediate-release tapentadol: randomized, double-blind, placebo-controlled study conducted in South Korea. Current Medical Research and Opinion 30:12, pages 2561-2570.
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Johan Raeder. (2014) Opioids in the treatment of postoperative pain: old drugs with new options?. Expert Opinion on Pharmacotherapy 15:4, pages 449-452.
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Nalini Vadivelu, Yili Huang, Brian Mirante, Michael Jacoby, Ferne R Braveman, Roberta L Hines & Raymond Sinatra. (2013) Patient considerations in the use of tapentadol for moderate to severe pain. Drug, Healthcare and Patient Safety 5, pages 151-159.
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Craig T Hartrick & Jose Rafael Rodríguez Hernandez. (2012) Tapentadol for pain: a treatment evaluation. Expert Opinion on Pharmacotherapy 13:2, pages 283-286.
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Nalini Vadivelu, Alexander Timchenko, Yili Huang & Raymond Sinatra. (2011) Tapentadol extended-release for treatment of chronic pain: a review. Journal of Pain Research 4, pages 211-218.
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Stephen E. Daniels, Ron J. Spivey, Sonia Singla, Michael Golf & Francis J. Clark. (2011) Efficacy and safety of oxycodone HCl/niacin tablets for the treatment of moderate-to-severe postoperative pain following bunionectomy surgery. Current Medical Research and Opinion 27:3, pages 593-603.
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Robert Buynak, Douglas Y Shapiro, Akiko Okamoto, Ilse Van Hove, Christine Rauschkolb, Achim Steup, Bernd Lange, Claudia Lange & Mila Etropolski. (2010) Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study. Expert Opinion on Pharmacotherapy 11:11, pages 1787-1804.
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Craig T Hartrick. (2010) Tapentadol immediate-release for acute pain. Expert Review of Neurotherapeutics 10:6, pages 861-869.
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Craig T Hartrick. (2009) Tapentadol immediate release for the relief of moderate-to-severe acute pain. Expert Opinion on Pharmacotherapy 10:16, pages 2687-2696.
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Stephen Daniels, Ed Casson, Jens-Ulrich Stegmann, Charles Oh, Akiko Okamoto, Christine Rauschkolb & David Upmalis. (2009) A randomized, double-blind, placebo-controlled phase 3 study of the relative efficacy and tolerability of tapentadol IR and oxycodone IR for acute pain. Current Medical Research and Opinion 25:6, pages 1551-1561.
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Martin Hale, David Upmalis, Akiko Okamoto, Claudia Lange & Christine Rauschkolb. (2009) Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study. Current Medical Research and Opinion 25:5, pages 1095-1104.
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Stephen E. Daniels, David Upmalis, Akiko Okamoto, Claudia Lange & Jüergen Häeussler. (2009) A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain. Current Medical Research and Opinion 25:3, pages 765-776.
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Lorenzo Franco-de la Torre, Eduardo Gómez-Sánchez, Othoniel Hugo Aragon-Martinez, Adriana Hernández-Gómez, Diana Laura Franco-González, Juan Manuel Guzmán-Flores, Angel Josabad Alonso-Castro, Vinicio Granados-Soto & Mario Alberto Isiordia-Espinoza. (2023) Analgesic Efficacy and Safety of Tapentadol Immediate Release in Bunionectomy: A Meta-Analysis. Pharmaceuticals 16:9, pages 1287.
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Marlin Comelon, Johan Raeder, Tomas Drægni, Marit Lieng & Harald Lenz. (2021) Tapentadol versus oxycodone analgesia and side effects after laparoscopic hysterectomy. European Journal of Anaesthesiology 38:9, pages 995-1002.
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V. V. Nikoda. (2021) Tapentadol in acute pain: a review of the results of international studies. Modern Rheumatology Journal 15:4, pages 113-119.
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Esben Bolvig Mark, Jens Brøndum Frøkjær, Tine Maria Hansen, Rasmus Bach Nedergaard & Asbjørn Mohr Drewes. (2021) Although tapentadol and oxycodone both increase colonic volume, tapentadol treatment resulted in softer stools and less constipation: a mechanistic study in healthy volunteers. Scandinavian Journal of Pain 21:2, pages 406-414.
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