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Original Article

Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension

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Pages 951-959 | Accepted 30 Jan 2009, Published online: 02 Mar 2009

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Giuseppe Mancia, Robert Fagard, Krzysztof Narkiewicz, Josep Redon, Alberto Zanchetti, Michael Böhm, Thierry Christiaens, Renata Cifkova, Guy De Backer, Anna Dominiczak, Maurizio Galderisi, Diederick E. Grobbee, Tiny Jaarsma, Paulus Kirchhof, Sverre E. Kjeldsen, Stéphane Laurent, Athanasios J. Manolis, Peter M. Nilsson, Luis Miguel Ruilope, Roland E. Schmieder, Per Anton Sirnes, Peter Sleight, Margus Viigimaa, Bernard Waeber & Faiez Zannad. (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension. Blood Pressure 22:4, pages 193-278.
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Yonghong Huan & Raymond Townsend. (2012) The single pill triple combination of aliskiren, amlodipine, and hydrochlorothiazide in the treatment of hypertension. Expert Opinion on Pharmacotherapy 13:16, pages 2409-2415.
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Fabio Angeli, Gianpaolo Reboldi, Giovanni Mazzotta, Cristina Poltronieri & Paolo Verdecchia. (2012) Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview. Expert Opinion on Drug Safety 11:4, pages 659-670.
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Eric Judd & Edgar A Jaimes. (2012) Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension. Expert Review of Cardiovascular Therapy 10:3, pages 293-303.
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Hernán Trimarchi. (2011) Role of aliskiren in blood pressure control and renoprotection. International Journal of Nephrology and Renovascular Disease 4, pages 41-48.
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Roberto Fogari, Annalisa Zoppi, Amedeo Mugellini, Pamela Maffioli, Pierangelo Lazzari, Claudio Monti & Giuseppe Derosa. (2011) Effect of aliskiren addition to amlodipine on ankle edema in hypertensive patients: a three-way crossover study. Expert Opinion on Pharmacotherapy 12:9, pages 1351-1358.
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Adrienne S Zion & Joseph L Izzo. (2011) Combination therapy with aliskiren and amlodipine in hypertension: treatment rationale and clinical results. Expert Review of Cardiovascular Therapy 9:4, pages 421-427.
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Roberto Fogari & Annalisa Zoppi. (2010) New class of agents for treatment of hypertension: focus on direct renin inhibition. Vascular Health and Risk Management 6, pages 869-882.
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Alberto F Rubio-Guerra, David Castro-Serna, Cesar I Elizalde Barrera & Luz M Ramos-Brizuela. (2009) Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors. Integrated Blood Pressure Control 2, pages 55-62.
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Giuseppe Mancia, Stéphane Laurent, Enrico Agabiti-Rosei, Ettore Ambrosioni, Michel Burnier, Mark J. Caulfield, Renata Cifkova, Denis Clément, Antonio Coca, Anna Dominiczak, Serap Erdine, Robert Fagard, Csaba Farsang, Guido Grassi, Hermann Haller, Antony Heagerty, Sverre E. Kjeldsen, Wolfgang Kiowski, Jean Michel Mallion, Athanasios Manolis, Krzysztof Narkiewicz, Peter Nilsson, Michael H. Olsen, Karl Heinz Rahn, Josep Redon, José Rodicio, Luis Ruilope, Roland E. Schmieder, Harry A.J. Struijker-Boudier, Pieter A. Van Zwieten, Margus Viigimaa & Alberto Zanchetti. (2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Pressure 18:6, pages 308-347.
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Nikolaos-Dimitrios Pantzaris, Evangelos Karanikolas, Konstantinos Tsiotsios & Dimitrios Velissaris. (2017) Renin Inhibition with Aliskiren: A Decade of Clinical Experience. Journal of Clinical Medicine 6:6, pages 61.
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S Friedrich, U Zeymer, R Dechend, I Hagedorn, T Riemer, C Zemmrich, P Bramlage, D Pittrow, J Senges & R E Schmieder. (2014) The impact of age on the benefits and risks of aliskiren treatment: analyses of the 3A registry. Journal of Human Hypertension 29:5, pages 316-323.
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Walid M. Ebeid, Ehab F. Elkady, Asmaa A. El-Zaher, Ramzia I. El-Bagary & Gabor Patonay. (2014) Steady-state and synchronous spectrofluorimetric methods for simultaneous determination of aliskiren hemifumarate and amlodipine besylate in dosage forms. Luminescence 29:7, pages 878-883.
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Gregg Lanier, Kedar Sankholkar & Wilbert S. Aronow. (2014) Azilsartan, Aliskiren, and Combination Antihypertensives Utilizing Renin–Angiotensin–Aldosterone System Antagonists. American Journal of Therapeutics 21:5, pages 419-435.
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Yukai Liu, Ken Chen, Xun Kou, Yu Han, Lin Zhou & Chunyu Zeng. (2013) Aliskiren and Amlodipine in the Management of Essential Hypertension: Meta-Analysis of Randomized Controlled Trials. PLoS ONE 8:7, pages e70111.
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. (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension. European Heart Journal 34:28, pages 2159-2219.
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Giuseppe Mancia, Robert Fagard, Krzysztof Narkiewicz, Josep Redón, Alberto Zanchetti, Michael Böhm, Thierry Christiaens, Renata Cifkova, Guy De Backer, Anna Dominiczak, Maurizio Galderisi, Diederick E. Grobbee, Tiny Jaarsma, Paulus Kirchhof, Sverre E. Kjeldsen, Stéphane Laurent, Athanasios J. Manolis, Peter M. Nilsson, Luis Miguel Ruilope, Roland E. Schmieder, Per Anton Sirnes, Peter Sleight, Margus Viigimaa, Bernard Waeber & Faiez Zannad. (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension. Journal of Hypertension 31:7, pages 1281-1357.
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T W LittlejohnIIIIII, S W Jones, J Zhang, H Hsu & D L Keefe. (2012) Efficacy and safety of aliskiren and amlodipine combination therapy in patients with hypertension: a randomized, double-blind, multifactorial study. Journal of Human Hypertension 27:5, pages 321-327.
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Michel Azizi & Joël Ménard. (2012) Renin Inhibitors and Cardiovascular and Renal Protection: An Endless Quest?. Cardiovascular Drugs and Therapy 27:2, pages 145-153.
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Alexander V. Murray, Wolfgang Koenig, Juan Garcia‐Puig, Samir Patel, Alkaz Uddin PhD & Jack Zhang. (2012) Safety and Efficacy of Aliskiren/Amlodipine/Hydrochlorothiazide Triple Combination in Patients With Moderate to Severe Hypertension: A 54‐Week, Open‐Label Study. The Journal of Clinical Hypertension 14:12, pages 821-827.
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Yves Lacourcière, Stefano Taddei, George Konis, Hui Fang, Thomas Severin & Jack Zhang. (2012) Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension. Journal of Hypertension 30:10, pages 2047-2055.
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R. C. Braun-Dullaeus, S. B. Shustov, C. Alvarez, G. G. Rogelio, J. Zhang, S. Hristoskova & D. A. Häring. (2012) Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial. International Journal of Clinical Practice 66:9, pages 834-842.
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Gowraganahalli Jagadeesh, Pitchai Balakumar & Norman Stockbridge. (2012) How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders?. Cellular Signalling 24:8, pages 1583-1591.
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Ludovit Paulis, Ulrike M. Steckelings & Thomas Unger. (2012) Key advances in antihypertensive treatment. Nature Reviews Cardiology 9:5, pages 276-285.
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Keith C. Ferdinand, Richard Weitzman, Das Purkayastha, Kanaka Sridharan & Edgar A. Jaimes. (2012) Aliskiren-based dual- and triple-combination therapies in high-risk US minority patients with Stage 2 hypertension. Journal of the American Society of Hypertension 6:3, pages 219-227.
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Matthew R. Weir, Donna S. Hanes & David K. Klassen. 2012. Brenner and Rector's The Kidney. Brenner and Rector's The Kidney 1824 1878 .
Julian Segura, Cesar Cerezo, Jose A. Garcia-Donaire, Roland E. Schmieder, Manuel Praga, Alejandro de la Sierra & Luis M. Ruilope. (2011) Validation of a therapeutic scheme for the treatment of resistant hypertension. Journal of the American Society of Hypertension 5:6, pages 498-504.
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Myron H. Weinberger, Joseph L. IzzoJr.Jr., Das Purkayastha, Richard Weitzman & Henry R. Black. (2011) Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension and obesity or metabolic syndrome. Journal of the American Society of Hypertension.
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Yu. V. Zhernakova, V. B. Mychka, Yu. A. Ponomarev, S. N. Tolstov, E. V. Tishina, K. P. Ivanov & I. E. Chazova. (2011) Direct renin inhibitor aliskiren in women with menopausal metabolic syndrome and arterial hypertension. Cardiovascular Therapy and Prevention 10:4, pages 33-38.
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Henry R. Black, Myron H. Weinberger, Das Purkayastha, Joleen Lee, Kanaka Sridharan, Marc Israel, Robert Hilkert & Joseph Izzo. (2011) Comparative Efficacy and Safety of Combination Aliskiren/Amlodipine and Amlodipine Monotherapy in African Americans With Stage 2 Hypertension. The Journal of Clinical Hypertension 13:8, pages 571-581.
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William B. White, Robert Bresalier, Allen P. Kaplan, Biff F. Palmer, Robert H. Riddell, Anastasia Lesogor, William Chang & Deborah L. Keefe. (2011) Safety and Tolerability of the Direct Renin Inhibitor Aliskiren in Combination With Angiotensin Receptor Blockers and Thiazide Diuretics: A Pooled Analysis of Clinical Experience of 12,942 Patients. The Journal of Clinical Hypertension 13:7, pages 506-516.
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Joseph L. Izzo & Adrienne S. Zion. (2011) Combined aliskiren-amlodipine treatment for hypertension in African Americans: clinical science and management issues. Therapeutic Advances in Cardiovascular Disease 5:3, pages 169-178.
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Natale Daniele BrunettiLuisa De GennaroPier Luigi PellegrinoAndrea CuculoLuigi ZiccardiAntonio GaglioneMatteo Di Biase. (2011) Direct renin inhibition: update on clinical investigations with aliskiren. European Journal of Cardiovascular Prevention & Rehabilitation 18:3, pages 424-437.
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M. Azizi, M. Frank, O. Steichen & A. Blanchard. (2011) Intérêts et limites de l’inhibition de la rénine par l’aliskiren. Annales Pharmaceutiques Françaises 69:3, pages 142-150.
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Keith C. Ferdinand, Richard Weitzman, Marc Israel, Joleen Lee, Das Purkayastha & Edgar A. Jaimes. (2011) Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension. Journal of the American Society of Hypertension 5:2, pages 102-113.
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Graziano Riccioni. (2011) Aliskiren in the Treatment of Hypertension and Organ Damage. Cardiovascular Therapeutics 29:1, pages 77-87.
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Muzaffar Iqbal. (2011) Clinical Perspective on the Management of Hypertension. Indian Journal of Clinical Medicine 2, pages IJCM.S5475.
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Vivencio Barrios & Carlos Escobar. (2010) Aliskiren in the Management of Hypertension. American Journal Cardiovascular Drugs 10:6, pages 349-358.
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Sean T. Duggan, Claudine M. Chwieduk & Monique P. Curran. (2010) Aliskiren. Drugs 70:15, pages 2011-2049.
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William B. White, Robert Bresalier, Allen P. Kaplan, Biff F. Palmer, Robert H. Riddell, Anastasia Lesogor, William Chang & Deborah L. Keefe. (2010) Safety and Tolerability of the Direct Renin Inhibitor Aliskiren: A Pooled Analysis of Clinical Experience in More Than 12,000 Patients With Hypertension. The Journal of Clinical Hypertension 12:10, pages 765-775.
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M. Azizi. (2010) Les nouvelles modalités d’inhibition du système rénine angiotensine : les inhibiteurs de la rénine et l’immunisation active contre l’angiotensine II. La Revue de Médecine Interne 31:10, pages 659-664.
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Giuseppe Mancia, Stéphane Laurent, Enrico Agabiti-Rosei, Ettore Ambrosioni, Michel Burnier, Mark J Caulfield, Renata Cifkova, Denis Clément, Antonio Coca, Anna Dominiczak, Serap Erdine, Robert Fagard, Csaba Farsang, Guido Grassi, Hermann Haller, Anthony Heagerty, Sverre E Kjeldsen, Wolfgang Kiowski, Jean Michel Mallion, Athanasios Manolis, Krzysztof Narkiewicz, Peter Nilsson, Michael H Olsen, Karl Heinz Rahn, Josep Redon, José Rodicio, Luis Ruilope, Roland E Schmieder, Harry AJ Struijker-Boudier, Pieter A van Zwieten, Margus Viigimaa & Alberto Zanchetti. (2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Journal of Hypertension 27:11, pages 2121-2158.
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