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Current Medical Research and Opinion Volume 25, 2009 - Issue 5
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Original Article

Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes*

Yan-Ling He Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA
,
Ron Sabo Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
Franck Picard Novartis Pharma A.G., Basel, Switzerland
,
Yibin Wang Novartis Pharmaceuticals Corporation, East Hanover, NJ, USACorrespondence[email protected]
,
Jerry Herron Arkansas Research, Little Rock, AR, USA
,
Monica Ligueros-Saylan Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
&
William P. Dole Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA
 show all
Pages 1265-1272 | Accepted 12 Mar 2009, Published online: 13 Apr 2009

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Liupeng Wang, Chunyong Wu, Lu Shen, Haiyan Liu, Ying Chen, Fang Liu, Youqun Wang & Jin Yang. (2016) Evaluation of drug–drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males. Xenobiotica 46:8, pages 703-708.
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Theodosios D Filippatos, Vasilios G Athyros & Moses S Elisaf. (2014) The pharmacokinetic considerations and adverse effects of DDP-4 inhibitors. Expert Opinion on Drug Metabolism & Toxicology 10:6, pages 787-812.
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Thomas Forst & Peter Bramlage. (2014) Vildagliptin, a DPP-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin. Expert Opinion on Pharmacotherapy 15:9, pages 1299-1313.
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Stephanie A Stein, Elizabeth M Lamos & Stephen N Davis. (2014) Vildagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 10:4, pages 599-608.
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Elisa Guarino, Laura Nigi, Aurora Patti, Cecilia Fondelli & Francesco Dotta. (2012) Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 13:9, pages 1377-1384.
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Mary Elizabeth Cox, Jennifer Rowell, Leonor Corsino & Jennifer B Green. (2010) Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy. Drug, Healthcare and Patient Safety 2, pages 7-19.
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Articles from other publishers (23)

Hyounggyoon Yoo, Wonsuk Shin, BackHwan Lee, JinSoo Park, Yilseob Lee & Anhye Kim. (2023) Pharmacokinetics and Food Effect Between a 100‐mg Sustained‐Release Tablet and a 50‐mg Immediate‐Release Tablet of Vildagliptin in Healthy Subjects. Clinical Pharmacology in Drug Development.
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N. A. Petunina, E. V. Goncharova & S. A. Potapova. (2017) CARDIOVASCULAR SAFETY OF GLIPTINS. FOCUS ON ALOGLIPTIN. Medical Council:3, pages 32-37.
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David Paul, Lingesh Allakonda & Nanjappan Satheeshkumar. (2017) A validated UHPLC-QTOF-MS method for quantification of metformin and teneligliptin in rat plasma: Application to pharmacokinetic interaction study. Journal of Pharmaceutical and Biomedical Analysis 143, pages 1-8.
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Mariana Millan Fachi, Letícia Bonancio Cerqueira, Letícia Paula Leonart, Thais Martins Guimarães de Francisco & Roberto Pontarolo. (2016) Simultaneous Quantification of Antidiabetic Agents in Human Plasma by a UPLC–QToF-MS Method. PLOS ONE 11:12, pages e0167107.
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Enrique Z. Fisman & Alexander Tenenbaum. (2015) Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes. Cardiovascular Diabetology 14:1.
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Yoshinobu Nakamaru, Yoshiharu Hayashi, Martin Davies, Horst Jürgen Heuer, Noriko Hisanaga & Kei Akimoto. (2015) Investigation of Potential Pharmacokinetic Interactions Between Teneligliptin and Metformin in Steady-state Conditions in Healthy Adults. Clinical Therapeutics 37:9, pages 2007-2018.
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Tore Bjerregaard Stage, Kim Brøsen & Mette Marie Hougaard Christensen. (2015) A Comprehensive Review of Drug–Drug Interactions with Metformin. Clinical Pharmacokinetics 54:8, pages 811-824.
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Damayanthi Devineni, Prasarn Manitpisitkul, Joseph Murphy, Donna Skee, Ewa Wajs, Rao N. V. S. Mamidi, Hong Tian, An Vandebosch, Shean-Sheng Wang, Tom Verhaeghe, Hans Stieltjes & Keith Usiskin. (2015) Effect of canagliflozin on the pharmacokinetics of glyburide, metformin, and simvastatin in healthy participants. Clinical Pharmacology in Drug Development 4:3, pages 226-236.
Crossref
Gillian M. Keating. (2014) Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus. Drugs 74:5, pages 587-610.
Crossref
Yi Ding, YanYan Jia, Ying Song, ChengTao Lu, YuWen Li, MinChun Chen, MingMing Wang & AiDong Wen. (2013) The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects. European Journal of Clinical Pharmacology 70:2, pages 141-146.
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Yan-Ling He. (2012) Clinical Pharmacokinetics and Pharmacodynamics of Vildagliptin. Clinical Pharmacokinetics 51:3, pages 147-162.
Crossref
George P Samraj. (2011) Vildagliptin for the treatment of diabetes. Therapy 8:6, pages 703-719.
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Kathleen R. Richard, Jamie S. Shelburne & Julienne K. Kirk. (2011) Tolerability of Dipeptidyl Peptidase-4 Inhibitors: A Review. Clinical Therapeutics 33:11, pages 1609-1629.
Crossref
Roberta Baetta & Alberto Corsini. (2011) Pharmacology of Dipeptidyl Peptidase-4 Inhibitors. Drugs 71:11, pages 1441-1467.
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Joshua J. Neumiller. (2011) Clinical Pharmacology of Incretin Therapies for Type 2 Diabetes Mellitus: Implications for Treatment. Clinical Therapeutics 33:5, pages 528-576.
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Garry G. Graham, Jeroen Punt, Manit Arora, Richard O. Day, Matthew P. Doogue, Janna K. Duong, Timothy J. Furlong, Jerry R. Greenfield, Louise C. Greenup, Carl M. Kirkpatrick, John E. Ray, Peter Timmins & Kenneth M. Williams. (2011) Clinical Pharmacokinetics of Metformin. Clinical Pharmacokinetics 50:2, pages 81-98.
Crossref
S. Kasichayanula, X. Liu, W. C. Shyu, W. Zhang, M. Pfister, S. C. Griffen, T. Li, F. P. LaCreta & D. W. Boulton. (2011) Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects. Diabetes, Obesity and Metabolism 13:1, pages 47-54.
Crossref
C. F. Deacon. (2011) Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes, Obesity and Metabolism 13:1, pages 7-18.
Crossref
Gillian M. Keating. (2010) Vildagliptin. Drugs 70:16, pages 2089-2112.
Crossref
André J. Scheen. (2010) Dipeptidylpeptitase-4 Inhibitors (Gliptins). Clinical Pharmacokinetics 49:9, pages 573-588.
Crossref
A. J. Scheen. (2010) Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes, Obesity and Metabolism 12:8, pages 648-658.
Crossref
Abd A. Tahrani, Milan K. Piya, Amy Kennedy & Anthony H. Barnett. (2010) Glycaemic control in type 2 diabetes: Targets and new therapies. Pharmacology & Therapeutics 125:2, pages 328-361.
Crossref
Shelley R Salpeter, Elizabeth Greyber, Gary A Pasternak & Edwin E Salpeter (posthumous). 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.

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