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Commentary

Cholinesterase inhibition: is there evidence for disease-modifying effects?

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Pages 2439-2446 | Accepted 24 Jul 2009, Published online: 13 Aug 2009

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Andrea Haake, Kevin Nguyen, Lauren Friedman, Binu Chakkamparambil & George T Grossberg. (2020) An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer’s disease. Expert Opinion on Drug Safety 19:2, pages 147-157.
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S. Bendjabeur, C. Bensouici & M. Hazzit. (2023) Study of Chemical Composition, Anticholinesterase and Antioxidant Properties of Essential Oil and Ethanolic Extract from Thymus Numidicus Poiret, an Algerian Endemic Medicinal Plant. Pharmaceutical Chemistry Journal 57:6, pages 858-868.
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Hamieh Goshtasbi, Parvin Samadi Pakchin, Ali Movafeghi, Jaleh Barar, Ana M. Castejon, Hossein Omidian & Yadollah Omidi. (2022) Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease. Neurochemistry International 153, pages 105268.
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Yijing Tang, Dong Zhang, Xiong Gong & Jie Zheng. (2022) A mechanistic survey of Alzheimer's disease. Biophysical Chemistry 281, pages 106735.
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Halit Kantekin, Halise Yalazan, Burak Barut, Ömer Güngör, Dilek Ünlüer, Ümit Demirbaş, Arzu Özel & Mahmut Durmuş. (2021) Dual-purpose both peripheral and non-peripheral triazole substituted ZnII, MgII and PbII phthalocyanines: Synthesis, characterization, photophysicochemical and acetylcholinesterase inhibitory properties. Polyhedron 208, pages 115416.
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Tayfun Arslan. (2021) Design, synthesis of novel peripherally tetra-chalcone substituted phthalocyanines and their inhibitory effects on acetylcholinesterase and carbonic anhydrases (hCA I and II). Journal of Organometallic Chemistry 951, pages 122021.
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Fatemeh Fereidooni, Gholamreza Komeili, Hamed Fanaei, Tahereh Safari, Sadegh Khorrami & Abdurrashid Khazaei Feizabad. (2020) ☆Protective effects of ginseng on memory and learning and prevention of hippocampal oxidative damage in streptozotocin-induced Alzheimer's in a rat model. Neurology, Psychiatry and Brain Research 37, pages 116-122.
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Tayfun Arslan, M. Buğrahan Ceylan, Hüseyin Baş, Zekeriya Biyiklioglu & Murat Senturk. (2020) Design, synthesis, characterization of peripherally tetra-pyridine-triazole-substituted phthalocyanines and their inhibitory effects on cholinesterases (AChE/BChE) and carbonic anhydrases (hCA I, II and IX). Dalton Transactions 49:1, pages 203-209.
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N. M. Zalutskaya, I. A. Beltceva & N. G. Neznanov. (2018) Tolerability of antidementive therapy: results of observational research. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY:2, pages 117-124.
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Makbule Ekiz, Ahmet Tutar, Salih Ökten, Burcu Bütün, Ümit M. Koçyiğit, Parham Taslimi & Gülaçtı Topçu. (2018) Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors. Archiv der Pharmazie 351:9, pages 1800167.
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Masood Fereidoonnezhad, Azar Mostoufi, Samaneh Zali, Maryam Eskandari, Davoud Afshar & Fariba Aliyan. (2017) Molecular Docking and PLIF Studies of Novel Tacrine-Naphtoquinone Hybrids Based on Multi-Target-Directed Ligand Approach for Alzheimer’s Disease. Jundishapur Journal of Natural Pharmaceutical Products 13:2.
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Rita Khoury, Kush Patel, Jake Gold, Stephanie Hinds & George T. Grossberg. (2017) Recent Progress in the Pharmacotherapy of Alzheimer’s Disease. Drugs & Aging 34:11, pages 811-820.
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Mohammad Eghtedari, Yaghoub Sarrafi, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Farshad Homayouni Moghadam, Saeed Emami, Loghman Firoozpour, Ali Asadipour, Omid Sabzevari & Alireza Foroumadi. (2017) New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates. European Journal of Medicinal Chemistry 128, pages 237-246.
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Dan Zhou, Wei Zhou, Jun-ke Song, Zhang-ying Feng, Ran-yao Yang, Song Wu, Lin Wang, Ai-lin Liu & Guan-hua Du. (2016) DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway. Acta Pharmacologica Sinica 37:11, pages 1401-1412.
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Ayokunle O. Ademosun, Ganiyu Oboh, Fatai Bello & Peluola O. Ayeni. (2016) Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities. Journal of Evidence-Based Complementary & Alternative Medicine 21:4, pages NP11-NP17.
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Carole Parsons. (2016) Withdrawal of Antidementia Drugs in Older People: Who, When and How?. Drugs & Aging 33:8, pages 545-556.
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Shaobing Cheng, Wei Zheng, Ping Gong, Qiang Zhou, Qiong Xie, Lining Yu, Peiyi Zhang, Liangkang Chen, Juan Li, Jianxing Chen, Hailin Chen & Hongzhuan Chen. (2015) (−)-Meptazinol–melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer’s therapy. Bioorganic & Medicinal Chemistry 23:13, pages 3110-3118.
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Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D.G. Wang, Jin-Shuai Lan, Zhong-Rui Li & Ling-Yi Kong. (2015) Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry 95, pages 153-165.
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Chien-Wei Hou, Shun-Yu Chang & Kee-Ching Jeng. (2014) Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on Aβ-stressed PC12 cells. Archives of Pharmacal Research 38:4, pages 543-548.
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Maria Digiacomo, Ziwei Chen, Shengnan Wang, Annalina Lapucci, Marco Macchia, Xiaohong Yang, Jiaqi Chu, Yifan Han, Rongbiao Pi & Simona Rapposelli. (2015) Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD. Bioorganic & Medicinal Chemistry Letters 25:4, pages 807-810.
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David B Hogan. (2014) Long-Term Efficacy and Toxicity of Cholinesterase Inhibitors in the Treatment of Alzheimer Disease. The Canadian Journal of Psychiatry 59:12, pages 618-623.
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Mauricio Alcolea-Palafox, Paloma Posada-Moreno, Ismael Ortuño-Soriano, José L. Pacheco-del-Cerro, Carmen Martínez-Rincón, Dolores Rodríguez-Martínez & Lara Pacheco-Cuevas. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 426 477 .
Annalena Venneri & Michael F Shanks. (2013) Central effects of cholinesterase inhibitors in Alzheimer’s disease: insights from advanced neuroimaging. Imaging in Medicine 5:5, pages 441-452.
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Rafael León, Antonio G. Garcia & José Marco‐Contelles. (2011) Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease. Medicinal Research Reviews 33:1, pages 139-189.
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María Isabel Fernández-Bachiller, Concepción Pérez, Leticia Monjas, Jörg Rademann & María Isabel Rodríguez-Franco. (2012) New Tacrine–4-Oxo-4 H -chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties . Journal of Medicinal Chemistry 55:3, pages 1303-1317.
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Volkmar Tell, Kazem Ahmed Mahmoud, Kanin Wichapong, Christoph Schächtele, Frank Totzke, Wolfgang Sippl & Andreas Hilgeroth. (2012) Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β. MedChemComm 3:11, pages 1413.
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Denise M. Boudreau, Onchee Yu, Shelly L. Gray, Marsha A. Raebel, Jeanene Johnson & Eric B. Larson. (2011) Concomitant Use of Cholinesterase Inhibitors and Anticholinergics: Prevalence and Outcomes. Journal of the American Geriatrics Society 59:11, pages 2069-2076.
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Stefano Rizzo, Alessandra Bisi, Manuela Bartolini, Francesca Mancini, Federica Belluti, Silvia Gobbi, Vincenza Andrisano & Angela Rampa. (2011) Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers. European Journal of Medicinal Chemistry 46:9, pages 4336-4343.
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Ignacio Lopez-Coviella, Tiffany J. Mellott, Aletta C. Schnitzler & Jan K. Blusztajn. (2011) BMP9 Protects Septal Neurons from Axotomy-Evoked Loss of Cholinergic Phenotype. PLoS ONE 6:6, pages e21166.
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Annalena VenneriMichael F Shanks. (2011) Using MRI neuroimaging methods to detect treatment responses in Alzheimer’s disease. Neurodegenerative Disease Management 1:3, pages 235-243.
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Ana Martinez, Carmen Gil & Daniel I. Perez. (2011) Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment. International Journal of Alzheimer's Disease 2011, pages 1-7.
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María Isabel Fernández-Bachiller, Concepción Pérez, Gema C. González-Muñoz, Santiago Conde, Manuela G. López, Mercedes Villarroya, Antonio G. García & María Isabel Rodríguez-Franco. (2010) Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties. Journal of Medicinal Chemistry 53:13, pages 4927-4937.
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A. J. Larner. (2010) Transdermal rivastigmine for Alzheimer’s disease: skin deep or scratching the surface?. International Journal of Clinical Practice 64:5, pages 534-536.
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