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Original Article

Impact of fixed-dose and multi-pill combination dyslipidemia therapies on medication adherence and the economic burden of sub-optimal adherence

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Pages 2765-2775 | Accepted 31 Aug 2009, Published online: 28 Sep 2009

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Sohan Deshpande, Ruben G.W. Quek, Carol A. Forbes, Shelley de Kock, Jos Kleijnen, Shravanthi R. Gandra & Ross J. Simpson$suffix/text()$suffix/text(). (2017) A systematic review to assess adherence and persistence with statins. Current Medical Research and Opinion 33:4, pages 769-778.
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Jing Hao, Rosa Rodriguez-Monguio & Enrique Seoane-Vazquez. (2016) Fixed-dose combination and single active ingredient drugs: a comparative cost analysis. Expert Review of Pharmacoeconomics & Outcomes Research 16:1, pages 127-134.
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Steven Han, Kristy Iglay, Michael J. Davies, Qiaoyi Zhang & Larry Radican. (2012) Glycemic effectiveness and medication adherence with fixed-dose combination or coadministered dual therapy of antihyperglycemic regimens: a meta-analysis. Current Medical Research and Opinion 28:6, pages 969-977.
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Siddhesh A. Kamat, Michael F. Bullano, Chun-Lan Chang, Sanjay K. Gandhi & Mark J. Cziraky. (2011) Adherence to single-pill combination versus multiple-pill combination lipid-modifying therapy among patients with mixed dyslipidemia in a managed care population. Current Medical Research and Opinion 27:5, pages 961-968.
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Serge Jabbour & Barry Ziring. (2011) Advantages of Extended-Release Metformin in Patients with Type 2 Diabetes Mellitus. Postgraduate Medicine 123:1, pages 15-23.
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Articles from other publishers (23)

Qiran Wei, Jiting Zhou, Hongchao Li, Luying Wang, Yao Wu, Aixia Ma & Xin Guan. (2023) Medication adherence with fixed-dose versus free-equivalent combination therapies: Systematic review and meta-analysis. Frontiers in Pharmacology 14.
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Won Sun Chen, Md. Rafiqul Islam, Sajini Ambepitiya, William Sim, Wai Yiu, Joseph Carey & Edward Ogden. (2022) Factors associated with patient experiences of the burden of using medicines and health-related quality of life: A cross-sectional study. PLOS ONE 17:4, pages e0267593.
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Giorgio Bosso, Mariarosaria De Luca, Giovanni Alma, Vincenzo Carbone, Ferdinando Ferrara, Biagio Fimiani, Franco Guarnaccia, Alessandro Iandolo, Sabato Murolo, Maurizio Olivares, Emanuele Romeo, Giosuè Santoro, Antonio Valvano, Giovanni Zito & Ugo Oliviero. (2021) ALERT-LDL: adherence to guidelines in the treatment of patients with dyslipidemia. Internal and Emergency Medicine 17:2, pages 387-395.
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Dat T. Tran, Dan Palfrey & Robert Welsh. (2021) The Healthcare Cost Burden in Adults with High Risk for Cardiovascular Disease. PharmacoEconomics - Open 5:3, pages 425-435.
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Eman Alefishat, Anan S. Jarab, Walid Al-Qerem & Lina Abu-Zaytoun. (2021) Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia. Healthcare 9:7, pages 813.
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Burkhard Weisser, Hans-Georg Predel, Anton Gillessen, Claudia Hacke, Johannes vor dem Esche, Gerd Rippin, Andrea Noetel & Olaf Randerath. (2020) Single Pill Regimen Leads to Better Adherence and Clinical Outcome in Daily Practice in Patients Suffering from Hypertension and/or Dyslipidemia: Results of a Meta-Analysis. High Blood Pressure & Cardiovascular Prevention 27:2, pages 157-164.
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Ana Baumgartner, Katarina Drame, Stijn Geutjens & Marja Airaksinen. (2020) Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review. Pharmaceutics 12:2, pages 190.
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Bruno Kusznir Vitturi, Ada Pellegrinelli & Berenice Cataldo Oliveira Valerio. (2019) Medication adherence in patients with myasthenia gravis in Brazil: a cross-sectional study. Acta Neurologica Belgica 120:1, pages 83-89.
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Dimitar Divchev & Georg Stöckl. (2019) Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice. Cardiology and Therapy 8:2, pages 317-328.
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Amy T Page, Michael O Falster, Melisa Litchfield, Sallie‐Anne Pearson & Christopher Etherton‐Beer. (2019) Polypharmacy among older Australians, 2006–2017: a population‐based study. Medical Journal of Australia 211:2, pages 71-75.
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Kyoung Won Shin, Hyo Jung Lee, Chung Mo Nam, Ki Tae Moon & Eun-Cheol Park. (2017) Hospital characteristics related to the hospital length of stay among inpatients receiving invasive cervical discectomy due to road traffic accidents under automobile insurance in South Korea. BMC Health Services Research 17:1.
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Andrea L. Schaffer, Nicholas A. Buckley & Sallie-Anne Pearson. (2017) Who benefits from fixed-dose combinations? Two-year statin adherence trajectories in initiators of combined amlodipine/atorvastatin therapy. Pharmacoepidemiology and Drug Safety 26:12, pages 1465-1473.
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Louise E. Bartlett, Nicole Pratt & Elizabeth E. Roughead. (2017) Does tablet formulation alone improve adherence and persistence: a comparison of ezetimibe fixed dose combination versus ezetimibe separate pill combination?. British Journal of Clinical Pharmacology 83:1, pages 202-210.
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Thangavel Mahalingam Vijayakumar, Jayasutha Jayram, Vishnu Meghana Cheekireddy, Dasari Himaja, Yalamanchili Dharma Teja & Damodharan Narayanasamy. (2017) Safety, Efficacy, and Bioavailability of Fixed-Dose Combinations in Type 2 Diabetes Mellitus: A Systematic Updated Review. Current Therapeutic Research 84, pages 4-9.
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. (2016) Parte III. Control clínico del tratamiento con fenofibrato. Clínica e Investigación en Arteriosclerosis 28, pages 20-25.
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Lydia A Chwastiak, Oliver Freudenreich, Cenk Tek, Christine McKibbin, Jaesu Han, Robert McCarron & Brent Wisse. (2015) Clinical management of comorbid diabetes and psychotic disorders. The Lancet Psychiatry 2:5, pages 465-476.
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Jennifer Briley Christian, Vincent Rabatin & Kimberly A Lowe. (2013) Adherence, Persistence, and Predictors Associated with Early Niacin Termination. Journal of Pharmacy Technology 29:4, pages 178-185.
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Patricia Maningat, Bruce R. Gordon & Jan L. Breslow. (2012) How Do We Improve Patient Compliance and Adherence to Long-Term Statin Therapy?. Current Atherosclerosis Reports 15:1.
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M. C. S. Wong, J. Y. Jiang & S. M. Griffiths. (2011) Adherence to lipid-lowering agents among 11,042 patients in clinical practice. International Journal of Clinical Practice 65:7, pages 741-748.
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Bradi B Granger & Hayden B Bosworth. (2011) Medication adherence: emerging use of technology. Current Opinion in Cardiology 26:4, pages 279-287.
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Eliot A. Brinton, Moti L. Kashyap, Anthony N. Vo, Roopal B. Thakkar, Ping Jiang & Robert J. Padley. (2011) Niacin Extended-Release Therapy in Phase III Clinical Trials is Associated with Relatively Low Rates of Drug Discontinuation due to Flushing and Treatment-Related Adverse Events. American Journal Cardiovascular Drugs 11:3, pages 179-187.
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Marie T. Brown & Jennifer K. Bussell. (2011) Medication Adherence: WHO Cares?. Mayo Clinic Proceedings 86:4, pages 304-314.
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I. Alam, T. Stainbrook, B. Cecil & K. D. Kistler. (2010) Enhanced adherence to HCV therapy with higher dose ribavirin formulation: final analyses from the ADHERE registry. Alimentary Pharmacology & Therapeutics 32:4, pages 535-542.
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