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Brief Review

Current therapy for Lambert–Eaton myasthenic syndrome: development of 3,4-diaminopyridine phosphate salt as first-line symptomatic treatment

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Pages 1363-1375 | Accepted 03 Mar 2010, Published online: 08 Apr 2010

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Chrissa Sioka, Andreas Fotopoulos & Athanassios P Kyritsis. (2014) Paraneoplastic immune-mediated neurological effects of systemic cancers. Expert Review of Clinical Immunology 10:5, pages 621-630.
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Agnes van Sonderen, Paul W Wirtz, Jan JGM Verschuuren & Maarten J Titulaer. (2014) Treatment options for Lambert–Eaton myasthenic syndrome. Expert Opinion on Orphan Drugs 2:2, pages 159-167.
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Sabine Lindquist & Martin Stangel. (2011) Update on treatment options for Lambert–Eaton myasthenic syndrome: focus on use of amifampridine. Neuropsychiatric Disease and Treatment 7, pages 341-349.
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Sofieke de Wilde, Maria G.H. de Jong, Alexander F. Lipka, Henk-Jan Guchelaar & Kirsten J.M. Schimmel. (2018) The possibility of obtaining marketing authorization of orphan pharmaceutical compounding preparations: 3,4-DAP for Lambert-Eaton Myasthenic Syndrome. European Journal of Pharmaceutical Sciences 114, pages 24-29.
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Simona Portaro, Teresa Brizzi, Stefano Sinicropi, Alberto Cacciola, Maria Cristina De Cola, Alessia Bramanti, Demetrio Milardi, Antonino Lupica, Placido Bramanti, Antonio Toscano & Carmelo Rodolico. (2017) Five years experience on 3,4-diaminopyridine phosphate in Lambert–Eaton syndrome. Medicine 96:38, pages e7839.
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Benedikt Schoser, Bruno Eymard, Joe Datt & Renato Mantegazza. (2017) Lambert–Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer. Journal of Neurology 264:9, pages 1854-1863.
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Peter E. Haroldsen, Zlatko Sisic, Joe Datt, Donald G. Musson & Gary Ingenito. (2017) Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function. Clinical Therapeutics 39:7, pages 1360-1370.
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Elena E. Perez, Jordan S. Orange, Francisco Bonilla, Javier Chinen, Ivan K. Chinn, Morna Dorsey, Yehia El-Gamal, Terry O. Harville, Elham Hossny, Bruce Mazer, Robert Nelson, Elizabeth Secord, Stanley C. Jordan, E. Richard Stiehm, Ashley A. Vo & Mark Ballow. (2017) Update on the use of immunoglobulin in human disease: A review of evidence. Journal of Allergy and Clinical Immunology 139:3, pages S1-S46.
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Fiona Ng, Diana C. Lee, Leah A. Schrumpf, Mary E. Mazurek, Victoria Lee Lo, Sharleen K. Gill & Ricardo A. Maselli. (2017) Effect of 3,4-diaminopyridine at the murine neuromuscular junction. Muscle & Nerve 55:2, pages 223-231.
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Shin J Oh, Natalya Shcherbakova, Anna Kostera-Pruszczyk, Mohammad Alsharabati, Mazen Dimachkie, Jose Munoz Blanco, Thomas Brannagan, Dragana Lavrnić, Perry B Shieh, Christophe Vial, Andreas Meisel, Samuel Komoly, Benedikt Schoser, Kumaraswamy Sivakumar & Yuen So. (2016) Amifampridine phosphate (Firdapse ® ) is effective and safe in a phase 3 clinical trial in LEMS . Muscle & Nerve 53:5, pages 717-725.
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Peter E. Haroldsen, Donald G. Musson, Boyd Hanson, Adrian Quartel & Charles A. O’Neill. (2015) Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults. Clinical Therapeutics 37:7, pages 1555-1563.
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Peter E. Haroldsen, Marvin R. Garovoy, Donald G. Musson, Huiyu Zhou, Laurie Tsuruda, Boyd Hanson & Charles A. O'Neill. (2014) Genetic variation in aryl N ‐acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4‐diaminopyridine) phosphate . Pharmacology Research & Perspectives 3:1.
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Can Ebru Bekircan-Kurt. (2015) Voltage gated calcium channel antibody-related neurological diseases. World Journal of Clinical Cases 3:3, pages 293.
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Mozaffar Asadi, Susan Torabi & Khosro Mohammadi. (2014) Synthesis, characterization, and thermodynamics of some new unsymmetrical Schiff bases of salicylaldehyde with 3,4-diaminopyridine and their cobalt(III) complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 122, pages 676-681.
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Jens Claassen, Rainer Spiegel, Roger Kalla, Mary Faldon, Christopher Kennard, Chotipat Danchaivijitr, Stanislaw Bardins, Nicole Rettinger, Erich Schneider, Thomas Brandt, Klaus Jahn, Julian Teufel, Michael Strupp & Adolfo Bronstein. (2013) A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus—effects on slowphase eye velocity, postural stability, locomotion and symptoms. Journal of Neurology, Neurosurgery & Psychiatry 84:12, pages 1392-1399.
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Bhupinder Sandhu, Marina S. Fonari, Kayla Sawyer & Tatiana V. Timofeeva. (2013) A series of crystalline solids composed of aminopyridines and succinic, fumaric, and sebacic acids. Journal of Molecular Structure 1052, pages 125-134.
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Hua Wen, Michael W. Linhoff, Jeffrey M. Hubbard, Nathan R. Nelson, Donald Stensland, Julia Dallman, Gail Mandel & Paul Brehm. (2013) Zebrafish Calls for Reinterpretation for the Roles of P/Q Calcium Channels in Neuromuscular Transmission. The Journal of Neuroscience 33:17, pages 7384-7392.
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John S. Stahl & Zachary C. Thumser. (2013) 4-Aminopyridine Does Not Enhance Flocculus Function in Tottering, a Mouse Model of Vestibulocerebellar Dysfunction and Ataxia. PLoS ONE 8:2, pages e57895.
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Charlotte Vrinten, Stephanie S. Weinreich, Rob JPM Scholten & Jan JGM Verschuuren. (2012) 3,4-Diaminopyridine for myasthenia gravis. Cochrane Database of Systematic Reviews.
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D. M. Green, A. C. Jones & K. R. Brain. (2012) Content variability of active drug substance in compounded oral 3,4-diaminopyridine products. Journal of Clinical Pharmacy and Therapeutics 37:1, pages 53-57.
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Roy G Beran. 2012. Neurology for general practitioners. Neurology for general practitioners 171 186 .
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E Pasqualoni, F Aubart, B Brihaye, K Sacré, T Maisonobe, J-P Laissy, O Lidove & T Papo. (2011) Lambert–Eaton Myasthenic syndrome and follicular thymic hyperplasia in systemic lupus erythematosus. Lupus 20:7, pages 745-748.
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Nils Erik Gilhus. (2011) Lambert-Eaton Myasthenic Syndrome; Pathogenesis, Diagnosis, and Therapy. Autoimmune Diseases 2011, pages 1-5.
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