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Original Article

Clinical outcomes after insulin initiation in patients with type 2 diabetes: 6-month data from the INSTIGATE observational study in five European countries

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Pages 887-895 | Accepted 14 Jan 2011, Published online: 22 Feb 2011

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Read on this site (6)

Nanette C. Schloot, Magaly Perez-Nieves, Hélène Sapin, Silvia Kruppert, Thorsten Otto, Sheila M. Corrigan & Carolina Piras de Oliveira. (2020) Patient characteristics of insulin lispro 200 units/mL users in real world setting in Germany. Current Medical Research and Opinion 36:10, pages 1611-1617.
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Magaly Perez-Nieves, Samaneh Kabul, Urvi Desai, Jasmina I. Ivanova, Noam Y. Kirson, Alice Kate Cummings, Howard G. Birnbaum, Ran Duan, Dachuang Cao & Irene Hadjiyianni. (2016) Basal insulin persistence, associated factors, and outcomes after treatment initiation among people with type 2 diabetes mellitus in the US. Current Medical Research and Opinion 32:4, pages 669-680.
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Kerstin Brismar, Marianna Benroubi, Claudia Nicolay, Henry Schmitt, Joseph Giaconia & Matthew Reaney. (2013) Evaluation of insulin initiation on resource utilization and direct costs of treatment over 12 months in patients with type 2 diabetes in Europe: results from INSTIGATE and TREAT observational studies. Journal of Medical Economics 16:8, pages 1022-1035.
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A. Oguz, M. Benroubi, K. Brismar, P. Melo, C. Morar, S.P. Cleall, J. Giaconia & H. Schmitt. (2013) Clinical outcomes after 24 months of insulin therapy in patients with type 2 diabetes in five countries: results from the TREAT study. Current Medical Research and Opinion 29:8, pages 911-920.
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Stephen Jones, Conxa Castell, Albert Goday, Helen T Smith, Claudia Nicolay, Alexander Simpson & Carole Salaun-Martin. (2012) Increase in direct diabetes-related costs and resource use in the 6 months following initiation of insulin in patients with type 2 diabetes in five European countries: data from the INSTIGATE study. ClinicoEconomics and Outcomes Research 4, pages 383-393.
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M Buysschaert, I Paris, Ph Selvais, Ph Oriot & V Preumont. (2012) GLYCEMIC CONTROL AND WEIGHT CHANGES IN PATIENTS WITH TYPE 2 DIABETES INTENSIFIED TO THREE INSULIN REGIMENS AFTER THERAPEUTIC FAILURE TO EXENATIDE. Acta Clinica Belgica 67:4, pages 250-254.
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Articles from other publishers (24)

Yasin Yuksel, Cennet Yildiz & Sennur Kose. (2023) Assessment of Predictive Value of SYNTAX-II Score for Adverse Cardiac Events and Clinical Outcomes in Patients With Acute Coronary Syndrome. Angiology, pages 000331972311819.
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Ashenafi Kibret Sendekie, Adeladlew Kassie Netere & Eyayaw Ashete Belachew. (2022) Hypoglycemic events and glycemic control effects between NPH and premixed insulin in patients with type 2 diabetes mellitus: A real-world experience at a comprehensive specialized hospital in Ethiopia. PLOS ONE 17:9, pages e0275032.
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Charalampos Margaritidis, Eleni Karlafti, Evangelia Kotzakioulafi, Konstantinos Kantartzis, Konstantinos Tziomalos, Georgia Kaiafa, Christos Savopoulos & Triantafyllos Didangelos. (2021) Comparison of Premixed Human Insulin 30/70 to Biphasic Aspart 30 in Well-Controlled Patients with Type 2 Diabetes Using Continuous Glucose Monitoring. Journal of Clinical Medicine 10:9, pages 1982.
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Cem Haymana, Alper Sonmez, Ibrahim Demirci, Guzin Fidan Yaylalı, Irfan Nuhoglu, Seda Sancak, Murat Yilmaz, Yuksel Altuntas, Nevin Dinccag, Tevfik Sabuncu, Fahri Bayram & Ilhan Satman. (2021) Patterns and preferences of antidiabetic drug use in Turkish patients with type 2 diabetes – A nationwide cross-sectional study (TEMD treatment study). Diabetes Research and Clinical Practice 171, pages 108556.
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Puhong Zhang, Heng Zhang, Xian Li, Minyuan Chen, Du Wang & Linong Ji. (2020) Factors and outcomes associated with discontinuation of basal insulin therapy in patients with type 2 diabetes mellitus. Endocrinology, Diabetes & Metabolism 3:2.
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Antonio Nicolucci, Antonio Ceriello, Paolo Di Bartolo, Antonella Corcos & Marco Orsini Federici. (2019) Rapid-Acting Insulin Analogues Versus Regular Human Insulin: A Meta-Analysis of Effects on Glycemic Control in Patients with Diabetes. Diabetes Therapy 11:3, pages 573-584.
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Grigory Sidorenkov, Job F. M. van Boven, Trynke Hoekstra, Giel Nijpels, Klaas Hoogenberg & Petra Denig. (2018) HbA1c response after insulin initiation in patients with type 2 diabetes mellitus in real life practice: Identifying distinct subgroups. Diabetes, Obesity and Metabolism 20:8, pages 1957-1964.
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William H. Polonsky, Joyce Arsenault, Lawrence Fisher, Pamela Kushner, Eden M. Miller, Teresa L. Pearson, Mariusz Tracz, Stewart Harris, Norbert Hermanns, Bernd-M. Scholz, Robyn K. Pollom, Magaly Perez-Nieves, Roy Daniel Pollom & Irene Hadjiyianni. (2017) Initiating insulin: How to help people with type 2 diabetes start and continue insulin successfully. International Journal of Clinical Practice 71:8, pages e12973.
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Linong Ji, Puhong Zhang, Dongshan Zhu, Juming Lu, Xiaohui Guo, Yangfeng Wu, Xian Li, Jiachao Ji, Weiping Jia, Wenying Yang, Dajin Zou, Zhiguang Zhou, Yan Gao, Satish K. Garg, Changyu Pan, Jianping Weng & Sanjoy K. Paul. (2017) Comparative effectiveness and safety of different basal insulins in a real-world setting. Diabetes, Obesity and Metabolism 19:8, pages 1116-1126.
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A.-J. Scheen. (2016) Instauration d’une insulinothérapie chez le patient diabétique de type 2 en médecine générale : Comparaison de l’étude belge InsuStar avec quelques études françaises et internationales. Médecine des Maladies Métaboliques 10:4, pages 334-340.
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A. Oguz, E. Cevizci, A. Ertekin & R. Abdulnabi. (2015) Clinical outcomes and resource use after 24 months of insulin therapy in Turkish patients with type 2 diabetes: subgroup analysis of the TREAT study. International Journal of Clinical Practice 69:5, pages 588-596.
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Angel Rodríguez, Santiago Tofe & Jesus Reviriego. (2014) Evolución clínica a 5 años desde el inicio de la insulinoterapia en pacientes con diabetes tipo 2 en España: resultados del estudio EDIN. Endocrinología y Nutrición 61:7, pages 369-376.
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Angel Rodríguez, Santiago Tofe & Jesus Reviriego. (2014) Clinical course after five years of insulin therapy in patients with type 2 diabetes in Spain: Results of the EDIN study. Endocrinología y Nutrición (English Edition) 61:7, pages 369-376.
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Alberto Goday Arnó. (2014) Epidemiología de la diabetes. La apasionante aventura de investigación de un diabetólogo. Avances en Diabetología 30:4, pages 109-114.
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Svetlana Elizarova, Gagik R. Galstyan & Bruce H.R. Wolffenbuttel. (2014) Role of premixed insulin analogues in the treatment of patients with type 2 diabetes mellitus: A narrative review (预混胰岛素类似物在2型糖尿病治疗中的作用:叙述性综述). Journal of Diabetes 6:2, pages 100-110.
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Kyriakos Aloumanis, Marianna Benroubi, Sotiria Sourmeli & Vangelis Drossinos. (2013) Clinical outcomes and costs for patients with type 2 diabetes mellitus initiating insulin therapy in Greece: Two-year experience from the INSTIGATE study. Primary Care Diabetes 7:3, pages 235-242.
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Salvatore Caputo, Henning Andersen, Marcel Kaiser, Eddy Karnieli, Luigi F. Meneghini & Anne Louise Svendsen. (2013) Effect of Baseline Glycosylated Hemoglobin A1C on Glycemic Control and Diabetes Management following Initiation of Once-daily Insulin Detemir in Real-Life Clinical Practice. Endocrine Practice 19:3, pages 462-470.
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Louise Heron, Matthew Reaney, Norbert Hermanns, Linda Abetz & Laura Gregg. (2013) Perceptions of Usability and Design for Prefilled Insulin Delivery Devices for Patients With Type 2 Diabetes. Diabetes Spectrum 26:1, pages 16-28.
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Craig J. Currie, Chris D. Poole, Marc Evans, John R. Peters & Christopher Ll. Morgan. (2013) Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyperglycemic Therapies in Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism 98:2, pages 668-677.
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Andreas Liebl, Steven Jones, Alberto Goday, Marian Benroubi, Conxa Castell, Axel Haupt, Claudia Nicolay & Helen T. Smith. (2012) Clinical Outcomes After Insulin Initiation in Patients with Type 2 Diabetes: 24-Month Results from INSTIGATE. Diabetes Therapy 3:1.
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Matthew Reaney, Katarzyna Cypryk, Nicholas Tentolouris, Michael Jecht, Simon Cleall, Ute Petzinger & Veikko Koivisto. (2012) Resource utilisation and clinical data before and after switching between short-acting human insulin and rapid-acting insulin analogues in patients with type 2 diabetes: The SWING study. Diabetes Research and Clinical Practice 97:2, pages 231-241.
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Wolfgang Rathmann, Klaus Strassburger, Teresa Tamayo & Karel Kostev. (2012) Longitudinal change in HbA1c after insulin initiation in primary care patients with type 2 diabetes: A database analysis in UK and Germany. Primary Care Diabetes 6:1, pages 47-52.
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Gregory A. Nichols, Teresa M. Kimes, Joyce B. Harp, Tzuyung Doug Kou & Kimberly G. Brodovicz. (2012) Glycemic Response and Attainment of A1C Goals Following Newly Initiated Insulin Therapy for Type 2 Diabetes. Diabetes Care 35:3, pages 495-497.
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Eugenia Farcasiu, Tibor Ivanyi, Barbara Mozejko-Pastewka, Zita Birkus, Jozsef Csog, Irina Kowalska, Thomas Frederic Coetzer, Sami Bulgurlu, Birgit Schinzel & Jacek Kiljanski. (2011) Efficacy and Safety of Prandial Premixed Therapy Using Insulin Lispro Mix 50/50 3 Times Daily Compared With Progressive Titration of Insulin Lispro Mix 75/25 or Biphasic Insulin Aspart 70/30 Twice Daily in Patients With Type 2 Diabetes Mellitus: A Randomized, 16-Week, Open-Label Study. Clinical Therapeutics 33:11, pages 1682-1693.
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