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Original Article

Tolerability and efficacy of memantine add-on therapy to rivastigmine transdermal patches in mild to moderate Alzheimer's disease: a multicenter, randomized, open-label, parallel-group study

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Pages 1375-1383 | Accepted 15 Apr 2011, Published online: 12 May 2011

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Read on this site (5)

Rachel A. Nieto, William James Deardorff & George T. Grossberg. (2016) Efficacy of rivastigmine tartrate, transdermal system, in Alzheimer’s disease. Expert Opinion on Pharmacotherapy 17:6, pages 861-870.
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Han-Chang Huang, Di Tang, Ke Xu & Zhao-Feng Jiang. (2014) Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway. Journal of Receptors and Signal Transduction 34:1, pages 26-37.
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Serge Gauthier, Alain Robillard, Sharon Cohen, Sandra Black, John Sampalis, Diane Colizza, Frederica de Takacsy & Robyn Schecter. (2013) Real-life effectiveness and tolerability of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer’s disease: the EMBRACE study. Current Medical Research and Opinion 29:8, pages 989-1000.
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Paul T Francis, Chris G Parsons & Roy W Jones. (2012) Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer’s disease. Expert Review of Neurotherapeutics 12:11, pages 1351-1365.
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Daphne Lo & George T Grossberg. (2011) Use of memantine for the treatment of dementia. Expert Review of Neurotherapeutics 11:10, pages 1359-1370.
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Crossref
Andrea C. Paula-Lima, Jordano Brito-Moreira & Sergio T. Ferreira. (2013) Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease. Journal of Neurochemistry 126:2, pages 191-202.
Crossref
Serge Gauthier & José L. Molinuevo. (2012) Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease. Alzheimer's & Dementia 9:3, pages 326-331.
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Hyun Jeong Han, Byeong C. Kim, Jun-Young Lee, Seung-Ho Ryu, Hae Ri Na, Soo Jin Yoon, Hyun Young Park, Joon Hyun Shin, Soo-Jin Cho, Hyon-Ah Yi, Mun Seong Choi, Jae-Hyeok Heo, Kyung Won Park, Kwang K. Kim & Seong Hye Choi. (2012) Response to Rivastigmine Transdermal Patch or Memantine plus Rivastigmine Patch is affected by Apolipoprotein E Genotype in Alzheimer Patients. Dementia and Geriatric Cognitive Disorders 34:3-4, pages 167-173.
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