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Cardiology: Review Article

Are fixed-dose combination antihypertensives suitable as first-line therapy?

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Pages 1685-1697 | Accepted 05 Sep 2012, Published online: 26 Sep 2012

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Read on this site (5)

Susanne Roas, Felix Bernhart, Michael Schwarz, Walter Kaiser & Georg Noll. (2014) Antihypertensive combination therapy in primary care offices: results of a cross-sectional survey in Switzerland. International Journal of General Medicine 7, pages 549-556.
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Steen Neldam, Helmut Schumacher, Sverre E. Kjeldsen & Joel M. Neutel. (2014) Telmisartan in combination with hydrochlorothiazide 12.5 mg for the management of patients with hypertension. Current Medical Research and Opinion 30:9, pages 1715-1724.
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Natalie Schellack & Lucille Malan. (2014) An overview of fixed-dose combinations of antihypertensive drugs in South Africa. South African Family Practice 56:4, pages 206-211.
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Julian Segura & Luis Miguel Ruilope. (2013) A review of the benefits of early treatment initiation with single-pill combinations of telmisartan with amlodipine or hydrochlorothiazide. Vascular Health and Risk Management 9, pages 521-528.
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Vasilios G. Athyros, Niki Katsiki & Asterios Karagiannis. (2013) Cardiovascular risk reduction with combination of anti-atherosclerotic medications in younger and older patients. Current Medical Research and Opinion 29:7, pages 791-792.
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Articles from other publishers (13)

Magdalena Paczkowska-Walendowska, Szymon Sip, Rafał Staszewski & Judyta Cielecka-Piontek. (2022) Single-Pill Combination to Improve Hypertension Treatment: Pharmaceutical Industry Development. International Journal of Environmental Research and Public Health 19:7, pages 4156.
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Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 133 198 .
Zuzana Zafarová. (2021) Jsou cílové hodnoty kontroly krevního tlaku nastavené správně?. Vnitřní lékařství 67:Suppl. B, pages 17-18.
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Gianfranco Parati, Sverre Kjeldsen, Antonio CocaWilliam C. Cushman & Jiguang Wang. (2021) Adherence to Single-Pill Versus Free-Equivalent Combination Therapy in Hypertension. Hypertension 77:2, pages 692-705.
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Gino Seravalle, Guido Grassi & Giuseppe Mancia. 2018. Disorders of Blood Pressure Regulation. Disorders of Blood Pressure Regulation 639 652 .
Sverre E. Kjeldsen, Gloria Cha, Giuseppe Villa & Giuseppe Mancia. (2016) Nifedipine GITS/Candesartan Combination Therapy Lowers Blood Pressure Across Different Baseline Systolic and Diastolic Blood Pressure Categories: DISTINCT Study Subanalyses. The Journal of Clinical Pharmacology 56:9, pages 1120-1129.
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Giuseppe Mancia. 2016. Interventional Therapies for Secondary and Essential Hypertension. Interventional Therapies for Secondary and Essential Hypertension 139 149 .
Y.-H. Kim, J. H. Hwang, K.-S. Kim, J.-R. Noh, G.-T. Gang, Y. Seo, K.-H. Nam, T. H. Kwak, H. G. Lee & C.-H. Lee. (2014) NAD(P)H:Quinone Oxidoreductase 1 Activation Reduces Blood Pressure Through Regulation of Endothelial Nitric Oxide Synthase Acetylation in Spontaneously Hypertensive Rats. American Journal of Hypertension 28:1, pages 50-57.
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Sverre Kjeldsen, Ross D. Feldman, Liu Lisheng, Jean-Jacques Mourad, Chern-En Chiang, Weizhong Zhang, Zhaosu Wu, Wei Li & Bryan Williams. (2014) Updated National and International Hypertension Guidelines: A Review of Current Recommendations. Drugs 74:17, pages 2033-2051.
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Dénes Páll, Ildikó Szántó & Zoltán Szabó. (2014) Triple Combination Therapy in Hypertension: The Antihypertensive Efficacy of Treatment with Perindopril, Amlodipine, and Indapamide SR. Clinical Drug Investigation 34:10, pages 701-708.
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Sverre E. Kjeldsen, Tonje A. Aksnes & Luis M. Ruilope. (2014) Clinical Implications of the 2013 ESH/ESC Hypertension Guidelines: Targets, Choice of Therapy, and Blood Pressure Monitoring. Drugs in R&D 14:2, pages 31-43.
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Dingliang Zhu, Pingjin Gao, Werner Holtbruegge & Chenglei Huang. (2014) A randomized, double-blind study to evaluate the efficacy and safety of a single-pill combination of telmisartan 80 mg/amlodipine 5 mg versus amlodipine 5 mg in hypertensive Asian patients. Journal of International Medical Research 42:1, pages 52-66.
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Dingliang Zhu, Pingjin Gao, Nobutaka Yagi & Helmut Schumacher. (2014) Efficacy and Tolerability of Telmisartan Plus Amlodipine in Asian Patients Not Adequately Controlled on Either Monotherapy or on Low-Dose Combination Therapy. International Journal of Hypertension 2014, pages 1-11.
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