2,515
Views
59
CrossRef citations to date
0
Altmetric
Critical care

Beta-blocker use in severe sepsis and septic shock: a systematic review

, , &
Pages 1817-1825 | Accepted 05 Jun 2015, Published online: 20 Aug 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Maria Heliste, Ville Pettilä, David Berger, Stephan M. Jakob & Erika Wilkman. (2022) Beta-blocker treatment in the critically ill: a systematic review and meta-analysis. Annals of Medicine 54:1, pages 1994-2010.
Read now
Thomas R Laws, Adam W. Taylor, Paul Russell & Diane Williamson. (2019) The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review. Expert Review of Anti-infective Therapy 17:12, pages 957-967.
Read now
Marc O. Maybauer & Dirk M. Maybauer. (2015) A new frontier for an old drug? A word of caution for beta-blockers in sepsis!. Current Medical Research and Opinion 31:10, pages 1829-1830.
Read now
Marinella Astuto. (2015) Sepsis and beta-blockade: a look into diastolic function. Current Medical Research and Opinion 31:10, pages 1827-1828.
Read now

Articles from other publishers (55)

Filippo Sanfilippo, Antonio Messina, Sabino Scolletta, Elena Bignami, Andrea Morelli, Maurizio Cecconi, Giovanni Landoni & Stefano Romagnoli. (2023) The “CHEOPS” bundle for the management of Left Ventricular Diastolic Dysfunction in critically ill patients: an experts’ opinion. Anaesthesia Critical Care & Pain Medicine 42:6, pages 101283.
Crossref
Lou'i Al-Husinat, Amer Abu Hmaid, Hadeel Abbas, Batool Abuelsamen, Mutaz Albelbisi, Said Haddad, Ibrahim Qamileh, Ossaid Quneis, Zaid Jehad Al Modanat, Giuseppe Ferrara, Fernando Suparregui Dias & Gilda Cinnella. (2023) Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review. Frontiers in Medicine 10.
Crossref
Maximilian Peter Forssten, Ahmad Mohammad Ismail, Ioannis Ioannidis, Per Wretenberg, Tomas Borg, Yang Cao, Marcelo A. F. RibeiroJr.Jr. & Shahin Mohseni. (2023) A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients. European Journal of Trauma and Emergency Surgery 49:3, pages 1485-1497.
Crossref
Shiao-Ya Hong, Chih-Cheng Lai, Nai-Chi Teng, Chao-Hsien Chen, Chun-Chun Hsu, Nai-Ju Chan, Cheng-Yi Wang, Ya-Hui Wang, You Shuei Lin & Likwang Chen. (2023) Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies. Frontiers in Medicine 10.
Crossref
NingTing CHEN, Guo CHENG, Bo WEI, QianQian BI, Cheng LU, ShanShan WANG & Peng SHI. (2022) Microglia contribute to the autonomic function and participate in neurogenic hypertension: non-immune function of central immune cells. SCIENTIA SINICA Vitae 52:12, pages 1773-1784.
Crossref
Filippo SANFILIPPO, Elena G. BIGNAMI, Marinella ASTUTO, Antonio MESSINA, Gianmaria CAMMAROTA, Salvatore M. MAGGIORE & Luigi VETRUGNO. (2022) Understanding left ventricular diastolic dysfunction in anesthesia and intensive care patients: a glass with progressive shape change. Minerva Anestesiologica 88:11.
Crossref
Shahin Mohseni, Bellal Joseph & Carol Jane Peden. (2021) Mitigating the stress response to improve outcomes for older patients undergoing emergency surgery with the addition of beta-adrenergic blockade. European Journal of Trauma and Emergency Surgery 48:2, pages 799-810.
Crossref
Daniela Luethy, Mary A. Robinson, Darko Stefanovski, Joanne Haughan, Catherine Torcivia, Alycia Kowalski, Matthew Ford, Youwen You, Jaclyn Missanelli & Joann Slack. (2021) Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses. Journal of Veterinary Pharmacology and Therapeutics 45:2, pages 177-187.
Crossref
Florence Boissier & Nadia Aissaoui. (2022) Septic cardiomyopathy: Diagnosis and management. Journal of Intensive Medicine 2:1, pages 8-16.
Crossref
Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun & Nicolas Girerd. (2021) Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study. Critical Care 25:1.
Crossref
Shih‐Yi Lin, Fung‐Chang Sung, Cheng‐Li Lin, Cheng‐Chieh Lin, Wu‐Huei Hsu, Wei‐Chih Liao, Mao‐Wang Ho, Po‐Chang Lin, Chung‐Y. Hsu & Chia‐Hung Kao. (2021) Association of antihypertensives during hospitalisation with acute respiratory failure in patients with viral pneumonia: A population‐based case‐control study. International Journal of Clinical Practice 75:12.
Crossref
Ichiro Matsuo, Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Yasumasa Mototani, Aiko Ito, Yoshio Hayakawa, Megumi Nariyama, Akinaka Morii, Kenichi Kiyomoto, Michinori Tsunoda, Kazuhiro Gomi & Satoshi Okumura. (2021) Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac dysfunction in mice. Journal of Oral Biosciences 63:4, pages 394-400.
Crossref
Ahmad Mohammad Ismail, Rebecka Ahl, Maximilian Peter Forssten, Yang Cao, Per Wretenberg, Tomas Borg & Shahin Mohseni. (2021) Beta-Blocker Therapy Is Associated With Increased 1-Year Survival After Hip Fracture Surgery: A Retrospective Cohort Study. Anesthesia & Analgesia 133:5, pages 1225-1234.
Crossref
Manuel Vélez-Gimón. 2021. Infections and Sepsis Development. Infections and Sepsis Development.
Rebecca Bruning, Hannah Dykes, Timothy W. Jones, Nathaniel B. Wayne & Andrea Sikora Newsome. (2021) Beta-Adrenergic Blockade in Critical Illness. Frontiers in Pharmacology 12.
Crossref
Kaiquan Tan, Martin Harazim, Andrew Simpson, Yi Chern Tan, Gunawan Gunawan, Kristy P. Robledo, Christina Whitehead, Benjamin Tang, Anthony Mclean & Marek Nalos. (2021) Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes—The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study. Critical Care Medicine 49:9, pages 1493-1503.
Crossref
Andrea Morelli & Filippo Sanfilippo. (2021) Ultrashort-Acting β-Blockers. Chest 159:6, pages 2139-2140.
Crossref
Weronika Wasyluk & Agnieszka Zwolak. (2021) Metabolic Alterations in Sepsis. Journal of Clinical Medicine 10:11, pages 2412.
Crossref
Ranjit Lall, Dipesh Mistry, Emma Skilton, Nafisa Boota, Scott Regan, Julian Bion, Simon Gates, Anthony C Gordon, Janet Lord, Daniel Francis McAuley, Gavin Perkins, Mervyn Singer, Duncan Young & Tony Whitehouse. (2021) Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial. BMJ Open 11:2, pages e043194.
Crossref
Dmitri Guz, Shira Buchritz, Alina Guz, Alon Ikan, Tania Babich, Vered Daitch, Anat Gafter-Gvili, Leonard Leibovici & Tomer Avni. (2021) β-Blockers, Tachycardia, and Survival Following Sepsis: An Observational Cohort Study. Clinical Infectious Diseases.
Crossref
Raouf Ramzy Gadallah, Eman Mohamed Kamal Aboseif, Dalia Ahmed Ibrahim, Hany Victor Zaki & Mohamed Nabil Mohamed Abdelmaksoud. (2020) Evaluation of the safety and efficacy of beta blockers in septic patients: a randomized control trial. Ain-Shams Journal of Anesthesiology 12:1.
Crossref
Andrea Morelli, Salvatore M. Romano, Filippo Sanfilippo, Cristina Santonocito, Giacomo Frati, Marco Chiostri, Felice E. Agrò, Christian Ertmer, Sebastian W. Rehberg & Antoine Vieillard-Baron. (2020) Systolic-dicrotic notch pressure difference can identify tachycardic patients with septic shock at risk of cardiovascular decompensation following pharmacological heart rate reduction. British Journal of Anaesthesia 125:6, pages 1018-1024.
Crossref
Zoe Meresse & Marc Leone. (2020) Dexmedetomidine as a promise. Minerva Anestesiologica 86:8.
Crossref
Roberta Domizi, Sara Calcinaro, Steve Harris, Christian Beilstein, Christiaan Boerma, Jean-Daniel Chiche, Annalia D'Egidio, Elisa Damiani, Abele Donati, Peter M. Koetsier, Mary P. Madden, Daniel F. McAuley, Andrea Morelli, Paolo Pelaia, Patrick Royer, Manu Shankar-Hari, Nadine Wickboldt, Parjam Zolfaghari & Mervyn Singer. (2020) Relationship between norepinephrine dose, tachycardia and outcome in septic shock: A multicentre evaluation. Journal of Critical Care 57, pages 185-190.
Crossref
You Li, Bo Wei, Xiaoli Liu, Xiao Z. Shen & Peng Shi. (2020) Microglia, autonomic nervous system, immunity and hypertension: Is there a link?. Pharmacological Research 155, pages 104451.
Crossref
F. M. Brunkhorst, M. A. Weigand, M. Pletz, P. Gastmeier, S. W. Lemmen, A. Meier-Hellmann, M. Ragaller, A. Weyland, G. Marx, M. Bucher, H. Gerlach, B. Salzberger, B. Grabein, T. Welte, K. Werdan, S. Kluge, H. G. Bone, C. Putensen, R. Rossaint, M. Quintel, C. Spies, B. Weiß, S. John, M. Oppert, A. Jörres, T. Brenner, G. Elke, M. Gründling, K. Mayer, A. Weimann, T. W. Felbinger & H. Axer. (2020) S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und NachsorgeS3 Guideline Sepsis—prevention, diagnosis, therapy, and aftercare. Medizinische Klinik - Intensivmedizin und Notfallmedizin 115:S2, pages 37-109.
Crossref
Angelos Arfaras-Melainis, Eftihia Polyzogopoulou, Filippos Triposkiadis, Andrew Xanthopoulos, Ignatios Ikonomidis, Alexander Mebazaa & John Parissis. (2019) Heart failure and sepsis: practical recommendations for the optimal management. Heart Failure Reviews 25:2, pages 183-194.
Crossref
Wan-Ting Hsu, Brandon Patrick GalmGregory SchrankTzu-Chun Hsu, Shih-Hao LeeJames Yeongjun Park & Chien-Chang Lee. (2020) Effect of Renin-Angiotensin-Aldosterone System Inhibitors on Short-Term Mortality After Sepsis. Hypertension 75:2, pages 483-491.
Crossref
Antoine Guillon, Sebastien Preau, Jérôme Aboab, Eric Azabou, Boris Jung, Stein Silva, Julien Textoris, Fabrice Uhel, Dominique Vodovar, Lara Zafrani, Nicolas de Prost & Peter Radermacher. (2019) Preclinical septic shock research: why we need an animal ICU. Annals of Intensive Care 9:1.
Crossref
Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean & Marek Nalos. (2019) The association between premorbid beta blocker exposure and mortality in sepsis—a systematic review. Critical Care 23:1.
Crossref
Manuel Ignacio Monge García, Ana Del Rio Lechuga, Nick Fletcher & Anselmo Gil Cano. (2019) Increased atrial contraction contribution to left ventricular filling during early septic shock. Journal of Critical Care 54, pages 220-227.
Crossref
Daiki Kobayashi, Nagato Kuriyama, Fumitaka Yanase, Osamu Takahashi, Kazuhiro Aoki & Yasuhiro Komatsu. (2019) Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker use prior to medical intensive care unit admission and in-hospital mortality: propensity score-matched cohort study. Journal of Nephrology 32:4, pages 595-603.
Crossref
Andrea Morelli, Filippo Sanfilippo, Sebastian Rehberg & Cristian Ertmer. (2019) The authors reply. Critical Care Medicine 47:5, pages e432-e433.
Crossref
Lex M. van Loon, Johannes G. van der Hoeven & Joris Lemson. (2019) Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature. Journal of Critical Care 50, pages 138-143.
Crossref
Andrea MorelliFilippo SanfilippoPhilip ArnemannMichael HesslerTim G. KampmeierAnnalia D’EgidioAlessandra OrecchioniCristina SantonocitoGiacomo FratiErnesto GrecoMartin WestphalSebastian W. RehbergChristian Ertmer. (2019) The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial. Critical Care Medicine 47:2, pages e89-e95.
Crossref
Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang, Feng Xu, Yingmei Zhang, Jun Ren & Yuguo Chen. 2019. Aldehyde Dehydrogenases. Aldehyde Dehydrogenases 175 194 .
F. Sanfilippo, S. Scolletta, A. Morelli & A. Vieillard-Baron. (2018) Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care. Annals of Intensive Care 8:1.
Crossref
Martin Unger, Andrea Morelli, Mervyn Singer, Peter Radermacher, Sebastian Rehberg, Helmut Trimmel, Michael Joannidis, Gottfried Heinz, Vladimír Cerny, Pavel Dostál, Christian Siebers, Fabio Guarracino, Francesca Pratesi, Gianni Biancofiore, Massimo Girardis, Pavla Kadlecova, Olivier Bouvet, Michael Zörer, Barbara Grohmann-Izay, Kurt Krejcy, Christoph Klade & Günther Krumpl. (2018) Landiolol in patients with septic shock resident in an intensive care unit (LANDI-SEP): study protocol for a randomized controlled trial. Trials 19:1.
Crossref
F. Sanfilippo, C. Corredor, N. Fletcher, L. Tritapepe, F. L. Lorini, A. Arcadipane, A. Vieillard-Baron & M. Cecconi. (2018) Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis. Critical Care 22:1.
Crossref
Robert R. Ehrman, Ashley N. Sullivan, Mark J. Favot, Robert L. Sherwin, Christian A. Reynolds, Aiden Abidov & Phillip D. Levy. (2018) Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. Critical Care 22:1.
Crossref
M.E. Jørgensen, C. Andersson, S. Venkatesan & R.D. Sanders. (2018) Beta-blockers in noncardiac surgery: Did observational studies put us back on safe ground?. British Journal of Anaesthesia 121:1, pages 16-25.
Crossref
Marion Griton & Jan Pieter Konsman. (2018) Neural pathways involved in infection-induced inflammation: recent insights and clinical implications. Clinical Autonomic Research 28:3, pages 289-299.
Crossref
Sebastian Nuding, Jochen Schröder, Peter Presek, Andreas Wienke, Ursula Müller-Werdan, Henning Ebelt & Karl Werdan. (2018) Reducing Elevated Heart Rates in Patients with Multiple Organ Dysfunction Syndrome with The I f (Funny Channel Current) Inhibitor Ivabradine. Shock 49:4, pages 402-411.
Crossref
Ping Liu, Qi Wu, Yu Tang, Zhiguo Zhou & Malong Feng. (2018) The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies. The American Journal of Emergency Medicine 36:3, pages 470-474.
Crossref
Saraschandra Vallabhajosyula, Jacob C. Jentzer, Jeffrey B. Geske, Mukesh Kumar, Ankit Sakhuja, Akhil Singhal, Joseph T. Poterucha, Kianoush Kashani, Joseph G. Murphy, Ognjen Gajic & Rahul Kashyap. (2018) New-Onset Heart Failure and Mortality in Hospital Survivors of Sepsis-Related Left Ventricular Dysfunction. Shock 49:2, pages 144-149.
Crossref
Koji HosokawaFuhong SuFabio Silvio TacconeEmiel Hendrik PostAdriano José PereiraAntoine HerpainJacques CreteurJean-Louis Vincent. (2017) Esmolol Administration to Control Tachycardia in an Ovine Model of Peritonitis. Anesthesia & Analgesia 125:6, pages 1952-1959.
Crossref
Andrea Morelli & Sebastian Rehberg. (2017) Microcirculation First!—Esmolol, a Candidate for the Next Term of Office*. Critical Care Medicine 45:12, pages 2115-2116.
Crossref
Wei Du, Dawei Liu, Yun Long & Xiaoting Wang. (2017) The β-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia*. Critical Care Medicine 45:12, pages e1247-e1253.
Crossref
C. Fuchs, S. Wauschkuhn, C. Scheer, M. Vollmer, K. Meissner, S.-O. Kuhn, K. Hahnenkamp, A. Morelli, M. Gründling & S. Rehberg. (2017) Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days. British Journal of Anaesthesia 119:4, pages 616-625.
Crossref
Kathleen E. Singer, Courtney E. Collins, Julie M. Flahive, Allison S. Wyman, M. Didem Ayturk & Heena P. Santry. (2017) Outpatient beta-blockers and survival from sepsis: Results from a national cohort of Medicare beneficiaries. The American Journal of Surgery 214:4, pages 577-582.
Crossref
K. Lewandowski & R. H. Bartlett. (2016) Der alte Mann und die „I sea U“The old man and the I sea U. Der Anaesthesist 66:1, pages 34-44.
Crossref
Xiuxiu Lv & Huadong Wang. (2016) Pathophysiology of sepsis-induced myocardial dysfunction. Military Medical Research 3:1.
Crossref
Daniel A. Reuter, James A. Russell & Armand Mekontso Dessap. (2016) Beta-blockers in septic shock to optimize hemodynamics? Yes. Intensive Care Medicine 42:10, pages 1607-1609.
Crossref
A. Morelli, M. Singer, V. M. Ranieri, A. D?Egidio, L. Mascia, A. Orecchioni, F. Piscioneri, F. Guarracino, E. Greco, M. Peruzzi, G. Biondi-Zoccai, G. Frati & S. M. Romano. (2016) Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study. Intensive Care Medicine 42:10, pages 1528-1534.
Crossref
Wei Du, Xiao-Ting Wang, Yun Long & Da-Wei Liu. (2016) Efficacy and Safety of Esmolol in Treatment of Patients with Septic Shock. Chinese Medical Journal 129:14, pages 1658-1665.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.