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Original Article

Efficacy and safety of diclofenac sodium 2% topical solution for osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled, 4 week study

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Pages 241-250 | Accepted 24 Oct 2015, Published online: 17 Nov 2015

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Corey W Hunter, Timothy R Deer, Mark R Jones, George C Chang Chien, Ryan S D’Souza, Timothy Davis, Erica R Eldon, Michael F Esposito, Johnathan H Goree, Lissa Hewan-Lowe, Jillian A Maloney, Anthony J Mazzola, John S Michels, Annie Layno-Moses, Shachi Patel, Jeanmarie Tari, Jacqueline S Weisbein, Krista A Goulding, Anikar Chhabra, Jeffrey Hassebrock, Chris Wie, Douglas Beall, Dawood Sayed & Natalie Strand. (2022) Consensus Guidelines on Interventional Therapies for Knee Pain (STEP Guidelines) from the American Society of Pain and Neuroscience. Journal of Pain Research 15, pages 2683-2745.
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Dylan G. Wolff, Christy Christophersen, Symone M. Brown & Mary K Mulcahey. (2021) Topical nonsteroidal anti-inflammatory drugs in the treatment of knee osteoarthritis: a systematic review and meta-analysis. The Physician and Sportsmedicine 49:4, pages 381-391.
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Articles from other publishers (21)

Shuai Yin, Yiniu Chang, Xiuli Yan, Xiaodong Feng & Nan Wu. (2023) Effect of acupuncture for patients with knee osteoarthritis: study protocol for a double-dummy randomized controlled trial. Journal of Orthopaedic Surgery and Research 18:1.
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Chen Shi, Zhaoming Ye, Zengwu Shao, Bifa Fan, Cibo Huang, Yuan Zhang, Xinying Kuang, Liyan Miao, Xin’an Wu, Rongsheng Zhao, Xiao Chen, Bikui Zhang, Rongsheng Tong, Xin Hu, Zhijian Fu, Jianhao Lin, Xiaomei Li, Tiezheng Sun, Guoqiang Liu, Haibin Dai, Cheng Guo, Bo Zhang, Ting Xu, Aidong Wen, Xiaocong Zuo, Jinmei Liu, Xu Chen, Huibo Li, Jing Wang, Min Luo, Tingting Fan, Yulan Qian, Xiu’mao Li, Wenjie Qiu, Xiaowen Lin, Yingchang Pang, Yunfei Hou, Difei Yao, Wen Kou, Bao Sun, Can Hu, Yanzhe Xia, Ming Zhao, Changyu Zhu, Qian Li & Yu Zhang. (2023) Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022). Journal of Clinical Medicine 12:4, pages 1544.
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Kamini, Anoop Kumar, Pooja A. Chawla & Bhupinder Kapoor. 2023. Recent Developments in Anti-Inflammatory Therapy. Recent Developments in Anti-Inflammatory Therapy 331 386 .
Wang Wen-yue, Xu Ying-peng, Ding Quan-mao, Xie Li-min, Wang De-zhi, Bai Yang, Wang Li-su, Li Yu-bin, Niu Zhi-jun, Ma Yan-xu, Chen Wu-zhong, Bai Li-qun, Liu Yang & Jin Li-kun. (2022) A randomized, parallel control and multicenter clinical trial of evidence-based traditional Chinese medicine massage treatment VS External Diclofenac Diethylamine Emulgel for the treatment of knee osteoarthritis. Trials 23:1.
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José Francisco Ribeiro, Maria do Livramento Fortes Figueiredo, Matheus Oliveira do Nascimento, Benedito Pereira de SousaNetoNeto & André Luís Menezes Carvalho. (2022) ANTI-INFLAMATÓRIOS NÃO ESTEROIDES TÓPICOS PARA O ALÍVIO DA DOR ARTRITICA, BENEFICIOS PARA IDOSOS. Enfermagem em Foco 13:spe1.
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Yuhui Wang, Miaozhen Fan, Huideng Wang, Yi You, Chengqiong Wei, Meng Liu, Ailin Luo, Xiaotian Xu & Xiaoqun Duan. (2022) Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis. Medicine 101:36, pages e30354.
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Huan Wang & Baoan Ma. (2022) Healthcare and Scientific Treatment of Knee Osteoarthritis. Journal of Healthcare Engineering 2022, pages 1-7.
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Olga A. Shavlovskaya, Irina A. Bokova & Nikita I. Shavlovskiy. (2021) The possibilities of using topical nonsteroidal anti-inflammatory drugs in the complex pain syndrome therapy of musculoskeletal system diseases. Consilium Medicum 23:11, pages 834-840.
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Sergey Yakushin, Svetlana Polyakova, Yury Shvarts, Alexander Kastanayan, Diana Krechikova, Olga Ershova, Natalia Nikulenkova, Irina Vinogradova, Bok Jin Hyun & Ji Eun Cha. (2021) Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. Clinical Therapeutics 43:10, pages 1720-1734.
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S. TOLU, M. M. KÖSE, M. C. KORKMAZ, A. ÜŞEN & A. REZVANİ. (2021) Comparison of the Efficacy of Different Concentrations of Diclofenac Sodium Phonophoresis (1.16% vs 2.32%) in Patients with Knee Osteoarthritis: a Randomized Double-Blind Controlled Trial. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 88:2, pages 117-123.
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Asger Reinstrup Bihlet, Inger Byrjalsen, Lee S. Simon, Dario Carrara, Laetitia Delpy & Caroline Derne. (2020) A novel diclofenac gel (AMZ001) applied once or twice daily in subjects with painful knee osteoarthritis: A randomized, placebo-controlled clinical trial. Seminars in Arthritis and Rheumatism 50:6, pages 1203-1213.
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Tao Ling, Jiao Jiao Li, Rui-Juan Xu, Bin Wang & Wei-Hong Ge. (2020) Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials. BioMed Research International 2020, pages 1-11.
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Frédérique Bariguian Revel, Marina Fayet & Martina Hagen. (2020) Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review. Rheumatology and Therapy 7:2, pages 217-236.
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Olivier Bruyère, Germain Honvo, Nicola Veronese, Nigel K. Arden, Jaime Branco, Elizabeth M. Curtis, Nasser M. Al-Daghri, Gabriel Herrero-Beaumont, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Rannou, René Rizzoli, Roland Roth, Daniel Uebelhart, Cyrus Cooper & Jean-Yves Reginster. (2019) An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Seminars in Arthritis and Rheumatism 49:3, pages 337-350.
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Germain Honvo, Victoria Leclercq, Anton Geerinck, Thierry Thomas, Nicola Veronese, Alexia Charles, Véronique Rabenda, Charlotte Beaudart, Cyrus Cooper, Jean-Yves Reginster & Olivier Bruyère. (2019) Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs & Aging 36:S1, pages 45-64.
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Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda & Kenji Miyamoto. (2018) Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac. BMC Musculoskeletal Disorders 19:1.
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M.S.M. Persson, J. Stocks, D.A. Walsh, M. Doherty & W. Zhang. (2018) The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: a network meta-analysis of randomised controlled trials. Osteoarthritis and Cartilage 26:12, pages 1575-1582.
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Mohan Stewart, Jolanda Cibere, Eric C. Sayre & Jacek A. Kopec. (2018) Efficacy of commonly prescribed analgesics in the management of osteoarthritis: a systematic review and meta-analysis. Rheumatology International 38:11, pages 1985-1997.
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Chao Zeng, Jie Wei, Monica S M Persson, Aliya Sarmanova, Michael Doherty, Dongxing Xie, YiLun Wang, Xiaoxiao Li, Jiatian Li, Huizhong Long, Guanghua Lei & Weiya Zhang. (2018) Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. British Journal of Sports Medicine 52:10, pages 642-650.
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Jorge L. Escobar Ivirico, Maumita Bhattacharjee, Emmanuel Kuyinu, Lakshmi S. Nair & Cato T. Laurencin. (2017) Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies. Engineering 3:1, pages 16-27.
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Soojung LeeJudee Grace E. NemeñoJeong Ik Lee. (2016) Repositioning Bevacizumab: A Promising Therapeutic Strategy for Cartilage Regeneration. Tissue Engineering Part B: Reviews 22:5, pages 341-357.
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