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Research Article

A multi-centre, double-blind comparative study of the efficacy and safety of aceclofenac and diclofenar in the treatment of rheumatoid arthritis

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Pages 305-315 | Received 03 Jul 1995, Published online: 12 Aug 2008

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Giovanni Iolascon, Sergio Giménez & Dorottya Mogyorósi. (2021) A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders. Journal of Pain Research 14, pages 3651-3663.
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Krishna Sanka, Rajeswara Rao Pragada & Prabhakar Reddy Veerareddy. (2015) A pH-triggered delayed-release chronotherapeutic drug delivery system of aceclofenac for effective management of early morning symptoms of rheumatoid arthritis. Journal of Microencapsulation 32:8, pages 794-803.
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Praveen Kumar Gaur, Suresh Purohit & Shikha Mishra. (2013) Development of aceclofenac nanovesicular system using biomaterial for transdermal delivery: physical characterization, ex vivo, in vivo, and anti-inflammatory studies. Journal of Biomaterials Science, Polymer Edition 24:18, pages 2126-2141.
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Maha Nasr, Samar Mansour, Nahed D. Mortada & A. A. Elshamy. (2008) Vesicular aceclofenac systems: A comparative study between liposomes and niosomes. Journal of Microencapsulation 25:7, pages 499-512.
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Erik Legrand. (2004) Aceclofenac in the management of inflammatory pain. Expert Opinion on Pharmacotherapy 5:6, pages 1347-1357.
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Ernst-Martin Lemmel, Burkhard Leeb, Johan De Bast & Spyros Aslanidis. (2002) Patient and Physician Satisfaction with Aceclofenac: Results of the European Observational Cohort Study (Experience with Aceclofenac for Inflammatory Pain in Daily Practice). Current Medical Research and Opinion 18:3, pages 146-153.
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Masahito Hatori & Shoichi Kokubun. (1998) The Long-term Efficacy and Tolerability of the New Anti-inflammatory Agent Zaltoprofen in Rheumatoid Arthritis. Current Medical Research and Opinion 14:2, pages 79-87.
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Articles from other publishers (20)

A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzhanova, E. S. Filatova & V. A. Nesterenko. (2021) Regular use of non-steroidal anti-inflammatory drugs can effectively control pain and global health in patients with moderate activity of rheumatoid arthritis. Modern Rheumatology Journal 15:2, pages 57-63.
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Mariana Del Grossi Paglia, Marcus Tolentino Silva, Luciane Cruz Lopes, Silvio Barberato-Filho, Lauren Giustti Mazzei, Flavia Casale Abe & Cristiane de Cássia Bergamaschi. (2021) Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis. PLOS ONE 16:4, pages e0248866.
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A. E. Karateev, E. L. Nasonov, S. I. Glukhova, A. A. Barakat, R. L. Gibadullina, E. A. Ageeva, O. S. Fedorova, T. S. Timofeeva, G. R. Mikhailova & A. E. Nasonova. (2019) Evaluation of efficacy and safety of long-term use of amtolmetin guacil in rheumatic diseases: results of a 9-month observational AURORA study (Amtolmetin guacil: allRussian Register for Osteoarthritis, Rheumatoid arthritis and Ankylosing spondylitis). Rheumatology Science and Practice 57:1, pages 66-74.
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Tae Kim, Subindra Thapa, Da Lee, Seung Chung, Jun Lim, Hyeon Jeong, Chang Song, Youn-Woong Choi, Sang-Min Cho, Kyu-Yeol Nam, Won-Ho Kang, Soyoung Shin & Beom Shin. (2018) Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats. Pharmaceutics 10:3, pages 152.
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Pragya Yadav, Vaibhav Rastogi, Mayur Porwal, Prashant Upadhyay & Anurag Verma. (2016) 3(2) Designing and optimization of aceclofenac transdermal films using response surface methodology: investigating the effect of hydrophilic and hydrophobic matrix on ex vivo and in vivo permeation characteristics. Journal of Pharmaceutical Investigation 47:6, pages 541-558.
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Eunyoung Kim, Chunhwa Ihm & Wonku Kang. (2016) Modeling of aceclofenac metabolism to major metabolites in healthy volunteers. Drug Metabolism and Pharmacokinetics 31:6, pages 458-463.
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P. V Markov, G. A Pal’shin & A. N Komissarov. (2014) Efficacy of Analgesic Therapy after Hip and Knee Arthroplasty. N.N. Priorov Journal of Traumatology and Orthopedics 21:1, pages 57-60.
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Mi Jo Kim, Hyeong-Seok Lim, Yook-Hwan Noh, Yo Han Kim, Hee Youn Choi, Kyung-Mi Park, Sei-Eun Kim & Kyun-Seop Bae. (2013) Pharmacokinetic Interactions Between Eperisone Hydrochloride and Aceclofenac: A Randomized, Open-Label, Crossover Study of Healthy Korean Men. Clinical Therapeutics 35:10, pages 1528-1535.
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Eunyoung Kim, Byoungki Ahn, Keumhan Noh, Wonku Kang & Hye sun Gwak. (2012) Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS. Journal of Separation Science 35:17, pages 2219-2222.
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Soo Kyung Bae, Soo-Hwan Kim, Hae Won Lee, Sook Jin Seong, Su-Yeon Shin, Sang Hun Lee, Mi-Sun Lim, Young-Ran Yoon & Hye Jung Lee. (2012) Pharmacokinetics of a New Once-Daily Controlled-Release Formulation of Aceclofenac in Korean Healthy Subjects Compared with Immediate-Release Aceclofenac and the Effect of Food. Clinical Drug Investigation 32:2, pages 111-119.
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Naomi Schlesinger, Marc De Meulemeester, Andrey Pikhlak, A Eftal Yücel, Dominik Richard, Valda Murphy, Udayasankar Arulmani, Peter Sallstig & Alexander So. (2011) Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study. Arthritis Research & Therapy 13:2.
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Sandra Pérez & Damià Barceló. (2008) First Evidence for Occurrence of Hydroxylated Human Metabolites of Diclofenac and Aceclofenac in Wastewater Using QqLIT-MS and QqTOF-MS. Analytical Chemistry 80:21, pages 8135-8145.
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Si-Youn Rhim, Jin-Hee Park, Yoo-Sin Park, Min-Ho Lee, Leslie M. Shaw & Ju-Seop Kang. (2008) Bioequivalence and pharmacokinetic evaluation of two branded formulations of aceclofenac 100 mg: a single-dose, randomized, open-label, two-period crossover comparison in healthy Korean adult volunteers. Clinical Therapeutics 30:4, pages 633-640.
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Wonku Kang & Eun-Young Kim. (2008) Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 46:3, pages 587-591.
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Angelo Zinellu, Ciriaco Carru, Salvatore Sotgia, Emanuela Porqueddu, Paolo Enrico & Luca Deiana. (2005) Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-d-glucamine as an effective electrolyte additive. European Journal of Pharmaceutical Sciences 24:4, pages 375-380.
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Burkhard Hinz, Daniel Auge, Thomas Rau, Stephan Rietbrock, Kay Brune & Ulrike Werner. (2003) Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high‐performance liquid chromatography. Biomedical Chromatography 17:4, pages 268-275.
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David Gurwitz & Abraham Weizman. (2002) The NR2B subunit of glutamate receptors as a potential target for relieving chronic pain: prospects and concerns. Drug Discovery Today 7:7, pages 403-406.
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Mukta Dooley, Caroline M. Spencer & Christopher J. Dunn. (2001) Aceclofenac. Drugs 61:9, pages 1351-1378.
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Albrecht Wiebalck, Roman Dertwinkel & Michael Zenz. (1998) 2a NSAIDs and other non-opioids in chronic pain. Baillière's Clinical Anaesthesiology 12:1, pages 19-38.
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