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Research Article

Treatment-Resistant Schizophrenia - The Role of Clozapine

Pages 1-20 | Accepted 29 Oct 1997, Published online: 26 Aug 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

Michelle I. Jakobsen, Julie P. Schaug, Jimmi Nielsen & Erik Simonsen. (2023) Antipsychotic prescribing practices for outpatients with schizophrenia and reasons for non-clozapine treatment - Data from a Danish quality assessment audit. Nordic Journal of Psychiatry 77:5, pages 481-490.
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Yu Funahashi, Yuta Yoshino, Jun-ichi Iga & Shu-ichi Ueno. (2023) Impact of clozapine on the expression of miR-675-3p in plasma exosomes derived from patients with schizophrenia. The World Journal of Biological Psychiatry 24:4, pages 303-313.
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Sharon Taub, Amir Krivoy, Eromona Whiskey & Sukhi S. Shergill. (2022) New approaches to antipsychotic medication adherence – safety, tolerability and acceptability. Expert Opinion on Drug Safety 21:4, pages 517-524.
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Zarrin Ansari, Sudhir Pawar & Rajmohan Seetharaman. (2022) Neuroinflammation and oxidative stress in schizophrenia: are these opportunities for repurposing?. Postgraduate Medicine 134:2, pages 187-199.
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Andreea Teodorescu, Petru Ifteni, Ana Dragan, Marius Alexandru Moga, Ana Aliana Miron & Lorena Dima. (2021) Clozapine Efficacy in a Case of Severe Treatment-Resistant Postpartum Psychosis. Risk Management and Healthcare Policy 14, pages 555-559.
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Wenying Yi, Shenglin She, Jie Zhang, Haibo Wu, Yingjun Zheng & Yuping Ning. (2020) Clozapine Use in Patients with Early-Stage Schizophrenia in a Chinese Psychiatric Hospital. Neuropsychiatric Disease and Treatment 16, pages 2827-2836.
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Kenya A. Costa-Dookhan, Sri Mahavir Agarwal, Araba Chintoh, Veronica N. Tran, Nicolette Stogios, Bjørn H. Ebdrup, Sanjeev Sockalingam, Tarek K. Rajji, Gary J. Remington, Dan Siskind & Margaret K. Hahn. (2020) The clozapine to norclozapine ratio: a narrative review of the clinical utility to minimize metabolic risk and enhance clozapine efficacy. Expert Opinion on Drug Safety 19:1, pages 43-57.
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Christoph U Correll, Thomas Brevig & Cecilia Brain. (2019) Exploration of Treatment-Resistant Schizophrenia Subtypes Based on a Survey of 204 US Psychiatrists. Neuropsychiatric Disease and Treatment 15, pages 3461-3473.
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Oddur Ingimarsson, James H. MacCabe & Engilbert Sigurdsson. (2018) Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in Iceland. Nordic Journal of Psychiatry 72:7, pages 497-500.
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John Lally, Fiona Gaughran, Philip Timms & Sarah R Curran. (2016) Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics. Pharmacogenomics and Personalized Medicine 9, pages 117-129.
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Shyam Sundar Arumugham, Jagadisha Thirthalli & Chittaranjan Andrade. (2016) Efficacy and safety of combining clozapine with electrical or magnetic brain stimulation in treatment-refractory schizophrenia. Expert Review of Clinical Pharmacology 9:9, pages 1245-1252.
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Maren Carbon & Christoph U. Correll. (2014) Clinical predictors of therapeutic response to antipsychotics in schizophrenia. Dialogues in Clinical Neuroscience 16:4, pages 505-524.
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Josiane Bourque, Nadia Lakis, Julie Champagne, Emmanuel Stip, Pierre Lalonde, Olivier Lipp & Adrianna Mendrek. (2013) Clozapine and visuospatial processing in treatment-resistant schizophrenia. Cognitive Neuropsychiatry 18:6, pages 615-630.
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Jian-Ping Zhang & Anil K Malhotra. (2013) Pharmacogenetics of antipsychotics: recent progress and methodological issues. Expert Opinion on Drug Metabolism & Toxicology 9:2, pages 183-191.
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Pietro Gareri, Pasquale De Fazio, Emilio Russo, Norma Marigliano, Salvatore De Fazio & Giovambattista De Sarro. (2008) The safety of clozapine in the elderly. Expert Opinion on Drug Safety 7:5, pages 525-538.
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Articles from other publishers (311)

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Y. Saleh, I. Jarratt-Barnham, P. Petitet, E. Fernandez-Egea, S. G. Manohar & M. Husain. (2023) Negative symptoms and cognitive impairment are associated with distinct motivational deficits in treatment resistant schizophrenia. Molecular Psychiatry.
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Pramod Chandru & Naren Gunja. (2023) Toxicity and Adverse Effects in Clozapine-Related Presentations to a Medical Toxicology Service in Western Sydney. Journal of Medical Toxicology.
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