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Journal of the International Society of Sports Nutrition Volume 10, 2013 - Issue 1
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Research Article

Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

James P Lugo1 InterHealth Nutraceuticals94510BeniciaCAUSA
,
Zainulabedin M Saiyed1 InterHealth Nutraceuticals94510BeniciaCAUSA
,
Francis C Lau1 InterHealth Nutraceuticals94510BeniciaCAUSA
,
Jhanna Pamela L Molina2 Medicus Research LLC28720 Roadside Drive, Suite 31091301Agoura HillsCAUSA
,
Michael N Pakdaman2 Medicus Research LLC28720 Roadside Drive, Suite 31091301Agoura HillsCAUSA
,
Arya Nick Shamie3 UCLA Medical Center90401Santa MonicaCAUSA
&
Jay K Udani2 Medicus Research LLC28720 Roadside Drive, Suite 31091301Agoura HillsCAUSA;4 Northridge Hospital Integrative Medicine Program91325NorthridgeCAUSACorrespondence[email protected]
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Article: 48 | Published online: 01 Apr 2022

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Jeffrey Pradeep Raj, Shreeraam Venkatachalam & Rajkumar S. Amaravati. (2024) Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study. Journal of Dietary Supplements 21:1, pages 28-37.
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Shiloah A. Kviatkovsky, Robert C. Hickner, Hannah E. Cabre, Stephanie D. Small & Michael J. Ormsbee. (2023) Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. Journal of the International Society of Sports Nutrition 20:1.
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Yoshiaki Shiojima, Megumi Takahashi, Ryohei Takahashi, Kazuo Maruyama, Hiroyoshi Moriyama, Debasis Bagchi, Manashi Bagchi & Masanori Akanuma. (2023) Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Journal of the American Nutrition Association 42:3, pages 224-241.
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Robert B. Harris, Fernando L. A Fonseca, Matthew H. Sharp & Charlie R. Ottinger. (2022) Functional Characterization of Undenatured Type II Collagen Supplements: Are They Interchangeable?. Journal of Dietary Supplements 19:6, pages 717-732.
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James P. Lugo. (2019) Letter to the editor UC-II® Undenatured type II collagen: update to analytical methods. Journal of the International Society of Sports Nutrition 16:1.
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Chad M. Kerksick, Colin D. Wilborn, Michael D. Roberts, Abbie Smith-Ryan, Susan M. Kleiner, Ralf Jäger, Rick Collins, Mathew Cooke, Jaci N. Davis, Elfego Galvan, Mike Greenwood, Lonnie M. Lowery, Robert Wildman, Jose Antonio & Richard B. Kreider. (2018) ISSN exercise & sports nutrition review update: research & recommendations. Journal of the International Society of Sports Nutrition 15:1.
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Articles from other publishers (29)

Érika Thatyana Nascimento Santana, Saulo da Cunha Machado, Viviane Nascimento Brandão Lima, Valter Joviniano DeSantana Filho, Leonardo Yung dos Santos Maciel, Jader Pereira de Farias Neto, Henrique Douglas Melo Coutinho, Natália Martins, Walderi Monteiro da Silva Júnior & Lucindo J. Quintans Júnior. (2022) Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis. Wiener klinische Wochenschrift 135:11-12, pages 291-300.
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Cheng Luo, Weike Su, Ying Song & Shalini Srivastava. (2022) Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial. Journal of Experimental Orthopaedics 9:1.
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O. A. Gromova, I. Yu. Torshin & A. M. Lila. (2022) Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence. Modern Rheumatology Journal 16:5, pages 108-113.
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O. A. Shavlovskaya, I. V. Sarvilina, O. A. Gromova, M. N. Sharov, I. A. Bokova, Y. S. Prokofieva & N. I. Shavlovskiy. (2022) Pharmacotherapy of pain in musculoskeletal diseases: evolution and revolution of views. Neurology, Neuropsychiatry, Psychosomatics 14:4, pages 87-95.
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I. S. Dydykina, P. S. Kovalenko, A. A. Kovalenko & A. V. Aboleshina. (2022) The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints. Meditsinskiy sovet = Medical Council:14, pages 145-153.
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I. S. Dydykina, P. S. Kovalenko, A. A. Aboleshina & A. A. Kovalenko. (2022) The optimal way to fill the deficiency of essential substances for the well-being of the joints. Meditsinskiy sovet = Medical Council:11, pages 80-86.
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Christiane Schön, Katharina KnaubWilfried AltShane DurkeeZainulabedin SaiyedVijaya Juturu. (2022) UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of Integrative and Complementary Medicine 28:6, pages 540-548.
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O.A. Shavlovskaya, O.A. Gromova & I.Yu. Torshin. (2022) Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122:11, pages 40.
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Christiane Schön, Claudia Reule, Katharina Knaub, Antje Micka, Manfred Wilhelm, Wilfried Alt & Daniel Menzel. (2021) Evaluation and Validation of a Joint Stress Test to Induce Activity-Related Knee Joint Discomfort — a Prospective Case-Control Study. Sports Medicine - Open 7:1.
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Ali Mobasheri, Armaghan Mahmoudian, Ursule Kalvaityte, Ilona Uzieliene, Christina E. Larder, Michèle M. Iskandar, Stan Kubow, Paulo Cesar Hamdan, Cyro Scala de AlmeidaJrJr, Lacey J. Favazzo, Luc J.C. van Loon, Pieter J. Emans, Pérola G. Plapler & Michael J. Zuscik. (2021) A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?. Current Rheumatology Reports 23:11.
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Mishti Khatri, Robert J. Naughton, Tom Clifford, Liam D. Harper & Liam Corr. (2021) The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids 53:10, pages 1493-1506.
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J L Varney, J W Fowler & C N Coon. (2021) Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy Labrador Retrievers during an exercise regimen. Translational Animal Science 5:2.
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Cemal Orhan, Emre Sahin, Besir Er, Mehmet Tuzcu, Andrey P. Lopes, Nurhan Sahin, Vijaya Juturu & Kazim Sahin. (2021) Effects of Exercise Combined with Undenatured Type II Collagen on Endurance Capacity, Antioxidant Status, Muscle Lipogenic Genes and E3 Ubiquitin Ligases in Rats. Animals 11:3, pages 851.
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Miguel Garcia Arauzo, Álvaro Antón & José Domingo Villarroel. (2020) Collagen in the media: An analysis of news published between 2016 and 2018. Biochemistry and Molecular Biology Education 49:2, pages 242-250.
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Bastien Bourdon, Romain Contentin, Frédéric Cassé, Chloé Maspimby, Sarah Oddoux, Antoine Noël, Florence Legendre, Nicolas Gruchy & Philippe Galéra. (2021) Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favor Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids. International Journal of Molecular Sciences 22:2, pages 580.
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Germain Honvo, Laetitia Lengelé, Alexia Charles, Jean-Yves Reginster & Olivier Bruyère. (2020) Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping. Rheumatology and Therapy 7:4, pages 703-740.
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Zheng Yan, Hongyu Zhao, Aiqing Liu, Shuang Liu, Guoqing Zou & Haiyan Wang. (2020) The Effects of Undenatured Type II Collagen on Inflammatory Mediators and Oxidative Stress in an Osteoarthritis Rat Model. IOP Conference Series: Earth and Environmental Science 598:1, pages 012067.
Crossref
Jeffrey Pradeep Raj, Shreeraam Venkatachalam, Pranathi Racha, Sreejith Bhaskaran & Rajkumar S. Amaravati. (2020) Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy participants – A randomized placebo-controlled trial. Complementary Therapies in Medicine 53, pages 102522.
Crossref
Coen C.W.G. BongersDominique S.M. Ten HaafMilène CatoireBregina KerstenJeroen A. WoutersThijs M.H. EijsvogelsMaria T.E. Hopman. (2020) Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial. Applied Physiology, Nutrition, and Metabolism 45:7, pages 793-800.
Crossref
I. S. Dydykina, D. A. Dibrov, K. S. Nurbaeva, P. S. Kovalenko & A. A. Kovalenko. (2020) Biologically active additives in the 21st century: undenatured type II collagen as an example of good medical practice. Modern Rheumatology Journal 14:2, pages 131-137.
Crossref
Hasan Gencoglu, Cemal Orhan, Emre Sahin & Kazim Sahin. (2020) Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals 10:4, pages 697.
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Vanessa Oertzen-Hagemann, Marius Kirmse, Britta Eggers, Kathy Pfeiffer, Katrin Marcus, Markus de Marées & Petra Platen. (2019) Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients 11:5, pages 1072.
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Qian-Bin Luo, Chang-Feng Chi, Fan Yang, Yu-Qin Zhao & Bin Wang. (2018) Physicochemical properties of acid- and pepsin-soluble collagens from the cartilage of Siberian sturgeon. Environmental Science and Pollution Research 25:31, pages 31427-31438.
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Bjørn S. Skålhegg & Halvor Holm. (2018) Kollagen som vidunderkur mot underernæring, rynker og leddplager – myte eller virkelighet?. Norsk tidsskrift for ernæring 16:2, pages 22-26.
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C.M. Bagi, E.R. Berryman, S. Teo & N.E. Lane. (2017) Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis and Cartilage 25:12, pages 2080-2090.
Crossref
James P. Lugo, Zainulabedin M. Saiyed & Nancy E. Lane. (2016) Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal 15:1.
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Gitte S. JensenMiki R. LenningerJoni L. BeamanRobert TaylorKathleen F. Benson. (2015) Support of Joint Function, Range of Motion, and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate. Journal of Medicinal Food 18:9, pages 1042-1048.
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Marco Castori, Silvia Morlino, Giulia Pascolini, Carlo Blundo & Paola Grammatico. (2015) Gastrointestinal and nutritional issues in joint hypermobility syndrome/ehlers–danlos syndrome, hypermobility type. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 169:1, pages 54-75.
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Marco Castori, Michela Bruschini & Carlo Blundo. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 161 170 .

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