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Research Article

L-leucine, beta-hydroxy-beta-methylbutyric acid (HMB) and creatine monohydrate prevent myostatin-induced Akirin-1/Mighty mRNA down-regulation and myotube atrophy

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Christopher Brooks Mobley, Carlton D Fox, Brian S Ferguson, Corrie A Pascoe, James C Healy, Jeremy S McAdam, Christopher M Lockwood & Michael D Roberts. (2015) Effects of protein type and composition on postprandial markers of skeletal muscle anabolism, adipose tissue lipolysis, and hypothalamic gene expression. Journal of the International Society of Sports Nutrition 12:1.
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Mingfa Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Haifang Li, Yunlei Zhou & Hai Lin. (2022) Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes. Poultry Science 101:12, pages 102177.
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Mingfa Sun, Hongchao Jiao, Xiaojuan Wang, Haifang Li, Yunlei Zhou, Jingpeng Zhao & Hai Lin. (2022) The regulating pathway of creatine on muscular protein metabolism depends on the energy state. American Journal of Physiology-Cell Physiology 322:5, pages C1022-C1035.
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Myung-Hun Lee, Jin-Ho Lee, Wan-Joong Kim, Seo Ho Kim, Sun-Young Kim, Han Sung Kim & Tack-Joong Kim. (2022) Linoleic Acid Attenuates Denervation-Induced Skeletal Muscle Atrophy in Mice through Regulation of Reactive Oxygen Species-Dependent Signaling. International Journal of Molecular Sciences 23:9, pages 4778.
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Benjamin Wax, Chad M. Kerksick, Andrew R. Jagim, Jerry J. Mayo, Brian C. Lyons & Richard B. Kreider. (2021) Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients 13:6, pages 1915.
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Hossein Shirvani, Saleh Rahmati-Ahmadabad, Elias Kowsari, Hillary Fry, Maryam Kazemi & Mojtaba Kaviani. (2020) Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations. Gene 760, pages 145018.
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K. S. Reedoy, D. T. Loots, D. Beukes, M. van Reenen, B. Pillay & M. Pillay. (2020) Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis. Metabolomics 16:11.
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Peter J. Bosch, Stacey L. Peek, Sarit Smolikove & Joshua A. Weiner. (2020) Akirin proteins in development and disease: critical roles and mechanisms of action. Cellular and Molecular Life Sciences 77:21, pages 4237-4254.
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Orjeta Kuci, Eliane Archambault, Agnes Dodacki, Esther Nubret, Jean-Pascal De Bandt & Luc Cynober. (2020) Effect of citrulline on muscle protein turnover in an in vitro model of muscle catabolism. Nutrition 71, pages 110597.
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Ye Zhao, Jin-Yang Li, Qin Jiang, Xiao-Qiu Zhou, Lin Feng, Yang Liu, Wei-Dan Jiang, Pei Wu, Jian Zhou, Juan Zhao & Jun Jiang. (2020) Leucine Improved Growth Performance, Muscle Growth, and Muscle Protein Deposition Through AKT/TOR and AKT/FOXO3a Signaling Pathways in Hybrid Catfish Pelteobagrus vachelli × Leiocassis longirostris. Cells 9:2, pages 327.
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Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, James J. Valdés, Agustín Estrada-Peña, Pilar Alberdi & José de la Fuente. (2018) Functional Evolution of Subolesin/Akirin. Frontiers in Physiology 9.
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Milan Holeček. (2017) Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions. Journal of Cachexia, Sarcopenia and Muscle 8:4, pages 529-541.
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V. J. Dalbo, M. D. Roberts, C. B. Mobley, C. Ballmann, W. C. Kephart, C. D. Fox, V. A. Santucci, C. F. Conover, L. A. Beggs, A. Balaez, F. J. Hoerr, J. F. Yarrow, S. E. Borst & D. T. Beck. (2017) Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle. Andrologia 49:3, pages e12622.
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C.Brooks Mobley, Petey W. Mumford, John J. McCarthy, Michael E. Miller, Kaelin C. Young, Jeffrey S. Martin, Darren T. Beck, Christopher M. Lockwood & Michael D. Roberts. (2017) Whey protein-derived exosomes increase protein synthesis and hypertrophy in C2­C12 myotubes. Journal of Dairy Science 100:1, pages 48-64.
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Michele Guescini, Luca Tiano, Maria Luisa Genova, Emanuela Polidori, Sonia Silvestri, Patrik Orlando, Carmela Fimognari, Cinzia Calcabrini, Vilberto Stocchi & Piero Sestili. (2017) The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10. Oxidative Medicine and Cellular Longevity 2017, pages 1-19.
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Wenqiang Sun, Huilan Huang, Shengchao Ma, Xiang Gan, Mou Zhu, Hehe Liu, Liang Li & Jiwen Wang. (2016) Akirin2 could promote the proliferation but not the differentiation of duck myoblasts via the activation of the mTOR/p70S6K signaling pathway. The International Journal of Biochemistry & Cell Biology 79, pages 298-307.
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Piero Sestili, Patrizia Ambrogini, Elena Barbieri, Stefano Sartini, Carmela Fimognari, Cinzia Calcabrini, Anna Rita Diaz, Michele Guescini, Emanuela Polidori, Francesca Luchetti, Barbara Canonico, Davide Lattanzi, Riccardo Cuppini, Stefano Papa & Vilberto Stocchi. (2016) New insights into the trophic and cytoprotective effects of creatine in in vitro and in vivo models of cell maturation. Amino Acids 48:8, pages 1897-1911.
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