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Research Article

Adenosine 5′-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans

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Article: 16 | Published online: 01 Apr 2022

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Read on this site (5)

Chad M. Kerksick, Colin D. Wilborn, Michael D. Roberts, Abbie Smith-Ryan, Susan M. Kleiner, Ralf Jäger, Rick Collins, Mathew Cooke, Jaci N. Davis, Elfego Galvan, Mike Greenwood, Lonnie M. Lowery, Robert Wildman, Jose Antonio & Richard B. Kreider. (2018) ISSN exercise & sports nutrition review update: research & recommendations. Journal of the International Society of Sports Nutrition 15:1.
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Martin Purpura, John A. Rathmacher, Matthew H. Sharp, Ryan P. Lowery, Kevin A. Shields, Jeremy M. Partl, Jacob M. Wilson & Ralf Jäger. (2017) Oral Adenosine-5′-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout. Journal of the American College of Nutrition 36:3, pages 177-183.
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Jordan M. Joy, Roxanne M. Vogel, Jordan R. Moon, Paul H. Falcone, Matt M. Mosman & Michael P. Kim. (2016) Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men. Journal of the International Society of Sports Nutrition 13:1.
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Ralf Jäger, Michael D Roberts, Ryan P Lowery, Jordan M Joy, Clayton L Cruthirds, Christopher M Lockwood, John A Rathmacher, Martin Purpura & Jacob M Wilson. (2014) Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. Journal of the International Society of Sports Nutrition 11:1.
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John A Rathmacher, John C Fuller$suffix/text()$suffix/text(), Shawn M Baier, Naji N Abumrad, Hector F Angus & Rick L Sharp. (2012) Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. Journal of the International Society of Sports Nutrition 9:1.
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Articles from other publishers (12)

Justyna Suwara, Ewa Radzikowska-Cieciura, Arkadiusz Chworos & Roza Pawlowska. (2023) The ATP-dependent Pathways and Human Diseases. Current Medicinal Chemistry 30:11, pages 1232-1255.
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Helton Pereira dos Santos Nunes de Moura, Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. FullerJr.Jr. & Fabrício E. Rossi. (2021) Dose Response of Acute ATP Supplementation on Strength Training Performance. Frontiers in Sports and Active Living 3.
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Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. FullerJr.Jr., Lisa M. Pitchford, Fabricio E. Rossi & Chad M. Kerksick. (2021) Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation. Journal of Functional Foods 78, pages 104357.
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Lilia Espada, Alexander Dakhovnik, Prerana Chaudhari, Asya Martirosyan, Laura Miek, Tetiana Poliezhaieva, Yvonne Schaub, Ashish Nair, Nadia Döring, Norman Rahnis, Oliver Werz, Andreas Koeberle, Joanna Kirkpatrick, Alessandro Ori & Maria A. Ermolaeva. (2020) Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans. Nature Metabolism 2:11, pages 1316-1331.
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Ralf Jäger, Martin Purpura & John C. FullerJr.Jr.. (2020) Subchronic (90-Day) repeated dose toxicity study of disodium adenosine-5′-triphosphate in rats. Regulatory Toxicology and Pharmacology 116, pages 104760.
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Ana Miguel Cruz & Craig Beall. (2020) Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Frontiers in Physiology 11.
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Marcelo C. FreitasJason M. CholewaJose Gerosa-NetoDaniela C. GonçalvesErico C. Caperuto, Fábio S. LiraFabrício E. Rossi. (2019) A Single Dose of Oral ATP Supplementation Improves Performance and Physiological Response During Lower Body Resistance Exercise in Recreational Resistance-Trained Males. Journal of Strength and Conditioning Research 33:12, pages 3345-3352.
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Pedro L. Valenzuela, Javier S. Morales, Enzo Emanuele, Helios Pareja-Galeano & Alejandro Lucia. (2019) Supplements with purported effects on muscle mass and strength. European Journal of Nutrition 58:8, pages 2983-3008.
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Eliza Oprea, Lavinia L. Ruta & Ileana C. Farcasanu. 2019. Sports and Energy Drinks. Sports and Energy Drinks 65 129 .
Marcelo Conrado de Freitas, Ana Laura Ricci-Vitor, Renan Valero Freire, Erico Chagas Caperuto, Luiz Carlos Marques Vanderlei, Fábio Santos Lira & Fabrício Eduardo Rossi. (2018) Oral adenosine 5′-triphosphate supplementation improved hemodynamic and autonomic parameters after exercise in hypertensive women. Journal of Exercise Rehabilitation 14:4, pages 671-679.
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Jordan M. Joy, Roxanne M. Vogel, Jordan R. Moon, Paul H. Falcone, Matt M. Mosman, Zbigniew Pietrzkowski, Tania Reyes & Michael P. Kim. (2016) Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC Complementary and Alternative Medicine 16:1.
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Jordan M. JoyPaul H. FalconeRoxanne M. VogelMatt M. MosmanMichael P. KimJordan R. Moon. (2015) Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Applied Physiology, Nutrition, and Metabolism 40:11, pages 1171-1177.
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