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Research Article

Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats

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Article: 18 | Published online: 01 Apr 2022

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Michael Munroe, Ziad S. Mahmassani, Svyatoslav Dvoretskiy, Justin J. Reid, Benjamin F. Miller, Karyn Hamilton, Justin S. Rhodes & Marni D. Boppart. (2020) Cognitive function is preserved in aged mice following long-term β-hydroxy β-methylbutyrate supplementation. Nutritional Neuroscience 23:3, pages 170-182.
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Jacob M Wilson, Peter J Fitschen, Bill Campbell, Gabriel J Wilson, Nelo Zanchi, Lem Taylor, Colin Wilborn, Douglas S Kalman, Jeffrey R Stout, Jay R Hoffman, Tim N Ziegenfuss, Hector L Lopez, Richard B Kreider, Abbie E Smith-Ryan & Jose Antonio. (2013) International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). Journal of the International Society of Sports Nutrition 10:1.
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Articles from other publishers (34)

Sena IWAMURA, Toshimi KAIDO, Akira WADA, Satoshi KIDO, Daisuke HARADA, Masaaki HIRATA, Yosuke MIYACHI, Siyuan YAO, Shintaro YAGI, Naoko KAMO, Satoshi MORITA, Shinji UEMOTO & Etsuro HATANO. (2022) Perioperative Oral β-Hydroxy-β-Methylbutyrate Supplementation Ameliorates Sarcopenia in Rats Undergoing Major Hepatectomy. Journal of Nutritional Science and Vitaminology 68:4, pages 276-283.
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Alireza Jahan-mihan & Natalie Wrightson. (2022) The Effect of Beta-Hydroxy-Beta-Methyl Butyrate in Response to Exercise and High-Fat Diet on Body Weight, Body Composition and Characteristics of Metabolic Syndrome in Male Wistar Rats. Journal of Exercise and Nutrition 5:3.
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Jie Zheng, Changbing Zheng, Bo Song, Qiuping Guo, Yinzhao Zhong, Shiyu Zhang, Lingyu Zhang, Geyan Duan, Fengna Li & Yehui Duan. (2021) HMB Improves Lipid Metabolism of Bama Xiang Mini-Pigs via Modulating the Bacteroidetes-Acetic Acid-AMPKα Axis. Frontiers in Microbiology 12.
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Jie Zheng, Hao Xiao, Yehui Duan, Bo Song, Changbing Zheng, Qiuping Guo, Fengna Li & Tiejun Li. (2021) Roles of amino acid derivatives in the regulation of obesity. Food & Function 12:14, pages 6214-6225.
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Ewa Tomaszewska, Janine Donaldson, Jakub Kosiński, Piotr Dobrowolski, Agnieszka Tomczyk-Warunek, Monika Hułas-Stasiak, Krzysztof Lamorski, Dorota Laskowska-Woźniak, Siemowit Muszyński, Rudolf Blicharski & Tomasz Blicharski. (2021) β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model. International Journal of Molecular Sciences 22:6, pages 3047.
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Roman Wójcik, Katarzyna Ząbek, Joanna Małaczewska, Stanisław Milewski & Edyta Kaczorek-Łukowska. (2019) The Effects of β-Hydroxy-β-Methylbutyrate (HMB) on Chemotaxis, Phagocytosis, and Oxidative Burst of Peripheral Blood Granulocytes and Monocytes in Goats. Animals 9:12, pages 1031.
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Yehui Duan, Changbing Zheng, Yinzhao Zhong, Bo Song, Zhaoming Yan, Xiangfeng Kong, Jinping Deng, Fengna Li & Yulong Yin. (2019) Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge . Food & Function 10:8, pages 5152-5165.
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Hossein Shirvani, Saleh Rahmati-Ahmadabad, David Robert Broom & Reza Mirnejad. (2019) Eccentric resistance training and β-Hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin. Journal of Experimental Biology.
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Orie Yoshinari & Hiroyoshi Moriyama. 2019. Nutrition and Enhanced Sports Performance. Nutrition and Enhanced Sports Performance 675 682 .
Mariëlle P.K.J. Engelen & Nicolaas E.P. Deutz. (2018) Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?. Current Opinion in Clinical Nutrition & Metabolic Care 21:3, pages 207-213.
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Rahima A. Bhanji, Praveena Narayanan, Alina M. Allen, Harmeet Malhi & Kymberly D. Watt. (2017) Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis. Hepatology 66:6, pages 2055-2065.
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Andrea P. Rossi, Alessia D’Introno, Sofia Rubele, Cesare Caliari, Stefano Gattazzo, Elena Zoico, Gloria Mazzali, Francesco Fantin & Mauro Zamboni. (2017) The Potential of β-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity. Drugs & Aging 34:11, pages 833-840.
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Krzysztof Durkalec-Michalski, Jan Jeszka & Tomasz Podgórski. (2017) The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study. Nutrients 9:7, pages 753.
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Tomasz Blicharski, Ewa Tomaszewska, Piotr Dobrowolski, Monika Hułas-Stasiak & Siemowit Muszyński. (2017) A metabolite of leucine (β-hydroxy-β-methylbutyrate) given to sows during pregnancy alters bone development of their newborn offspring by hormonal modulation. PLOS ONE 12:6, pages e0179693.
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David W. Russ, C. Acksel, K. W. McCorkle, N. K. Edens & S. M. Garvey. (2016) Effects of running wheel activity and dietary HMB and B—alanine co-supplementation on muscle quality in aged male rats. The journal of nutrition, health & aging 21:5, pages 554-561.
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Daniel G. Kougias, Emily R. Hankosky, Joshua M. Gulley & Janice M. Juraska. (2017) Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats. Physiology & Behavior 170, pages 93-99.
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Peter J. Fitschen, Annabel Biruete, Jinny Jeong & Kenneth R. Wilund. (2017) Efficacy of beta-hydroxy-beta-methylbutyrate supplementation in maintenance hemodialysis patients. Hemodialysis International 21:1, pages 107-116.
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Michael Munroe, Yair Pincu, Jennifer Merritt, Adam Cobert, Ryan Brander, Tor Jensen, Justin Rhodes & Marni D. Boppart. (2017) Impact of β-hydroxy β-methylbutyrate (HMB) on age-related functional deficits in mice. Experimental Gerontology 87, pages 57-66.
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Giovana Rampazzo Teixeira, Luis Alberto Gobbo, Nilton José dos Santos, Rafael Gavassa de Araújo, Carolina Cabral dos Santos, Olga Cristina de Mello Malheiro, Robson Chacon Castoldi, Jose Carlos Silva Camargo-Filho & Marcelo Papoti. (2016) The effect of β-hydroxy-β-methylbutyrate (HMB) on the morphology of skeletal muscle after concurrent training. Motriz: Revista de Educação Física 22:3, pages 190-197.
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Krzysztof Durkalec-Michalski & Jan Jeszka. (2016) The Effect of β-Hydroxy-β-Methylbutyrate on Aerobic Capacity and Body Composition in Trained Athletes. Journal of Strength and Conditioning Research 30:9, pages 2617-2626.
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Rebecca Kuriyan, Deepa P. Lokesh, Sumithra Selvam, J. Jayakumar, Mamatha G. Philip, Sathyavageeswaran Shreeram & Anura V. Kurpad. (2016) The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans. Experimental Gerontology 81, pages 13-18.
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Daniel G. Kougias, Suzanne O. Nolan, Wendy A. Koss, Taehyeon Kim, Emily R. Hankosky, Joshua M. Gulley & Janice M. Juraska. (2016) Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats. Neurobiology of Aging 40, pages 78-85.
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Akira Wagatsuma, Masataka Shiozuka, Yuzo Takayama, Takayuki Hoshino, Kunihiko Mabuchi & Ryoichi Matsuda. (2015) Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle. Molecular and Cellular Biochemistry 412:1-2, pages 59-72.
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David W. RussCara AckselIva M. BoydJohn MaynardKatherine W. McCorkleNeile K. EdensSean M. Garvey. (2015) Dietary HMB and β-alanine co-supplementation does not improve in situ muscle function in sedentary, aged male rats. Applied Physiology, Nutrition, and Metabolism 40:12, pages 1294-1301.
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Mary Hickson. (2015) Nutritional interventions in sarcopenia: a critical review. Proceedings of the Nutrition Society 74:4, pages 378-386.
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Rafael Salto, Jose D. Vílchez, María D. Girón, Elena Cabrera, Nefertiti Campos, Manuel Manzano, Ricardo Rueda & Jose M. López-Pedrosa. (2015) β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells. PLOS ONE 10:8, pages e0135614.
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K. A. Szcześniak, P. Ostaszewski, J. C. FullerJrJr, A. Ciecierska & T. Sadkowski. (2015) Dietary supplementation of β-hydroxy-β-methylbutyrate in animals - a review. Journal of Animal Physiology and Animal Nutrition 99:3, pages 405-417.
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María D. Girón, Jose D. Vílchez, Sathyavageeswaran Shreeram, Rafael Salto, Manuel Manzano, Elena Cabrera, Nefertiti Campos, Neile K. Edens, Ricardo Rueda & Jose M. López-Pedrosa. (2015) β-Hydroxy-β-Methylbutyrate (HMB) Normalizes Dexamethasone-Induced Autophagy-Lysosomal Pathway in Skeletal Muscle. PLOS ONE 10:2, pages e0117520.
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Nathaniel D.M. Jenkins, Samuel L. Buckner, Kristen C. Cochrane, Haley C. Bergstrom, Ty B. Palmer, Glen O. Johnson, Richard J. Schmidt, Terry J. Housh & Joel T. Cramer. (2014) Age-related differences in rates of torque development and rise in EMG are eliminated by normalization. Experimental Gerontology 57, pages 18-28.
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Everson A. NunesLuiz M. Gonçalves-NetoFrancielle B.D. FerreiraCristiane dos SantosLuiz C. FernandesAntonio C. BoscheroPhilip C. CalderAlex Rafacho. (2013) Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats. Applied Physiology, Nutrition, and Metabolism 38:11, pages 1137-1146.
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Jeffrey R. Stout, Abbie E. Smith-Ryan, David H. Fukuda, Kristina L. Kendall, Jordan R. Moon, Jay R. Hoffman, Jacob M. Wilson, Jeffery S. Oliver & Vikkie A. Mustad. (2013) Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial. Experimental Gerontology 48:11, pages 1303-1310.
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Brennan J. Thompson, Eric D. Ryan, Eric J. Sobolewski, Eric C. Conchola & Joel T. Cramer. (2013) Age related differences in maximal and rapid torque characteristics of the leg extensors and flexors in young, middle-aged and old men. Experimental Gerontology 48:2, pages 277-282.
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Peter J. Fitschen, Gabriel J. Wilson, Jacob M. Wilson & Kenneth R. Wilund. (2013) Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations. Nutrition 29:1, pages 29-36.
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Jeong-Su Kim, Young-Min Park, Sang-Rok Lee, Ihssan S. Masad, Andy V. Khamoui, Edward Jo, Bong-Sup Park, Bahram H. Arjmandi, Lynn B. Panton, Won Jun Lee & Samuel C. Grant. (2012) β-hydroxy-β-methylbutyrate did not enhance high intensity resistance training-induced improvements in myofiber dimensions and myogenic capacity in aged female rats. Molecules and Cells 34:5, pages 439-448.
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