Latent Class Models for Joint Analysis of Longitudinal Biomarker and Event Process Data

Application to Longitudinal Prostate-Specific Antigen Readings and Prostate Cancer

Haiqun Lin Haiqun Lin is Assistant Professor, Division of Biostatistics, Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520 (Email: . Bruce W. Turnbull is Professor and Chair, Department of Statistical Science, Cornell University, Ithaca, NY 14853 . Charles E. McCulloch is Professor and Head, Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 . Elizabeth H. Slate is Associate Professor, Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425 (Email: . This article is based in part on the thesis of the first author in partial satisfaction for Ph.D. degree requirements at Cornell University. The research was supported by grants from the U.S. National Institutes of Health. The authors acknowledge Larry Clark of the Arizona Cancer Center for making the NPC trials data available to them and for his support of this research. Larry Clark passed away on March 20, 2000 from complications of prostate cancer before he could see the results. He was an esteemed colleague who highly valued the contributions of statistics to medical research. He will be dearly missed. The authors thank the editor, the associate editor, and the three referees for their constructive and thoughtful comments.

Bruce W Turnbull Haiqun Lin is Assistant Professor, Division of Biostatistics, Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520 (Email: . Bruce W. Turnbull is Professor and Chair, Department of Statistical Science, Cornell University, Ithaca, NY 14853 . Charles E. McCulloch is Professor and Head, Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 . Elizabeth H. Slate is Associate Professor, Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425 (Email: . This article is based in part on the thesis of the first author in partial satisfaction for Ph.D. degree requirements at Cornell University. The research was supported by grants from the U.S. National Institutes of Health. The authors acknowledge Larry Clark of the Arizona Cancer Center for making the NPC trials data available to them and for his support of this research. Larry Clark passed away on March 20, 2000 from complications of prostate cancer before he could see the results. He was an esteemed colleague who highly valued the contributions of statistics to medical research. He will be dearly missed. The authors thank the editor, the associate editor, and the three referees for their constructive and thoughtful comments.

Charles E McCulloch Haiqun Lin is Assistant Professor, Division of Biostatistics, Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520 (Email: . Bruce W. Turnbull is Professor and Chair, Department of Statistical Science, Cornell University, Ithaca, NY 14853 . Charles E. McCulloch is Professor and Head, Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 . Elizabeth H. Slate is Associate Professor, Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425 (Email: . This article is based in part on the thesis of the first author in partial satisfaction for Ph.D. degree requirements at Cornell University. The research was supported by grants from the U.S. National Institutes of Health. The authors acknowledge Larry Clark of the Arizona Cancer Center for making the NPC trials data available to them and for his support of this research. Larry Clark passed away on March 20, 2000 from complications of prostate cancer before he could see the results. He was an esteemed colleague who highly valued the contributions of statistics to medical research. He will be dearly missed. The authors thank the editor, the associate editor, and the three referees for their constructive and thoughtful comments.

Elizabeth H Slate Haiqun Lin is Assistant Professor, Division of Biostatistics, Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520 (Email: . Bruce W. Turnbull is Professor and Chair, Department of Statistical Science, Cornell University, Ithaca, NY 14853 . Charles E. McCulloch is Professor and Head, Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 . Elizabeth H. Slate is Associate Professor, Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425 (Email: . This article is based in part on the thesis of the first author in partial satisfaction for Ph.D. degree requirements at Cornell University. The research was supported by grants from the U.S. National Institutes of Health. The authors acknowledge Larry Clark of the Arizona Cancer Center for making the NPC trials data available to them and for his support of this research. Larry Clark passed away on March 20, 2000 from complications of prostate cancer before he could see the results. He was an esteemed colleague who highly valued the contributions of statistics to medical research. He will be dearly missed. The authors thank the editor, the associate editor, and the three referees for their constructive and thoughtful comments.

Latent Class Models for Joint Analysis of Longitudinal Biomarker and Event Process Data

Application to Longitudinal Prostate-Specific Antigen Readings and Prostate Cancer

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Latent Class Models for Joint Analysis of Longitudinal Biomarker and Event Process Data

Application to Longitudinal Prostate-Specific Antigen Readings and Prostate Cancer

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