Comparison of Discrimination Methods for the Classification of Tumors Using Gene Expression Data

Sandrine Dudoit Sandrine Dudoit is Assistant Professor, Division of Biostatistics, University of California, Berkeley, Berkeley, CA 94720 . Jane Fridlyand is a Postdoctoral Scientist at the UCSF Cancer Center, San Francisco, CA 94143 . Terence P. Speed is Professor, Department of Statistics, University of California, Berkeley, Berkeley, CA 94720 . This work was supported in part by an MSRI postdoctoral fellowship, a PMMB Burroughs–Wellcome fellowship, and by National Institutes of Health grant R01GM59506 (TPS). The authors are grateful to Ash Alizadeh, Pat Brown, Mike Eisen, and Doug Ross for providing access to their data. Pablo Tamayo's assistance with the ALL/AML data is greatly appreciated. Finally, the authors thank Leo Breiman, Yoram Gat, David Nelson, Mark van der Laan, and Yee Hwa Yang for many helpful discussions and suggestions, Sam Buttrey for his nearest-neighbor program, and the referees for their comments on an earlier version of this article. Supplementary analyses and figures are available at http://www.stat.berkeley.edu/users/terry/zarray/html. Dudoit and Fridlyand contributed equally to this work.

Jane Fridlyand Sandrine Dudoit is Assistant Professor, Division of Biostatistics, University of California, Berkeley, Berkeley, CA 94720 . Jane Fridlyand is a Postdoctoral Scientist at the UCSF Cancer Center, San Francisco, CA 94143 . Terence P. Speed is Professor, Department of Statistics, University of California, Berkeley, Berkeley, CA 94720 . This work was supported in part by an MSRI postdoctoral fellowship, a PMMB Burroughs–Wellcome fellowship, and by National Institutes of Health grant R01GM59506 (TPS). The authors are grateful to Ash Alizadeh, Pat Brown, Mike Eisen, and Doug Ross for providing access to their data. Pablo Tamayo's assistance with the ALL/AML data is greatly appreciated. Finally, the authors thank Leo Breiman, Yoram Gat, David Nelson, Mark van der Laan, and Yee Hwa Yang for many helpful discussions and suggestions, Sam Buttrey for his nearest-neighbor program, and the referees for their comments on an earlier version of this article. Supplementary analyses and figures are available at http://www.stat.berkeley.edu/users/terry/zarray/html. Dudoit and Fridlyand contributed equally to this work.

Terence P Speed Sandrine Dudoit is Assistant Professor, Division of Biostatistics, University of California, Berkeley, Berkeley, CA 94720 . Jane Fridlyand is a Postdoctoral Scientist at the UCSF Cancer Center, San Francisco, CA 94143 . Terence P. Speed is Professor, Department of Statistics, University of California, Berkeley, Berkeley, CA 94720 . This work was supported in part by an MSRI postdoctoral fellowship, a PMMB Burroughs–Wellcome fellowship, and by National Institutes of Health grant R01GM59506 (TPS). The authors are grateful to Ash Alizadeh, Pat Brown, Mike Eisen, and Doug Ross for providing access to their data. Pablo Tamayo's assistance with the ALL/AML data is greatly appreciated. Finally, the authors thank Leo Breiman, Yoram Gat, David Nelson, Mark van der Laan, and Yee Hwa Yang for many helpful discussions and suggestions, Sam Buttrey for his nearest-neighbor program, and the referees for their comments on an earlier version of this article. Supplementary analyses and figures are available at http://www.stat.berkeley.edu/users/terry/zarray/html. Dudoit and Fridlyand contributed equally to this work.

Comparison of Discrimination Methods for the Classification of Tumors Using Gene Expression Data

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Comparison of Discrimination Methods for the Classification of Tumors Using Gene Expression Data

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