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Journal of the American Statistical Association Volume 104, 2009 - Issue 486
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Applications and Case Studies

Nonparametric Residue Analysis of Dynamic PET Data With Application to Cerebral FDG Studies in Normals

Finbarr O'Sullivan Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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Mark Muzi Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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Alexander M. Spence Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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David M. Mankoff Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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Janet N. O'Sullivan Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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Niall Fitzgerald Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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George C. Newman Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
&
Kenneth A. Krohn Finbarr O'Sullivan is Professor of Statistics, University College Cork, Ireland and Affiliate Professor of Radiology, University of Washington, Seattle, WA 98195 . Mark Muzi is Director of Image Analysis, Department of Radiology, University of Washington, Seattle, WA 98195. Alexander M. Spence is Professor of Neurology, University of Washington, Seattle, WA 98195. David M. Mankoff is Professor of Radiology, University of Washington, Seattle, WA 98195. Janet N. O'Sullivan is Research Scientist, University College Cork, Ireland. Niall Fitzgerald is Ph.D. student, University College Cork, Ireland. George C. Newman is Chair of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA. Kenneth A. Krohn is Professor of Radiology, University of Washington, Seattle, WA 98195. This research was supported in part by the National Institutes of Health (USA) under CA-42045 and by the Health Research Board (Ireland) under RP-289 and Science Foundation Ireland under MI-2007
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Pages 556-571 | Received 01 Nov 2007, Published online: 01 Jan 2012

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Yakuan Chen, Jeff Goldsmith & R. Todd Ogden. (2019) Functional Data Analysis of Dynamic PET Data. Journal of the American Statistical Association 114:526, pages 595-609.
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Ci-Ren Jiang, John A. D. Aston & Jane-Ling Wang. (2016) A Functional Approach to Deconvolve Dynamic Neuroimaging Data. Journal of the American Statistical Association 111:513, pages 1-13.
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Articles from other publishers (22)

Fengyun Gu & Qi Wu. (2023) Quantitation of dynamic total-body PET imaging: recent developments and future perspectives. European Journal of Nuclear Medicine and Molecular Imaging.
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Zhaoyan Xiu, Mark Muzi, Jian Huang & Eric Wolsztynski. (2023) Patient-Adaptive Population-Based Modeling of Arterial Input Functions. IEEE Transactions on Medical Imaging 42:1, pages 132-147.
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G. P. Ralli, R. D. Carter, D. R. McGowan, W.-C. Cheng, D. Liu, E. J. Teoh, N. Patel, F. Gleeson, A. L. Harris, S. R. Lord, F. M. Buffa & J. D. Fenwick. (2022) Radiogenomic analysis of primary breast cancer reveals [18F]-fluorodeoxglucose dynamic flux-constants are positively associated with immune pathways and outperform static uptake measures in associating with glucose metabolism. Breast Cancer Research 24:1.
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Yaping Wu, Tao Feng, Yu Shen, Fangfang Fu, Nan Meng, Xiaochen Li, Tianyi Xu, Tao Sun, Fengyun Gu, Qi Wu, Yun Zhou, Hui Han, Yan Bai & Meiyun Wang. (2022) Total‐body parametric imaging using the Patlak model: Feasibility of reduced scan time. Medical Physics 49:7, pages 4529-4539.
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Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot & David A. Mankoff. (2022) Principles of Tracer Kinetic Analysis in Oncology, Part I: Principles and Overview of Methodology. Journal of Nuclear Medicine 63:3, pages 342-352.
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Baoyi Shi & R. Todd Ogden. (2021) Inference in functional mixed regression models with applications to Positron Emission Tomography imaging data. Statistics in Medicine 40:21, pages 4640-4659.
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Finbarr O’Sullivan, Fengyun Gu, Qi Wu & Liam D O’Suilleabhain. (2021) A Generalized Linear modeling approach to bootstrapping multi-frame PET image data. Medical Image Analysis 72, pages 102132.
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Fengyun Gu, Finbarr O’Sullivan, Mark Muzi & David A Mankoff. (2021) Quantitation of multiple injection dynamic PET scans: an investigation of the benefits of pooling data from separate scans when mapping kinetics. Physics in Medicine & Biology 66:13, pages 135010.
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Varsha Viswanath, Rhea Chitalia, Austin R. Pantel, Joel S. Karp & David A. Mankoff. (2021) Analysis of Four-Dimensional Data for Total Body PET Imaging. PET Clinics 16:1, pages 55-64.
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Fengyun Gu, Finbarr O'Sullivan, Mark Muzi & David A. Mankoff. (2019) A Simple Evaluation of the Benefit of Combined Kinetic Analysis of Multiple Injection Dynamic PET Scans. A Simple Evaluation of the Benefit of Combined Kinetic Analysis of Multiple Injection Dynamic PET Scans.
Fengyun Gu, Qi Wu, Finbarr O'Sullivan, Jian Huang, Mark Muzi & David A. Mankoff. (2019) An Illustration of the Use of Model-Based Bootstrapping for Evaluation of Uncertainty in Kinetic Information Derived from Dynamic PET. An Illustration of the Use of Model-Based Bootstrapping for Evaluation of Uncertainty in Kinetic Information Derived from Dynamic PET.
George P Ralli, Michael A Chappell, Daniel R McGowan, Ricky A Sharma, Geoff S Higgins & John D Fenwick. (2018) 4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties. Physics in Medicine & Biology 63:9, pages 095013.
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Georgia Keramida, Constantinos D. Anagnostopoulos & A. Michael Peters. (2017) The extent to which standardized uptake values reflect FDG phosphorylation in the liver and spleen as functions of time after injection of 18F-fluorodeoxyglucose. EJNMMI Research 7:1.
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Francesca Zanderigo, J. John Mann & R. Todd Ogden. (2017) A hybrid deconvolution approach for estimation of in vivo non-displaceable binding for brain PET targets without a reference region. PLOS ONE 12:5, pages e0176636.
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Francesca Zanderigo, Ramin V Parsey & R Todd Ogden. (2015) Model-Free Quantification of Dynamic PET Data Using Nonparametric Deconvolution. Journal of Cerebral Blood Flow & Metabolism 35:8, pages 1368-1379.
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Finbarr O’Sullivan, Mark Muzi, David A. Mankoff, Janet F. Eary, Alexander M. Spence & Kenneth A. Krohn. (2014) Voxel-level mapping of tracer kinetics in PET studies: A statistical approach emphasizing tissue life tables. The Annals of Applied Statistics 8:2.
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Jian Huang & Finbarr O'Sullivan. (2014) An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction. IEEE Transactions on Medical Imaging 33:5, pages 1093-1108.
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Mark Muzi, Finbarr O'Sullivan, David A. Mankoff, Robert K. Doot, Larry A. Pierce, Brenda F. Kurland, Hannah M. Linden & Paul E. Kinahan. (2012) Quantitative assessment of dynamic PET imaging data in cancer imaging. Magnetic Resonance Imaging 30:9, pages 1203-1215.
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David Hawe, Francisco R. Hernández Fernández, Liam O'Suilleabháin, Jian Huang, Eric Wolsztynski & Finbarr O'Sullivan. (2012) Kinetic analysis of dynamic positron emission tomography data using open-source image processing and statistical inference tools. Wiley Interdisciplinary Reviews: Computational Statistics 4:3, pages 316-322.
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Giampaolo Tomasi, Federico Turkheimer & Eric Aboagye. (2011) Importance of Quantification for the Analysis of PET Data in Oncology: Review of Current Methods and Trends for the Future. Molecular Imaging and Biology 14:2, pages 131-146.
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Francisco Hernandez Fernandez, David Hawe, Liam O'Suilleabhain, Eric Wolsztynski, Jian Huang, Mark Muzi & Finbarr O'Sullivan. (2011) Kinetic analysis of dynamic <sup>18</sup>F-FDG and <sup>15</sup>O-H<inf>2</inf>O PET studies by parametric and nonparametric methods: A statistical analysis. Kinetic analysis of dynamic <sup>18</sup>F-FDG and <sup>15</sup>O-H<inf>2</inf>O PET studies by parametric and nonparametric methods: A statistical analysis.
Stephen Cunnane, Scott Nugent, Maggie Roy, Alexandre Courchesne-Loyer, Etienne Croteau, Sébastien Tremblay, Alex Castellano, Fabien Pifferi, Christian Bocti, Nancy Paquet, Hadi Begdouri, M’hamed Bentourkia, Eric Turcotte, Michèle Allard, Pascale Barberger-Gateau, Tamas Fulop & Stanley I. Rapoport. (2011) Brain fuel metabolism, aging, and Alzheimer’s disease. Nutrition 27:1, pages 3-20.
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