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Original Articles

Effects of the Bowman-Birk Inhibitor on Clonogenic Survival and Cisplatin- or Radiation-Induced Cytotoxicity in Human Breast, Cervical, and Head and Neck Cancer Cells

Pages 165-173 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Chanchitha Chandran, P. Smitha & D. Gayathri Devi. (2022) Seed Protein from Artocarpus hirsutus Lam. with Trypsin Inhibitory, Micro-bicidal and Antioxidant Activities Induces Depletion of Human Skin Cancer (A431) and Colon Cancer (HT29) Cells. Journal of Biologically Active Products from Nature 12:1, pages 65-76.
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Sladjana P. Stanojevic, Miroljub B. Barać, Aleksandar Ž. Kostić & Mirjana B. Pešić. (2021) Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing. Journal of Environmental Science and Health, Part B 56:3, pages 292-296.
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PamelaJ. Magee, Richard Owusu-Apenten, MarkJ. McCann, ChrisI. Gill & IanR. Rowland. (2012) Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro. Nutrition and Cancer 64:5, pages 741-748.
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Articles from other publishers (23)

M. S. Cid-Gallegos, L. J. Corzo-Ríos, C. Jiménez-Martínez & X. M. Sánchez-Chino. (2022) Protease Inhibitors from Plants as Therapeutic Agents- A Review. Plant Foods for Human Nutrition 77:1, pages 20-29.
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Sheyla V. Lucena, Fabíola P. Rufino, Gioconda Emanuella Diniz de Dantas Moura, Luciana M. A. Rabêlo, Norberto K. V. Monteiro, André T. Ferreira, Jonas E. Aguilar Perales, Adriana F. Uchôa, Giselle Z. Justo, Caio F. R. de Oliveira, Ludovico Migliolo, Helena Bonciani Nader, Elizeu A. Santos & Adeliana S. Oliveira. (2021) The Kunitz chymotrypsin inhibitor from Erythrina velutina seeds displays activity against HeLa cells through arrest in cell cycle. 3 Biotech 12:1.
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Agata Gitlin-Domagalska, Aleksandra Maciejewska & Dawid Dębowski. (2020) Bowman-Birk Inhibitors: Insights into Family of Multifunctional Proteins and Peptides with Potential Therapeutical Applications. Pharmaceuticals 13:12, pages 421.
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Sanja Milkovska‐Stamenova, Laura Krieg & Ralf Hoffmann. (2018) Products of Early and Advanced Glycation in the Soy Milk Proteome. Molecular Nutrition & Food Research 63:2, pages 1800725.
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Graziella Anselmo Joanitti, Rupa S. Sawant, Vladimir P. Torchilin, Sonia Maria de Freitas & Ricardo Bentes Azevedo. (2018) Optimizing liposomes for delivery of Bowman-Birk protease inhibitors — Platforms for multiple biomedical applications. Colloids and Surfaces B: Biointerfaces 167, pages 474-482.
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Xiaodong Cui, Zhuanhua Wang, Yuying Li & Chen Li. (2013) Buckwheat trypsin inhibitor enters Hep G2 cells by clathrin-dependent endocytosis. Food Chemistry 141:3, pages 2625-2633.
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Hari B. Krishnan, Sungchan Jang, Ivan Baxter & William J. Wiebold. (2012) Growing Location has a Pronounced Effect on the Accumulation of Cancer Chemopreventive Agent Bowman-Birk Inhibitor in Soybean Seeds. Crop Science 52:4, pages 1786-1794.
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Manoj H. Palavalli, Savithiry S. Natarajan, Thomas T. Y. Wang & Hari B. Krishnan. (2012) Imbibition of Soybean Seeds in Warm Water Results in the Release of Copious Amounts of Bowman–Birk Protease Inhibitor, a Putative Anticarcinogenic Agent. Journal of Agricultural and Food Chemistry 60:12, pages 3135-3143.
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J. K. Sanzari, C. Wambi, J. S. Lewis-Wambi & A. R. Kennedy. (2011) Antioxidant Dietary Supplementation in Mice Exposed to Proton Radiation Attenuates Expression of Programmed Cell Death-Associated Genes. Radiation Research 175:5, pages 650-656.
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Graziella Anselmo Joanitti, Ricardo Bentes Azevedo & Sonia Maria Freitas. (2010) Apoptosis and lysosome membrane permeabilization induction on breast cancer cells by an anticarcinogenic Bowman–Birk protease inhibitor from Vigna unguiculata seeds. Cancer Letters 293:1, pages 73-81.
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Blanca Hernández-LedesmaBen O. De Lumen. (2008) Lunasin: A Novel Cancer Preventive Seed Peptide. Perspectives in Medicinal Chemistry 2, pages PMC.S372.
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Alessio Scarafoni, Chiara Magni & Marcello Duranti. (2007) Molecular nutraceutics as a mean to investigate the positive effects of legume seed proteins on human health. Trends in Food Science & Technology 18:9, pages 454-463.
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Stefano Capaldi, Massimiliano Perduca, Beniamino Faggion, Maria E. Carrizo, Aldo Tava, Laura Ragona & Hugo L. Monaco. (2007) Crystal structure of the anticarcinogenic Bowman–Birk inhibitor from snail medic (Medicago scutellata) seeds complexed with bovine trypsin. Journal of Structural Biology 158:1, pages 71-79.
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Raushan T. Kurmasheva & Peter J. Houghton. (2006) IGF-I mediated survival pathways in normal and malignant cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1766:1, pages 1-22.
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Alfonso Clemente, Jennifer M. Gee, Ian T. Johnson, Donald A. MacKenzie & Claire Domoney. (2005) Pea ( Pisum sativum L.) Protease Inhibitors from the Bowman−Birk Class Influence the Growth of Human Colorectal Adenocarcinoma HT29 Cells in Vitro . Journal of Agricultural and Food Chemistry 53:23, pages 8979-8986.
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Ann Kennedy. 2005. Soy in Health and Disease Prevention. Soy in Health and Disease Prevention 207 223 .
Miroljub BaracB.B., Sladjana StanojevicP.P. & Mirjana PesicB.B.. (2005) Biologically active components of soybeans and soy protein products: A review. Acta Periodica Technologica:36, pages 155-168.
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John F. Dicello. (2003) THE IMPACT OF THE NEW BIOLOGY ON RADIATION RISKS IN SPACE. Health Physics 85:1, pages 94-102.
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Trevor L. Wang, Claire Domoney, Cliff L. Hedley, Rod Casey & Michael A. Grusak. (2003) Can We Improve the Nutritional Quality of Legume Seeds?. Plant Physiology 131:3, pages 886-891.
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Ann R. Kennedy & X. Steven Wan. (2002) Effects of the Bowman‐Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells*. The Prostate 50:2, pages 125-133.
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David J. Sessa & Walter J Wolf. (2001) Bowman–Birk inhibitors in soybean seed coats. Industrial Crops and Products 14:1, pages 73-83.
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Mendel Friedman & David L. Brandon. (2001) Nutritional and Health Benefits of Soy Proteins. Journal of Agricultural and Food Chemistry 49:3, pages 1069-1086.
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Ali Reza Waladkhani & Michael Clemens. 2000. Vegetables, Fruits, and Herbs in Health Promotion. Vegetables, Fruits, and Herbs in Health Promotion.

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